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| 1 | An in vivo study of the biodistribution of gold nanoparticles after intervaginal space injection in the tarsal tunnel显示文摘金 nanoparticles (AuNPs ) 的 biodistribution 是仔细与毒物学的效果有关并且因为他们的潜在的申请,担心大。与为液体运输的新奇解剖、组织学的结构的发现,然而,内在的机制包含了在在里面 AuNPs 的 vivo 运输和 biodistribution 要求进一步深入的调查。在当前的学习,在腱,容器,和神经纤维的一个焦点的点可以最佳地与另外的遥远的结缔组织连接的地方,我们在跗骨的隧道在 intervaginal 空间注射(ISI ) 以后在老鼠调查了 10-nm AuNPs 的 biodistribution。AuNPs 的静脉内的注射(IVI ) 用作控制。血和机关与诱导地联合的血浆团 spectrometry (ICPMS ) 为 Au 分发的定量分析在注射以后在 5, 15,和 30 min 并且在 1, 4, 12,和 24 h 被收集。IVI 和 ISI 产出显著地不同的结果:在在 ISI 以后的血的 AuNP 内容在 IVI 以后是比那低得多的;在肺,心,和肠是类似的;并且在皮和肌肉是更高的。这些调查结果被 AuNP 内容和相对机关 AuNP 分发比例的比率支持。我们表明的结果一快,直接并且发行量无关的 AuNP 器官运输小径,它可以改进我们生理、病理学的 biodistribution 的理解在生物系统处理。而且,这些结果提供新奇卓见进在里面 vivo 运输和 AuNPs 的 biodistribution,它可以导致新奇、有效治疗学并且管理策略。 | Xiaoli Shi Yuting Zhu Wenda Hua Yinglu Ji Qing Ha Xinxiao Han Yang Liu Jingwei Gao Qiang Zhang Sidi Liu Keli Ren Xiaochun Wu Hongyi Li Dong Han | 2016 | Nano Research2016，9，7： | 7 |
| 2 | Experimental study of viscosity characteristics of hightemperature heat transfer molten salts显示文摘In this paper several kinds of high temperature molten salts were investigated experimentally on viscosity-temperature characteristics with high-temperature viscometer.The viscosities of the molten salts were measured and compared with those from references to verify the reliability of the viscometer and measuring methods,and a good agreement was observed from the comparisons.Then,two new high-temperature molten salts were made from the HITEC salt by some additives and the viscosity-temperature profiles of them were obtained by experiments.The results show that the new molten salts have much lower viscosities,thus suitable for reducing the flow resistance in transportation system of high-temperature solar thermal power generation. | CHEN YongChang WU YuTing REN Nan MA ChongFang | 2011 | Science China(Technological Sciences)2011，54，11： | 5 |
| 3 | Exogenous SA or 6-BA maintains photosynthetic activity in maize leaves under high temperature stress显示文摘With global warming, high-temperature(HT) stress has become a major abiotic stress for crops, in particular summer maize in China. Photosynthesis is sensitive to HT. Salicylic acid(SA) and 6-benzyladenine(6-BA) can improve the adaptation of plants to various biotic and abiotic stresses. However, their contribution to maintaining photosynthetic activity and alleviating photoinhibition in maize leaves under HT stress is still unclear. The effects of exogenous SA or 6-BA on growth, photosynthesis capacity, photosystem Ⅱ(PSII) activity, subcellular ultrastructure, antioxidant system, and plant hormones in maize leaves under HT stress were investigated. Under HT conditions, application of SA or 6-BA up-regulated gibberellin and zeatin content in leaves, increasing leaf area index(LAI). It also expanded the stomata by reducing abscisic acid and jasmonic acid content in leaves, cooling them and increasing CO2supply to photosynthesis. A higher net photosynthetic rate, combined with increased activity of the antioxidant system, alleviated oxidative stress in maize plants sprayed with SA or 6-BA, allowing them to maintain their chloroplast ultrastructure and PSII activity, in particular electron transfer from QAto QB. The increased LAI and net photosynthetic rate per unit leaf area also resulted in the accumulation of more biomass. | Yuting Li Xuetao Han Hao Ren Bin Zhao Jiwang Zhang Baizhao Ren Huiyuan Gao Peng Liu | 2023 | The Crop Journal2023，11，2： | 2 |
| 4 | Dynamic Simulation of Closed Brayton Cycle Solar Thermal Power System 显示文摘 | WU Yuting REN Jianxun GUO Zengyuan | 2004 | ICSETN2004，16，： | 1 |
| 5 | Experimental study on optimized composition of mixed carbonate salt for sensible heat storage in solar thermal power plant 显示文摘 | Wu Yuting Ren Nan Wang Tao | 2011 | Solar Energy2011，85，9： | 1 |
| 6 | Experimental study on optimized composition of mixed carbonate for phase change thermal storage in solar thermal power plant显示文摘 | Ren Nan Wu Yuting Wang Tao | 2011 | Journal of Thermal Analysis and Calorimetry2011，104，3： | 1 |
| 7 | Experimental study on optimized composition of mixed carbonate salt for sensible heat storage in solar thermal power plant显示文摘 | Wu Yuting Ren Nan Wang Tao | 2011 | Solar Energy2011，85，9： | 1 |
| 8 | Transport Patterns and Potential Sources of Atmospheric Pollution during the ⅩⅩⅣ Olympic Winter Games Period显示文摘The attainment of suitable ambient air quality standards is a matter of great concern for successfully hosting the ⅩⅩⅣ Olympic Winter Games(OWG). Transport patterns and potential sources of pollutants in Zhangjiakou(ZJK) were investigated using pollutant monitoring datasets and a dispersion model. The PM_(2.5) concentration during February in ZJK has increased slightly(28%) from 2018 to 2021, mostly owing to the shift of main potential source regions of west-central Inner Mongolia and Mongolian areas(2015–18) to the North China Plain and northern Shanxi Province(NCPS) after 2018.Using CO as an indicator, the relative contributions of the different regions to the receptor site(ZJK) were evaluated based on the source-receptor-relationship method(SRR) and an emission inventory. We found that the relative contribution of pollutants from NCPS increased from 33% to 68% during 2019–21. Central Inner Mongolia(CIM) also has an important impact on ZJK under unfavorable weather conditions. This study demonstrated that the effect of pollution control measures in the NCPS and CIM should be strengthened to ensure that the air quality meets the standard during the ⅩⅩⅣ OWG. | Yuting ZHANG Xiaole PAN Yu TIAN Hang LIU Xueshun CHEN Baozhu GE Zhe WANG Xiao TANG Shandong LEI Weijie YAO Yuanzhe REN Yongli TIAN Jie LI Pingqing FU Jinyuan XIN Yele SUN Junji CAO Zifa WANG | 2022 | Advances in Atmospheric Sciences2022，39，10： | 1 |
| 9 | Experimental study on optimized composition of mixed carbonate forphase change thermal storage in solar thermal power plant显示文摘 | Ren Nan Wu Yuting Wang Tao | 2011 | Therm Anal Calorim2011，104，3： | 1 |
| 10 | Optimal analysis of a space solar dynamic power system显示文摘 | Wu Yuting Ren Jianxun | 2003 | Solar Energy2003，74，： | 1 |
| 11 | Multi-modal Correlated Network for emotion recognition in speech显示文摘With the growing demand of automatic emotion recognition system,emotion recognition is becoming more and more crucial for human-computer interaction(HCI)research.Recently,there is a continuous improvement in the performance of automatic emotion recognition due to the development of both hardware and deep learning methods.However,because of the abstract concept and multiple expressions of emotion,automatic emotion recognition is still a challenging task.In this paper,we propose a novel Multi-modal Correlated Network for emotion recognition aiming at exploiting the information from both audio and visual channels to achieve more robust and accurate detection.In the proposed method,the audio signals and visual signals are first preprocessed for the feature extraction.After preprocessing,we obtain the Mel-spectrograms,which can be treated as images,and the representative frames from visual segments.Then the Mel-spectrograms are fed to the convolutional neural network(CNN)to get the audio features and the representative frames are fed to the CNN and LSTM to get features.Specially,we employ the triplet loss to increase the differentiation of inter-class.Meanwhile,we propose a novel correlated loss to reduce the differentiation of intra-class.Finally,we apply the feature fusion method to fuse the audio and visual feature for emotion recognition classification.The experimental result on AEFW dataset demonstrates the correlation information of multiple modals is crucial for automatic emotion recognition and the proposed method can achieve the state-of-the-art performance on the classification task. | Minjie Ren Weizhi Nie Anan Liu Yuting Su | 2019 | Visual Informatics2019，3，3： | 1 |
| 12 | Thermal and power characteristics of ordinary solar cells in concentrating solar collectors 显示文摘 | Wu Yuting Zhu Hongye Ren Jianxun | 2003 | J Tsinghua Univ(Sci & Tech)2003，43，8： | 1 |
| 13 | Synergistic lubrication of few-layer Ti_(3)C_(2)T_(x)/MoS_(2) heterojunction as a lubricant additive显示文摘The few-layer Ti_(3)C_(2)T_(x)/MoS_(2) heterostructure was successfully prepared via vertically growing of MoS_(2) nanosheets on the few-layer Ti3C2Tx matrix using hydrothermal method.The tribological properties as additive in mineral oil(150N)were evaluated in detail.The 0.3 wt% of few-layer Ti_(3)C_(2)T_(x)/MoS_(2) heterostructure addition amount can reduce the friction and wear of 150N by 39% and 85%,respectively.Moreover,the enhancement effect of few-layer Ti_(3)C_(2)T_(x)/MoS_(2) on tribological properties of 150N is superior to that of few-layer Ti_(3)C_(2)T_(x),MoS_(2) nanosheets,and their mechanical mixture.Based on the characterization and analysis of wear debris and wear track,such excellent tribological properties of the few-layer Ti_(3)C_(2)T_(x)/MoS_(2) heterostructure derive from its structural advantage toward good dispersion,the synergistic lubrication of Ti_(3)C_(2)T_(x) and MoS_(2) nanosheets during the rubbing process,and the formation of tribo-film. | Peng FENG Yanping REN Yuting LI Jifan HE Zhuang ZHAO Xiaoliang MA Xiaoqiang FAN Minhao ZHU | 2022 | Friction2022，10，12： | 1 |
| 14 | Evidence of bisphosphonate-conjugated sitafloxacin eradication of established methicillin-resistant S.aureus infection with osseointegration in murine models of implant-associated osteomyelitis显示文摘Eradication of MRSA osteomyelitis requires elimination of distinct biofilms.To overcome this,we developed bisphosphonateconjugated sitafloxacin(BCS,BV600072)and hydroxybisphosphonate-conjugate sitafloxacin(HBCS,BV63072),which achieve“target-and-release”drug delivery proximal to the bone infection and have prophylactic efficacy against MRSA static biofilm in vitro and in vivo.Here we evaluated their therapeutic efficacy in a murine 1-stage exchange femoral plate model with bioluminescent MRSA(USA300LAC::lux).Osteomyelitis was confirmed by CFU on the explants and longitudinal bioluminescent imaging(BLI)after debridement and implant exchange surgery on day 7,and mice were randomized into seven groups:1)Baseline(harvested at day7,no treatment);2)HPBP(bisphosphonate control for BCS)+vancomycin;3)HPHBP(hydroxybisphosphonate control for HBCS)+vancomycin;4)vancomycin;5)sitafloxacin;6)BCS+vancomycin;and 7)HBCS+vancomycin.BLI confirmed infection persisted in all groups except for mice treated with BCS or HBCS+vancomycin.Radiology revealed catastrophic femur fractures in all groups except mice treated with BCS or HBCS+vancomycin,which also displayed decreases in peri-implant bone loss,osteoclast numbers,and biofilm.To confirm this,we assessed the efficacy of vancomycin,sitafloxacin,and HBCS monotherapy in a transtibial implant model.The results showed complete lack of vancomycin efficacy while all mice treated with HBCS had evidence of infection control,and some had evidence of osseous integrated septic implants,suggestive of biofilm eradication.Taken together these studies demonstrate that HBCS adjuvant with standard of care debridement and vancomycin therapy has the potential to eradicate MRSA osteomyelitis. | Youliang Ren Jason Weeks Thomas Xue Joshua Rainbolt Karen L.de Mesy Bentley Ye Shu Yuting Liu Elysia Masters Philip Cherian Charles E.McKenna Jeffrey Neighbors Frank H.Ebetino Edward M.Schwarz Shuting Sun Chao Xie | 2023 | Bone Research2023，11，4： | 0 |
| 15 | Cryo-EM structures for the Mycobacterium tuberculosis iron-loaded siderophore transporter IrtAB显示文摘The adenosine 5'-triphosphate(ATP)-binding cassette(ABC)transporter,IrtAB,plays a vital role in the replication and viability of Mycobacterium tuberculosis(Mtb),where its function is to import iron-loaded siderophores.Unusually,it adopts the canonical type IV exporter fold.Herein,we report the structure of unliganded Mtb IrtAB and its structure in complex with ATP,ADP,or ATP analogue(AMP-PNP)at resolutions ranging from 2.8 to 3.5Å.The structure of IrtAB bound ATP-Mg2+shows a“head-to-tail”dimer of nucleotide-binding domains(NBDs),a closed amphipathic cavity within the transmembrane domains(TMDs),and a metal ion liganded to three histidine residues of IrtA in the cavity.Cryo-electron microscopy(Cryo-EM)structures and ATP hydrolysis assays show that the NBD of IrtA has a higher affinity for nucleotides and increased ATPase activity compared with IrtB.Moreover,the metal ion located in the TM region of IrtA is critical for the stabilization of the conformation of IrtAB during the transport cycle.This study provides a structural basis to explain the ATP-driven conformational changes that occur in IrtAB. | Shan Sun Yan Gao Xiaolin Yang Xiuna Yang Tianyu Hu Jingxi Liang Zhiqi Xiong Yuting Ran Pengxuan Ren Fang Bai Luke WGuddat Haitao Yang Zihe Rao Bing Zhang | 2023 | Protein & Cell2023，14，6： | 0 |
| 16 | VvBBX44 and VvMYBA1 form a regulatory feedback loop to balance anthocyanin biosynthesis in grape显示文摘Anthocyanins are essential for the quality of perennial horticultural crops,such as grapes.In grapes,ELONGATED HYPOCOTYL 5(HY5)and MYBA1 are two critical transcription factors that regulate anthocyanin biosynthesis.Our previous work has shown that Vitis vinifera B-box protein 44(VvBBX44)inhibits anthocyanin synthesis and represses VvHY5 expression in grape calli.However,the regulatory mechanism underlying this regulation was unclear.In this study,we found that loss of VvBBX44 function resulted in increased anthocyanin accumulation in grapevine callus.VvBBX44 directly represses VvMYBA1,which activates VvBBX44.VvMYBA1,but not VvBBX44,directly modulates the expression of grape UDP flavonoid 3-O-glucosyltransferase(VvUFGT).We demonstrated that VvBBX44 represses the transcriptional activation of VvUFGT and VvBBX44 induced by VvMYBA1.However,VvBBX44 and VvMYBA1 did not physically interact in yeast.The application of exogenous anthocyanin stimulated VvBBX44 expression in grapevine suspension cells and tobacco leaves.These findings suggest that VvBBX44 and VvMYBA1 form a transcriptional feedback loop to prevent overaccumulation of anthocyanin and reduce metabolic costs.Our work sheds light on the complex regulatory network that controls anthocyanin biosynthesis in grapevine. | Wenwen Liu Huayuan Mu Ling Yuan Yang Li Yuting Li Shenchang Li Chong Ren Wei Duan Peige Fan Zhanwu Dai Yongfeng Zhou Zhenchang Liang Shaohua Li Lijun Wang | 2023 | Horticulture Research2023，10，10： | 0 |
| 17 | Efficacy of verbascoside,echinacoside,crenatoside on altitudeinduced fatigue in rats and possible mechanism显示文摘OBJECTIVE:To study the efficacy and mechanism of three phenylethanoid glycosides(PhG s)(verbascoside,echinacoside,and crenatoside)on altitude-induced fatigue in rats.METHODS:Altitude-induced fatigue model rats were established in a large hypobaric chamber.Swimming time,energy storage substances,metabolic enzymes,and metabolites were used to evaluate the anti-fatigue activities and mechanism of three PhG s(verbascoside,echinacoside,and crenatoside)(150 mg/kg,intragastric administration)in the hypoxic environment.RESULTS:The three PhGs,especially verbascoside,could prolong the swimming time of rats,ameliorate the edema and inflammatory infiltration of liver and skeletal muscle,increase the level of energy storage substances,reduce the decomposition of proteins,and exhibit positive effects on the metabolism-related enzyme activity and metabolites.CONCLUSIONS:The PhG s,especially verbascoside,are very potential with anti-fatigue activity in hypoxia.The mechanism may be explained with regulation of energy metabolism and reduction of oxidative stress. | GUO Ziliang QIAN Qingyuan LI Xiaolin ZHU Yuting REN Jun LI Maoxing | 2023 | Journal of Traditional Chinese Medicine2023，43，5： | 0 |
| 18 | The successful treatment for cardiac tamponade during radiofrequency ablation of hepatocellular carcinoma显示文摘To the Editor:Hepatocellular carcinoma(HCC)is the second most common cause of cancer-related death worldwide[1].Repeated liver resection remains a valid and safe curative therapy option for recurrent HCC in a minority of patients,because of multifocal intrahepatic or extra-hepatic recurrence and tumors in unresectable locations[2].HCC nodules less than 3 cm located in the hepatic dome beneath the diaphragm may represent one of the most difficult sites for resection[3].Therefore,some local invasive therapies,such as radiofrequency ablation(RFA),microwave ablation,transarterial chemoembolization(TACE)and laser hyperthermia,have been developed and applied in clinical HCC treatment[4].RFA has high frequency energy which heats the surrounding tissues and causes severe complications such as acute massive hemorrhage,thermal injury to viscera,pneumothorax and cardiac tamponade[5]. | Chen Xue Zhigang Ren Xiaobo Hu Yuting He Ranran Sun Juan Li Guangying Cui Zujiang Yu | 2019 | Hepatobiliary & Pancreatic Diseases International2019，18，1： | 0 |
| 19 | Regulation of serotonin production by specific microbes from piglet gut显示文摘Background Serotonin is an important signaling molecule that regulates secretory and sensory functions in the gut.Gut microbiota has been demonstrated to affect serotonin synthesis in rodent models.However,how gut microbes regulate intestinal serotonin production in piglets remains vague.To investigate the relationship between microbiota and serotonin specifically in the colon,microbial composition and serotonin concentration were analyzed in ileum-cannulated piglets subjected to antibiotic infusion from the ileum when comparing with saline infusion.Microbes that correlated positively with serotonin production were isolated from piglet colon and were further used to investi-gate the regulation mechanisms on serotonin production in IPEC-J2 and a putative enterochromaffin cell line RIN-14B cells.Results Antibiotic infusion increased quantities of Lactobacillus amylovorus(LA)that positively correlated with increased serotonin concentrations in the colon,while no effects observed for Limosilactobacillus reuteri(LR).To understand how microbes regulate serotonin,representative strains of LA,LR,and Streptococcus alactolyticus(SA,enriched in feces from prior observation)were selected for cell culture studies.Compared to the control group,LA,LR and SA supernatants significantly up-regulated tryptophan hydroxylase 1(TPH1)expression and promoted serotonin production in IPEC-J2 cells,while in RIN-14B cells only LA exerted similar action.To investigate potential mechanisms mediated by microbe-derived molecules,microbial metabolites including lactate,acetate,glutamine,andγ-aminobutyric acid were selected for cell treatment based on computational and metabolite profiling in bacte-rial supernatant.Among these metabolites,acetate upregulated the expression of free fatty acid receptor 3 and TPH1 while downregulated indoleamine 2,3-dioxygenase 1.Similar effects were also recapitulated when treating the cells with AR420626,an agonist targeting free fatty acid receptor 3.Conclusions Overall,these results suggest that Lactobacillus amylovorus showed a positive correlation with sero-tonin production in the pig gut and exhibited a remarkable ability to regulate serotonin production in cell cultures.These findings provide evidence that microbial metabolites mediate the dialogue between microbes and host,which reveals a potential approach using microbial manipulation to regulate intestinal serotonin biosynthesis. | Ziyu Liu Yidan Ling Yu Peng Shuibing Han Yuting Ren Yujia Jing Wenlu Fan Yong Su Chunlong Mu Weiyun Zhu | 2023 | Journal of Animal Science and Biotechnology2023，14，6： | 0 |
| 20 | A neuropsin-based optogenetic tool for precise control of Gq signaling显示文摘G_(q)-coupled receptors regulate numerous physiological processes by activating enzymes and inducing intracellular Ca^(2+)signals.There is a strong need for an optogenetic tool that enables powerful experimental control over G_(q) signaling.Here,we present chicken opsin 5(cOpn5)as the long sought-after,single-component optogenetic tool that mediates ultra-sensitive optical control of intracellular G_(q) signaling with high temporal and spatial resolution.Expressing cOpn5 in HEK 293T cells and primary mouse astrocytes enables blue light-triggered,G_(q)-dependent Ca^(2+) release from intracellular stores and protein kinase C activation.Strong Ca^(2+) transients were evoked by brief light pulses of merely 10 ms duration and at 3 orders lower light intensity of that for common optogenetic tools.Photostimulation of cOpn5-expressing cells at the subcellular and single-cell levels generated fast intracellular Ca^(2+)transition,thus demonstrating the high spatial precision of cOpn5 optogenetics.The cOpn5-mediated optogenetics could also be applied to activate neurons and control animal behavior in a circuit-dependent manner.cOpn5 optogenetics may find broad applications in studying the mechanisms and functional relevance of G_(q) signaling in both non-excitable cells and excitable cells in all major organ systems. | Ruicheng Dai Tao Yu Danwei Weng Heng Li Yuting Cui Zhaofa Wu Qingchun Guo Haiyue Zou Wenting Wu Xinwei Gao Zhongyang Qi Yuqi Ren Shu Wang Yulong Li Minmin Luo | 2022 | Science China(Life Sciences)2022，65，7： | 0 |
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