|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Immune mechanisms of Concanavalin A model of autoimmune hepatitis显示文摘As a chronic inflammatory disease of the liver,the pathogenic mechanisms of autoimmune hepatitis (AIH) have not yet been elucidated,with prognosis and diagnosis remaining unsatisfied.Currently the only viable treatments of AIH are immunosuppressant application and liver transplantation.It is considered that lack of good animal AIH models is the main reason for the shortage of a simple and efficient cure.The Concanavalin A (Con A) model is a typical and well established model for investigating T-cell and macrophage dependent liver injury in mice,which closely mimics the pathogenesis mechanisms and pathological changes of patients,and is regarded as the best experimental model for AIH research so far.In this paper we eluci-dated the pathogenic mechanisms of AIH and the evolution of relative animal models.We go on to further focus on Con A-induced liver injury from the point of immunological mechanisms and the change of cytokine levels.Finally,we manifested the clinical significance of the AIH animal models and the challenges they would meet during their future development. | Hai-Xia Wang Man Liu Shun-Yan Weng Jing-Jing Li Chao Xie Hong-Lin He Wen Guan Yun-Sheng Yuan Jin Gao | 2012 | World Journal of Gastroenterology2012，18，2： | 52 |
| 2 | AXL is a candidate receptor for SARS-CoV-2 that promotes infection of pulmonary and bronchial epithelial cells显示文摘The current coronavirus disease 2019(COVID-19)pandemic presents a global public health challenge.The viral pathogen responsible,severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),binds to the host receptor ACE2 through its spike(S)glycoprotein,which mediates membrane fusion and viral entry.Although the role of ACE2 as a receptor for SARS-CoV-2 is clear,studies have shown that ACE2 expression is extremely low in various human tissues,especially in the respiratory tract.Thus,other host receptors and/or co-receptors that promote the entry of SARS-CoV-2 into cells of the respiratory system may exist.In this study,we found that the tyrosine-protein kinase receptor UFO(AXL)specifically interacts with the N-terminal domain of SARS-CoV-2 S.Using both a SARS-CoV-2 virus pseudotype and authentic SARS-CoV-2,we found that overexpression of AXL in HEK293T cells promotes SARS-CoV-2 entry as efficiently as overexpression of ACE2,while knocking out AXL significantly reduces SARS-CoV-2 infection in HI 299 pulmonary cells and in human primary lung epithelial cells.Soluble human recombinant AXL blocks SARS-CoV-2 infection in cells expressing high levels of AXL.The AXL expression level is well correlated with SARS-CoV-2 S level in bronchoalveolar lavage fluid cells from COVID-19 patients.Taken together,our findings suggest that AXL is a novel candidate receptor for SARS-CoV-2 which may play an important role in promoting viral infection of the human respiratory system and indicate that it is a potential target for future clinical intervention strategies. | Shuai Wang Zongyang Qiu Yingnan Hou Xiya Deng Wei Xu Tingting Zheng Peihan Wu Shaofang Xie Weixiang Bian Chong Zhang Zewei Sun Kunpeng Liu Chao Shan Aifu Lin Shibo Jiang Youhua Xie Qiang Zhou Lu Lu Jing Huang Xu Li | 2021 | Cell Research2021，31，2： | 39 |
| 3 | 四肢创伤性骨折术后细菌感染及耐药的地域性特征分析显示文摘目的探讨四肢创伤性骨折术后Gram阳性和阴性细菌感染的地域性分布态势及耐药率,旨在为手术前、后经验性使用抗菌素提供循证医学依据。方法回顾性分析筛查2012年1月至2015年1月因四肢创伤性骨折住院治疗的3728例患者,按照CLSIM.100-S22标准,收集经手术、病理及细菌培养证实细菌感染的51例患者的病历资料,整理其病理、窦道分泌物或病灶穿刺标本的细菌培养和药敏试验数据,对金黄色葡萄球菌(S.aureus)等主要菌株的分布及耐药性进行分析。结果四肢创伤性骨折术后细菌感染率为1.37%(51/3728)。常见感染骨折部位依次为胫腓骨(25例,49.02%)、股骨(11例,21.57%)、尺桡骨(8例,15.69%)。单株菌感染45例(88.23%),混合感染6例(11.76%)。Gram阳性细菌感染以S.aureus(27例,47.37%)、表皮葡萄球菌(4例,7.02%)、鸟肠球菌(2例,3.51%)为主;Gram阴性细菌感染以大肠埃希菌(E.coli)(9例,15.79%)、阴沟肠杆菌(4例,7.02%)、肺炎克雷伯氏菌(2例,3.51%)为主。药敏试验发现主要Gram阳性菌耐药率为40.74%-100.00%,以耐林可霉素、红霉素、青霉素、四环素、头孢西丁和苯唑西林为主,未检出对万古霉素、替加环素、呋喃妥因耐药的S.aureus、表皮葡萄球菌和鸟肠球菌。主要Gram阴性细菌耐药率为44.44%~100.00%,以耐左氧氟沙星、氨苄西林、氨曲南、头孢曲松、头孢替坦、头孢他啶等为主,未检出对亚硫胺霉素耐受的主要Gram阴性菌。S.aureus感染的27例患者中耐甲氧西林金黄色葡萄球菌(MRSA)占11例(40.74%),全部对吗啉恶酮、氨苄西林、替加环素、万古霉素等敏感。结论创伤性四肢骨折术后感染以下肢长骨和尺桡骨感染单株S.aureus、E.coli、表皮葡萄球菌或阴沟肠杆菌为主,有明显的地域性特点。不仅MRSA感染率较高,且混合感染多以S.aureus合并其他细菌感染为主。根据耐药谱结果分析、对本地区感染病灶彻底清除术前后经验性抗生素治疗的选择建议为:Gram阳性细菌感染选用替加环素、呋喃妥因、万古霉素,Gram阴性细菌感染选用亚胺硫霉素为宜。 | 任有亮 彭笳宸 李政道 刘曦明 杨晋 Stephen L. Kates Edward M.Schwarz Chao Xie | 2016 | 中华创伤骨科杂志2016，18，3： | 32 |
| 4 | Linearization method of nonlinear aeroelastic stability for complete aircraft with high-aspect-ratio wings显示文摘A linearization method and an engineering approach for the geometric nonlinear aeroelastic stability analysis of the very flexi- ble aircraft with high-aspect-ratio wings are established based on the little dynamic perturbation assumption.The engineering practicability of the method is validated by a complex example.For a high-altitude long-endurance unmanned aircraft,the nonlinear static deformations under straight flight and the gust loads are calculated.At the corresponding nonlinear equilibrium state,the complete aircraft is linearized dynamically and the vibration modes are calculated considering the large deformation effects.Then the unsteady aerodynamics are calculated by the double lattice method.Finally,the aeroelastic stability of the complete aircraft is analyzed.The results are compared with the traditional linear calculation.The work shows that the geometric nonlinearity induced by the large structural deformation leads to the motion coupling of the wing chordwise bending and the torsion,which changes the mode frequencies and mode shapes.This factors change the aeroelastic coupling relationship of the flexible modes leading to the decrease of the flutter speed.The traditional linear method would give not only an imprecise flutter speed but also a possible dramatic mistake on the stability.Hence,for a high-altitude long-endurance unmanned aircraft with high-aspect-ratio wings,or a similar very flexible aircraft,the geometric nonlinear aeroelastic analysis should be a necessary job in engineering practice. | XIE ChangChuan YANG Chao | 2011 | Science China(Technological Sciences)2011，54，2： | 27 |
| 5 | 3D打印技术在髋臼后壁骨折手术治疗中的应用显示文摘目的初步探讨3D打印技术在髋臼后壁骨折手术治疗中的应用效果。方法回顾性分析2014年1月至2015年4月收治的34例髋臼后壁骨折患者资料,男18例,女16例;年龄为21~65岁;骨折按Letournel.Judet分型:后壁骨折17例,后柱伴后壁骨折11例,横形伴后壁骨折6例。根据术前术中是否应用3D打印技术分为2组:3D技术组15例,男7例,女8例;平均年龄为(45.1±14.2)岁;常规组19例,男11例,女8例;平均年龄为(43.7±13.2)岁。3D技术组患者术前应用3D快速成型打印个体化骨折模型进行预手术,制定手术方案。所有患者均采用Kocher.Langenbeck入路AO微型联合重建接骨板内固定治疗。比较两组患者的手术时间、术中出血量、术中透视次数、骨折复位质量、末次随访时髋关节功能及术后并发症发生率等。结果34例患者术后获3~16个月(平均11.1个月)随访。3D技术组患者的手术时间【(83.2±13.5)min】较常规组患者[(96.8±13.1)min】短、术中出血量【(257.3±54.7)mL】和术中透视次数【(2.7±0.8)次】较常规组患者【(327.1±70.4)mL、(3.3±0.9)次】少,差异均有统计学意义(P〈0,05)。3D技术组和常规组患者术后骨折复位质量优良率分别为93.3%(14/15)、89.5%(17/19),末次随访时改良Merled’Aubign6和Postel评分平均分别为(16.2±1.6)、(16.0±1.5)分,术后并发症发生率分别为20.O%(3/15)、26.3%(5/19),差异均无统计学意义(P〉0.05)。结论3D打印技术可减少髋臼后壁骨折患者的手术时间、术中出血量及术中透视次数,是一种治疗髋臼后壁骨折的有效辅助手段。 | 王锋 汪国栋 Chao Xie 刘曦明 Edward M. Schwarz 蔡贤华 齐凤宇 钟炎军 | 2016 | 中华创伤骨科杂志2016，18，2： | 22 |
| 6 | The second natural gas hydrate production test in the South China Sea显示文摘Clayey silt reservoirs bearing natural gas hydrates(NGH)are considered to be the hydrate-bearing reservoirs that boast the highest reserves but tend to be the most difficult to exploit.They are proved to be exploitable by the first NGH production test conducted in the South China Sea in 2017.Based on the understanding of the first production test,the China Geological Survey determined the optimal target NGH reservoirs for production test and conducted a detailed assessment,numerical and experimental simulation,and onshore testing of the reservoirs.After that,it conducted the second offshore NGH production test in 1225 m deep Shenhu Area,South China Sea(also referred to as the second production test)from October 2019 to April 2020.During the second production test,a series of technical challenges of drilling horizontal wells in shallow soft strata in deep sea were met,including wellhead stability,directional drilling of a horizontal well,reservoir stimulation and sand control,and accurate depressurization.As a result,30 days of continuous gas production was achieved,with a cumulative gas production of 86.14×104 m3.Thus,the average daily gas production is 2.87×10^4 m^3,which is 5.57 times as much as that obtained in the first production test.Therefore,both the cumulative gas production and the daily gas production were highly improved compared to the first production test.As indicated by the monitoring results of the second production test,there was no anomaly in methane content in the seafloor,seawater,and atmosphere throughout the whole production test.This successful production test further indicates that safe and effective NGH exploitation is feasible in clayey silt NGH reservoirs.The industrialization of hydrates consists of five stages in general,namely theoretical research and simulation experiments,exploratory production test,experimental production test,productive production test,and commercial production.The second production test serves as an important step from the exploratory production test to experimental production test. | Jian-liang Ye Xu-wen Qin Wen-wei Xie Hai-long Lu Bao-jin Ma Hai-jun Qiu Jin-qiang Liang Jing-an Lu Zeng-gui Kuang Cheng Lu Qian-yong Liang Shi-peng Wei Yan-jiang Yu Chunsheng Liu Bin Li Kai-xiang Shen Hao-xian Shi Qiu-ping Lu Jing Li Bei-bei Kou Gang Song Bo Li He-en Zhang Hong-feng Lu Chao Ma Yi-fei Dong Hang Bian | 2020 | China Geology2020，3，2： | 22 |
| 7 | Titanium mesh for bone augmentation in oral implantology: current application and progress显示文摘Guided bone regeneration(GBR)is an effective and simple method for bone augmentation,which is often used to reconstruct the alveolar ridge when the bone defect occurs in the implant area.Titanium mesh has expanded the indications of GBR technology due to its excellent mechanical properties and biocompatibility,so that the GBR technology can be used to repair alveolar ridges with larger bone defects,and can obtain excellent and stable bone augmentation results.Currently,GBR with titanium mesh has various clinical applications,including different clinical procedures.Bone graft materials,titanium mesh covering methods,and titanium mesh fixing methods are also optional.Moreover,the research of GBR with titanium mesh has led to multifarious progresses in digitalization and material modification.This article reviews the properties of titanium mesh and the difference of titanium mesh with other barrier membranes;the current clinical application of titanium mesh in bone augmentation;common complications and management and prevention methods in the application of titanium mesh;and research progress of titanium mesh in digitization and material modification.Hoping to provide a reference for further improvement of titanium mesh in clinical application and related research of titanium mesh. | Yu Xie Songhang Li Tianxu Zhang Chao Wang Xiaoxiao Cai | 2020 | International Journal of Oral Science2020，12，4： | 22 |
| 8 | Evolving concepts in bone infection: redefining “biofilm”,“acute vs. chronic osteomyelitis”, “the immune proteome” and “local antibiotic therapy”显示文摘Osteomyelitis is a devastating disease caused by microbial infection of bone. While the frequency of infection following elective orthopedic surgery is low, rates of reinfection are disturbingly high. Staphylococcus aureus is responsible for the majority of chronic osteomyelitis cases and is often considered to be incurable due to bacterial persistence deep within bone. Unfortunately, there is no consensus on clinical classifications of osteomyelitis and the ensuing treatment algorithm. Given the high patient morbidity,mortality, and economic burden caused by osteomyelitis, it is important to elucidate mechanisms of bone infection to inform novel strategies for prevention and curative treatment. Recent discoveries in this field have identified three distinct reservoirs of bacterial biofilm including: Staphylococcal abscess communities in the local soft tissue and bone marrow, glycocalyx formation on implant hardware and necrotic tissue, and colonization of the osteocyte-lacuno canalicular network(OLCN) of cortical bone. In contrast, S.aureus intracellular persistence in bone cells has not been substantiated in vivo, which challenges this mode of chronic osteomyelitis. There have also been major advances in our understanding of the immune proteome against S. aureus, from clinical studies of serum antibodies and media enriched for newly synthesized antibodies(MENSA), which may provide new opportunities for osteomyelitis diagnosis, prognosis, and vaccine development. Finally, novel therapies such as antimicrobial implant coatings and antibiotic impregnated 3D-printed scaffolds represent promising strategies for preventing and managing this devastating disease. Here, we review these recent advances and highlight translational opportunities towards a cure. | Elysia A. Masters Ryan P. Trombetta Karen L. de Mesy Bentley Brendan F Boyce Ann Lindley Gill Steven R. Gill Kohei Nishitani Masahiro Ishikawa Yugo Morita Hiromu Ito Sheila N. Bello-Irizarry Mark Ninomiya James D. Brodell Jr. Charles C. Lee Stephanie P. Hao Irvin Oh Chao Xie Hani A. Awad John L. Daiss John R. Owen Stephen L. Kates Edward M. Schwarz Gowrishankar Muthukrishnan | 2019 | Bone Research2019，7，3： | 19 |
| 9 | Impact of disinfection on drinking water biofilm bacterial community显示文摘Disinfectants are commonly applied to control the growth of microorganisms in drinking water distribution systems. However, the effect of disinfection on drinking water microbial community remains poorly understood. The present study investigated the impacts of different disinfectants(chlorine and chloramine) and dosages on biofilm bacterial community in bench-scale pipe section reactors. Illumina MiS eq sequencing illustrated that disinfection strategy could affect both bacterial diversity and community structure of drinking water biofilm. Proteobacteria tended to predominate in chloraminated drinking water biofilms, while Firmicutes in chlorinated and unchlorinated biofilms. The major proteobacterial groups were influenced by both disinfectant type and dosage. In addition, chloramination had a more profound impact on bacterial community than chlorination. | Zilong Mi Yu Dai Shuguang Xie Chao Chen Xiaojian Zhang | 2015 | Journal of Environmental Sciences2015，27，11： | 16 |
| 10 | Masquelet技术治疗感染性骨缺损的研究进展显示文摘在感染性骨缺损的治疗过程中对感染控制与骨重建是制约临床疗效的两大难题。尽管Ilizarov骨搬移技术、带血管的自体骨移植技术、Papineau技术等能够成功修复骨缺损,但仍存在明显的不足。Masquelet骨重建技术虽在其他国家报道较多,但国内尚未予以足够重视。本文综述近年来Masquelet技术治疗感染性骨缺损的相关文献,旨在提高对其疗效的认识及重视。 | 黄进成 刘曦明 蔡贤华 Edward M.Schwarz Chao Xie | 2017 | 中国矫形外科杂志2017，25，20： | 15 |
| 11 | Ammonium removal pathways and microbial community in GAC-sand dual media filter in drinking water treatment显示文摘A GAC-sand dual media filter(GSF) was devised as an alternative solution for drinking water treatment plant to tackle the raw water polluted by ammonium in place of expensive ozone-GAC processes or bio-pretreatments.The ammonium removal pathways and microbial community in the GSFs were investigated.The concentrations of ammonium,nitrite and nitrate nitrogen were monitored along the filter.Total inorganic nitrogen(TIN) loss occurred during the filtration.For 1 mg ammonium removal,the TIN loss was as high as 0.35 mg,DO consumption was 3.06 mg,and alkalinity consumption was 5.55 mg.It was assumed that both nitrification and denitrification processes occur in the filters to fit the TIN loss and low DO consumption.During the filtration,nitritation,nitrification and nitritation-anaerobic ammonium oxidation processes probably occur,while traditional nitrification and denitrification and simultaneous nitrification and denitrification processes may occur.In the GSFs,Nitrosomonas and Nitrospira are likely to be involved in nitrification processes,while Novosphingobium,Comamonadaceae and Oxalobacteraceae may be involved in denitrification processes. | Shuo Feng Shuguang Xie Xiaojian Zhang Zhiyu Yang Wei Ding Xiaobin Liao Yuanyuan Liu Chao Chen | 2012 | Journal of Environmental Sciences2012，24，9： | 14 |
| 12 | A reliability assessment method based on support vector machines for CNC equipment显示文摘With the applications of high technology,a catastrophic failure of CNC equipment rarely occurs at normal operation conditions.So it is difficult for traditional reliability assessment methods based on time-to-failure distributions to deduce the reliability level.This paper presents a novel reliability assessment methodology to estimate the reliability level of equipment with machining performance degradation data when only a few samples are available.The least squares support vector machines(LS-SVM) are introduced to analyze the performance degradation process on the equipment.A two-stage parameter optimization and searching method is proposed to improve the LS-SVM regression performance and a reliability assessment model based on the LS-SVM is built.A machining performance degradation experiment has been carried out on an OTM650 machine tool to validate the effectiveness of the proposed reliability assessment methodology. | WU Jun DENG Chao SHAO XinYu XIE S Q | 2009 | Science China(Technological Sciences)2009，52，7： | 14 |
| 13 | Effect of human umbilical cord-derived mesenchymal stem cells on lung damage in severe COVID-19 patients:a randomized,double-blind,placebo-controlled phase 2 trial显示文摘Treatment of severe Coronavirus Disease 2019(COVID-19)is challenging.We performed a phase 2 trial to assess the efficacy andsafety of human umbilical cord-mesenchymal stem cells(UC-MScs)to treat severe coViD-19 patients with lung damage,based onour phase 1 data.In this randomized,double-blind,and placebo-controlled trial,we recruited 101 severe coVID-19 patients withlung damage.They were randomly assigned at a 2:1 ratio to receive either UC-MSCs(4×10^(7)cells per infusion)or placebo on day 0,3,and 6.The primary endpoint was an altered proportion of whole lung lesion volumes from baseline to day 28.Other imagingoutcomes,6-minute walk test(6-MWT),maximum vital capacity,diffusing capacity,and adverse events were recorded and analyzed.In all,100 COVID-19 patients were finally received either UC-MSCs in=65)or placebo(n=35).UC-MSCs administrationexerted numerical improvement in whole lung lesion volume from baseline to day 28 compared with the placebo(the mediandifference was-13.31%,95%Cl-29.14%,2.13%,P=0.08).UC-MSCs significanty reduced the proportions of solid componentlesion volume compared with the placebo(median difference:-15.45%;95%CI-30.82%,-0.39%;P=0.043).The 6-MWT showedan increased distance in patients treated with UC-MSCs(difference:27.00 m;95%CI 0.00,57.00;P=0.057).The incidence of adverseevents was similar in the two groups.These results suggest that UC-MSCs treatment is a safe and potentially effective therapeuticapproach for COVID-19 patients with lung damage.A phase 3 trial is required to evaluate effects on reducing mortality andpreventing long-term pulmonary disability. | Lei Shi Hai Huang Xuechun Lu Xiaoyan Yan Xiaojing Jiang Ruonan Xu Siyu Wang Chao Zhang Xin Yuan Zhe Xu Lei Huang Jun-Liang Fu Yuanyuan Li Yu Zhang Wei-Qi Yao Tianyi Liu Jinwen Song Liangliang Sun Fan Yang Xin Zhang Bo Zhang Ming Shi Fanping Meng Yanning Song Yongpei Yu Jiqiu Wen Qi Li Qing Mao Markus Maeurer Alimuddin Zumla Chen Yao Wei-Fen Xie Fu-Sheng Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，3： | 13 |
| 14 | Protective effect of recombinant human IL-1Ra on CCl_4-induced acute liver injury in mice显示文摘AIM: To evaluate the effects of positive regulation of recombinant human interleukin 1 receptor antagonist (rhIL-1Ra) on hepatic tissue recovery in acute liver injury in mice induced by carbon tetrachloride (CCl 4 ). METHODS: Acute liver damage was induced by injecting 8-wk-old mice with CCl 4 1 mL/kg (1:3 dilution in corn oil) intraperitoneally (ip). Survival after liver failure was assessed by injecting 8-wk-old mice with a lethal dose of CCl 4 2.6 mL/kg (1:1 dilution in corn oil) ip. Mice were subcutaneously injected with 1 mg/kg recombinant human IL-1Ra twice a day after CCl 4 treatment for 5 d. Serum alanine amino transferase (ALT) and aspartate aminotransferase (AST) levels were determined with a commercial assay kit. Serum IL-1β, IL-1Ra levels were measured by enzyme-linked immunosorbent assay kit. Quantitative real-time polymerase chain reaction was used to determine liver IL-1β, IL-1Ra and IL-6 expression during CCl 4-induced acute liver injury. Liver sections were stained with hematoxylin-eosin. A histology-injury grading system was used to evaluate the degree of necrosis after acute liver injury. Proliferating cell nuclear antigen (PCNA) staining was used to evaluate the role of rhIL-1Ra in promoting hepatocyte proliferation. RESULTS: Quantitative analysis showed a higher level of IL-6 mRNA expression and reduced serum AST and ALT levels in the livers of the rhIL-1Ra-treated group at the early phase of CCl 4-induced acute liver injury. Histological examination indicated a decrease in centrilobular necrotic areas in mice treated with rhIL-1Ra, and a novel role of rhIL-1Ra in promoting hepatocyte proliferation was also supported by an increase of PCNA staining. All these results, accompanied by a strong survival benefit in rhIL-1Ra-treated vs PBS-treated groups, demonstrated that rhIL-1Ra administration ameliorated the histological damage and accelerated the regeneration and recovery process of the liver. CONCLUSION: rhIL-1Ra could be further developed as a novel therapeutic agent for the treatment of acute liver injury because of its ability to reduce hepatocellular damage and facilitate liver regeneration. | Zhu, Run-Zhi Xiang, Di Xie, Chao Li, Jing-Jing Hu, Jian-Jun He, Hong-Lin Yuan, Yun-Sheng Gao, Jin Han, Wei Yu, Yan | 2010 | World Journal of Gastroenterology2010，16，22： | 13 |
| 15 | Static aeroelastic analysis of very flexible wings based on non-planar vortex lattice method显示文摘A rapid and efficient method for static aeroelastic analysis of a flexible slender wing when considering the structural geometric nonlinearity has been developed in this paper. A non-planar vortex lattice method herein is used to compute the non-planar aerodynamics of flexible wings with large deformation. The finite element method is introduced for structural nonlinear statics analysis. The surface spline method is used for structure/aerodynamics coupling. The static aeroelastic characteristics of the wind tunnel model of a flexible wing are studied by the nonlinear method presented, and the nonlinear method is also evaluated by comparing the results with those obtained from two other methods and the wind tunnel test. The results indicate that the traditional linear method of static aeroelastic analysis is not applicable for cases with large deformation because it produces results that are not realistic. However, the nonlinear methodology, which involves combining the structure finite element method with the non-planar vortex lattice method, could be used to solve the aeroelastic deformation with considerable accuracy, which is in fair agreement with the test results. Moreover, the nonlinear finite element method could consider complex structures. The non-planar vortex lattice method has advantages in both the computational accuracy and efficiency. Consequently, the nonlinear method presented is suitable for the rapid and efficient analysis requirements of engineering practice. It could be used in the preliminary stage and also in the detailed stage of aircraft design. | Xie Changchuan Wang Libo Yang Chao Liu Yi | 2013 | Chinese Journal of Aeronautics2013，26，3： | 13 |
| 16 | Spurious Thermoluminescence Characteristics of the Ediacaran Doushantuo Formation(ca. 635–551 Ma) and Its Implications for Marine Dissolved Organic Carbon Reservoir显示文摘The Ediacaran Doushantuo Formation(ca. 635–551 Ma) deposited immediately after the last Neoproterozoic glaciations and recorded the most prominent negative excursions of carbonate carbon isotopic composition(δ^(13)C_(carb)). These excursions have been interpreted as a result of widespread remineralization of a large dissolved organic carbon(DOC) reservoir in the Ediacaran deep oceans. However, there is no direct evidence so far found in rocks for the proposed DOC reservoir, which devalues such an interpretation. Here, we conducted a detailed study on the glow-curves characteristics and signal origins of spurious thermoluminescence(TL) of the Doushantuo Formation at Jiulongwan in Yangtze Gorges area, South China, through sequential tests under CO_2, N_2 and air. Spurious TL intensities for test samples before and after removing soluble organic matter via accelerated solvent extraction(ASE) are nearly identical. Further, significant positive correlation between the spurious TL intensity and total inorganic carbon(TIC) content(R^2=0.7) indicate that the Doushantuo spurious TL with the characteristic peak at 393.5 °C from the sequential test is chemiluminescence(CL) which is derived from the oxidation of a type of non-volatile organic matter strongly associated with carbonate mineral lattice(termed as 'X-OM'). A most likely explanation is that the X-OM is a type of dissolved organic matter which co-precipitated with carbonate minerals into sediments in the Ediacaran Doushantuo Ocean. Furthermore, a significant exponential negative correlation(R^2=0.55) is observed between the CL data and the isotopic difference between carbonate and coexisting bulk organic matter(i.e., Δ^(13)C_(carb-org), a proxy for remineralization degree of DOC reservoir in proposed DOC hypothesis), suggesting that the X-OM was derived from the oxidation of the DOC reservoir in the Ediacaran Ocean. We thus propose that the X-OM and its CL detected in our study may have recorded the evolution of the possible DOC reservoir in the Ediacaran Doushantuo Ocean. If this is correct, the stratigraphic variations of the CL intensity in the Doushantuo Formation at Jiulongwan support the pulsed oxidation of the DOC reservoir in the Ediacaran Ocean. Our findings indicate that the CL derived from the oxidation of non-volatile organic matter which is strongly associated with carbonate mineral lattices in rocks may provide a feasible approach for probing the evolution of DOC reservoir in the ancient oceans, thus likely provide direct geological evidence for the development of oceanic DOC reservoir in geological times. | Haiyang Wang Chao Li Chaoyong Hu Shucheng Xie | 2015 | Journal of Earth Science2015，26，6： | 12 |
| 17 | Ultrasensitive broadband phototransistors based on perovskite/organic-semiconductor vertical heterojunctions显示文摘Organolead halide perovskites have emerged as the most promising materials for various optoelectronic devices,especially solar cells,because of their excellent optoelectronic properties.Here,we present the first report of low-voltage high-gain phototransistors based on perovskite/organic-semiconductor vertical heterojunctions,which show ultrahigh responsivities of~10^(9)A W^(–1) and specific detectivities of~10^(14) Jones in a broadband region from the ultraviolet to the near infrared.The high sensitivity of the devices is attributed to a pronounced photogating effect that is mainly due to the long carrier lifetimes and strong light absorption in the perovskite material.In addition,flexible perovskite photodetectors have been successfully prepared via a solution process and show high sensitivity as well as excellent flexibility and bending durability.The high performance and facile solution-based fabrication of the perovskite/organic-semiconductor phototransistors indicate their promise for potential application for ultrasensitive broadband photodetection. | Chao Xie Peng You Zhike Liu Li Li Feng Yan | 2017 | Light(Science & Applications)2017，6，1： | 12 |
| 18 | Essential role of autophagy in fucoxanthin-induced cytotoxicity to human epithelial cervical cancer HeLa cells显示文摘 | Li-li HOU Chao GAO Liang CHEN Guo-qiang HU Song-qiang XIE | 2013 | Acta Pharmacologica Sinica2013，34，11： | 11 |
| 19 | A theoretical prediction of chemical zonation in early oceans(>520 Ma)显示文摘Early oceans(>520 Ma) were characterized by widespread water-column anoxia, stratification, and limited oxidant availability, which are comparable to the chemical characteristics of modern marine sedimentary pore-waters in productive continental margins. Based on this similarity and our current understanding of the formation mechanism of early Earth ocean chemistry, we propose an idealized chemical zonation model for early oceans that includes the following redox zones(from shallow nearshore to deep offshore regions): oxic, nitrogenous(NO3?-NO2?-enriched), manganous-ferruginous(Mn2+ or Fe2+-enriched), sulfidic(H2S-enriched), methanic(CH4-enriched), and ferruginous(Fe2+-enriched). These zones were dynamically maintained by a combination of processes including surface-water oxygenation by atmospheric free oxygen, nitrate reduction beneath the chemocline, nearshore manganese-iron reduction, sulfate reduction, methanogenesis, and hydrothermal Fe2+ inputs from the deep ocean. Our modified 'euxinic wedge' model expands on previous versions of this model, providing a more complete theoretical framework for the chemical zonation of early Earth oceans that helps to explain observations of unusual Mo-S-C isotope patterns. This model may provide a useful foundation for future studies of ocean chemistry evolution and elemental biogeochemical cycles in early Earth history. | LI Chao CHENG Meng Thomas J.ALGEO XIE ShuCheng | 2015 | Science China Earth Sciences2015，58，11： | 11 |
| 20 | Mortality and morbidity of acute hypoxemic respiratory failure and acute respiratory distress syndrome in infants and young children显示文摘 | ZHU Yan-feng XU Feng LU Xiu-lan WANG Ying CHEN Jian-li CHAO Jian-xin ZHOU Xiao-wen ZHANG Jian-hui HUANG Yan-zhi YU Wen-liang XIE Min-hui YAN Chao-ying LU Zhu-jin SUN Bo | 2012 | Chinese Medical Journal2012，，13： | 11 |
您所在的机构暂未开通此部分的功能，请联系管理员