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| 1 | Effects of a 24-week course of interferon-αtherapy after curative treatment of hepatitis C virus-associated hepatocellular carcinoma显示文摘AIM:To assess whether a 24-wk course of interferon (IFN)could prevent hepatocellular carcinoma(HCC) recurrence and worsening of liver function in patients with hepatitis C virus(HCV)-infected patients after receiving curative treatment for primary HCC. METHODS:Outcomes in 42 patients with HCV infection treated with IFN-α,after curative treatment for primary HCC(IFN group),were compared with 42 matched curatively treated historical controls not given IFN(non- IFN group). RESULTS:Although the rate of initial recurrence did not differ significantly between IFN group and non-IFN group (0%,44%,61%,and 67% vs 4.8%,53%,81%,and 87% at 1,3,5,and 7 years,P=0.153,respectively), IFN group showed a lower rate than the non-IFN group for second recurrence(0%,10.4%,28%,and 35% vs 0%,30%,59%,and 66% at 1,3,5 and 7 years, P=0.022,respectively).Among the IFN group,patients with sustained virologic response(SVR)were less likely to have a second HCC recurrence than IFN patients without an SVR,or non-IFN patients.Multivariate analysis identified the lack of SVR as the only independent risk factor for a second recurrence,while SVR and Child-Pugh class A independently favored overall survival. CONCLUSION:Most intrahepatic recurrences of HCV- related HCC occurred during persistent viral infection. Eradication of HCV is essential for the prevention of HCC recurrence and improvement of survival. | Soo Cheol Jeong Hiroshi Aikata Yoshio Katamura Takahiro Azakami Tomokazu Kawaoka Hiromi Saneto Kiminori Uka Nami Mori Shintaro Takaki Hideaki Kodama Koji Waki Michio Imamura Hiroo Shirakawa Yoshiiku Kawakami Shoichi Takahashi Kazuaki Chayama | 2007 | World Journal of Gastroenterology2007，13，40： | 3 |
| 2 | Dual oral therapy with daclatasvir and asunaprevir for patients with HCV genotype 1b infection and limited treatment options显示文摘 | Yoshiyuki Suzuki Kenji Ikeda Fumitaka Suzuki Joji Toyota Yoshiyasu Karino Kazuaki Chayama Yoshiiku Kawakami Hiroki Ishikawa Hideaki Watanabe Wenhua Hu Timothy Eley Fiona McPhee Eric Hughes Hiromitsu Kumada | 2012 | Journal of Hepatology2012，，： | 2 |
| 3 | Low-dose intermittent interferon-alpha therapy for HCV-related liver cirrhosis after curative treatment of hepatocellular carcinoma显示文摘AIM: To assess the efficacy of low-dose intermittent interferon (IFN) therapy in patients with hepatitis C virus (HCV)-related compensated cirrhosis who had received curative treatment for primary hepatocellular carcinoma (HCC). METHODS: We performed a prospective case controlled study. Sixteen patients received 3 MIU of natural IFN- alpha intramuscularly 3 times weekly for at least 48 wk (IFN group). They were compared with 16 matched historical controls (non-IFN group). RESULTS: The cumulative rate of first recurrence of HCC was not significantly different between the IFN group and the non-IFN group (0% vs 6.7% and 68.6% vs 80% at 1- and 3-year, P = 0.157, respectively). The cumulative rate of second recurrence was not also significantly different between the IFN group and the non-IFN group (0% vs 6.7% and 35.9% vs 67% at 1- and 3-year, P = 0.056, respectively). Although the difference in the Child-Pugh classification score between the groups at initial treatment of HCC was not signifi cant, the score was signifi cantly worse at the time of data analysis in the non-IFN group than IFN group (7.19 ± 1.42 vs 5.81 ± 0.75, P = 0.0008). The cumulative rate of deviation from objects of any treatment for recurrentHCC was also higher in the non-IFN group than IFN group (6.7% and 27% vs 0 and 0% at 1- and 3-year, P = 0.048, respectively). CONCLUSION: Low-dose intermittent IFN-alpha therapy for patients with HCV-related compensated cirrhosis after curative HCC treatment was effective by making patients tolerant to medical or surgical treatment for recurrent HCC in the later period of observation. | Soocheol Jeong Hiroshi Aikata Yoshio Katamura Takahiro Azakami Tomokazu Kawaoka Hiromi Saneto Kiminori Uka Nami Mori Shintaro Takaki Hideaki Kodama Koji Waki Michio Imamura Hiroo Shirakawa Yoshiiku Kawakami Shoichi Takahashi Kazuaki Chayama | 2007 | World Journal of Gastroenterology2007，13，39： | 2 |
| 4 | Telomere Reduction in Human Liver Tissues with Age and Chronic Inflammation显示文摘 | Hiroshi Aikata Hideki Takaishi Yoshiiku Kawakami Shoichi Takahashi Mikiya Kitamoto Toshio Nakanishi Yasuhiro Nakamura Fumio Shimamoto Goro Kajiyama Toshinori Ide | 2000 | Experimental Cell Research2000，，2： | 2 |
| 5 | Intra-arterial 5-fluorouracil/interferon combination therapy for advanced hepatocellular carcinoma with or without three-dimensional conformal radiotherapy for portal vein tumor thrombosis显示文摘 | Yoshio Katamura Hiroshi Aikata Shintaro Takaki Takahiro Azakami Tomokazu Kawaoka Koji Waki Akira Hiramatsu Yoshiiku Kawakami Shoichi Takahashi Masahiro Kenjo Naoyuki Toyota Katsuhide Ito Kazuaki Chayama | 2009 | Journal of Gastroenterology2009，，5： | 2 |
| 6 | Daclatasvir plus asunaprevir for chronic HCV genotype 1b infection显示文摘 | Hiromitsu Kumada Yoshiyuki Suzuki Kenji Ikeda Joji Toyota Yoshiyasu Karino Kazuaki Chayama Yoshiiku Kawakami Akio Ido Kazuhide Yamamoto Koichi Takaguchi Namiki Izumi Kazuhiko Koike Tetsuo Takehara Norifumi Kawada Michio Sata Hidetaka Miyagoshi Timothy Ele | 2014 | Hepatology2014，，6： | 2 |
| 7 | Dual oral therapy with daclatasvir and asunaprevir for patients with HCV genotype 1b infection and limited treatment options显示文摘 | Yoshiyuki Suzuki Kenji Ikeda Fumitaka Suzuki Joji Toyota Yoshiyasu Karino Kazuaki Chayama Yoshiiku Kawakami Hiroki Ishikawa Hideaki Watanabe Wenhua Hu Timothy Eley Fiona McPhee Eric Hughes Hiromitsu Kumada | 2012 | Journal of Hepatology2012，，： | 1 |
| 8 | Interleukin‐28B single nucleotide polymorphism of donors and recipients can predict viral response to pegylated interferon/ribavirin therapy in patients with recurrent hepatitis C after living donor liver transplantation显示文摘 | Tomokazu Kawaoka Shoichi Takahashi Shintaro Takaki Akira Hiramatsu Koji Waki Nobuhiko Hiraga Daiki Miki Masataka Tsuge Michio Imamura Yoshiiku Kawakami Hiroshi Aikata Hidenori Ochi Takashi Onoe Hirotaka Tashiro Hideki Ohdan Kazuaki Chayama | 2012 | Journal of Gastroenterology and Hepatology2012，，9： | 1 |
| 9 | Long term persistence of NS5A inhibitor‐resistant hepatitis C virus in patients who failed daclatasvir and asunaprevir therapy显示文摘 | Satoshi Yoshimi Michio Imamura Eisuke Murakami Nobuhiko Hiraga Masataka Tsuge Yoshiiku Kawakami Hiroshi Aikata Hiromi Abe C. Nelson Hayes Tamito Sasaki Hidenori Ochi Kazuaki Chayama | 2015 | J. Med. Virol2015，，11： | 1 |
| 10 | The long-term outcome of patients with bleeding gastric varices after balloon-occluded retrograde transvenous obliteration显示文摘 | Nobuhiko Hiraga Hiroshi Aikata Shintaro Takaki Hideaki Kodama Hiroo Shirakawa Michio Imamura Yoshiiku Kawakami Shoichi Takahashi Naoyuki Toyota Katsuhide Ito Shinji Tanaka Mikiya Kitamoto Kazuaki Chayama | 2007 | Journal of Gastroenterology2007，，8： | 1 |
| 11 | Recent trend of clinical features in patients with hepatocellular carcinoma显示文摘 | Yuko Nagaoki Hideyuki Hyogo Hiroshi Aikata Mio Tanaka Noriaki Naeshiro Takashi Nakahara Yoji Honda Daisuke Miyaki Tomokazu Kawaoka Shintaro Takaki Akira Hiramatsu Koji Waki Michio Imamura Yoshiiku Kawakami Shoichi Takahashi Kazuaki Chayama | 2012 | Hepatology Research2012，，4： | 1 |
| 12 | Dual oral therapy with daclatasvir and asunaprevir for patients with HCV genotype 1b infection and limited treatment options显示文摘 | Yoshiyuki Suzuki Kenji Ikeda Fumitaka Suzuki Joji Toyota Yoshiyasu Karino Kazuaki Chayama Yoshiiku Kawakami Hiroki Ishikawa Hideaki Watanabe Wenhua Hu Timothy Eley Fiona McPhee Eric Hughes Hiromitsu Kumada | 2012 | Journal of Hepatology2012，，： | 1 |
| 13 | Clinicopathological features of elderly patients with hepatitis C virus-related hepatocellular carcinoma显示文摘 | Daiki Miki Hiroshi Aikata Kiminori Uka Hiromi Saneto Tomokazu Kawaoka Takahiro Azakami Shintaro Takaki Soo Cheol Jeong Michio Imamura Yoshiiku Kawakami Shoichi Takahashi Toshiyuki Itamoto Toshimasa Asahara Koji Arihiro Kazuaki Chayama | 2008 | Journal of Gastroenterology2008，，7： | 1 |
| 14 | Characterization of virologic escape in hepatitis C virus genotype 1b patients treated with the direct-acting antivirals daclatasvir and asunaprevir显示文摘 | Yoshiyasu Karino Joji Toyota Kenji Ikeda Fumitaka Suzuki Kazuaki Chayama Yoshiiku Kawakami Hiroki Ishikawa Hideaki Watanabe Dennis Hernandez Fei Yu Fiona McPhee Hiromitsu Kumada | 2012 | Journal of Hepatology2012，，： | 1 |
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