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| 1 | Treatment outcomes for multidrug-resistant tuberculosis under DOTS-Plus:a systematic review and meta-analysis of published studies显示文摘Background:Anti-tuberculosis drug resistance is a major public health problem that threatens the progress made in tuberculosis care and control worldwide.Treatment success rates of multidrug-resistant tuberculosis(MDR-TB)is a key issue that cannot be ignored.There is a paucity of evidence that assessed studies on the treatment of MDR-TB,which focus on the effectiveness of the directly observed treatment,short-course(DOTS)-Plus program.Therefore,it is crucial to assess and summarize the overall treatment outcomes for MDR-TB patients enrolled in the DOTS-Plus program in recent years.The purpose of this study was to thus assess and summarize the available evidence for MDR-TB treatment outcomes under DOTS-Plus.Methods:A systematic review and meta-analysis of published literature was conducted.Original studies were identified using the databases MEDLINE®/PubMed®,Hinari,and Google Scholar.Heterogeneity across studies was assessed using the Cochran’s Q test and I2 statistic.Pooled estimates of treatment outcomes were computed using the random effect model.Results:Based on the 14 observational studies included in the meta-analysis,it was determined that 5047 patients reported treatment outcomes.Of these,the pooled prevalence,63.5%(95%CI:58.4-68.5%)successfully completed full treatment(cured or treatment completed)with a pooled cure rate of 55.6%,whereas 12.6%(95%CI:9.0-16.2%)of the patients died,14.2%(95%CI:11.6-16.8%)defaulted from therapy,and 7.6%(95%CI:5.6-9.7%)failed therapy.Overall 35.4%(95%CI:30-40.8%)of patients had unsuccessful treatment outcomes.An unsatisfactorily high percentage 43%(95%CI:32-54%)of unsuccessful treatment outcomes was observed among patients who were enrolled in standardized treatment regimens.Conclusion:This study revealed that patients with MDR-TB exhibited a very low treatment success rate compared to the World Health Organization 2015 target of at least 75 to 90%.The high default rate observed by conducting this literature review could possibly explain the spread of the MDR-TB strain in various populations.A better treatment success rate was observed among patients in individualized treatment regimens than in standardized ones.Conducting further individual-based meta-analysis is recommended to identify potential factors for defaulting treatment using large-scale and multi-center studies. | Kelemu Tilahun Kibret Yonatan Moges Peter Memiah Sibhatu Biadgilign | 2017 | Infectious Diseases of Poverty2017，6，1： | 4 |
| 2 | “Hot”electrons in metallic nanostructures—nonthermal carriers or heating?显示文摘Understanding the interplay between illumination and the electron distribution in metallic nanostructures is a crucial step towards developing applications such as plasmonic photocatalysis for green fuels,nanoscale photodetection and more.Elucidating this interplay is challenging,as it requires taking into account all channels of energy flow in the electronic system.Here,we develop such a theory,which is based on a coupled Boltzmann-heat equations and requires only energy conservation and basic thermodynamics,where the electron distribution,and the electron and phonon(lattice)temperatures are determined uniquely.Applying this theory to realistic illuminated nanoparticle systems,we find that the electron and phonon temperatures are similar,thus justifying the(classical)singletemperature models.We show that while the fraction of high-energy“hot”carriers compared to thermalized carriers grows substantially with illumination intensity,it remains extremely small(on the order of 10^(-8)).Importantly,most of the absorbed illumination power goes into heating rather than generating hot carriers,thus rendering plasmonic hot carrier generation extremely inefficient.Our formulation allows for the first time a unique quantitative comparison of theory and measurements of steady-state electron distributions in metallic nanostructures. | Yonatan Dubi Yonatan Sivan | 2019 | Light(Science & Applications)2019，8，1： | 3 |
| 3 | Tunable sharp and highly selective microwave-photonic band-pass filters based on stimulated Brillouin scattering显示文摘Stimulated Brillouin scattering(SBS)in optical fibers has long been used in frequency-selective optical signal processing,including in the realization of microwave-photonic(MWP)filters.In this work,we report a significant enhancement in the selectivity of SBS-based MWP filters.Filters having a single passband of 250 MHz–1 GHz bandwidth are demonstrated,with selectivity of up to 44 dB.The selectivity of the filters is better than that of the corresponding previous arrangements by about 15 dB.The shape factor of the filters,defined as the ratio between their−20 dB bandwidth and their−3 dB bandwidth,is between 1.35 and 1.5.The central transmission frequency,bandwidth,and spectral shape of the passband are all independently adjusted.Performance enhancement is based on two advances,compared with previous demonstrations of tunable SBS-basedMWPfilters:(a)the polarization attributes of SBS in standard,weakly birefringent fibers are used to discriminate between in-band and out-of-band components and(b)a sharp and uniform power spectral density of the SBS pump waves is synthesized through external modulation of an optical carrier by broadband,frequency-swept waveforms.The signal-to-noise ratio of filtered radio-frequency waveforms and the linear dynamic range of the filters are estimated analytically and quantified experimentally.Lastly,a figure of merit for the performance of the filters is proposed and discussed.The filters are applicable to radio-over-fiber transmission systems. | Yonatan Stern Kun Zhong Thomas Schneider Ru Zhang Yossef Ben-Ezra Moshe Tur Avi Zadok | 2014 | Photonics Research2014，2，4： | 2 |
| 4 | Frequency conversion in novel materials and its application to high resolution gas sensing显示文摘 | ADY A KEREN F K YONATAN S | | 0，，2： | 1 |
| 5 | Global mobility management by replicated databases in personal communication networks 显示文摘 | Kin K Leung Yonatan Levy | 1997 | IEEE Journal on Selected Areas in Communications1997，15，8： | 1 |
| 6 | Enhanced physiologic discriminability of stop consonants with prolonged formant transitions in awake monkeys based on the tonotopic organization of primary auditory cortex显示文摘 | Mitchell Steinschneider Yonatan I. Fishman | 2010 | Hearing Research2010，，1： | 1 |
| 7 | Phase locking of a two-dimensional laser array by controlling the far-field pattern显示文摘 | Zhou Yi Liu Liping Yonatan Abranyos | 2004 | Appl Phys Lett2004，84，16： | 1 |
| 8 | The relationship between water loss, lipid content, membrane integrity and LOX activity in ripe pepper fruit after storage显示文摘 | Kissinger Maalekuu Yonatan Elkind Alicia Leikin-Frenkel Susan Lurie Elazar Fallik | 2006 | Postharvest Biology and Technology2006，，3： | 1 |
| 9 | Myocardial infarction after vascular surgery: the role of prolonged, stress-induced, ST depression-type ischemia显示文摘 | Giora Landesberg Morris Mosseri Doron Zahger Yehuda Wolf Misha Perouansky Haim Anner Benjamin Drenger Yonatan Hasin Yacov Berlatzky Charles Weissman | 2001 | Journal of the American College of Cardiology2001，，7： | 1 |
| 10 | A vesiculararbuscular mycorrhizal fungus (Glomus intraradix)induces a defense response in alfalfa roots 显示文摘 | Hanne V Yonatan E Yaacov O | 1994 | PlantPhysiol1994，104，： | 1 |
| 11 | Update on the pathogenesis of diabetic neuropathy显示文摘 | Yonatan Serlin Jaime Levy and Hadar Shalev 'Vascular Pathology and Blood-Brain Barrier Disruption in Cogni- tive and Psychiatric Complications of Type 2 Diabetes- Mellitus ' Obrosova IG | 2003 | Curr Diab Rep2003，3，： | 1 |
| 12 | Manufacturing Employees and Technological Change显示文摘 | Brian Bemmels Yonatan Reshef | 1991 | Journal of Labor Research1991，，3： | 1 |
| 13 | Immunization with HIV-1 gp41 Subunit Virosomes Induces Mucosal Antibodies Protecting Nonhuman Primates against Vaginal SHIV Challenges显示文摘 | Morgane Bomsel Daniela Tudor Anne-Sophie Drillet Annette Alfsen Yonatan Ganor Marie-Ga?lle Roger Nicolas Mouz Mario Amacker Anick Chalifour Lorenzo Diomede Gilles Devillier Zhe Cong Qiang Wei Hong Gao Chuan Qin Gui-Bo Yang Rinaldo Zurbriggen Lucia Lopalco | 2011 | Immunity2011，，2： | 1 |
| 14 | Identification of many microRNAs that copurify with polyribosomes in mammalian neurons 显示文摘 | KIM J ANNA K YONATAN G | 2004 | Proceedings of the National Academy of Sciences2004，101，36： | 1 |
| 15 | Almost Sure Convergence of the Multiple Ergodic Average for Certain Weakly Mixing Systems显示文摘 | Yonatan GUTMAN Wen HUANG Song SHAO Xiang Dong YE | 2018 | Acta Mathematica Sinica,English Series2018，34，1： | 1 |
| 16 | Secular Trends in Helicobacter pylori Seroprevalence in Adults in the United States:Evidence for Sustained Race/Ethnic Disparities显示文摘 | Grad Y Lipsitch M Yonatan H | 2012 | Am J Epidemiol2012，175，1： | 1 |
| 17 | 查看详情显示文摘 | Yonatan Dubi Yigal Meir Yshai Avishai | | 0，，： | 1 |
| 18 | Generalized laws of refraction and reflection at interfaces between different photonic artificial gauge fields显示文摘Artificial gauge fields the control over the dynamics of uncharged particles by engineering the potential landscape such that the particles behave as if effective external fields are acting on them.Recent years have witnessed a growing interest in artificial gauge fields generated either by the geometry or by time-dependent modulation,as they have been enablers of topological phenomena and synthetic dimensions in many physical settings,e.g.,photonics,cold atoms,and acoustic waves.Here,we formulate and experimentally demonstrate the generalized laws of refraction and reflection at an interface between two regions with different artificial gauge fields.We use the symmetries in the system to obtain the generalized Snell law for such a gauge interface and solve for reflection and transmission.We identify total internal reflection(TIR)and complete transmission and demonstrate the concept in experiments.In addition,we calculate the artificial magnetic flux at the interface of two regions with different artificial gauge fields and present a method to concatenate several gauge interfaces.As an example,we propose a scheme to make a gauge imaging system-a device that can reconstruct(image)the shape of an arbitrary wavepacket launched from a certain position to a predesigned location. | Moshe-Ishay Cohen Christina Jörg Yaakov Lumer Yonatan Plotnik Erik H.Waller Julian Schulz Georg von Freymann Mordechai Segev | 2020 | Light(Science & Applications)2020，9，1： | 1 |
| 19 | Neuro- blastoma Cell Lines Contain Pluripotent Tumor Initiating Cells That Are Susceptible to a Targeted Oncolytie Vires 显示文摘 | Yonatan Y Mahller Jon P Williams Baird | 2009 | LoSONE2009，4，1： | 1 |
| 20 | Autoimmune epilepsy: Distinct subpopulations of epilepsy patients harbor serum autoantibodies to either glutamate/AMPA receptor GluR3, glutamate/NMDA receptor subunit NR2A or double-stranded DNA显示文摘 | Yonatan Ganor Hadassa Goldberg-Stern Tally Lerman-Sagie Vivian I. Teichberg Mia Levite | 2005 | Epilepsy Research2005，，1： | 1 |
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