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| 1 | Burden of colorectal cancer in China, 1990-2017: Findings from the Global Burden of Disease Study 2017显示文摘Objective: Our goal is to analyze the trend of colorectal cancer(CRC) regarding the death, incidence and prevalence rates over time, and to provide epidemiological knowledge basis for health policy revision by comparing data about fatal outcomes of CRC in 2017 to those data in 1990, which was extracted from the Global Burden of Disease(GBD).Methods: The time trend and changes of CRC burden from 1990 to 2017 were measured by using the methods and results from the Institute for Health Metrics and Evaluation(IHME) GBD 2017, based on the rates of death,incidence and prevalence.Results: The death rate of CRC is 13.24/100,000, accounting for 1.79% of total deaths in China in 2017. In1990, CRC ranked 21 st in all causes of death in China compared to its 11 th ranking in 2017. The death, incidence and prevalence rate of CRC were standardized by the age scale of the global population in 2010, the change of standardized death rate of CRC was not significant, from 9.33/100,000 in 1990 to 10.10/100,000 in 2017. The standardized incidence rate of CRC significantly increased from 12.18/100,000 in 1990 to 22.42/100,000 in 2017.The standardized prevalence rate of CRC significantly increased from 44.55/100,000 in 1990 to 118.40/100,000 in2017. The trend of the prevalence rate in both genders grow higher in 2017 compared to the 1990, resulting in141.6%, 209.8% and 189.0% for the studied three age groups(15-49, 50-69 and 70+ years old), respectively. The death rate increased in the age groups of 50-69 and 70+ years in both genders(8.6% and 31.0% respectively), in contrast to a decrease of death rate in the age group of 15-49 years old(-10.8%).Conclusions: China experienced a stunning increase in terms of incidence and prevalence rate of CRC from1990 to 2017. To decrease the burden of CRC, prevention and management of known risk factors should be promoted through national polices. | Jie Yin Zhigang Bai Jun Zhang Zhi Zheng Hongwei Yao Pengpeng Ye Jun Li Xin Gao Zhongtao Zhang | 2019 | Chinese Journal of Cancer Research2019，31，3： | 16 |
| 2 | 1990—2017年中国伤害负担:2017年全球疾病负担研究结果(摘译)显示文摘伤害是全球性的公共卫生挑战,涉及各年龄组和不同性别的人群。过去三十年来,中国经济快速发展,人口老龄化趋势加重,社会呈现出城镇化、机动化和老龄化等特征。随着人们生活环境和生活方式的改变,伤害已跃居人群致死原因第五位,仅排在恶性肿瘤、心脑血管疾病、呼吸系统疾病和心肌梗死之后。据估计,中国每年在伤害方面消耗的直接医疗费用约为650亿元人民币. | 林泽婷(译) 吕来文(译) 黄晓晴(译) 李丽萍(审校) Duan Leilei Ye Pengpeng Juanita A Haagsma Jin Ye Wang Yuan Er Yuliang Deng Xiao Gao Xin Ji Cuirong Wang Linhong Marlena S Bannick W Cli Mountjoy-Venning Caitlin N Hawley Zichen Liu Mari Smith Spencer L James Theo Vos Christopher J L Murray | 2020 | 伤害医学(电子版)2020，9，2： | 15 |
| 3 | Benefit of everolimus as a monotherapy for a refractory breast cancer patient bearing multiple genetic mutations in the PI3K/AKT/mTOR signaling pathway显示文摘A postmenopausal patient with a diagnosis of estrogen receptor(ER)(+), progesterone receptor(PR)(+), and human epidermal growth factor receptor-2(HER2)(-) breast cancer was reported. The patient refused surgery and was resistant to conventional chemotherapy regimens. Computed tomography and the circulating tumor cell test indicated that the patient's tumor burden increased rapidly even after several chemotherapy sessions. Multiple genetic aberrances in the phosphatidylinositol3-kinases(PI3 K) signaling pathway were detected via next-generation sequencing(NGS)-based liquid biopsy, including a p. G1007 R missense mutation in exon 21 of PIK3 CA(33.61%), a p.L70 fs frameshift mutation in exon 3 of phosphatase and tension homolog deleted on chromosome ten(PTEN)(49.14%), and a p. D1542 Y missense mutation in exon 32 of mammalian target of rapamycin(m TOR)(1.66%). Therefore, only the m TOR inhibitor everolimus was administered to the patient. Partial remission(PR) was observed after 2 months, and sustained stable disease(SD) was observed after a year and a half. Subsequent sequencing showed that the mutation ratio of PIK3 CA decreased to 4.17%, and that the PTEN and m TOR mutations disappeared, which revealed the significant curative effect of everolimus. We report the first case of successful monotherapy treatment using everolimus in a patient with advanced breast cancer bearing mutations in genes involved in the PI3 K/ARK/m TOR signaling pathway. The success of this case highlights the invaluable clinical contribution of NGS-based liquid biopsy, as it successfully provided an optimal therapeutic target for the patient with advanced breast cancer. | Yehui Shi Wenwen Zhang Yingnan Ye Yanan Cheng Lei Han Pengpeng Liu Weipeng Zhao Zhongsheng Tong Jinpu Yu | 2018 | Cancer Biology & Medicine2018，15，3： | 6 |
| 4 | Characteristics of Injury Diagnosis among Primary and Secondary School Student--China,2018显示文摘What is already known about this topic?Child injury is a serious public health problem in China.The epidemiological characteristics injuries related to primary and secondary school students were usually reported from school-based population surveys conducted in developed regions of China.Medical and health institution-based data were rarely adopted to explore the typical patterns of injury occurrence among primary and secondary school students in China.What is added by this report?This study found that among primary and secondary school students with injury diagnosis in the National Injury Surveillance System(NISS),the high-risk group of primary and secondary school students with injury diagnosis was male students.The frequent incidence season was spring and early summer.Noon was the peak incidence time.Falling was the most common cause of injury among students,but other frequent causes of injury differs in students with different education levels.Home and school were the most common places where injury occurs.Students were more likely to suffer injury when they were engaged in leisure and sport activities.Limbs and the head were easily injured with contusions/bruises.What are the implications for public health practice?Medical and health institution-based data could be an additional data source for student-related injury research.Typical patterns could be summarized to provide data-driven basis for the improved formulation of injury prevention and control strategies and measures towards students.The characteristics of injury events differs in students with different education levels and requires more specific attentions towards students when conducting relevant programs in school and school-related places. | Pengpeng Ye Yuliang Er Yuan Wang Leilei Duan | 2020 | China CDC weekly2020，2，13： | 1 |
| 5 | Rapid magnetic removal of aqueous heavy metals and their relevant mechanisms using nanoscale zero valent iron (nZVI) particles显示文摘 | Pengpeng Huang Zhengfang Ye Wuming Xie Qi Chen Jing Li Zhencheng Xu Maosheng Yao | 2013 | Water Research2013，，12： | 1 |
| 6 | Rapid response of brain metastasis to crizotinib in a patient with KLC1-ALK fusion and MET gene amplification positive non-small cell lung cancer:a case report显示文摘Non-small cell lung cancer(NSCLC) ranks as the leading cause of cancer-related death in the world. Brain metastasis(BM) is a common complication of NSCLC, with 25%–40% of patients developing BM during the course of the disease. A significant strategy of local disease control in the central nervous system is radiation therapy. With the development of precision medicine,the concept of treating lung cancer BM has gradually changed. In this case, we performed a surgical procedure to obtain enough tumor tissue for the detection of the target gene and other related experiments after the patient was informed. Finally, we found that the patient had both hepatocyte growth factor receptor(MET) gene amplification and kinesin light chain 1-anaplastic lymphoma kinase fusion(KLC1-ALK) through next-generation sequencing and showed sensitivity to the targeted therapy of crizotinib. The patient exhibited good response. Our case was successful and underwent targeted therapy with the guidance of precise diagnosis. | Peng Wang Pei Xiao Yingnan Ye Pengpeng Liu Lei Han Li Dong Chunhua She Jinpu Yu | 2017 | Cancer Biology & Medicine2017，14，2： | 1 |
| 7 | Characteristics of Poisoning Cases Admitted to Outpatient and Emergency Department—China,2019显示文摘Summary What is already known about this topic?Poisoning constitutes a significant cause of mortality among individuals aged 1 to 44 in China.Nonetheless,the epidemiological understanding of poisoning incidents within emergency departments remains fragmented across the region. | Xiao Deng Ye Jin Yuan Wang Pengpeng Ye Yuan Yuan Chengye Sun Leilei Duan | 2023 | China CDC weekly2023，5，47： | 1 |
| 8 | Future challenges and solutions for safety in China:China CDC’s exploration of injury prevention strategies显示文摘As an important component of worldwide injury prevention,China has made great contribution to the development.China is serving as a model for other countries in the world,especially developing countries,and China’s experience has great implications for them.Besides the description of the present situation and trends of China’s injury prevention work and review for its development history,this paper has also introduced the existing issues and the current challenges,and informed the e orts of the sta in related eld to nd solutions from di erent aspects.All of them jointly boosted the development of global injury prevention. | Leilei Duan Pengpeng Ye Linhong Wang | 2018 | Global Health Journal2018，2，2： | 1 |
| 9 | Rapid magnetic removal of aqueous heavy metals and their relevant mechanisms using nanoscale zero valent iron (nZVI) particles显示文摘 | HUANG Pengpeng YE Zhengfang XIE Wuming | 2013 | Water Research2013，47，12： | 1 |
| 10 | Characteristics of Falls Among Older People-China,2018显示文摘What is already known about this topic?The incidence of falls among older people is 20.7%in China.Falls are the top cause for death from injuries in people aged 65 years and above,and mortality rates increase with age in China.There are few reports on the epidemiological characteristics of falls in older people nationwide in recent years.What is added by this report?This study found that among older people with falls reported in the National Injury Surveillance System(NISS)in 2018,there were more females than males.The peak time for falls was in the morning.Home was the most common site where falls occurred,and leisure activities and housework were the main activities when falls occurred.After falling,the lower limbs and head were most often injured with bruises and fractures.The degree of injury was mainly mild and moderate.What are the implications for public health practice?Data based on the NISS can be used as an additional data source for research on falls in China.This study identified priorities for the control and prevention of falls. | Zhiming Lu Pengpeng Ye Yuan Wang Leilei Duan Yuliang Er | 2021 | China CDC weekly2021，3，4： | 0 |
| 11 | Presence of multiple abnormal immunologic markers is an independent prognostic factor of diffuse large B-cell lymphoma显示文摘Autoimmune diseases (ADs) increase the risk of non-Hodgkin's lymphoma and contribute to poor prognosis of patients. However, the association between immunologic markers and clinical outcome has rarely been investigated. This study aims to analyze the prognostic value of pretreatment immunologic markers in newly diagnosed patients with diffuse large B-cell lymphoma (DLBCL). We retrospectively reviewed the data on 502 patients with DLBCL treated in our institution from January 2013 to March 2018. Survival functions were estimated using Kaplan Meier method and Cox regression model. The 3-year progression free survival (PFS) and overall survival (OS) rates were 70.2% and 80.9%, respectively, and the complete remission (CR) rate was 78.1%. Among the patients, those with multiple (≥3) abnormal immunologic markers had significantly shorter 3-year PFS (52.7% vs. 77.3%, P < 0.001) and OS (68.5% vs. 85.8%, P=0.001) than those without multiple abnormal immunologic markers.Multivariate analysis revealed that the presence of multiple abnormal immunologic markers and the elevated serum levels of lactate dehydrogenase were the independent adverse prognostic factors for PFS (P= 0.008, P < 0.001) and OS (P = 0.003, P < 0.001). Meanwhile, advanced Ann Arbor stage was an independent adverse prognostic factor for PFS (P= 0.001) and age > 60 years for OS (P= 0.014). In conclusion, the immunologic status was closely related to lymphoma progression, and this study provides new insights into the risk stratification of patients with DLBCL. | Yiwen Cao Zhenhua Liu Wen Wu Ying Qian Qin Shi Rong Shen Binshen Ouyang Pengpeng Xu Shu Cheng Jin Ye Yiming Lu Chaofu Wang Chengde Yang Li Wang Weili Zhao | 2019 | Frontiers of Medicine2019，13，1： | 0 |
| 12 | A novel ameliorated rat model of reversible obstructive jaundice显示文摘Obstructive jaundice is a common clinical symptom generally caused by bile duct stones,inflammatory hyperplasia,and tumors.It is characterized by hyperbilirubinemia and may trigger a variety of complications such as hypotension,kidney injury,endotoxemia,multiple organ dysfunction syndrome,and even death(Pavlidis and Pavlidis,2018;Liu et al.,2021).Relieving bile duct obstruction and providing adequate drainage have been considered as the most effective therapies for obstructive jaundice.However,it has not yet been established whether it is beneficial to treat affected patients by pre-operative biliary drainage(Blacker et al.,2021).Moreover,the pathophysiological changes or mechanisms associated with the reversal of organ function following the relief of bile-duct obstruction are unclear(Huang et al.,2004).Therefore,it is necessary to establish an experimental model of reversible obstructive jaundice to simulate biliary drainage in clinical practice. | Yongkang ZOU Pengpeng YUE Hankun CAO Liqin WU Li XU Zhongzhong LIU Shuangquan WU Qifa YE | 2023 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2023，24，4： | 0 |
| 13 | Effectiveness of Group-Based Interventions for Fall Prevention Among Community-Dwelling Older Adults—7 Regions,6 PLADs,China,2019–2020显示文摘Summary What is already known about this topic?Many of the current studies focusing on fall prevention interventions have been conducted in hospital settings within a select few urban areas in China,thus yielding limited evidence on the effectiveness of large-scale,multicenter,community-based interventions. | Yuliang Er Zhiming Lu Ye Jin Pengpeng Ye Leilei Duan | 2023 | China CDC weekly2023，5，47： | 0 |
| 14 | Unintentional Drowning Mortality Among Individuals Under Age 20—China,2013–2021显示文摘ABSTRACT Introduction:This study seeks to elucidate the evolving trend and identify disparities among subgroups in the mortality rate due to unintentional drowning in individuals under the age of 20 from the timeframe of 2013 to 2021 in China. | Zi Li Xiao Deng Ye Jin Leilei Duan Pengpeng Ye | 2023 | China CDC weekly2023，5，47： | 0 |
| 15 | Unintentional Injury Mortality Among Children Under Five Years--China,2006−2017显示文摘What is already known about this topic?Unintentional injuries among children aged under five years is still a serious public health problem in China.Epidemiological characteristics of under-five unintentional injury are reported in single provinces and cities for China but not nationally based on the Disease Surveillance Points(DSPs)dataset.What is added by this report?Unintentional injury mortality rates for under-five decreased substantially between 2006 and 2017 in China,with the decrease occurring primarily for males and rural children.Children living in rural areas and males had higher unintentional injury mortality rates than children in urban areas and females.The major fatal types of under-five unintentional injury were drowning and road injury.What are the implications for public health practice?Further interventions need to be taken in accordance with the main types of unintentional injuries,especially effective prevention strategies used in other countries or recommended by the World Health Organization(WHO).Even with equal access to injury prevention and control services for different sexes,policy efforts should focus on higher-risk populations,especially children aged under five years who are males or reside in rural areas. | Bo Chen Pengpeng Ye Biwei Tang Siqi Wang Jia Guo Jing Wu | 2020 | China CDC weekly2020，2，10： | 0 |
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