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| 1 | Analysis of in vivo patterns of caspase 3 gene expression in primary hepatocellular carcinoma and its relationship to p21^(WAF1) expression and hepatic apoptosis显示文摘AIM To detect the expression of caspase 3gene in primary human hepatocellular carcinoma(HCC)and investigate its relationship to p21WAF1gene expression and HCC apoptosis.METHODS In situ hybridization was employedto determine caspase 3 and p21WAF1expression inHCC.In situ end-labeling was used to detecthepatocytic apoptosis in HCC.RESULTS Twenty-one of 39(53.8%)cases ofHCC were found to express caspase 3transcripts,while 45.2% of HCC failed toexpress caspase 3.Non-cancerous adjacent livertissues showed more positive caspase 3(87.5%,7/8)as compared with HCC(P<0.05).The expression of caspase 3 is correlated withHCC differentiation,72.2%(13/18)ofmoderately to highly differentiated HCC showedcaspase 3 transcripts positive,while only 38.1%of poorly differentiated HCC harbored caspase 3transcripts(P<0.05).No relationship wasfound between caspase 3 expression and tumorsize or grade or metastasis,although 52.5%(5/8)of HCC with metastasis were caspase 3positive and a little higher than that with nometastasis(51.6%,P>0.05).Expression of caspase 3 alone did not affect the apoptosisindex(AI)of HCC.The AI was 7.12%o in caspase3-positive tumors(n=21),while in caspase 3-negative cases(n=18)6.59%0(P>0.05).Expression of caspase 3 clearly segregated withp21WAF1positive tumors as compared withp21WAF1-negative cases(16 of 23,69.6% versus5 of 16,31.3%)with statistical significance(P=0.017).In the cases with positive caspase 3and negative p21WAF1,the Al was found slightlyhigher,but with no statistical significance,thanthat with expression of p21WAF1and caspase 3(7.21‰ vs 6.98‰,P>0.05).CONCLUSION Loss of caspase 3 expressionmay contribute to HCC carcinogenesis,althoughthe expression of caspase 3 does not correlatewell with cell apoptosis in HCC.p21WAF1may bemerely one of the inhibitors which can reducecaspase 3 mediated cell apoptosis in HCCs. | Bao Hua Sun Jun Zhang Bao JǜWang Xi Ping Zhao You Kun Wang Zhi Qun Yu Dong Liang Yang Lian Jie Hao Department of Clinical Immunology,Tongji Hospital,Tongji Medical University,Wuhan 430030,Hubei Province,China | 2000 | World Journal of Gastroenterology2000，6，3： | 65 |
| 2 | 门静脉高压并非肝细胞癌肝切除术的绝对禁忌证显示文摘在肝细胞癌(hepatocellular carcinoma,HCC)的各种临床分期系统中,Bruix J团队领衔的巴塞罗那肝癌临床分期标准(Barcelona Clinic Liver Cancer,BCLC)最受推崇,美国和欧洲肝病协会指南的制定亦基于该分期系统。BCLC认为门静脉高压显著增加HCC肝切除术后患者发生肝功能衰竭的风险, | Zhong JH Li H Xiao N Ye XP Ke Y Wang YY Ma L Chen J You XM Zhang ZY Lu SD Li LQ 钟鉴宏 齐鲁楠 | 2014 | 中国癌症防治杂志2014，6，4： | 18 |
| 3 | Juvenile hominoid cranium from the terminal Miocene of Yunnan,China显示文摘Fossil apes are known from several late Miocene localities in Yunnan Province,southwestern China,principally from Shihuiba(Lufeng)and the Yuanmou Basin,and represent three species of Lufengpithecus.They mostly comprise large samples of isolated teeth,but there are also several partial or complete adult crania from Shihuiba and a single juvenile cranium from Yuanmou.Here we describe a new,relatively complete and largely undistorted juvenile cranium from the terminal Miocene locality of Shuitangba,also in Yunnan.It is only the second ape juvenile cranium recovered from the Miocene of Eurasia and it is provisionally assigned to the species present at Shihuiba,Lufengpithecus lufengensis.Lufengpithecus has most often been linked to the extant orangutan,Pongo pygmaeus,but recent studies of the crania from Shihuiba and Yuanmou have demonstrated that this is unlikely.The new cranium reinforces the view that Lufengpithecus represents a distinct,late surviving lineage of large apes in the late Miocene of East Asia that does not appear to be closely affiliated with any extant ape lineage.It substantially increases knowledge of cranial morphology in Lufengpithecus and demonstrates that species of this genus represent a morphologically diverse radiation of apes,which is consistent with the dynamic tectonic and biotic milieu of southwestern China in the late Miocene. | JI XuePing JABLONSKI Nina G SU Denise F DENG ChengLong FLYNN Lawrence J YOU YouShan KELLEY Jay | 2013 | Chinese Science Bulletin2013，58，31： | 8 |
| 4 | Screening for gastric cancer in Asia: current evidence and practice显示文摘 | Wai K Leung Ming-shiang Wu Yasuo Kakugawa Jae J Kim Khay-guan Yeoh Khean Lee Goh Kai-chun Wu Deng-chyang Wu Jose Sollano Udom Kachintorn Takuji Gotoda Jaw-town Lin Wei-cheng You Enders KW Ng Joseph JY Sung | 2008 | Lancet Oncology2008，，3： | 7 |
| 5 | Screening for gastric cancer in Asia: current evidence and practice显示文摘 | Wai K Leung Ming-shiang Wu Yasuo Kakugawa Jae J Kim Khay-guan Yeoh Khean Lee Goh Kai-chun Wu Deng-chyang Wu Jose Sollano Udom Kachintorn Takuji Gotoda Jaw-town Lin Wei-cheng You Enders KW Ng Joseph JY Sung | 2008 | Lancet Oncology2008，，3： | 3 |
| 6 | Cisplatin ototoxicity involves cytokines and STAT6 signaling network显示文摘我们此处调查了在支持 inflammatory cytokines 和 cisplatin ototoxicity 的生产表明串联的 STAT 的角色。cisplatin 注射引起的一个重要听觉缺陷在 Balb/c 被观察(野类型, WT ) 并且 STAT4 −/−, 然而并非在 STAT6 −/− 老鼠。而且,蛋白质的表示层次和支持 inflammatory cytokines 的 mRNA,包括 TNF-α, IL-1β,并且 IL-6,显著地在 WT 和 STAT4 −/−, 然而并非 STAT6 −/− 老鼠的浆液和蜗被增加。Organotypic 文化表明 stereocilia 捆的形状和在从 STAT6 −/− 鼠标的 Corti 的机关的感觉毛细胞层的数组在有 cisplatin 的处理以后是未经触动的,而那些高度在处理以后从 WT 和 STAT4 −/− 鼠标被弄歪并且弄乱。Cisplatin 在 HEI-OC1 听觉的房间导致了 STAT6 的 phosphorylation,并且由显著地保护的 STAT6 特定的 siRNA 的 STAT6 击倒从导致 cisplatin 的房间死亡的 HEI-OC1 听觉的房间和禁止的支持 inflammatory cytokine 生产。我们进一步证明 cisplatin 导致的 IL-4 和 IL-13 与 IL-4 受体 alpha 和 IL-13Rα 由绑定调制了 STAT6 的 phosphorylation; 1。这些调查结果建议发信号的 STAT6 在调停 cisplatin 的支持 inflammatory cytokine 生产和 ototoxicity 起一个枢轴的作用。 | Hyung-Jin Kim Gi-Su Oh Jeong-Han Lee Ah-Ra Lyu Hye-Min Ji Sang-Heon Lee Jeho Song Sung-Joo Park Yong-Ouk You Jeong-Dug Sul Channy Park Sang-Young Chung Sung-Kyun Moon David J Lim Hong-Seob So Raekil Park | 2011 | Cell Research2011，21，6： | 2 |
| 7 | 呼出气冷凝液代谢组学对慢加急性肝衰竭预后的预测价值显示文摘[据Hepatology Research 2021年4月报道]题:呼出气冷凝液代谢组学对慢加急性肝衰竭预后的预测价值(作者Jing J等)慢加急性肝衰竭(ACLF)是导致慢性失代偿肝病患者死亡的重要原因之一,也是国内外临床肝病研究领域的热点和难题。部分ACLF患者在治疗“黄金窗”阶段通过积极救治,能够获得可逆性的恢复,因此早期预测ACLF预后对患者及早施救以及重症化防控十分有益。 | 景婧 牛明 王睿林 JING J SANG X YOU S | 2021 | 临床肝胆病杂志2021，37，7： | 2 |
| 8 | Quantitative Histological Study on Changes of the Cortical Bones after Internal Fixation with Plates of Different Rigidity显示文摘In an effect to explore the potemtial role of bone microcirculation causing plate-induced reginal | Wang You et al. Dept Orth, Ninth People’s Hospital, Shanghai Second Med Uni, Shanghai 200011. Chin J Orth | 1995 | Chinese Medical Journal1995，，11： | 2 |
| 9 | A 10-fold improvement in the precision of boron isotopic analysis by negative thermal ionization mass spectrometry 显示文摘 | Shen J J You C F | 2003 | Anal Chem2003，75，9： | 1 |
| 10 | Repression of telomerase reverse transcriptase mRNA and hTERT promoter by inhibitory effects of oncogene C-myc in gambogic acid treated-human gastric carcinoma cells显示文摘 | Guo QL You QD | 2006 | Cancer Chemother Pharmacol2006，58，6： | 1 |
| 11 | 显示文摘 | Mirror on the Wall: You're Omnidirectional After All | 1998 | Science1998，282，： | 1 |
| 12 | Quantum chemistry study on superstructure and Raman spectra of binary sodium silicates显示文摘 | | 2004 | J Raman Spectrosc2004，36，3： | 1 |
| 13 | Skin color detection through estimation and conversion of illuminant color under various illuminations 显示文摘 | Do H C You J Y Chien S | 2007 | IEEE Transactions on Consumer Electronics2007，53，3： | 1 |
| 14 | The cell cycle kinetics of craniophawgnioma and its clinical ilgnificance显示文摘 | Xu J You C Zhou L | 2010 | J Neurooncol2010，98，1： | 1 |
| 15 | Some anzahl theorems is vectorspace over Z/p^kZ 显示文摘 | You H Nan J Z | 1996 | Acta Math Scientia1996，1，16： | 1 |
| 16 | Transitional cell carcinoma of the urinary tract:radiologic_pathologic correlation 显示文摘 | Weng You cheng J | 1998 | Radiographics1998，18，1： | 1 |
| 17 | Effect of gas bubbling and impeller agitation on degassing kinetics during magnesium alloy (AZ91D) melt recycling-water model approach 显示文摘 | Han J W Kim D J You B D | 2003 | Materials Science Forum2003，439，： | 1 |
| 18 | Prevalence of sleep disorders breathing in middle-aged Korean men and women显示文摘 | KIM J IN K YOU S | 2004 | J Respir Crit Care Med2004，170，： | 1 |
| 19 | PB/PANI-modified electrode used as a novel oxygen reduction cathode in microbial fuel eell显示文摘 | FU L YOU S J ZHANG GQ | 2011 | Biosens Bioeleetron2011，26，5： | 1 |
| 20 | Interfacial fracture behavior of tungsten wire/tungsten matrix composites with copper-coated interfaces 显示文摘 | DU J HOSCHEN T RASINSKI M YOU J H | 2010 | Mater Sci Eng A2010，527，6： | 1 |
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