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| 1 | 门静脉高压并非肝细胞癌肝切除术的绝对禁忌证显示文摘在肝细胞癌(hepatocellular carcinoma,HCC)的各种临床分期系统中,Bruix J团队领衔的巴塞罗那肝癌临床分期标准(Barcelona Clinic Liver Cancer,BCLC)最受推崇,美国和欧洲肝病协会指南的制定亦基于该分期系统。BCLC认为门静脉高压显著增加HCC肝切除术后患者发生肝功能衰竭的风险, | Zhong JH Li H Xiao N Ye XP Ke Y Wang YY Ma L Chen J You XM Zhang ZY Lu SD Li LQ 钟鉴宏 齐鲁楠 | 2014 | 中国癌症防治杂志2014，6，4： | 18 |
| 2 | Polymorphisms of MTHFD,plasma homocysteine levels, and risk of gastric cancer in ahigh-risk Chinese population显示文摘Purpose:Accumulative evidence suggests that folate has a protective effect on gastric cancer. The methylenetetrahyd-rofolate dlehydrogenase(MTHFD) plays an important role in folate and homocysteine metabolisms, and polymorphisms of MTHFD may result in disturbance of the folate-mediated homocysteine pathway. The aim of this study is to test the hypothesis that genetic variants of MTHFD and plasma homocysteine levels are associated with risk of gastric cancer and modulated by genotypes of methylenetetrahydrofolate reductase(MTHFR). Experimental Design: We genotyped G1958A and T401C in MTHFD and C677T in MTHFR and detected total plasma homocysteine(tHcy) levels in a case-control study of 589 gastric cancer cases and 635 cancer-free controls in a high-risk Chinese population. Results:The variant genotypes of MTHFD 1958AA and 401CC were associated with a significantly increased risk of gastric canceradjusted odds ratio(OR), 2.05; 95% confidence interval(95% CI),1.34-3.13 for 1958AA; adjusted OR,1.43; 95% CI,1.14-1.80 for 401CC compared with 1958GG/GA and 401TT/TC genotypes, respectively. Both of the effects were more evident in the subjects carrying MTHFR 677CT/TT genotypes. The average tHcy level was significantly higher in gastric cancer cases than in controls(P < 0.01), and the upper quartile of tHcy (> 13.6 mu mol/L) was associated with an 82% significantly increased risk of gastric cancer, compared with the lowest quartile of tHcy(<= 8.0 pmol/L;adjusted OR,1.82; 95% CI,1.20-2.75). Conclusions:The strong associations between MTHFD variants and the plasma tHcy levels and gastric cancer risk suggest, for the first time, a possible gene-environment interaction between genetic variants of folate-metabolizing genes and high tHcy levels in gastric carcinogenesis. | Wang, L. N Ke, Q Chen, W. S Wang, J. M Tan, Y. F Zhou, Y Hua, Z. L Ding, W. L Niu, J. Y Shen, J Zhang, Z. F Wang, X. R Xu, Y. H Shen, H. B Yi Xing | 2007 | 南京医科大学学报(自然科学版)2007，27，7： | 10 |
| 3 | 中国卫生人力资源:数量、质量和分布显示文摘在本文中,我们从数量、质量和分布的角度对中国现有的卫生人力资源进行了分析。与绝大多数国家不同,2005年中国拥有的医生总数大于护士总数——注册的执业医师和执业助理医师总数达190多万,注册的护士总数为140多万。城市地区的医生密度是农村地区的2倍多,而城市地区护士的密度是农村地区的3倍多。中国大多数医生(67.2%)和护士(97.5%)所接受的教育仅为大专或中专水平。自1998年以来,中国的医学卫生教育事业有了很大的发展,医学院校不断扩招又导致了卫生人员供过于求的局面。 | Sudhir Anand Victoria Y Fan Junhua Zhang Lingling Zhang Yang Ke Zhe Dang Lincoln C Chen | 2009 | 世界临床医学2009，3，1： | 9 |
| 4 | Small interfering RNA inhibits SARS-CoV nucleocapsid gene expression in cultured cells and mouse muscles显示文摘 | Zhao P Qin ZL Ke JS Lu Y Liu M Pan W Zhao LJ Cao J Qi ZT | 2005 | 第二军医大学学报2005，26，10： | 4 |
| 5 | BCL2 inhibits cell adhesion, spreading, and motility by enhancing actin polymerization显示文摘BCL2 最好作为多功能的 anti-apoptotic 蛋白质被知道。然而,很少在房间粘合剂和活动性事件对它的角色被知道。这里,我们证明 BCL2 可以在房间粘附的规定起一个作用,传播,并且活动性。BCL2 什么时候是在有教养的鼠科、人的房间线,传播的房间,粘附,和活动性的 overexpressed,被损害。与这些结果一致, Bcl2 的损失导致了在 Bcl2 空的老鼠观察的更高的活动性与野类型相比的胚胎的成纤维细胞(MEF ) 房间。房间粘附和活动性的 BCL2 规定的机制可以包含包含 BCL2,肌动朊,和 gelsolin 的建筑群的形成,它看起来机能上地减少 gelsolin 的切断的活动。我们观察到从 overexpressed BCL2 提高了的 MCF-7 和 NIH3T3 房间的 lysate 肌动朊聚合在在 vitro 试金没有房间。BCL2 和 F 肌动朊的共焦的 immunofluorescent 本地化在一致地传播期间证明 BCL2 的那增加的表情导致了增加的 F 肌动朊聚合。因此, BCL2 和 gelsolin 建筑群的形成(它可能包含另外的蛋白质) 看起来在房间粘附和移植的规定起一个关键作用。与癌症转移给房间活动性的确定的关联,这结果可以解释在一些肿瘤房间类型的 BCL2 的表示为什么为转移减少潜力并且与改进耐心的预后被联系。 | Hengning Ke Vandy I Parron Jeff Reece Jennifer Y Zhang Steven K Akiyama John E French | 2010 | Cell Research2010，20，4： | 3 |
| 6 | Preparation and photocatalytic activity of dysprosium doped tungsten trioxide nanoparticles 显示文摘 | Liu H J Peng T Y Ke D N | 2007 | Materials Chemistry and Physics2007，104，23： | 1 |
| 7 | Photocatalytic degradation of a cationic azo dye by TiO2/bentonite nanocomposite 显示文摘 | Sun Z S Chen Y X Ke Q | 2002 | J Photochem Photobiol A2002，149，13： | 1 |
| 8 | DGCR6L, a novel PAK4 interaction protein, regulates PAK4-mediated migration of human gastric cancer cell via LIMK 1 显示文摘 | Li X Ke Q Li Y | 2010 | Int J Biochem Cell Biol2010，42，1： | 1 |
| 9 | The MYB transcription factor super-family of Arabidopsis:expression analysis and phylogenetic comparisonwith the rice MYB family显示文摘 | CHEN Y H YANG X Y HE Ke t al | 2006 | Plant Molecular Biology2006，60，： | 1 |
| 10 | Mechanical method determining precipitation in an ultra-low carbon bainitic steel显示文摘 | Z J Dang Y Zhang J Ke | 1988 | Journal of University of Science and Technology Beijing1988，5，3： | 1 |
| 11 | Proteomic modification by nitric oxide显示文摘 | BAIN K KE Y KAMINSKI Y | 2006 | Pharmacol Sci2006，101，4： | 1 |
| 12 | Facile fabrication of magnetic metal-organic framework nanoparticles for potential targeted drug delivery显示文摘 | KE F YUAN Y P QIU L G | | 0，，： | 1 |
| 13 | Changes of predominant species/bi- ovars and sequence types of Brucella isolates, Inner Mongolia, Chi- na显示文摘 | Chen Y Ke Y Wang Y | 2015 | BMC Infect Dis2015，11，13： | 1 |
| 14 | Periodontal disease as a potential risk factor for the development of diabetes in women with a prior history of gestational diabetes mellitus显示文摘 | Xiong X Elkind-Hirsch KE Xie Y | 2013 | J Public Health Dent2013，73，1： | 1 |
| 15 | PCA-SIFT:a more distinctive representation for local image descriptors显示文摘 | Ke Y Sukthankar R | 2004 | Proceedings of IEEE Computer Society Conference on Computer Vision and Pattern Recognition2004，2，2： | 1 |
| 16 | Metal-organic frameworks for lithium ion batteries and supercapacitors显示文摘 | Ke F S Wu Y S Deng H X | 2015 | Journal of the Solid State Chemistry2015，223，： | 1 |
| 17 | Microstructure and property evolution of Cr-DLC films with different Cr content deposited by a hybrid beam technique 显示文摘 | DAI W KE P L WANG A Y | 2006 | Thin Solid Films2006，514，： | 1 |
| 18 | Preparation and photocatalytic activity of WO3/TiO2 nanocomposite particles 显示文摘 | Ke D N Liu H J Peng T Y | 2008 | Materials Letters2008，62，3： | 1 |
| 19 | Effect of SNP at position 40237 in exon 7 of the TPH2 gene on susceptibility to suicide显示文摘 | Ke L Qi ZY Ping Y el al | 2006 | Brain Res2006，1122，1： | 1 |
| 20 | Initial clinical experience with dextran-coated superparamagnetic iron oxide for detection of lymph node memstases in patients with head and neck cancer显示文摘 | Blackwell KE Hirschowitz SL | 1994 | Radiology1994，192，3： | 1 |
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