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| 1 | Mettl3-/Mettl14-mediated mRNA N6-methyladenosine modulates murine spermatogenesis显示文摘精子发生在双 spermatogonial 干细胞(SSC ) 哪个生产 haploid 精子期间是一个区别过程。这个高度专业化的过程精确在 transcriptional, posttranscriptional,和翻译层次被控制。这里,我们报导那 N 6-methyladenosine (m 6 一) ,调整基因表示的一个 epitranscriptomic 标记,在精子发生期间起必要作用。我们现在的全面 m 6 从五个发展阶段的老鼠 spermatogenic 房间的 mRNA methylomes:无差别的 spermatogonia,类型 A 1 spermatogonia, preleptotene spermatocytes, pachytene/diplotene spermatocytes,和圆 spermatids。m 6 有 Vasa-Cre 的 RNA methyltransferase Mettl3 或 Mettl14 引起 m 6 SSC 的 A 和弄空。m 6 为 SSC 增长 / 区别被要求的抄本的一个弄空 dysregulates 翻译。在有 Stra8-GFPCre 的先进细菌房间的 Mettl3 和 Mettl14 的联合删除破坏精子形式,而有在先进细菌房间的 Mettl3 或 Mettl14 的单个删除的老鼠显示出正常精子发生。从双异种老鼠展览的 spermatids 损害了为精子形式是必要的 haploid 特定的基因的翻译。这研究加亮 mRNA m 6 在 germline 开发的修正,潜在地保证在精子发生的不同阶段协调了翻译。 | Zhen Lin Phillip J Hsu Xudong Xing Jianhuo Fang Zhike Lu Qin Zou Ke-Jia Zhang Xiao Zhang Yuchuan Zhou Teng Zhang Youcheng Zhang Wanlu Song Guifang Jia Xuerui Yang Chuan He Ming-Han Tong | 2017 | Cell Research2017，27，10： | 61 |
| 2 | Coning motion stability of wrap around fin rockets显示文摘Both the asymptotical stability criterion and the bounded stability criterion of the coning motion for wrap around fin(WAF) rockets are proposed through the analy-sis of coning motion equations,which can be easily used to determine the exis-tence of the coning motion during the rocket design. The correctness of the crite-rions is verified by mathematical simulation examples of a WAF rocket with differ-ent setting angles. It is also found that the setting angle of WAF has great effects on the rolling moment and side moment of the rocket. | MAO XueRui YANG ShuXing XU Yong | 2007 | Science China(Technological Sciences)2007，50，3： | 7 |
| 3 | Repression of PKR mediates palmitate-induced apoptosis in HepG2 cells through regulation of Bcl-2显示文摘现在的学习显示出 RNA 依赖的蛋白质 kinase (PKR ) 调整的那双 stranded 蛋白质表示水平和 Bcl-2 和戏的 phosphorylation 在人的 hepatocellular 癌房间(HepG2 ) 的一个 anti-apoptotic 角色。在房间的各种各样的类型,浸透了免费的丰满的酸(船边交货) 例如 palmitate,被显示了由几机制导致细胞的 apoptosis。Palmitate 下面调整 PKR 并且从而的活动减少 Bcl-2 蛋白质的水平,由 NF-魏 B 抄写因素的减少的激活部分地调停了。除了 Bcl-2 蛋白质的水平,在不同氨基酸残余的 Bcl-2 的 phosphorylation 例如 Ser70 和 Ser87,在调整细胞的 apoptosis 也是重要的。在在在到 palmitate 的暴露之上的 Ser70 的 Bcl-2 的 phosphorylation 的减少被 c6 月 N 终端 kinase (JNK ) 被 PKR 并且可能的抑制调停,而在 Ser87 的 Bcl-2 的 phosphorylation 由 palmitate 或 PKR 是未受影响的。在摘要, PKR 调停蛋白质水平和 Bcl-2 的 phosphorylation 地位的规定,在 HepG2 房间提供导致 palmitate 的 apoptosis 的新奇机制。 | Xuerui Yang | 2009 | Cell Research2009，19，4： | 5 |
| 4 | COPII mitigates ER stress by promoting formation of ER whorls显示文摘Cells mitigate ER stress through the unfolded protein response(UPR).Here,we report formation of ER whorls as an effector mechanism of the ER stress response.We found that strong ER stress induces formation of ER whorls,which contain ER-resident proteins such as the Sec61 complex and PKR-like ER kinase(PERK).ER whorl formation is dependent on PERK kinase activity and is mediated by COPII machinery,which facilitates ER membrane budding to form tubular-vesicular ER whorl precursors.ER whorl precursors then go through Sec22b-mediated fusion to form ER whorls.We further show that ER whorls contribute to ER stressinduced translational inhibition by possibly modulating PERK activity and by sequestering translocons in a ribosome-free environment.We propose that formation of ER whorls reflects a new type of ER stress response that controls inhibition of protein translation. | Fang Xu Wanqing Du Qin Zou Yuting Wang Xin Zhang Xudong Xing Ying Li Dachuan Zhang Huimin Wang Wenhao Zhang Xinyao Hu Xin Liu Xiaoling Liu Shaojin Zhang Jinqiang Yu Jianhuo Fang Fajin Li Ying Zhou Tieqiang Yue Na Mi Haiteng Deng Peng Zou Xiaowei Chen Xuerui Yang Li Yu | 2021 | Cell Research2021，31，2： | 4 |
| 5 | Lateral transfer of mRNA and protein by migrasomes modifies the recipient cells显示文摘Dear Editor,Migrasomes are recently discovered vesicular organelles which form on the retraction fibers(RFs)of migrating cells.'Once detached from cells,migrasomes can rupture and release their luminal contents'in a process named migracytosis.Recently,migrasomes have been shown to play an important role in zebrafish organ morphogenesis by releasing chemokine signals to defined regions of the embryo.2 Thus,migracytosis is considered as a major mechanism for migrasomes to carry out their functions.It has been frequently observed that intact migrasomes can be engulfed by surrounding cells,'and this has been proposed as a potential mechanism for lateral transfer of cellular contents between cells.However,it is not clear whether the lateral transfer of cellular contents by migrasomes has functional consequences for the recipient cells. | Mingli Zhu Qin Zou Rongyao Huang Ying Li Xudong Xing Jianhuo Fang Liang Ma Lifei Li Xuerui Yang Li Yu | 2021 | Cell Research2021，31，2： | 3 |
| 6 | Mutual dependency between lncRNA LETN and protein NPM1 in controlling the nucleolar structure and functions sustaining cell proliferation显示文摘Fundamental processes such as ribosomal RNA synthesis and chromatin remodeling take place in the nucleolus,which is hyperactive in fast-proliferating cells.The sophisticated regulatory mechanism underlying the dynamic nucleolar structure and functions is yet to be fully explored.The present study uncovers the mutual functional dependency between a previously uncharacterized human long non-coding RNA,which we renamed LETN,and a key nucleolar protein,NPM1.Specifically,being upregulated in multiple types of cancer,LETN resides in the nucleolus via direct binding with NPM1.LETN plays a critical role in facilitating the formation of NPM1 pentamers,which are essential building blocks of the nucleolar granular component and control the nucleolar functions.Repression of LETN or NPM1 led to similar and profound changes of the nucleolar morphology and arrest of the nucleolar functions,which led to proliferation inhibition of human cancer cells and neural progenitor cells.Interestingly,this inter-dependency between LETN and NPM1 is associated with the evolutionarily new variations of NPM1 and the coincidental emergence of LETN in higher primates.We propose that this human-specific protein–lncRNA axis renders an additional yet critical layer of regulation with high physiological relevance in both cancerous and normal developmental processes that require hyperactive nucleoli. | Xianteng Wang Xiaolin Hu Wanlu Song Hui Xu Zhengtao Xiao Rongyao Huang Qingran Bai Fan Zhang Yongzhen Chen Yu Liu Jianhuo Fang Xin Li Qin Shen Haitao Zhao Xuerui Yang | 2021 | Cell Research2021，31，6： | 3 |
| 7 | Compound Danshen Dripping Pill inhibits hypercholesterolemia/atherosclerosis-induced heart failure in ApoE and LDLR dual deficient mice via multiple mechanisms显示文摘Heart failure is the leading cause of death worldwide.Compound Danshen Dripping Pill(CDDP)or CDDP combined with simvastatin has been widely used to treat patients with myocardial infarction and other cardiovascular diseases in China.However,the effect of CDDP on hypercholesterolemia/atherosclerosis-induced heart failure is unknown.We constructed a new model of heart failure induced by hypercholesterolemia/atherosclerosis in apolipoprotein E(ApoE)and LDL receptor(LDLR)dual deficient(ApoE^(–/–)LDLR^(–/–))mice and investigated the effect of CDDP or CDDP plus a low dose of simvastatin on the heart failure.CDDP or CDDP plus a low dose of simvastatin inhibited heart injury by multiple actions including anti-myocardial dysfunction and anti-fibrosis.Mechanistically,both Wnt and lysine-specific demethylase 4A(KDM4A)pathways were significantly activated in mice with heart injury.Conversely,CDDP or CDDP plus a low dose of simvastatin inhibited Wnt pathway by markedly up-regulating expression of Wnt inhibitors.While the anti-inflammation and anti-oxidative stress by CDDP were achieved by inhibiting KDM4A expression and activity.In addition,CDDP attenuated simvastatin-induced myolysis in skeletal muscle.Taken together,our study suggests that CDDP or CDDP plus a low dose of simvastatin can be an effective therapy to reduce hypercholesterolemia/atherosclerosis-induced heart failure. | Yanfang Yang Ke Feng Liying Yuan Yuxin Liu Mengying Zhang Kaimin Guo Zequn Yin Wenjia Wang Shuiping Zhou He Sun Kaijing Yan Xijun Yan Xuerui Wang Yajun Duan Yunhui Hu Jihong Han | 2023 | Acta Pharmaceutica Sinica B2023，13，3： | 2 |
| 8 | IDH1 fine-tunes cap-dependent translation initiation显示文摘The metabolic enzyme isocitrate dehydrogenase 1(IDH1)catalyzes the oxidative decarboxylation of isocitrate to a-ketoglutarate(a-KG).Its mutation often leads to aberrant gene expression in cancer.IDH1 was reported to bind thousands of RNA transcripts in a sequence-dependent manner;yet,the functional significance of this RNA-binding activity remains elusive.Here,we report that IDH1 promotes mRNA translation via direct associations with polysome mRNA and translation machinery.Comprehensive proteomic analysis in embryonic stem cells(ESCs)revealed strikingenrichmentof ribosomal proteins and translation regulators in IDH1-bound protein interactomes.We performed ribosomal profiling and analyzed mRNA transcripts that are associated with actively translating polysomes.Interestingly,knockout of IDH1 in ESCs led to significant downregulation of polysome-bound mRNA in IDH1 targets and subtle upregulation of ribosome densities at the start codon,indicating inefficient translation initiation upon loss of IDH1.Tethering IDH1 to a luciferase mRNA via the MS2-MBP system promotes luciferase translation,independently of the catalytic activity of IDH1.Intriguingly,IDH1 fails to enhance luciferase translation driven by an internal ribosome entry site.Together,these results reveal an unforeseen role of IDH1 in fine-tuning cap-dependent translation via the initiation step. | Lichao Liu JYuyang Lu Fajin Li Xudong Xing Tong Li Xuerui Yang Xiaohua Shen | 2019 | Journal of Molecular Cell Biology2019，11，10： | 2 |
| 9 | Oxygen dependent oxidation of trimethoprim by sulfate radical:Kinetic and mechanistic investigations显示文摘Trimethoprim(TMP)is a typical antibiotic to treat infectious disease,which is among the most commonly detected antibacterial agents in natural waters and municipal wastewaters.In the present study,the impacts of dissolved oxygen(DO)on the oxidation efficiency and pathways of TMP by reaction with sulfate radicals(SO_(4)^(-1))were investigated.Our results revealed that the presence of DO was favourable for TMP degradation.Specifically,TMP would react initially with SO_(4)^(-1)via electron-transfer process to form a carbon-centered radical.In the absence of oxygen,the carbon-centered radical could undergo hydrolysis to produceα-hydroxytrimethoprim(TMPàOH),followed by the further oxidation which generatedα-ketotrimethoprim(TMP=O).However,in the presence of oxygen,the carbon-centered radical would alternatively combine with oxygen,leading to a sequential reaction in which peroxyl radical and a tetroxide were formed,and finally generated TMPàOH and TMP=O simultaneously.The proposed pathways were further confirmed by density functional theory(DFT)calculations.The results obtained in this study would emphasize the significance of DO on the oxidation of organic micropollutants by SO_(4)^(-1). | Xuerui Yang Xi Ding Lei Zhou Yuefei Ji Guangli Xiu | 2021 | Chinese Chemical Letters2021，32，10： | 1 |
| 10 | Precision Medicine:What Challenges Are We Facing?显示文摘Following the publication of the US National Research Council(NRC)report‘‘Toward Precision Medicine:Building a Knowledge Network for Biomedical Research and a New Taxonomy of Diseases'in 2011[1],several nations have announced that their national research programs would definitely head toward this direction.Now,precision medicine(PM)became a banner for many large-scale | Yu Xue Eric-Wubbo Lameijer Kai Ye Kunlin Zhang Suhua Chang Xiaoyue Wang Jianmin Wu Ge Gao Fangqing Zhao Jian Li Chunsheng Han Shuhua Xu Jingfa Xiao Xuerui Yang Xiaomin Ying Xuegong Zhang Wei-Hua Chen Yun Liu Zhang Zhang Kun Huang Jun Yu | 2016 | Genomics, Proteomics & Bioinformatics2016，14，5： | 1 |
| 11 | Surface deformation under overlapping impacts of solid particles显示文摘To improve the accuracy of erosion prediction,the effect of subsequent particles impacting the same area while the first single particle rebounds from the substrate must be considered.This issue has rarely been considered in studies pertaining to erosion damage.In the present study,the ABAQUS software is used to investigate the erosion crater morphology and stress distribution on a target material subjected to overlapping impacts of spherical particles.Subsequently,the validated model is applied to investigate the effect of the overlapping impacts of particles on the target.Accordingly,the correlation between erosion severity and the impact locations of the two incident particles is quantified.The results show that the horizontal distance between two solid particle impact locations can significantly affect the erosion magnitude and pattern.The interactions of the resulting craters diminish when the horizontal distance exceeds 0.6 times the particle diameter.When the horizontal distance is approximately 0.06 times the particle diameter,the energy loss originating from collisions reaches the maximum,which modifies the crater morphology.The present study is expected to provide in-depth insights into erosion mechanisms and erosion modeling. | Xuerui ZANG Xuewen CAO Zhenqiang XIE Jun ZHANG Farzin DARIHAKI Yang LIU | 2023 | Friction2023，11，2： | 1 |
| 12 | 显示文摘 | Chen Guiguang Luo Guangsheng Yang Xuerui | 2004 | Materials Science and Engineering A2004，380，12： | 1 |
| 13 | 显示文摘 | Chen Guiguang Luo Guangsheng Yang Xuerui | 2004 | Materials Science and Engineering A2004，380，： | 1 |
| 14 | 酵母的 CryoEM 结构细胞质的 exosome 建筑群显示文摘真核细胞的多子单元 RNA exosome 建筑群在 3 ′ 起关键作用; -to-5′RNA 处理和腐烂。Rrp6 和 Ski7 分别地是为原子、细胞质的 exosomes 的主要余因子。在细胞质, Ski7 帮助 exosome 经由一条通过核心小径为降级和周转指向 mRNAs。然而,在 Ski7 之间的相互作用和 exosome 建筑群仍然保持不清楚。在 exosome 以内的 RNA 底层的办理也是逃犯的。在这个工作,我们使用了单个粒子的 cryo 电子显微镜学在 4.2 Å 的决定在 RNA 免费、 RNA 固定的形式解决 Ski7-exosome 建筑群的结构;并且 5.8 Å分别地。这些结构表明 Ski7 的 N 终端领域采用结构的安排并且以一种类似的方式与 exosome 交往到原子 Rrp6 的 C 终端领域。与怀有 3 ′ 的 RNA 底层推进 exosomes 的结构的分析;不同长度悬于在 RNA 处理的通过核心小径建议导致 RNA 的 exosome 激活的开关机制。 | Jun-Jie Liu Chu-Ya Niu Yao Wu Dan Tan Yang Wang Ming-Da Ye Yang Liu Wenwei Zhao Ke Zhou Quan-Sheng Liu Junbiao Dai Xuerui Yang Meng-Qiu Dong Niu Huang Hong-Wei Wang | 2016 | Cell Research2016，26，7： | 1 |
| 15 | Comparison of the Arctic upper-air temperatures from radiosonde and radio occultation observations显示文摘The air temperature is one of the most important parameters used for monitoring the Arctic climate change. The constellation observing system for meteorology, ionosphere, and climate and Formosa Satellite Mission 3(COSMIC/FORMOSAT-3) radio occultation(RO) 'wet' temperature product(i.e., 'wet Prf') is used to analyze the Arctic air temperature profiles at 925–200 hPa in 2007–2012. The 'wet' temperatures are further compared with radiosonde(RS) observations. The results from the spatially and temporally synchronized RS and COSMIC observations show that their temperatures agree well with each other, especially at 400 hPa. Comparisons of seasonal temperatures and anomalies from the COSMIC and homogenized RS observations suggest that the limited number of COSMIC observations during the spatial matchup may be insufficient to describe the smallscale spatial structure of temperature variations. Furthermore, comparisons of the seasonal temperature anomalies from the RS and 5°×5° gridded COSMIC observations at 400 hPa during the sea ice minimum(SIM) of2007 and 2012 are also made. The results reveal that similar Arctic temperature variation patterns can be obtained from both RS and COSMIC observations over the land area, while extra information can be further provided from the densely distributed COSMIC observations. Therefore, despite COSMIC observations being unsuitable to describe the Arctic temperatures in the lowest level, they provide a complementary data source to study the Arctic upper-air temperature variations and related climate change. | CHANG Liang GUO Lixin FENG Guiping WU Xuerui GAO Guoping ZHANG Yang ZHANG Yu | 2018 | Acta Oceanologica Sinica2018，37，1： | 1 |
| 16 | Grey relational analyzing factors in hypertensives with cardiac insufficiency显示文摘 | Tan Xuerui Yang Yuhua Deng Julong | 1998 | J Grey System1998，10，1： | 1 |
| 17 | Ribosome Profiling Reveals Genome-wide Cellular Translational Regulation upon Heat Stress in Escherichia coli显示文摘Heat shock response is a classical stress-induced regulatory system in bacteria, characterized by extensive transcriptional reprogramming. To compare the impact of heat stress on the transcriptome and translatome in Escherichia coli, we conducted ribosome profiling in parallel with RNA-Seq to investigate the alterations in transcription and translation efficiency when E. coli cells were exposed to a mild heat stress(from 30 °C to 45 °C). While general changes in ribosome footprints correlate with the changes of mRNA transcripts upon heat stress, a number of genes show differential changes at the transcription and translation levels. Translation efficiency of a few genes that are related to environment stimulus response is up-regulated, and in contrast, some genes functioning in mRNA translation and amino acid biosynthesis are down-regulated at the translation level in response to heat stress. Moreover, our ribosome occupancy data suggest that in general ribosomes accumulate remarkably in the starting regions of ORFs upon heat stress. This study provides additional insights into bacterial gene expression in response to heat stress, and suggests the presence of stress-induced but yet-to-be characterized cellular regulatory mechanisms of gene expression at translation level. | yanqing zhang zhengtao xiao qin zou jianhuo fang qifan wang xuerui yang ning gao | 2017 | Genomics, Proteomics & Bioinformatics2017，15，5： | 1 |
| 18 | Fluid Analysis and Structure Optimization of Impeller Based on Surrogate Model显示文摘The surrogate model technology has a good performance in solving black-box optimization problems,which is widely used in multi-domain engineering optimization problems.The adaptive surrogate model is the mainstream research direction of surrogate model technology,which can realize model fitting and global optimization of engineering problems by infilling criteria.Based on the idea of the adaptive surrogate model,this paper proposes an efficient global optimization algorithm based on the local remodeling method(EGO-LR),which aims at improving the accuracy and optimization efficiency of the model.The proposed algorithm firstly constructs the expectation improvement(EI)function in the local area and optimizes it to get the update points.Secondly,the obtained update points are added to the global region until the global accuracy of the model meets the requirements.Then the differential evolution algorithm is used for global optimization.Sixteen benchmark functions are used to compare the EGO-LR algorithm with the existing algorithms.The results show that the EGO-LR algorithm can quickly converge to the accuracy requirements of the model and find the optimal value efficiently when facing complex problems with many local extrema and large variable spaces.The proposed algorithm is applied to the optimization design of the structural parameter of the impeller,and the outflow field analysis of the impeller is realized through finite element analysis.The optimization with the maximum fluid pressure(MP value)of the impeller as the objective function is completed,which effectively reduces the pressure value of the impeller under load. | Huanwei Xu Wenzhang Wei Hanjin He Xuerui Yang | 2022 | Computer Modeling in Engineering & Sciences2022，，7： | 0 |
| 19 | Key technologies of the emergency platform in China显示文摘An emergency platform is an informatization support platform for disaster information perception,disaster situa-tional awareness,and emergency decision command.This is a key tool for ensuring the efficiency and effectiveness of emergency responses.Numerous large countries have conducted in-depth research on the key technologies of emergency platforms.Over the past 20 years,with the reform of emergency management mechanisms,China has developed two generations of emergency platform systems.This paper reviews the two generations of emergency platforms and summarizes their key technologies including multi-source-based monitoring and early warning,multi-hazard risk assessment,“scenario-response”-based decision support,synthetical forecasting based on in-cident chain,and emergency common operational picture(COP)for command and dispatch.Future research directions for the next generation emergency platforms are also proposed. | Hongyong Yuan Lida Huang Tao Chen Yang Chen Hui Zhang Xuerui Chen Qing Deng Zhichao He Jiajun Wang Yiting Wang | 2022 | Journal of Safety Science and Resilience2022，3，4： | 0 |
| 20 | Duality of Li_(2)CO_(3) in Solid-State Batteries显示文摘Solid-state batteries(SSBs)have been considered the most promising technology because of their superior energy density and safety.Among all the solid-state electrolytes(SEs),Li_(7) La_(3) Zr_(2) O_(12)(LLZO)with high ionic conductivity(3×10^(−4) S/cm)has been widely investigated.However,its large-scale production in ambient air faces a challenge.After air exposure,the generated Li_(2)CO_(3) layer deteriorates the ionic conductivity and interfacial wettability,thus greatly compromising the electrochemical performance of SSBs.Many works aim to eliminate this layer to recover the pristine LLZO surface.Unfor-tunately,few articles have emphasized the merits of Li_(2)CO_(3).In this review,we focus on the two-sidedness of Li_(2)CO_(3).We discuss the various characteristics of Li_(2)CO_(3) that can be used and recapitulate the strategies that utilize Li_(2)CO_(3).Insulating Li_(2)CO_(3) is no longer an obstacle but an opportunity for realizing intimate interfacial contact,high air stability,and outstand-ing electrochemical performance.This review aims to off er insightful guidelines for treating air-induced Li_(2)CO_(3) and lead to developing the enhanced air stability and electrochemical performance of LLZO. | Xuerui Yi Yong Guo Siyuan Pan Yiqiao Wang Sijia Chi Shichao Wu Quan-Hong Yang | 2023 | Transactions of Tianjin University2023，29，1： | 0 |
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