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| 1 | Transplantation of collagen scaffold with autologous bone marrow mononuclear cells promotes functional endometrium reconstruction via downregulating ΔNp63 expression in Asherman's syndrome显示文摘Asherman's syndrome(AS) is a common disease that presents endometrial regeneration disorder. However, little is known about its molecular features of this aregenerative endometrium in AS and how to reconstruct the functioning endometrium for the patients with AS. Here, we report that ΔNp63 is significantly upregulated in residual epithelial cells of the impaired endometrium in AS; the upregulated-ΔNp63 induces endometrial quiescence and alteration of stemness. Importantly, we demonstrate that engrafting high density of autologous bone marrow mononuclear cells(BMNCs) loaded in collagen scaffold onto the uterine lining of patients with AS downregulates ΔNp63 expression, reverses ΔNp63-induced pathological changes, normalizes the stemness alterations and restores endometrial regeneration. Finally, five patients achieved successful pregnancies and live births. Therefore, we conclude that ΔNp63 is a crucial therapeutic target for AS. This novel treatment significantly improves the outcome for the patients with severe AS. | Guangfeng Zhao Yun Cao Xianghong Zhu Xiaoqiu Tang Lijun Ding Haixiang Sun Juan Li Xinan Li Chenyan Dai Tong Ru Hui Zhu Jingjie Lu Caimei Lin Jingmei Wang Guijun Yan Huiyan Wang Lei Wang Yimin Dai Bin Wang Ruotian Li Jianwu Dai Yan Zhou Yali Hu | 2017 | Science China(Life Sciences)2017，60，4： | 39 |
| 2 | Gastrodin Attenuates Pentylenetetrazole-Induced Seizures by Modulating the Mitogen-Activated Protein Kinase-Associated Inflammatory Responses in Mice显示文摘Gastrodin, the major component isolated from the rhizome of the Chinese traditional medicinal herb Gastrodia elata(‘‘Tianma''), has a long history in the treatment of epilepsy and other neurological disorders.However, the molecular mechanisms are not clear. Here,we found that gastrodin ameliorated pentylenetetrazole(PTZ)-induced epileptic seizures with improvement of the electroencephalographic pattern in mice. Further studies demonstrated that gastrodin decreased the levels of the pro-inflammatory cytokines interleukin-1b and tumor necrosis factor-a while increasing interleukin-10, an antiinflammatory cytokine in the brain. Furthermore, gastrodin attenuated the PTZ-induced microglial activation along with inhibition of mitogen-activated protein kinases,c AMP response element binding protein, and NF-j B. Our data suggest that gastrodin attenuates seizures by modulating the mitogen-activated protein kinase-associated inflammatory responses. | Liming Chen Xinan Liu Hua Wang Min Qu | 2017 | Neuroscience Bulletin2017，33，3： | 31 |
| 3 | Comparison of anti-atherosclerotic effects of two different extracts from leaves of Mallotus furetianus显示文摘Objective:To compare the anti-atherosclerotic effects of two different extracts from the leaves of Mallotus fiiretianus by using rat model of atherosclerosis.Methods:The air-flriefl powdered Mallotus fiiretianus leaves were extracted with ethanol and then evaporated.The ethanol extract was experienced Diaion HP-20 CC with a gradient of MeOH and H2O(50:50,100:0,v/v) and two fractions,Mallotus fiiretianus A(Mf A) and Mallotus fiiretianus B(MfB) were obtained.RaLs were divided into control,atherosclerosis and vitamin E,Mf A and Mf B treated groups.Atherosclerotic model was established by administering u loading dose of vitamin D3 and feeding standard diet enriched with 2%cholesterol,0.5%porcine chelate,0.2%methimazole,5%sugar,10%pork fat. Vitamin E(0.20 g/kg),Mf A(0.053 g/kg),Mf B(0.057 g/kg)(with the potential) were administered to interfere with the development of atherosclerosis.After 9 weeks,rats were sacrificed and the blood lipid as well as composition of bile was examined.In addition,the thoracic aorta was harvested to evaluate histological changes and the intima-media thickness ratio.Results: Atherosclerosis model was successfully established,administration of vitamin E,Mf A and Mf B increased excretion of total bilirubin in bile,decreased triglycridc(TO),total cholesterol(TC), low density lipoprotein-cholesterol(LDL-C) level,enhanced ratio of high density lipoprotein-cholesterol and LDL-C in blood,improved histological changes and diminished intimamedia thickness ratio of thoracic aorta in atherosclerotic rats.As for the difference in antiatherosclerotic effects between Mf A and MfB,Mf A may be more powerful in declining TG level and Mf B may be more effective in decreasing TC level.Conclusions:The two different extracts. Mf A and Mf B can prevent the development of atherosclerosis.In detail,Mf A is more effective in regulating TG level and Mf B is more powerful in modulating TC.level in atherosclerotic rats. | Liu Yueli Wang Liqun Wu Haitao Lin Lianbo Yi Xinan | 2011 | Asian Pacific Journal of Tropical Medicine2011，4，11： | 15 |
| 4 | A Domestication-Associated Gene GmPRR3b Regulates the Circadian Clock and Flowering Time in Soybean显示文摘Improved soybean cultivars have been adapted to grow at a wide range of latitudes,enabling expansion of cultivation worldwide.However,the genetic basis of this broad adaptation is still not clear.Here,we report the identification of GmPRR3b as a major flowering time regulatory gene that has been selected during domestication and genetic improvement for geographic expansion.Through a genome-wide association study of a diverse soybean landrace panel consisting of 279 accessions,we identified 16 candidate quantitative loci associated with flowering time and maturity time.The strongest signal resides in the known flowering gene E2,verifying the effectiveness of our approach.We detected strong signals associated with both flowering and maturity time in a genomic region containing GmPRR3b.Haplotype analysis revealed that GmPRR3bH6 is the major form of GmPRR3b that has been utilized during recent breeding of modern cultivars.mRNA profiling analysis showed that GmPRR3bH6 displays rhythmic and photoperiod-dependent expression and is preferentially induced under long-day conditions.Overexpression of GmPRR3bH6 increased main stem node number and yield,while knockout of GmPRR3bH6 using CRISPR/Cas9 technology delayed growth and the floral transition.GmPRR3bH6 appears to act as a transcriptional repressor of multiple predicted circadian clock genes,including GmCCAIa,which directly upregulates J/GmELF3a to modulate flowering time.The causal SNP(Chr12:5520945)likely endows GmPRR3bH6 a moderate but appropriate level of activity,leading to early flowering and vigorous growth traits preferentially selected during broad adaptation of landraces and improvement of cultivars. | Cong Li Ying-hui Li Yanfei Li Hongfeng Lu Huilong Hong Yu Tian Hongyu Li Tao Zhao Xiaowei Zhou Jun Liu Xinan Zhou Scott A.Jackson Bin Liu Li-juan Qiu | 2020 | Molecular Plant2020，13，5： | 11 |
| 5 | Development of a middle and low latitude theoretical ionospheric model and an observation system data assimilation experiment显示文摘On the basis of previous work, we develop a middle and low latitude theoretical ionospheric model in this paper, named Theoretical Ionospheric Model of the Earth in the Institute of Geology and Geophysics, Chinese Academy of Sciences (TIME-IGGCAS). TIME-IGGCAS solves the equations of mass continuity, motion and energy of electron and ions self-consistently and uses an eccentric dipole field approxima-tion to the Earth’s magnetic field. We combine the Eulerian and Lagrangian approaches in the model and take account of the plasma E×B drift velocity. Calculation results reveal that the model is steady and credible and can reproduce most large-scale features of ionosphere. By using TIME-IGGCAS, we carried out an observation system data assimilation experiment. Assimilation results show that the E×B drift velocity can be accurately estimated by ingesting the observed foF2 and hmF2 into the model ap-plying nonlinear least-square fit method. We suggest that this work is of great significance in the de-velopment of ionospheric data assimilation model to give better nowcast and forecast of ionosphere. | YUE XinAn WAN WeiXing LIU LiBo LE HuiJun CHEN YiDing YU Tao | 2008 | Chinese Science Bulletin2008，53，1： | 7 |
| 6 | Genome editing technology and application in soybean improvement显示文摘Soybean(Glycine max)is a legume crop with great economic value that provides rich protein and oil for human food and animal feed.In order to cope with the ever-increasing need for soybean products and the changing environment,soybean genetic improvement needs to be accelerated.In recent years,the rapid developed genome editing technologies,such as zinc finger nuclease(ZFNs),transcription activator-like effector nucleases(TALENs),and clustered regularly interspaced short palindromic repeats/CRISPR associated protein(CRISPR/Cas),have shown broad application prospects in gene function research and improvement of important agronomic traits in many crops,and has also brought opportunities for soybean breeding.Here we systematically reviewed recent advances in genome editing technology.We also summarized the significances,current applications,challenges and future perspectives in soybean genome editing,which could provide references for exerting the feature and advantage of this technology to better soybean improvement. | Aili Bao Chanjuan Zhang Yi Huang Haifeng Chen Xinan Zhou Dong Cao | 2020 | Oil Crop Science2020，5，1： | 7 |
| 7 | Liquid crystal integrated metalens with tunable chromatic aberration显示文摘Overcoming chromatic aberrations is a vital concern in imaging systems in order to facilitate fullcolor and hyperspectral imaging.By contrast,large dispersion holds opportunities for spectroscopy and tomography.Combining both functions into a single component will significantly enhance its versatility.A strategy is proposed to delicately integrate two lenses with a static resonant phase and a switchable geometric phase separately.The former is a metasurface lens with a linear phase dispersion.The latter is composed of liquid crystals(LCs)with space-variant orientations with a phase profile that is frequency independent.By this means,a broadband achromatic focusing from 0.9 to 1.4 THz is revealed.When a saturated bias is applied on LCs,the geometric phase modulation vanishes,leaving only the resonant phase of the metalens.Correspondingly,the device changes from achromatic to dispersive.Furthermore,a metadeflector with tunable dispersion is demonstrated to verify the universality of the proposed method.Our work may pave a way toward active metaoptics,promoting various imaging applications. | Zhixiong Shen Shenghang Zhou Xinan Li Shijun Ge Peng Chen Wei Hu Yanqing Lu | 2020 | Advanced Photonics2020，2，3： | 7 |
| 8 | Role of nitric oxide in the genotoxic response to chronic microcystin-LR exposure in human–hamster hybrid cells显示文摘Microcystin-LR(MC-LR) is the most abundant and toxic microcystin congener and has been classified as a potential human carcinogen(Group 2B) by the International Agency for Research on Cancer. However, the mechanisms underlying the genotoxic effects of MC-LR during chronic exposure are still poorly understood. In the present study, human–hamster hybrid(AL) cells were exposed to MC-LR for varying lengths of time to investigate the role of nitrogen radicals in MC-LR-induced genotoxicity. The mutagenic potential at the CD59 locus was more than 2-fold higher(p < 0.01) in ALcells exposed to a cytotoxic concentration(1 μmol/L) of MC-LR for 30 days than in untreated control cells, which was consistent with the formation of micronucleus. MC-LR caused a dose-dependent increase in nitric oxide(NO) production in treated cells. Moreover, this was blocked by concurrent treatment with the NO synthase inhibitor NG-methyl-L-arginine(L-NMMA), which suppressed MC-LRinduced mutations as well. The survival of mitochondrial DNA-depleted(ρ0) ALcells was markedly decreased by MC-LR treatment compared to that in ALcells, while the CD59 mutant fraction was unaltered. These results provided clear evidence that the genotoxicity associated with chronic MC-LR exposure in mammalian cells was mediated by NO and might be considered as a basis for the development of therapeutics that prevent carcinogenesis. | Xiaofei Wang Pei Huang Yun Liu Hua Du Xinan Wang Meimei Wang Yichen Wang Tom K.Hei Lijun Wu An Xu | 2015 | Journal of Environmental Sciences2015，27，3： | 6 |
| 9 | Laboratory testing and molecular analysis of the resistance of wild and cultivated soybeans to cotton bollworm, Helicoverpa armigera(Hübner)显示文摘Identifying a superior soybean variety with high defoliator resistance is important to avoid yield loss. Cotton bollworm(Helicoverpa armigera Hübner) is one of the major defoliators of soybean(Glycine max [L.] Merr.) worldwide. In this study, we evaluated the effect of H. armigera larvae on ED059, a wild soybean(Glycine soja Sieb. et Zucc.), and three cultivated soybean varieties: Tianlong 2, PI 535807, and PI 533604, in choice and no-choice assays. The percentage of ED059 leaflets consumed by H. armigera was lower than that of the three cultivated soybeans. Larvae that fed on ED059 exhibited low weight gain and high mortality rate.Waldbauer nutritional indices suggested that ED059 reduced the growth, consumption, and frass production of H. armigera larvae. Larvae that fed on ED059 showed lower efficiency of conversion of ingested and of digested food than those that fed on Tianlong 2 and PI 533604.However, they showed statistically similar consumption index and approximate digestibility compared with those fed on the three cultivated soybeans. Quantitative real-time PCR analysis revealed that 24 h after insect attack, ED059 had higher transcript levels of Kunitz trypsin inhibitor 3, Cysteine proteinase inhibitor 2, and Nerolidol synthase 1 but a lower transcript level of Pathogenesis-related protein 1 than Tianlong 2. The gene expression results were consistent with the presence of higher levels of jasmonic acid(JA) and transcript levels of the JA biosynthesis enzyme allene oxide cyclase 3 in ED059 than in Tianlong 2. Our findings indicate that ED059 is a superior soybean line with strong insect resistance that may be mediated via the JA pathway. | Xiaoyi Wang Haifeng Chen Aihua Sha Rong Zhou Zhihui Shang Xiaojuan Zhang Chanjuan Zhang Limiao Chen Qingnan Hao Zhonglu Yang Dezhen Qiu Shuilian Chen Xinan Zhou | 2015 | The Crop Journal2015，3，1： | 6 |
| 10 | Chimeric flagellin expressed by Salmonella typhimurium induces an ESAT-6-specific Th1-type immune response and CTL effects following intranasal immunization显示文摘The flagellin component FliC of Salmonella typhimurium is capable of activating the innate immune system via specific interactions with TLR5 and can also act as a carrier of foreign antigen to elicit antigen-specific immune responses.Thus,we constructed an attenuated Salmonella strain SL5928(fliC/esat)expressing chimeric flagellin that contained the ESAT-6 antigen coding sequence of Mycobacterium tuberculosis inserted into the highly variable region of the Salmonella flagellin coding gene fliCi.The chimeric flagellin functioned normally,as demonstrated using a flagella swarming assay and electron microscopy.To analyze the effects of chimeric flagellin,the cell-mediated immune response and cytotoxic T lymphocyte(CTL)effects specific for ESAT-6 antigen were tested after intranasal immunization of mice with flagellated Salmonella SL5928(fliC/esat).The results showed that SL5928(fliC/esat)intranasal immunization can strongly elicit an ESAT-6-specific T helper(Th)1-type immune response in mucosal lymphoid tissues,such as nasopharynx-associated lymph nodes,lung and Peyer’s patches,and a Th1/Th2 response was elicited in spleen and mesenteric lymph nodes.Furthermore,intranasal immunization of SL5928(fliC/esat)produced efficient CTL effects,as demonstrated using a 5-and 6-carboxyfluorescein diacetate succinimidyl ester(CFSE)assay.Thus,our study revealed that Salmonella flagellin acts as a carrier for foreign antigen and triggers strong Th1 and CTL responses during intranasal immunization.Chimeric flagellin is potentially an effective strategy for the development of novel vaccines against tuberculosis in humans and animals. | Hui Zhang Liu Liu Ke Wen Jinlin Huang Shizhong Geng Junsong Shen Zhiming Pan Xinan Jiao | 2011 | Cellular & Molecular Immunology2011，8，6： | 6 |
| 11 | Amino acids 89-96 of Salmonella typhimunum Tlagell=n represent the major domain responsible for TLR5-independent adjuvanticity in the humoral immune response显示文摘 | Lei Zhang Zhiming Pan Xilong Kang Yun Yang Heekap Kang Na Zhang James M Rosati Xinan Jiao | 2015 | Cellular & Molecular Immunology2015，12，5： | 6 |
| 12 | Differential expression of microRNAs in dorsal root ganglia after sciatic nerve injury显示文摘This study investigated the possible involvement of microRNAs in the regulation of genes that participate in peripheral neural regeneration.A microRNA microarray analysis was conducted and 23 microRNAs were identified whose expression was significantly changed in rat dorsal root ganglia after sciatic nerve transection.The expression of one of the downregulated microRNAs,microRNA-214,was validated using quantitative reverse transcriptase-PCR.MicroRNA-214 was predicted to target the 3′-untranslated region of Slit-Robo GTPase-activating protein 3.In situ hybridization verified that microRNA-214 was located in the cytoplasm of dorsal root ganglia primary neurons and was downregulated following sciatic nerve transection.Moreover,a combination of in situ hybridization and immunohistochemistry revealed that microRNA-214 and Slit-Robo GTPase-activating protein 3 were co-localized in dorsal root ganglion primary neurons.Western blot analysis suggested that Slit-Robo GTPase-activating protein 3 was upregulated in dorsal root ganglion neurons after sciatic nerve transection.These data demonstrate that microRNA-214 is located and differentially expressed in dorsal root ganglion primary neurons and may participate in regulating the gene expression of Slit-Robo GTPase-activating protein 3 after sciatic nerve transection. | Anjie Lu Zufa Huang Chaoyue Zhang Xianfang Zhang Jiuhong Zhao Haiying Zhang Quanpeng Zhang Song Wu Xinan Yi | 2014 | Neural Regeneration Research2014，9，10： | 5 |
| 13 | A planetary perspective on Earth's space environment evolution显示文摘The planet Earth is an integrated system, in which its multi-spheres are coupled, from the space to the inner core. Whether the space environment in short to long terms has been controlled by the earth's interior process is contentious. In the past several decades,space weather and space climate have been extensively studied based on either observation data measured directly by man-made instruments or ancient data inferred indirectly from some historical medium of past thousands of years. The acquired knowledge greatly helps us to understand the dynamic processes in the space environment of modern Earth, which has a strong magnetic dipole and an oxygen-rich atmosphere. However, no data is available for ancient space weather and climate(>5 ka). Here, we propose to take the advantage of ' space-diversity' to build a ' generalized planetary space family', to reconcile the ancient space environment evolution of planet Earth from modern observations of other planets in our solar system. Such a method could also in turn give us a valuable insight into other planets' evolution. | Yong Wei XinAn Yue ZhaoJin Rong YongXin Pan WeiXing Wan RiXiang Zhu | 2017 | Earth and Planetary Physics2017，1，1： | 4 |
| 14 | The combination of chidamide with the CHOEP regimen in previously untreated patients with peripheral T-cell lymphoma: a prospective, multicenter, single arm, phase 1b/2 study显示文摘Objective:To assess the efficacy and safety of the novel histone deacetylase inhibitor,chidamide,in combination with cyclophosphamide,doxorubicin,vincristine,etoposide,and prednisone(Chi-CHOEP)for untreated peripheral T-cell lymphoma(PTCL).Methods:A prospective,multicenter,single arm,phase 1 b/2 study was conducted.A total of 128 patients with untreated PTCL(18–70 years of age)were enrolled between March 2016 and November 2019,and treated with up to 6 cycles with the Chi-CHOEP regimen.In the phase 1 b study,3 dose levels of chidamide were evaluated and the primary endpoint was determination of the maximumtolerated dose and recommended phase 2 dose(RP2 D).The primary endpoint of the phase 2 study was 2-year progression-free survival(PFS).Results:Fifteen patients were enrolled in the phase 1 b study and the RP2 D for chidamide was determined to be 20 mg,twice a week.A total of 113 patients were treated at the RP2 D in the phase 2 study,and the overall response rate was 60.2%,with a complete response rate of 40.7%.At a median follow-up of 36 months,the median PFS was 10.7 months,with 1-,2-,and 3-year PFS rates of 49.9%,38.0%,and 32.8%,respectively.The Chi-CHOEP regimen was well-tolerated,with grade 3/4 neutropenia occurring in approximately two-thirds of the patients.No unexpected adverse events(AEs)were reported and the observed AEs were manageable.Conclusions:This large cohort phase 1 b/2 study showed that Chi-CHOEP was well-tolerated with modest efficacy in previously untreated PTCL patients. | Wei Zhang Liping Su Lihong Liu Yuhuan Gao Quanshun Wang Hang Su Yuhuan Song Huilai Zhang Jing Shen Hongmei Jing Shuye Wang Xinan Cen Hui Liu Aichun Liu Zengjun Li Jianmin Luo Jianxia He Jingwen Wang O.A.O’Connor Daobin Zhou | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
| 15 | A novel intelligent verification platform based on a structured analysis model显示文摘An intelligent verification platform based on a structured analysis model is presented.Using an abstract model mechanism with specific signal interfaces for user callback,the unified structured analysis data,shared by the electronic system level design,functional verification,and performance evaluation,enables efficient management review,auto-generation of code,and modeling in the transaction level.We introduce the class tree,flow parameter diagram,structured flow chart,and event-driven finite state machine as structured analysis models.As a sand table to carry maps from different perspectives and levels via an engine,this highly reusable platform provides the mapping topology to search for unintended consequences and the graph theory for comprehensive coverage and smart test cases.Experimental results show that the engine generates efficient test sequences,with a sharp increase in coverage for the same vector count compared with a random test. | XIE Zheng WANG XinAn LIAN ZhiBin LUO YongGui HU ZiYi | 2013 | Science China(Information Sciences)2013，56，6： | 4 |
| 16 | Curvature Estimates for the Level Sets of Solutions to the Monge-Ampère Equation det D^2u = 1显示文摘For the Monge-Amp`ere equation det D2u = 1, the authors find new auxiliary curvature functions which attain their respective maxima on the boundary. Moreover, the upper bounded estimates for the Gauss curvature and the mean curvature of the level sets for the solution to this equation are obtained. | Chuanqiang CHEN Xinan MA Shujun SHI | 2014 | Chinese Annals of Mathematics,Series B2014，35，6： | 4 |
| 17 | Effect of Cultural Measures on Nutrient Contellts in Rice Plants with Erect Panicles显示文摘Since1981,newricevarietieswitherectpanicles,suchasLiaojing5,Shennong91,Liaojing326andShennong8801,havebeenbredinLiaoningProvinceofChina.Experimelltalresultsindicatedthatthegrainyieldsofvarietieswitherectpaniclesnotonlyexceededthoseofcultivarswithcurv... | WANG BOLUN LIU XINAN YU GUIRUI WANG SHUI and ZOU BANGJI(Shenyang Agricultural University, Shenyang 110161 (China))(Institute Of Applied Ecolopy, the Chinese Academy of Sciences, Shenyany 110015 (China))(Received November 8, 1998 revised December 21, 1998) | 1999 | Pedosphere1999，9，3： | 3 |
| 18 | A comparative study of magnetic properties between whole cells and isolated magnetosomes of Magnetospirillum magneticum AMB-1显示文摘The magnetic properties of magnetosome magnetite are of interdisciplinary interest because magnetosomes are potential carriers of natural remanent magnetization and paleoenvironment, as well as novel nano-biomaterials in biotechnological and biomedical applications. We carried out magnetic and electron transmission microscopy analyses of fresh Magnetospirillum magneticum AMB-1 whole cells and isolated magnetosomes. Results revealed that AMB-1 synthesized single-domain magnetite magneto-somes, which are arranged in the form of linear fragmental chain. The distinct differences of magnetic properties between these two samples can be faithfully interpreted in terms of spatial arrangement of magnetosomes and magnetostatic interaction. For the whole cells, the strong intra-chain interactions and weak inter-chain interactions generate behaviors of non-interacting uniaxial single-domain particles. Its δ-ratio is 3.0 and passes the Moskowitz test. In contrast, the isolated magnetosome sample has reduced values of coercivity and δ-ratio (1.5), due to increasing three-dimensional magnetostatic interactions and collapse of magneto-some chains. These observations provide useful insights into applications of the biogenic magnetite (magnetosomes) in magnetic nano-materials and magnetofossils in the paleomagnetic and environmental magnetism. | LI JinHua PAN YongXin LIU QingSong QIN HuaFeng DENG ChengLong CHE RenChao YANG XinAn | 2010 | Chinese Science Bulletin2010，55，1： | 3 |
| 19 | Large-Scale Synthesis of the Stable Co-Free Layered Oxide Cathode by the Synergetic Contribution of Multielement Chemical Substitution for Practical Sodium-Ion Battery显示文摘The O3-type layered oxide cathodes for sodium-ion batteries(SIBs)are considered as one of the most promising systems to fully meet the requirement for future practical application.However,fatal issues in several respects such as poor air stability,irreversible complex multiphase evolution,inferior cycling lifespan,and poor industrial feasibility are restricting their commercialization development.Here,a stable Co-free O3-type NaNi_(0.4)Cu_(0.05)Mg_(0.05)Mn_(0.4)Ti_(0.1O2) cathode material with large-scale production could solve these problems for practical SIBs.Owing to the synergetic contribution of the multielement chemical substitution strategy,this novel cathode not only shows excellent air stability and thermal stability as well as a simple phase-transition process but also delivers outstanding battery performance in half-cell and full-cell systems.Meanwhile,various advanced characterization techniques are utilized to accurately decipher the crystalline formation process,atomic arrangement,structural evolution,and inherent effect mechanisms.Surprisingly,apart from restraining the unfavorable multiphase transformation and enhancing air stability,the accurate multielement chemical substitution engineering also shows a pinning effect to alleviate the lattice strains for the high structural reversibility and enlarges the interlayer spacing reasonably to enhance Na^(+)diffusion,resulting in excellent comprehensive performance.Overall,this study explores the fundamental scientific understandings of multielement chemical substitution strategy and opens up a new field for increasing the practicality to commercialization. | Yao Xiao Tao Wang Yan-Fang Zhu Hai-Yan Hu Shuang-Jie Tan Shi Li Peng-Fei Wang Wei Zhang Yu-Bin Niu En-Hui Wang Yu-Jie Guo Xinan Yang Lin Liu Yu-Mei Liu Hongliang Li Xiao-Dong Guo Ya-Xia Yin Yu-Guo Guo | 2020 | Research2020，，1： | 3 |
| 20 | Preliminary experimental results by the prototype of Sanya Incoherent Scatter Radar显示文摘In the past decades,the Incoherent Scatter Radar(ISR)has been demonstrated to be one of the most powerful instruments for ionosphere monitoring.The Institute of Geology and Geophysics at the Chinese Academy of Sciences was founded to build a state-ofthe-art phased-array ISR at Sanya(18.3°N,109.6°E),a low-latitude station on Hainan Island,named the Sanya ISR(SYISR).As a first step,a prototype radar system consisting of eight subarrays(SYISR-8)was built to reduce the technical risk of producing the entire large array.In this work,we have summarized the preliminary experimental results based on the SYISR-8.The amplitude and phase among 256 channels were first calibrated through an embedded internal monitoring network.The mean oscillation of the amplitude and phase after calibration were about 1 dB and 5°,respectively,which met the basic requirements.The beam directivity was confirmed by crossing screen of the International Space Station.The SYISR-8 was further used to detect the tropospheric wind profile and meteors.The derived winds were evaluated by comparison with independent radiosonde and balloon-based GPS measurements.The SYISR-8 was able to observe several typical meteor echoes,such as the meteor head echo,range-spread trail echo,and specular trail echo.These results confirmed the validity and reliability of the SYISR-8 system,thereby reducing the technical risk of producing the entire large array of the SYISR to some extent. | XinAn Yue WeiXing Wan Han Xiao LingQi Zeng ChangHai Ke BaiQi Ning Feng Ding BiQiang Zhao Lin Jin Chen Li MingYuan Li JunYi Wang HongLian Hao Ning Zhang | 2020 | Earth and Planetary Physics2020，4，6： | 3 |
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