|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Experimental study on the role of endotoxin in the development of hepatopulmonary syndrome显示文摘AIM: To evaluate the role of intestinal endotoxemia in the genesis of hepatopulmonary syndrome.METHODS: A rat model of cirrhosis was prepared with the method of compound factors. At the end of the eighth week, rats with cirrhosis were treated with 300 μg LPS/100 g body weight, and 1 g/rat of glycine about four h prior to LPS. After three h of LPS treatment, blood and tissues were collected for various measurements. Kupffer cells were isolated from male Wistar rats and cultured, and divided into five groups. Supernatant was harvested at 3 h after treatment with LPS for measurement of tumor necrosis factor-alpha (TNF-α).RESULTS: Our results showed that in rats with cirrhosis, zslowed and deepened breath with occasional pause was.PaO2, PaCO2 and standard bicarbonate (SB) in arterial blood were decreased. Arterial O2 and actual bicarbonate (AB) were markedly decreased. There was a close correlation between decreased O2 and endotoxin. Metabolic acidosis accompanying respiratory alkalosis was the primary type of acid-base imbalance. The alveolar-arterial oxygen gradient was sharply widened. Massive accumulation of giant macrophages in the alveolar spaces and its wall and widened alveolar wall architecture were observed. The number of bacterial translocations in mesenteric lymph nodes increased. The ratio of TC99M-MAA brain-over-lung radioactivity rose. Endotoxin, and TNF-α, endothelin-1 (ET-1), nitric oxide (NO) in plasma and ET-1, carbon monoxide (CO) in lung homogenates increased. After administration of a given dosage of LPS in rats with cirrhosis, various pathological parameters worsened.Plasma level of endotoxin was related to TNF-α, ET-1, NO in plasma and ET-1, NO, CO in lung homogenates. TNF-α level was related to ET-1 and NO in plasma and lung homogenates and CO in lung homogenate as well. The level of TNF-α increased after infusion of LPS into culture supernatant of Kupffer cells in vitro. However, TNF-α significantly decreased after pretreatment with glycine,PD98059 and SB212850. Glycine could antagonize the effect of LPS in vivo and in vitro.CONCLUSION: Intestinal endotoxemia accompanying by cirrhosis may be an important mechanism in the development of hepatopulmonary syndrome in rats. Overproduction of TNF-α due to endotoxin stimulation of Kupffer cells via mitogen-activated protein kinase (MAPK) signal transduction pathway may be a major mechanism mediating the pathologic alterations of hepatopulmonary syndrome. | Hui-YingZhang De-WuHan Xin-GuoWang Yuan-ChangZhao XinZhou Hai-ZhenZhao | 2005 | World Journal of Gastroenterology2005，11，4： | 46 |
| 2 | Expression of survivin in primary and metastatic gastric cancer cells obtained by laser capture microdissection显示文摘AIM:Survivin, a recently identified member of the inhibitor of apoptosis protein family, is expressed during development and in various human cancers. However, its expression in normal tissues and clinical relevance in cancers are still debated. In the present study, we analyzed the expression of the survivin gene in human primary and metastatic gastric cancer cells as well as in paired epithelial cells from normal gastric mucosa by means of a novel laser capture microdissection (LCM) technique coupled with reverse transcription -polymerase chain reaction (RT-PCR).METHODS: Thirty patients who had undergone gastrectomy with lymph node dissection for gastric cancer without preoperative treatments were included. Neoplastic tissue, metastatic lymph nodes, and apparently uninvolved normal tissue were collected from each patient. LCM-captured 'pure' cell groups were respectively subjected to RT-PCR analysis with primers specific for the survivin gene.RESULTS: Of the paired samples from 30 gastric cancer patients studied, 24 (80%) primary gastric cancer cell groups and 7 (23%) adjacent morphologically 'normal' gastric epithelial cell groups were shown to have a detectable survivin expression. There was a statistically significant difference in suvivin expression between these two groups (P<0.01). Meanwhile, 95% (19/20) of the metastatic gastric cancer cell groups from lymph nodes had a clear expression of the survivin gene. However, no significant correlation between survivin expression and clinicopathological features of gastric cancer was observed in the present study. CONCLUSION: Survivin expression is present in the majority of gastric cancer cell groups obtained by LCM techniques. The high expression rate in metastatic lesions suggests a possible role of survivin in cancer invasiveness and metastasis. It may contribute to the detection of gastric cancer micrometastasis as a potential molecular marker. In addition, the high expression percentage renders survivin a potential target in the therapy for gastric cancer. | Zhen-NingWang Hui-MianXu LiJiang XinZhou ChongLu XueZhang | 2004 | World Journal of Gastroenterology2004，10，21： | 23 |
| 3 | Traveling Wave Based Single-Phase-to-Ground Protection Method for Power Distribution System显示文摘Correct detection and identification of single-phase to-ground faults not effectively grounded in distribution systems is a major challenge for protection engineers.This paper proposes a novel traveling wave based protection method to solve this problem.The proposed method compares the polarities of current and voltage traveling waves measured immediately after the fault inception to determine the fault direction.Nuisance tripping is avoided by using the power frequency voltages detected on the busbar to inhibit operation.The power frequency voltages ensure that the system does not mal-operate due to noise and also provide discrimination for phase-to-phase and three-phase faults.The wavelet transform and modulus maxima theories are used to extract the polarity of traveling waves measured at the relaying point.The simulation studies demonstrate correct operation of protection,which is independent of fault distance,fault inception angle,fault path resistance,and the method used for neutral grounding. | Xinzhou Dong Jun Wang Shenxing Shi Bin Wang Bak Dominik Miles Redfern | 2015 | CSEE Journal of Power and Energy Systems2015，1，2： | 15 |
| 4 | Geo-rough Space显示文摘Rough set is a new approach to uncertainties in spatial analysis.In this paper,rough set symbols are simplified and standardized in terms of rough interpretation and specialized indication.Rough spatial entities and their topological relationships are also proposed in rough space,thus a universal intersected equation is developed,and rough membership function is further extended with the gray scale in our case study.We complete three works.First,a set of simplified rough symbols is advanced on the basis of existing rough symbols.Second,rough spatial entity is put forward to study the real world as it is,without forcing uncertainties into crisp set.Third,rough spatial topological relationships are studied by using rough matrix and their figures.The relationships are divided into three types,crisp entity and crisp entity (CC),rough entity and crisp entity (RC),and rough entity and rough entity (RR).A universal intersected equation is further proposed.Finally,the maximum and minimum maps of river thematic classification are generated via rough membership function and rough relationships in our case study. | WANG Shuliang LI Deren SHI Wenzhong WANG Xinzhou | 2003 | Geo-Spatial Information Science2003，6，1： | 12 |
| 5 | Nanoparticle-immersed paper imprinting mass spectrometry imaging reveals uptake and translocation mechanism of pesticides in plants显示文摘Design and discovery of carrier-mediated modified pesticides are vital for reducing pesticide dosage and increasing utilization,yet it remains a great challenge due to limited insights into plant translocation mechanisms.Nanostructure/nanoparticle assisted laser desorption/ionization strategy has established itself as a preferential analytical tool for biological tissue analysis,whereas potential applications in plant sciences are hindered with regard to the inability to slice plant leaves and petals.Herein,we report gold nanoparticle(AuNP)-immersed paper imprinting mass spectrometry imaging(MSI)for the spatiotemporal visualization of pesticide translocation in plant leaves.This approach plays a dual role in preserving spatial information and improving ionization efficiency for pesticides regardless of imaging artifacts due to homogenous AuNP deposition.Using this MSI platform,we proposed the elaborate plant translocation mechanism of agrochemicals for the first time,which is currently poorly understood.The dynamic processes of carrier-mediated pesticides can be clearly visualized,including crossing of plasma membranes by transporters,translocation downward in stems through the phloem,diffusion to the xylem and,conversely,accumulation at margins of the treated leaves.Moreover,this AuNP-assisted paper imprinting method could be highly compatible with laser-based MSI instruments,expediting researches across a broad range of fields,especially in nanomaterial development and life sciences. | Xinzhou Wu Run Qin Hanxiang Wu Guangkai Yao Yue Zhang Ping Li Yizhu Xu Zhixiang Zhang Zhibin Yin Hanhong Xu | 2020 | Nano Research2020，13，3： | 8 |
| 6 | EFFECT OF PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR ACTIVATORS ON TUMOR NECROSIS FACTOR-αEXPRESSION IN NEONATAL RAT CARDIAC MYOCYTES显示文摘Objective To investigate the effect of peroxisome proliferator-activated receptor-α(PPARα) and PPARγactivators on tumor necrosis factor-α(TNFα) expression in neonatal rat cardiac myocytes. Methods Primary cultures of cardiac myocytes from 1- to 3-day-old Wistar rats were prepared, and myocytes were ex-posed to lipopolysaccharide (LPS) and varying concentrations of PPARαor PPARγactivator (fenofibrate or pioglitazone).RT-PCR and ELISA were used to measure TNFα, PPARα, and PPARγexpression in cultured cardiac myocytes. Transient tr-ansfection of TNFαpromoter with or without nuclear factor-kappaB (NF-κB) binding site to cardiac myocytes was performed. Results Pretreatment of cardiac myocytes with fenofibrate or pioglitazone inhibited LPS-induced TNFαmRNA and protein expression in a dose-dependent manner. However, no significant changes were observed on PPARαor PPARγmRNA expression when cardiac myocytes were pretreated with fenofibrate or pioglitazone. Proportional suppression of TNFαpromoter activity was observed when myocytes was transiently transfected with whole length of TNFαpromoter (-721/+17) after being stimulated with LPS and fenofibrate or pioglitazone, whereas no change of promoter activity was observed with transfection of TNFαreporter construct in deletion of NF-κB binding site (-182/+17). Conclusions PPARαand PPARγactivators may inhibit cardiac TNFαexpression but not accompanied by change of PPARαor PPARγmRNA expression. Therefore PPARαand PPARγactivators appear to play a role in anti-inflammation. The mechanism may partly be involved in suppression of the NF-κB pathway. | PingYe HongFang XinZhou Yan-liHe Yong-xueLiu | 2004 | Chinese Medical Sciences Journal2004，19，4： | 7 |
| 7 | Printed stretchable circuit on soft elastic substrate for wearable application显示文摘In this paper, a flexible and stretchable circuit has been fabricated by the printing method based on Ag NWs/PDMS composite. The randomly oriented Ag NWs were buried in PDMS to form a conductive and stretchable electrode. Stable conductivity was achieved with a large range of tensile strain(0-50%) after the initial stretching/releasing cycle. The stable electrical response is due to the buckling of the Ag NWs/PDMS composite layer. Furthermore, printed stretchable circuits integrated with commercial ICs have been demonstrated for wearable applications. | Wei Yuan Xinzhou Wu Weibing Gu Jian Lin Zheng Cui | 2018 | Journal of Semiconductors2018，39，1： | 4 |
| 8 | Optimizing solution of fault location using single terminal quantities显示文摘This paper firstly evaluated the impedance method and traveling waves method for fault location, and studied the robustness of fault location method based on im-pedance. Then it proposed an assembled fault location method for a transmission line based on single-terminal electrical quantities, in which the fault zone was firstly determined by impedance method with robustness then the accurate fault position was pinpointed by traveling waves method. EMTP (Electromagnetic Transient Pro-gram) simulations showed that the proposed method can overcome the drawbacks of impedance method and traveling waves method when either one is used alone, and improve both the accuracy and the reliability of fault location. | DONG XinZhou SHI ShenXing CUI Tao LU Qiang | 2008 | Science China(Technological Sciences)2008，51，6： | 4 |
| 9 | Islanding detection based on asymmetric tripping of feeder circuit breaker in ungrounded power distribution system显示文摘An islanding detection method in ungrounded power distribution system based on single-phase operating mechanisms of the circuit breaker(CB)is proposed in this paper.When CB opens three phase circuits to form an island,one phase circuit is opened firstly and the other two phase circuits are opened secondly after certain duration.During the period when only one phase circuit is opened,negative sequence voltage with certain duration is obtained at DG side because of the asymmetric operation of the system.After all three phase circuits are opened,the voltage variation direction of the two phases that are secondly disconnected from the grid follows the voltage variation direction of the firstly disconnected phase.Based on the above voltage characteristics,an islanding detection scheme is proposed to identify genuine islanding from system disturbances.The performance of the proposed scheme is tested in PSCAD/EMTDC using a 10 kV distribution network with synchronous DG interconnection.Simulation results demonstrate the proposed method is effective and reliable to detect islanding formation. | Yuwei SHANG Shenxing SHI Xinzhou DONG | 2015 | Journal of Modern Power Systems and Clean Energy2015，3，4： | 4 |
| 10 | DEVELOPMENT OF A DATA MINING METHOD FOR LAND CONTROL显示文摘Land resources are facing crises of being misused,especially for an intersection area between town and country,and land control has to be enforced.This paper presents a development of data mining method for land control.A vector_match method for the prerequisite of data mining i.e., data cleaning is proposed,which deals with both character and numeric data via vectorizing character_string and matching number.A minimal decision algorithm of rough set is used to discover the knowledge hidden in the data warehouse.In order to monitor land use dynamically and accurately,it is suggested to set up a real_time land control system based on GPS,digital photogrammetry and online data mining.Finally,the means is applied in the intersection area between town and country of Wuhan city,and a set of knowledge about land control is discovered. | Wang Shuliang Wang Xinzhou Shi Wenzhong | 2001 | Geo-Spatial Information Science2001，4，1： | 3 |
| 11 | The mass and heat transfer process through the door seal of refrigeration显示文摘As one of the main reasons causing leakage heat load in a refrigerator,mass and heat transfer through refrigerator door seal is of great importance to be studied.In this paper,a model is presented for numerical simulation of mass and heat transfer process through refrigerator door seal,and an experiment apparatus is designed and set up as well for comparison.A two-dimensional model and tracer gas method are used in simulation and experiment,respectively.It can be found that the relative deviations of air infiltration rate between the simulated results and experimental results were less than 1%,and the temperature difference errors at two special points of the door seal were less than 2.03℃.In conclusion,the simulated results are in good agreement with the experimental results.This paper initially sets up a model that can accurately simulate the heat and mass transfer through the refrigerator door seal,and the model can be used in refrigerator door seal optimization research in the follow-up study. | Haoshu Tan Xinzhou Song Ying Zhang Maogang He | 2017 | Chinese Journal of Chemical Engineering2017，25，8： | 3 |
| 12 | Analysis on the fault characteristics of three-phase short-circuit for half-wavelength AC transmission lines显示文摘Half-wavelength AC transmission(HWACT) is an ultra-long distance AC transmission technology, whose electrical distance is close to half-wavelength at the system power frequency. It is very important for the construction and operation of HWACT to analyze its fault features and corresponding protection technology. In this paper, the steady-state voltage and current characteristics of the bus bar and fault point and the steady-state overvoltage distribution along the line will be analyzed when a three-phase symmetrical short-circuit fault occurs on an HWACT line. On this basis, the threephase fault characteristics for longer transmission lines are also studied. | Xuankun Song Teng Feng Liu Han Travis MSmith Xinzhou Dong Wenxuan Liu Rui Zhang | 2018 | Global Energy Interconnection2018，1，2： | 2 |
| 13 | Novel directional comparison protection for distribution lines显示文摘For quickly clearing up a fault of distribution lines, which concerned with complex structure and operating modes, a directional comparison protection is necessary. The paper evaluated the traditional directional relay through modeling a typical distribution system and presented a novel negative sequence directional relay and a new directional comparison protection scheme specially designed for distribution systems. In the relay and the protection scheme, a particular negative sequence component has been constructed to solve the problem that there is no negative sequence component in a symmetrical fault case so that they could operate correctly in both asymmetrical fault and symmetrical fault. Extensive EMTP simulation studies proved that the protection schemes are able to provide fast and reliable responses for all fault conditions. In particular, they are able to give correct responses adapting to the change of system operation conditions, including the changing of system configuration, power flow direction, and source and tapped-offload conditions. | DONG XinZhou YUAN DingDing LU Qiang BO ZhiQian | 2008 | Science China(Technological Sciences)2008，51，4： | 2 |
| 14 | Epidemiological Characteristics of An Outbreak of Severe Acute Respiratory Syndrome in Dongcheng District of Beijing From March to May 2003显示文摘Objective To describe epidemiologic features of an outbreak of severe acute respiratory syndrome (SARS) in Dongcheng District, Beijing occurred in a period between March and May 2003.Methods Data of SARS cases notified from Dongcheng District Center for Disease Control and Prevention(CDC)and supplemented by other channels were collected. Clinicians and officials of local hospitals were interviewed in groups and medical records of fatal cases of SARS were reviewed to verify the diagnosis. Stored serum specimens of the patients were detected for IgG antibody against SARS Co-V by enzyme-linked immunosorbent assay (ELISA). All the data were input into dataset files by Microsoft Excel-2000 software and analyzed with SPSS version 10.0 software. Results Outbreak of SARS in Dongcheng District started on March 14, 2003 with a peak in mid- and late April, and dropped in early May. A total of 572 reported cases were collected during this period in Dongcheng District, Beijing, and 99 of them were excluded from SARS, because of diagnosis of common cold, regular pneumonia, measles and rubella, etc. Actually, 473 SARS cases, which included390 (82.5%) probable cases and 83 (17.5%) suspect cases, were analyzed. About 90% of the probablecases were positive for IgG antibody. Attack rate of SARS in permanent residents of Dongcheng District was 28.3 per 100000. Forty-one of them died, with a case-fatality rate of 8.7%. Persons were all susceptible to infection of SARS Co-V, with the highest proportion at ages of 20-50 years, which accounted for 68.7% of the total cases. Average age of the patients at their onset was 40.7 years. Nogender difference in SARS cases was found. Number of SARS cases in health-care workers (HCWs)accounted for 18.0% and that in retired workers accounted for 15.4% of the total cases. Cases occurred in all 10 sub-districts of Dongcheng, with the highest in Beixinqiao and Andingmen Sub-districts. Totally, 230 of the 572 notified cases (40.2%) were hospitalized at local hospitals under the jurisdiction of Dongcheng District. Eighteen of 85 cases of SARS occurred in HCWs of local hospitals, accounting for 4.5% of the total number of HCWs working at wards caring for SARS patients or fever clinics. There were 34.7% of SARS cases without any histories of contact before theonset of the disease. Familial aggregation phenomena were observed in 41.8% of the cases and 18.1%of households. And 7.4% ( attack rate ) of those exposed to SARS cases suffered from the illness during the periods of quarantine. Conclusions SARS appeared to be infectious in origin and caused outbreak in Dongcheng District, Beijing introduced by an imported case traveling from Hong Kong in a period between March and May 2003. People are all susceptible to infection of SARS Co-V, which mainly threatens the young adults and the middle-aged, as well as HCWs and the retired workers. The main mode of transmission is direct exposure to SARS patients in a near distance at hospitals orfamilies via droplets spread. Prevention and control of SARS should be focused on early isolation of patients and quarantine for close contacts. Current available measures to prevent and control SARS are proved to be effective. | WAN—NIANLIANG‘ YONGHUANG WAN—XINZHOU LEIQIAO JIAN—HuIHUANG ZHENG—LAIWU | 2003 | Biomedical and Environmental Sciences2003，16，4： | 2 |
| 15 | Oscillation of Second Order Nonlinear Delay Dynamic Equations on Time Scales显示文摘 | Xinzhou Yan | 2000 | Computers and Mathematics with Applications2000，49，： | 1 |
| 16 | Identifying single phase to ground feeder in neutral non-effectively grounded distribution system using wavelet transform 显示文摘 | DONG Xinzhou SHI Shenxing | 2008 | IEEE Trans on Power Delivery2008，20，4： | 1 |
| 17 | Relaxation studies on power equipment显示文摘 | BIRLASEKARAN S YU Xinzhou | 2003 | IEEE Transactions on Dielectrics and Electrical Insulation2003，10，6： | 1 |
| 18 | Surge impedance relay显示文摘 | Dong Xinzhou Ge Yaozhong He Jiali | 2005 | IEEE Transactions on Power Delivery2005，20，2： | 1 |
| 19 | Voltage sag source location based on instantaneous energy detection显示文摘 | Kong Wei Dong Xinzhou Chen Zhe | 2008 | Electric Power Systems Research2008，78，3： | 1 |
| 20 | Investigation of anisotropic mechanisms in ultra-precision diamond machining of KDP crystal显示文摘 | Qingliang Zhao Yilong Wang Guang Yu Shen Dong Xinzhou Zhang | 2008 | Journal of Materials Processing Tech2008，，8： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员