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| 1 | Design, synthesis and biological evaluation of chalcone analogues with novel dual antioxidant mechanisms as potential anti-ischemic stroke agents显示文摘Scavenging reactive oxygen species(ROS) by antioxidants is the important therapy to cerebral ischemia-reperfusion injury(CIRI) in stroke. The antioxidant with novel dual-antioxidant mechanism of directly scavenging ROS and indirectly through antioxidant pathway activation may be a promising CIRI therapeutic strategy. In our study, a series of chalcone analogues were designed and synthesized, and multiple potential chalcone analogues with dual antioxidant mechanisms were screened. Among these compounds, the most active 33 not only conferred cytoprotection of H2 O2-induced oxidative damage in PC12 cells through scavenging free radicals directly and activating NRF2/ARE antioxidant pathway at the same time, but also played an important role against ischemia/reperfusion-related brain injury in animals. More importantly, in comparison with mono-antioxidant mechanism compounds, 33 exhibited higher cytoprotective and neuroprotective potential in vitro and in vivo. Overall, our findings showed compound 33 couldemerge as a promising anti-ischemic stroke drug candidate and provided novel dual-antioxidant mechanism strategies and concepts for oxidative stress-related diseases treatment. | Jiabing Wang Lili Huang Chanchan Cheng Ge Li Jingwen Xie Mengya Shen Qian Chen Wulan Li Wenfei He Peihong Qiu Jianzhang Wu | 2019 | Acta Pharmaceutica Sinica B2019，9，2： | 13 |
| 2 | Lipschitz spaces and Q_K type spaces显示文摘If f(z) =Σ∞ n=0 anzn and g(z) =Σ∞n=0bnzn for functions f, g are analytic in the unit disc, the Hadamard products of f and g is defined by f * g = ∞ n=0 a n b n z n . In this paper, the Lipschitz spaces Λ(s, α) and QK type spaces are studied in terms of the Hadamard products. | LI Hao 1 , WULAN Hasi 1, & ZHOU JiZhen 1,2 1 Department of Mathematics, Shantou University, Shantou 515063, China 2 School of Sciences, Anhui University of Science and Technology, Huainan 232001, China | 2010 | Science China Mathematics2010，53，3： | 2 |
| 3 | Chemical Constituents and Biological Activities of Plants from the genus Ehretia Linn.显示文摘The plants of the genus Ehretia Linn.composed of about 50 species mainly distributed in tropical Asia and Africa.They have been used as folk medicines or traditional tea to treat various ailments in China for a long time.This contribution reviews the chemical constituents isolated from the plants of the genus Ehretia Linn.and related biological activities of these species in the past few decades.The compounds in the genus mainly belong to the classes of phenolic acids,flavonoids,benzoquinones,cyanogenetic glycosides,and fatty acids.The main biological activities include antioxidant,anti-inflammatory,antisnake venom,and anti-allergic activities. | LI Li1,2,PENG Yong1,YAO Xia1,XU Li-jia1,WULAN Ta-na1,LIU Yong2,SHI Ren-bing2,XIAO Pei-gen1 1.Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine(Peking Union Medical College),Ministry of Education,Institute of Medicinal Plant Development,Chinese Academy of Medical Sciences,Beijing 100193,China 2.School of Chinese Materia Medica,Beijing University of Chinese Medicine,Beijing 100102,China | 2010 | Chinese Herbal Medicines2010，2，2： | 2 |
| 4 | Characterizations ofα-Bloch spaces on the unit ball显示文摘 | LI S HASI Wulan | 2008 | Math Anal Appl2008，343，1： | 1 |
| 5 | Genomic amplification of the human telomerase RNA gene for differential diagnosis of cervical disorders显示文摘 | Zheng Tu Aipeng Zhang Ruifang Wu Jing Jiang Yali Li Na Wulan Jingran Li Yongmei Zhang Yibing Li Zhong Chen Lihui Wei | 2009 | Cancer Genetics and Cytogenetics2009，，1： | 1 |
| 6 | A novel assay for human papillomavirus testing among women in guizhou显示文摘 | Suzanne E B Na Wulan Ruizhen Li | | 0，，05： | 1 |
| 7 | Volterra type operators on QK spaces显示文摘 | LI Song-xiao WULAN H | 2010 | Taiwanese J Math2010，14，1： | 1 |
| 8 | A Highly Infectious Chimeric Adenovirus Expressing Basic Fibroblast Growth Factor Exerts Potent Targeted Therapy for Rabbit Ear Chronic Ischemic Wounds显示文摘 | Lingli Guo Xiaoya Li Shuocheng Yang Yang Xu Ran Tao Hasi Wulan Changqing Su Yan Han | 2014 | Plastic and Reconstructive Surgery2014，，： | 1 |
| 9 | Parallel dif erence schemes in time direction for convection dif usion equation显示文摘 | Wulan Li Dakai Zhang Xu Da Chunhua Fang | | 0，，01： | 1 |
| 10 | SNIPER:a novel assay for human papillomavirus testing among women in Guizhou,China显示文摘 | Belinson SE Wulan N Li R | | 0，，06： | 1 |
| 11 | Composition operators on QK spaces显示文摘 | Li Songxiao Wulan Hasi | 2007 | J Math Anal Appl2007，327，2： | 1 |
| 12 | Synthesis and anti-inflammatory evaluation of novel mono-carbonyl analogues of curcumin in LPS-stimulated RAW 264.7 macrophages显示文摘 | Chengguang Zhao Yuepiao Cai Xuzhi He Jianling Li Li Zhang Jianzhang Wu Yunjie Zhao Shulin Yang Xiaokun Li Wulan Li Guang Liang | 2010 | European Journal of Medicinal Chemistry2010，，12： | 1 |
| 13 | Enhanced electromagnetic wave absorption via optical fiber-like PMMA@Ti_(3)C_(2)T_(x)@SiO_(2) composites with improved impedance matching显示文摘Ti_(3)C_(2)T_(x) nanosheets have attracted significant attention for their potential in electromagnetic wave absorption(EWA).However,their inherent self-stacking and exorbitant electrical conductivity inevitably lead to serious impedance mismatch,restricting their EWA application.Therefore,the optimization of impedance matching becomes crucial.In this work,we developed polymethyl methacrylate(PMMA)@Ti_(3)C_(2)T_(x)@SiO_(2) composites with a sandwich-like core–shell structure by coating SiO_(2) on PMMA@Ti_(3)C_(2)T_(x).The results demonstrate that the superiority of the SiO_(2) layer in combination with PMMA@Ti_(3)C_(2)T_(x),outperforming other relative graded distribution structures and meeting the requirements of EWA equipment.The resulting PMMA@Ti_(3)C_(2)T_(x)@SiO_(2) composites achieved a minimum reflection loss of-58.08 dB with a thickness of 1.9 mm,and an effective absorption bandwidth of 2.88 GHz.Mechanism analysis revealed that the structural design of SiO_(2) layer not only optimized impedance matching,but also synergistically enhanced multiple loss mechanisms such as interfacial polarization and dipolar polarization.Therefore,this work provides valuable insights for the future preparation of high-performance electromagnetic wave absorbing Ti_(3)C_(2)T_(x)-based composites. | Huanhuan Niu Xuewen Jiang Wei Li Zhiyu Min Budi Riza Putra Wulan Tri Wahyuni Hailong Wang Rui Zhang Bingbing Fan | 2024 | Nano Research2024，17，3： | 0 |
| 14 | Author correction to ‘Design, synthesis and biological evaluation of chalcone analogues with novel dual antioxidant mechanisms as potential anti-ischemic stroke agents’ [Acta Pharmaceutica Sinica B 9 (2019) 335e350]显示文摘The authors regret that there was a picture error in Fig.5D and Fig.5E,owing to the authors’mistakes of copying and pasting in the process of assembling figures and making a diagram.In Fig.5D,the image of the edaravone 6 h group(ED-6h group)was repeated with the model group(NS group),and thus the image of the ED-6h group needs to be corrected.In Fig.5E,the data of the edaravone 3h group(ED-3h group)was repeated with the 336h group(33-6h group),and thus the data of the ED-3h group needs to be corrected. | Jiabing Wang Lili Huang Chanchan Chen Ge Li Jingwen Xie Mengya Shen Qian Chen Wulan Li Wenfei He Peihong Qiu Jianzhang Wu | 2022 | Acta Pharmaceutica Sinica B2022，12，8： | 0 |
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