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| 1 | Improving Jatropha curcas seed protein recovery by using counter current multistage ex-taction显示文摘 | DIANIKA Lestari WIM Mulder JOHN Sanders | | 0，，50： | 1 |
| 2 | Improving Jatropha curcas seed protein recovery by using counter current multistage extraction显示文摘 | Dianika Lestari Wim Mulder Johan Sanders | 2010 | Biochemical Engineering Journal2010，，1： | 1 |
| 3 | Near-surface attenuation esti-mation using wave propagation modeling显示文摘 | Nizare El Y Fabian E Wim Mulder | 2008 | Geophysics2008，73，6： | 1 |
| 4 | Near-surface attenuation esti- mation using wave propagation modeling 显示文摘 | Nizare E1 Y Fabian E Wim Mulder | 2008 | Geophysics2008，73，6： | 1 |
| 5 | Assessing the Response to Targeted Therapies in Renal Cell Carcinoma: Technical Insights and Practical Considerations显示文摘 | Axel Bex Laure Fournier Nathalie Lassau Peter Mulders Paul Nathan Wim J.G. Oyen Thomas Powles | 2013 | European Urology2013，，： | 1 |
| 6 | Endovascular treatment in anterior circulation stroke beyond 6.5 hours after onset or time last seen well:results from the MR CLEAN Registry显示文摘Background Randomised controlled trials with perfusion selection have shown benefit of endovascular treatment(EVT)for ischaemic stroke between 6 and 24 hours after symptom onset or time last seen well.However,outcomes after EVT in these late window patients without perfusion imaging are largely unknown.We assessed their characteristics and outcomes in routine clinical practice.Methods The Multicenter Randomized Clinical Trial of Endovascular Treatment for Acute Ischemic Stroke in the Netherlands Registry,a prospective,multicentre study in the Netherlands,included patients with an anterior circulation occlusion who underwent EVT between 2014 and 2017.CT perfusion was no standard imaging modality.We used adjusted ordinal logistic regression analysis to compare patients treated within versus beyond 6.5 hours after propensity score matching on age,prestroke modified Rankin Scale(mRS),National Institutes of Health Stroke Scale,Alberta Stroke Programme Early CT Score(ASPECTS),collateral status,location of occlusion and treatment with intravenous thrombolysis.Outcomes included 3-month mRS score,functional independence(defined as mRS 0-2),and death.Results Of 3264 patients who underwent EVT,106(3.2%)were treated beyond 6.5 hours(median 8.5,IQR 6.9-10.6),of whom 93(87.7%)had unknown time of stroke onset.CT perfusion was not performed in 87/106(80.2%)late window patients.Late window patients were younger(mean 67 vs 70 years,p<0.04)and had slightly lower ASPECTS(median 8 vs 9,p<0.01),but better collateral status(collateral score 2-3:68.3%vs 57.7%,p=0.03).No differences were observed in proportions of functional independence(43.3%vs 40.5%,p=0.57)or death(24.0%vs 28.9%,p=0.28).After matching,outcomes remained similar(adjusted common OR for 1 point improvement in mRS 1.04,95%CI 0.56 to 1.93).Conclusions Without the use of CT perfusion selection criteria,EVT in the 6.5-24-hour time window was not associated with poorer outcome in selected patients with favourable clinical and CT/CT angiography characteristics.randomised controlled trials with lenient inclusion criteria are needed to identify more patients who can benefit from EVT in the late window. | Luuk Dekker Esmee Venema F Anne V Pirson Charles B L M Majoie Bart J Emmer Ivo G H Jansen Maxim J H L Mulder Robin Lemmens Robert-Jan B Goldhoorn Marieke J H Wermer Jelis Boiten Geert J LycklamaàNijeholt Yvo B W E M Roos Adriaan C G M van Es Hester F Lingsma Diederik W J Dippel Wim H van Zwam Robert J van Oostenbrugge Ido R van den Wijngaard on behalf of the MR CLEAN Registry investigators | 2021 | Stroke & Vascular Neurology2021，6，4： | 1 |
| 7 | Improving Jatropha cur-cas seed protein recovery by using counter current multistage extraction显示文摘 | Dianika Lestari Wim Mulder Johan Sanders | 2010 | Biochemical Engineering Journal2010，50，： | 1 |
| 8 | A promising resilience parameter for breeding:the use of weight and feed trajectories in growing pigs显示文摘Background Increasing resilience is a priority in modern pig breeding.Recent research shows that general resilience can be quantified via variability in longitudinal data.The collection of such longitudinal data on weight,feed intake and feeding behaviour in pigs has been facilitated by the development of technologies such as automated feeding stations.The goal of this study was to investigate resilience traits,which were estimated as deviations from longitudinal weight,feed intake and feeding behaviour data during the finishing phase.A dataset with 324,207 records between the age of 95 and 155 days on 5,939 Pietrain pigs with known pedigree and genomic information was used.We provided guidelines for a rigid quality control of longitudinal body weight data,as we found that outliers can significantly affect results.Gompertz growth curve analysis,linear modelling and trajectory analyses were used for quantifying resilience traits.Results To our knowledge,this is the first study comparing resilience traits from longitudinal body weight,feed intake and feeding behaviour data in pigs.We demonstrated that the resilience traits are lowly to moderately heritable for deviations in body weight(h2=2.9%–20.2%),in feed intake(9.4%–23.3%)and in feeding behaviour(16.2%–28.3%).Additionally,these traits have good predictive abilities in cross-validation analyses.Deviations in individual body weight and feed intake trajectories are highly correlated(rg=0.78)with low to moderate favourable genetic correlations with feed conversion ratio(rg=0.39–0.49).Lastly,we showed that some resilience traits,such as the natural logarithm of variances of observed versus predicted body weights(lnvarweight),are more robust to lower observation frequencies and are repeatable over three different time periods of the finishing phase.Conclusions Our results will help future studies investigating resilience traits and resilience-related traits.Moreover,our study provides first results on standardization of quality control and efficient data sampling from automated feeding station data.Our findings will be valuable for breeding organizations as they offer evidence that pigs’general resilience can be selected on with good accuracy.Moreover,this methodology might be extended to other species to quantify resilience based on longitudinal data. | Wim Gorssen Carmen Winters Roel Meyermans Lea Chapard Katrijn Hooyberghs Steven Janssens Abe Huisman Katrijn Peeters Han Mulder Nadine Buys | 2023 | Journal of Animal Science and Biotechnology2023，14，6： | 0 |
| 9 | 社区小乐园显示文摘本项目位于荷兰乌特勒支的一个社区公园内。场馆将社区广场分成了两部分,一边是青少年游玩的地方,另一边则是更幼小孩子的天堂。场馆内部也被分成三个独立的游乐室,配以颜色鲜艳的互动性家具和摆设。特别设计的'墙纸'则给每间屋子提供了一种不同的识别符号。所有的设计和布置,都旨在邀请孩子们入内玩耍, | Joost Mulders Chris van den Berk Robert van der Lee Lucas Torres Cecilia Thomsen Idette de Boer Wim Hanenberg Roel Backaert | 2010 | 设计家2010，，2： | 0 |
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