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| 1 | Colonoscopic yield of colorectal neoplasia in daily clinical practice显示文摘AIM:To assess the prevalence and location of ad-vanced neoplasia in patients undergoing colonoscopy,and to compare the yield per indication.METHODS:In a multicenter colonoscopy survey (n = 18 hospitals) in the Amsterdam area (Northern Holland),data of all colonoscopies performed during a three month period in 2005 were analyzed. The location and the histological features of all colonic neoplasia were recorded. The prevalence and the distribution ofadvanced colorectal neoplasia and differences in yield between indication clusters were evaluated. Advanced neoplasm was defi ned as adenoma > 10 mm in size,with > 25% villous features or with high-grade dyspla-sia or cancer.RESULTS:A total of 4623 eligible patients underwent a total colonoscopy. The prevalence of advanced neo-plasia was 13%,with 281 (6%) adenocarcinomas and 342 (7%) advanced adenomas. Sixty-seven percent and 33% of advanced neoplasia were located in the distal and proximal colon,respectively. Of all patients with right-sided advanced neoplasia (n = 228),51% had a normal distal colon,whereas 27% had a syn-chronous distal adenoma. Ten percent of all colono-scopies were performed in asymptomatic patients,7% of whom had advanced neoplasia. In the respective procedure indication clusters,the prevalence of right-sided advanced neoplasia ranged from 11%-57%. CONCLUSION:One out of every 7-8 colonoscopies yielded an advanced colorectal neoplasm. Colonoscopy is warranted for the evaluation of both symptomatic and asymptomatic patients. | Jochim S Terhaar sive Droste Mike E Craanen Rene WM van der Hulst Joep F Bartelsman Dick P Bezemer Kim R Cappendijk Gerrit A Meijer Linde M Morsink Pleun Snel Hans ARE Tuynman Roy LJ van Wanrooy Eric IC Wesdorp Chris JJ Mulder | 2009 | World Journal of Gastroenterology2009，15，9： | 6 |
| 2 | 中国的酸化问题——一项基于重庆—广州森林监测点研究结果的评估显示文摘中国经济的快速增长一直伴随着污染的加剧。本文在现场观测和文献研究的基础上讨论了酸性降水及其先兆的范围和影响。目前酸性降水的主要原因是二氧化硫的排放,但氮氧化物的排放也在增加。中国污染最严重地区的硫化合物沉降比东欧和中欧经受严重污染的地区要高。中国南部很多地区的土壤和土壤水看来已经被酸化。这些地区的污染已经影响了森林和其他植物的生命力,特别是在位于和靠近城市地区的地方。地表水的酸化似乎在近期不会成为主要的区域性问题,但一些地区的河流,目前虽仅接受少量的酸沉降,却对酸化显得较敏感。 | Hans M. Seip Per Aagaard Valter Angell Odd Eilertsen ThorjφrnLarssen Espen Lydersen Jan Mulder Ivar P. Muniz Arne Semb 汤大钢 Rolf D. Vogt 肖劲松 赵大为 孔国辉 岳欣 | 1999 | AMBIO-人类环境杂志1999，28，6： | 5 |
| 3 | Coeliac disease in Dutch patients with Hashimoto’s thyroiditis and vice versa显示文摘AIM: To define the association between Hashimoto’s thyroiditis and coeliac disease in Dutch patients. METHODS: A total of 104 consecutive patients with Hashimoto’s thyroiditis underwent coeliac serological tests (antigliadins, transglutaminase and endomysium antibodies) and HLA-DQ typing. Small intestinal biopsy was performed when any of coeliac serological tests was positive. On the other hand, 184 patients with coeliac disease were subjected to thyroid biochemical (thyroid stimulating hormone and free thyroxine) and thyroid serological tests (thyroglobulin and thyroid peroxidase antibodies). RESULTS: Of 104 patients with Hashimoto’s thyroiditis, sixteen (15%) were positive for coeliac serology and five patients with documented villous atrophy were diagnosed with coeliac disease (4.8%; 95% CI 0.7-8.9). HLA-DQ2 (and/or -DQ8) was present in all the five and 53 patients with Hashimoto’s thyroiditis (50%; 95% CI 43-62). Of 184 patients with coeliac disease, 39 (21%) were positive for thyroid serology. Based on thyroid biochemistry, the 39 patients were subclassified into euthyroidism in ten (5%; 95% CI 2-9), subclinicalhypothyroidism in seven (3.8%; 95% CI 1.8-7.6), and overt hypothyroidism (Hashimoto’s thyroiditis) in 22 (12%; 95% CI 8-16). Moreover, four patients with coeliac disease had Graves’ disease (2%; 95% CI 0.8-5) and one patient had post-partum thyroiditis. CONCLUSION: The data from a Dutch population confirm the association between Hashimoto’s thyroiditis and coeliac disease. Screening patients with Hashimoto’s thyroiditis for coeliac disease and vice versa is recom- mended. | Muhammed Hadithi Hans de Boer Jos WR Meijer Frans Willekens Jo A Kerckhaert Roel Heijmans Amado Salvador Pea Coen DA Stehouwer Chris JJ Mulder | 2007 | World Journal of Gastroenterology2007，13，11： | 4 |
| 4 | Acid deposition and its effects in China: an overview显示文摘 | Thorj?rn Larssen Hans Martin Seip Arne Semb Jan Mulder Ivar P. Muniz Rolf D. Vogt Espen Lydersen Valter Angell Tang Dagang Odd Eilertsen | 1999 | Environmental Science and Policy1999，，1： | 1 |
| 5 | The derivatisation of avermectins and milbemycins in milk: New insights and improvement of the procedure显示文摘 | Bjorn J.A. Berendsen Patrick P.J. Mulder Hans (J.)A. van Rhijn | 2006 | Analytica Chimica Acta2006，，1： | 1 |
| 6 | The Association Between HTR2C Gene Polymorphismsb and the Metabolic Syndrome in Patients With Schizophrenia显示文摘 | Hans Mulder Barbara Franke Annemarie Aart | 2007 | J Clin Psychopharmacol2007，27，： | 1 |
| 7 | HTR2C Gene Polymorphisms and the Metabolic Syndrome in Patients With Schizophrenia A Replication Study显示文摘 | Hans Mulder T Dan Cohen Hans Scheffer | 2009 | J Clin Psychopharmacol2009，29，： | 1 |
| 8 | Pravatatin reduce both clinical and angiographic restenosis two years after percutaneous transluminal coronary angioplasty:an analysis of the PTCA stratrum of the REGRESS trial显示文摘 | Han J G H Mulder J W Jukema E T | 1999 | JACC1999，33，： | 1 |
| 9 | Hepatitis B Surface Antigen Declines and Clearance During Long-Term Tenofovir Therapy in Patients Coinfected With HBV and HIV显示文摘 | Roeland Zoutendijk Hans L. Zaaijer Theodora E. M. S. de Vries-Sluijs Jurrien G. P. Reijnders Jan W. Mulder Frank P. Kroon Clemens Richter Annemiek A. van der Eijk Milan J. Sonneveld Bettina E. Hansen Robert A. de Man Marchina E. van der Ende Harry L. A. J | 2012 | Journal of Infectious Diseases2012，，6： | 1 |
| 10 | Digoxin in patients with permanent atrial fibrillation: Data from the RACE II study显示文摘 | Bart A. Mulder Dirk J. Van Veldhuisen Harry J.G.M. Crijns Jan G.P. Tijssen Hans L. Hillege Marco Alings Michiel Rienstra Maarten P. Van den Berg Isabelle C. Van Gelder | 2014 | Heart Rhythm2014，，9： | 1 |
| 11 | What’s a proper push? T he V alsalva manoeuvre revisited显示文摘 | Femke E. M. Mulder Ka L. Shek Hans P. Dietz | 2012 | Aust N Z J Obstet Gynaecol2012，，3： | 1 |
| 12 | 监控世界的无线传感器显示文摘一种药盒大小的计算机初露端倪,它们配备了传感器,通过无线电互联,能组成监测工厂、商店甚至生态系统的感知网络.这些设备将会使网络世界和真实世界的联系更紧密. | David E.Culler Hans Mulder 何毓嵩 | 2004 | 科学(中文版)2004，，8： | 0 |
| 13 | A promising resilience parameter for breeding:the use of weight and feed trajectories in growing pigs显示文摘Background Increasing resilience is a priority in modern pig breeding.Recent research shows that general resilience can be quantified via variability in longitudinal data.The collection of such longitudinal data on weight,feed intake and feeding behaviour in pigs has been facilitated by the development of technologies such as automated feeding stations.The goal of this study was to investigate resilience traits,which were estimated as deviations from longitudinal weight,feed intake and feeding behaviour data during the finishing phase.A dataset with 324,207 records between the age of 95 and 155 days on 5,939 Pietrain pigs with known pedigree and genomic information was used.We provided guidelines for a rigid quality control of longitudinal body weight data,as we found that outliers can significantly affect results.Gompertz growth curve analysis,linear modelling and trajectory analyses were used for quantifying resilience traits.Results To our knowledge,this is the first study comparing resilience traits from longitudinal body weight,feed intake and feeding behaviour data in pigs.We demonstrated that the resilience traits are lowly to moderately heritable for deviations in body weight(h2=2.9%–20.2%),in feed intake(9.4%–23.3%)and in feeding behaviour(16.2%–28.3%).Additionally,these traits have good predictive abilities in cross-validation analyses.Deviations in individual body weight and feed intake trajectories are highly correlated(rg=0.78)with low to moderate favourable genetic correlations with feed conversion ratio(rg=0.39–0.49).Lastly,we showed that some resilience traits,such as the natural logarithm of variances of observed versus predicted body weights(lnvarweight),are more robust to lower observation frequencies and are repeatable over three different time periods of the finishing phase.Conclusions Our results will help future studies investigating resilience traits and resilience-related traits.Moreover,our study provides first results on standardization of quality control and efficient data sampling from automated feeding station data.Our findings will be valuable for breeding organizations as they offer evidence that pigs’general resilience can be selected on with good accuracy.Moreover,this methodology might be extended to other species to quantify resilience based on longitudinal data. | Wim Gorssen Carmen Winters Roel Meyermans Lea Chapard Katrijn Hooyberghs Steven Janssens Abe Huisman Katrijn Peeters Han Mulder Nadine Buys | 2023 | Journal of Animal Science and Biotechnology2023，14，6： | 0 |
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