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| 1 | In situ tumor vaccination with adenovirus vectors encoding measles virus fusogenic membrane proteins and cytokines显示文摘AIM: To evaluate whether intratumoral expression of measles virus fusogenic membrane glycoproteins H and F (MV-FMG), encoded by an adenovirus vector Ad.MV-H/ F, alone or in combination with local coexpression of cytokines (IL-2, IL-12, IL-18, IL-21 or GM-CSF), can serve as a platform for inducing tumor-specifi c immune responses in colon cancer. METHODS: We used confocal laser scanning microscopy and flow cytometry to analyze cell-cell fusion after expression of MV-FMG by dye colocalization. In a syngeneic bilateral subcutaneous MC38 and Colon26 colon cancer model in C57BL/6 and BALB/c mice, we assessed the effect on both the directly vector-treated tumor as well as the contralateral, not directly vector- treated tumor. We assessed the induction of a tumor- specific cytotoxic T lymphocyte (CTL) response with a lactate dehydrogenase (LDH) release assay. RESULTS: We demonstrated in vitro that transduction of MC38 and Colon26 cells with Ad.MV-H/F resulted in dye colocalization, indicative of cell-cell fusion. In addition, in the syngeneic bilateral tumor model we demonstrated a signifi cant regression of the directly vector-inoculated tumor upon intratumoral expression of MV-FMG alone or in combination with the tested cytokines. We observed the highest anti-neoplastic efficacy with MV-FMG and IL-21 coexpression. The degree of tumor regression of the not directly vector-treated tumor correlated with the anti-neoplastic response of the directly vector-treated tumor. This regression was mediated by a tumor-specifi c CTL response. CONCLUSION: Our data indicate that intratumoral expression of measles virus fusogenic membraneglycoproteins is a promising tool both for direct tumor treatment as well as for tumor vaccination approaches that can be further enhanced by cytokine coexpression. | Dennis Hoffmann Wibke Bayer Oliver Wildner | 2007 | World Journal of Gastroenterology2007，13，22： | 4 |
| 2 | Expression of glycine receptors and gephyrin in the rat cochlea显示文摘 | Julia Dlugaiczyk Wibke Singer Bernhard Schick Heinrich Iro Kristina Becker Cord-Michael Becker Ulrike Zimmermann Karin Rohbock Marlies Knipper | 2008 | Histochemistry and Cell Biology2008，，4： | 1 |
| 3 | Comics and Interactive Information Graphics 显示文摘 | Weber Wibke | 2013 | Information Design Journal2013，20，2： | 1 |
| 4 | Noise-induced inner hair cell ribbon loss disturbs central arc mobilization: a novel mo- lecular paradigm for understanding tinnitus显示文摘 | Wibke S Annalisa Z Mirko J | 2013 | Mol Neurobi- ol2013，47，： | 1 |
| 5 | Interferon-lambda serum levels in hepatitis C显示文摘 | Bettina Langhans Bernd Kupfer Ingrid Braunschweiger Simone Arndt Wibke Schulte Hans Dieter Nischalke Jacob Nattermann Johannes Oldenburg Tilman Sauerbruch Ulrich Spengler | 2010 | Journal of Hepatology2010，，5： | 1 |
| 6 | Mapping Urban Malaria and Diarrhea Mortality in Accra, Ghana: Evidence of Vulnerabilities and Implications for Urban Health Policy显示文摘 | Julius N. Fobil Christian Levers Tobia Lakes Wibke Loag Alexander Kraemer Juergen May | 2012 | Journal of Urban Health2012，，6： | 1 |
| 7 | Molecular Analysis of Helicobacter pylori - associated Gastric Inflammation in naive versus previously immunized mice 显示文摘 | Wibke Rahn Raymond W Redline Thomas G Blanchard | 2004 | Vaccine2004，23，6： | 1 |
| 8 | Heritability of Early Repolarization: A Population-Based Study显示文摘 | Wibke Reinhard Bernhard M. Kaess Radoslaw Debiec Christopher P. Nelson Klaus Stark Martin D. Tobin Peter W. Macfarlane Maciej Tomaszewski Nilesh J. Samani Christian Hengstenberg | 2011 | Circulation: Cardiovascular Genetics2011，，2： | 1 |
| 9 | Interferon-lambda serum levels in hepatitis C显示文摘 | Bettina Langhans Bernd Kupfer Ingrid Braunschweiger Simone Arndt Wibke Schulte Hans Dieter Nischalke Jacob Nattermann Johannes Oldenburg Tilman Sauerbruch Ulrich Spengler | 2010 | Journal of Hepatology2010，，5： | 1 |
| 10 | Methylation determines fibroblast activation and fibrogenesis in the kidney 显示文摘 | Wibke Bechtel Scott McGoohan Elisabeth M Zeisberg | 2010 | Nat Med2010，16，5： | 1 |
| 11 | Data Visualization in Online Journalism and Its Implications for the Production Process显示文摘 | Wibke Weber & Hannes Rail | 2012 | 16th International Conference on Information Visualization2012，，： | 1 |
| 12 | Magnetic resonance imaging of the normal placenta 显示文摘 | Wibke B Brugger PC Christoph M | 2006 | Eur J Radiol2006，57，2： | 1 |
| 13 | Extracellular and Intracellular Pattern Recognition Receptors Cooperate in the Recognition of Helicobacter pylori显示文摘 | Roland Rad Wibke Ballhorn Petra Voland Katharina Eisen?cher J?rg Mages Lena Rad Ruth Ferstl Roland Lang Hermann Wagner Roland M. Schmid Stefan Bauer Christian Prinz Carsten J. Kirschning Anne Krug | 2009 | Gastroenterology2009，，7： | 1 |
| 14 | Nonribosomal peptide synthetases-evidence for a second ATP-binding site显示文摘 | Wibke K Maj a PV Ralf D | 2002 | Biochimica et Biophysica Acta2002，11，： | 1 |
| 15 | The utility of transrectal sonoelastography in preoperative prostate cancer assessment 显示文摘 | Steffen R Wibke A Hartmut A | 2012 | Medical Ultrasonogr-aphy2012，14，： | 1 |
| 16 | Mucopolysaccharidoses (MPS):Clinical and Neuroradiological Aspects of the Different Types显示文摘 | Wibke Müller-Forell Gudrun Schulze Frenking Yasmina Amraoui | 2007 | Clinical Neuroradiology2007，32，1： | 1 |
| 17 | Catalase Protects Tumor Cells from Apoptosis Induction by Intercellular ROS Signaling显示文摘 | Wibke B Georg B | | 0，，11： | 1 |
| 18 | ?-catenin, Cox-2 and p53 immunostaining in colorectal adenomas to predict recurrence after endoscopic polypectomy显示文摘 | Linda Brand Johanna Munding Christian P. Pox Wibke Ziebarth Markus Reiser Dietrich Hüppe Wolff Schmiegel Anke Reinacher-Schick Andrea Tannapfel | 2013 | International Journal of Colorectal Disease2013，，8： | 1 |
| 19 | Interventional Radiological Treatment of Perihepatic Vascular Stenosis or Occlusion in Pediatric Patients After Liver Transplantation显示文摘 | Wibke Uller Birgit Knoppke Andreas G. Schreyer Peter Heiss Hans J. Schlitt Michael Melter Christian Stroszczynski Niels Zorger Walter A. Wohlgemuth | 2013 | CardioVascular and Interventional Radiology2013，，6： | 1 |
| 20 | Magnetic resonance imaging of the normal placenta显示文摘 | Wibke Blaicher Peter C. Brugger Christoph Mittermayer Jens Schwindt Josef Deutinger Gerhard Bernaschek Daniela Prayer | 2005 | European Journal of Radiology2005，，2： | 1 |
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