|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Distribution and effects of polymorphic RANTES gene alleles in HIV/HCV coinfection - A prospective cross-sectional study显示文摘AIM: Chemokines and their receptors are crucial for immune responses in HCV and HIV infection. RANTES gene polymorphisms lead to altered gene expression and influence the natural course of HIV infection. Therefore,these mutations may also affect the course of HIV/HCV coinfection.METHODS: We determined allele frequencies of RANTES-403 (G→A), RANTES-28 (C→G) and RANTESIN1.1 (T→C) polymorphisms using real-time PCR and hybridization probes in patients with HIV (n = 85), HCV (n= 112), HIV/HCV coinfection (n = 121), and 109 healthy controls. Furthermore, HIV and HCV loads as well as CD4+ and CD8+ cell counts were compared between different RANTES genotypes.RESULTS: Frequencies of RANTES-403 A, RANTES-28 G and RANTES-IN1.1 C alleles were higher in HIV infected patients than in healthy controls (-403: 28.2% vs 15.1%,P = 0.002; -28: 5.4% vs 2.8%, not significant; IN1.1:19.0% vs 11.0%, P = 0.038). In HIV/HCV coinfected patients, these RANTES alleles were less frequent than in patients with HIV infection alone (15.4% P = 0.002;1.7%; P = 0.048; 12.0%; not significant). Frequencies of these alleles were not significantly different between HIV/HCV positive patients, HCV positive patients and healthy controls.CONCLUSION: All three RANTES polymorphisms showed increased frequencies of the variant allele exclusively in patients with HIV monoinfection. The finding that the frequencies of these alleles remained unaltered in HIV/HCV coinfected patients suggests that HCV coinfection interferes with selection processes associated with these alleles in HIV infection. | Golo Ahlenstiel Agathe Iwan Jacob Nattermann Karin Bueren Jürgen K Rockstroh Hans H Brackmann Bernd Kupfer Olfert Landt Amnon Peled Tilman Sauerbruch Ulrich Spengler Rainer P Woitas | 2005 | World Journal of Gastroenterology2005，11，48： | 3 |
| 2 | Behavior of concrete under biaxial stress 显示文摘 | Kupfer H Hilesdorf H K Rusch H | 1969 | ACI Structure Journals1969，66，2： | 2 |
| 3 | Behavior of concrete under biaxial stresses显示文摘 | KUPFER H B GERSTLE K H | 1973 | Journal of Engineering Mechanics Division ASCE1973，99，： | 1 |
| 4 | Microwave Moisture Measurement Systems and Their Applications显示文摘 | Kupfer K | 2001 | Sensors Update2001，7，1： | 1 |
| 5 | Major depressive disorder: new clinical, neurobiological, and treatment perspectives显示文摘 | Kupfer DJ Frank E Phillips ML | 2012 | Lancet2012，379，9820： | 1 |
| 6 | Sleep research in affective illness显示文摘 | Reynolds CF III Kupfer DJ | | 0，，03： | 1 |
| 7 | Shape of the red edge as vitality indicator for ptants显示文摘 | Boochs F Kupfer G Dockter K | 1990 | International Journal of Remote Sensing1990，11，10： | 1 |
| 8 | Perfection as Negation in the Aesthetics of Sport 显示文摘 | Kupfer J | 2001 | Journal of the Philosophy of Sport2001，，1： | 1 |
| 9 | Comparison of Cellular and Transcriptional Responses to 1,25-Dihydroxyvitamin D3 and Glucocortic oids in Peripheral Blood Mononuclear Ceils 显示文摘 | Kupfer SS Maranville JC Baxter SS | 2013 | PLoS ONE2013，8，76： | 1 |
| 10 | Type 1 Diabetes and Celiac Disease: Clinical Overlap and New Insights into Disease Pathogenesis显示文摘 | Aaron Cohn Anthony M. Sofia Sonia S. Kupfer | 2014 | Current Diabetes Reports2014，，8： | 1 |
| 11 | National assessments of forest fragmentation in the US显示文摘 | Kupfer J | 2006 | Global Environmental Change2006，16，： | 1 |
| 12 | Behavior of concrete under biaxial stresses 显示文摘 | KUPFER H | 1969 | ACI Journal1969，66，8： | 1 |
| 13 | CYP2D6catalyzes tamoxifen 4 -hydroxylation in human liver 显示文摘 | Dehal SS Kupfer D | 1997 | Cancer Res1997，57，： | 1 |
| 14 | Behaviour of Concrete Under Biaxial Stress显示文摘 | Kupfer H H K Hilsdoff H Rüsch | 1969 | Journal of American Concrete Institute1969，66，8： | 1 |
| 15 | Sleep,depression and suicide显示文摘 | Sabo E Reynolds CF Kupfer DJ | 1991 | Psychiatry Research1991，36，： | 1 |
| 16 | Long-term safety of pioglitazone versus glyburide in patients with recently diagnosed type 2 diabetes mellitus 显示文摘 | Jain R Osei K Kupfer S | 2006 | Pharmacotherapy2006，26，10： | 1 |
| 17 | Major depressive disorder: new clinical, neurobiological, and treatment perspectives显示文摘 | Kupfer DJ Frank E Phillips ML | 2012 | Lancet2012，379，： | 1 |
| 18 | Hypothyroidism in patients with bipolar I disorder treated primarily with lithium显示文摘 | Fagiolini A Kupfer DJ Scott J | 2006 | Epidemiol Psichiatr Soc2006，15，2： | 1 |
| 19 | Behavior of concrete under biaxial stresses显示文摘 | Kupfer H Hilsdorf H K Rtisch H | 1969 | ACI Journal1969，66，8： | 1 |
| 20 | Chromosomal evolution in Balsaminaceae with cytological observations on 45 species from Southeast Asia 显示文摘 | Song Y Yuan YM Kupfer P 2003 | 2003 | Caryolog2003，56，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员