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| 1 | Purification and Photodynamic Bioactivity of Phycoerythrin and Phycocyanin from Porphyra yezoensis Ueda显示文摘Phycoerythrin and phycocyanin were purified from Porphyra yezoensis Ueda with their bioactivity determined in this study. Continuous precipitation with ammonium sulfate at different concentrations(10%, 20%, 40% and 50%) increased the purity(A564:A280) of phycoerythrin to 1.49, 3.92 fold of the raw extract(0.38) and the purity(A615:A280) of phycocyanin to 0.70, 3.33 fold of the raw extract(0.21). Two more times of chromatography with hydroxylapatites finally made the purity of phycoerythrin and phycocyanin reach 5.50, 14.47 fold of the raw extract, and 5.10, 24.29 fold of the raw extract, respectviely. The yield of high purity phycoerythrin and phycocyanin were 0.21% and 0.09% of dried P. yezoensis blade, respectively. The photodynamic cytotoxic experiment showed that both phycoerythrin and phycocyanin inhibited the growth of liver tumor cells significantly. It was found that 250 mg L-1 purified phycoerythrin and phycocyanin inhibited the growth of hepatocellular carcinoma cells 24 h after laser-irradiation by 80% and 59%, respectively, and 100 mg L-1 purified phycoerythrin and phycocyanin induced the apoptosis of 31.54% and 32.54% of the cells, respectively, 8 h after photodynamic therapy. Oue findings demonstrated that P. yezoensis can serve as photosensitizer(phycoerythrin and phycocyanin) producer. | CAI Chuner WANG Yuan LI Chunxia GUO Ziye JIA Rui WU Weining HU Yan HE Peimin | 2014 | Journal of Ocean University of China2014，13，3： | 2 |
| 2 | Control of citrus postharvest green and blue mold and sour rot by tea saponin combined with imazalil and prochloraz显示文摘 | HAO Weining ZHONG Guohua HU Meiying | 2010 | Postharvest Biology and Technology2010，56，1： | 1 |
| 3 | lntegrated control of citrus green and blue mold and sour rot by Bacillus amyloliquefaciens in combination with tea saponin显示文摘 | HAO Weining H Hui HU Meiying | 2011 | Postharvest Biolory and Technology2011，59，3： | 1 |
| 4 | Fault-tolerant precise data access on distributed log-structured merge-tree显示文摘Log-structured merge tree has been adopted by many distributed storage systems. It decomposes a large database into multiple parts: an in?writing part and several read-only ones. Records are firstly written into a memoryoptimized structure and then compacted into in-disk struc? tures periodically. It achieves high write throughput. However, it brings side effect that read requests have to go through multiple structures to find the required record. In a distributed database system, different parts of the LSM-tree are stored in distributed fashion. To this end, a server in the query layer has to issues multiple network communications to pull data items from the underlying storage layer. Coming to its rescue, this work proposes a precise data access strategy which includes: an efficient structure with low maintaining overhead designed to test whether a record exists in the in?writing part of the LSM-tree;a lease-based synchronization strategy proposed to maintain consistent copies of the structure on remote query servers. We further prove the technique is capable of working robustly when the LSM-Tree is re?organizing multiple structures in the backend. It is also fault-tolerant, which is able to recover the structures used in data access after node failures happen. Experiments using the YCSB benchmark show that the solution has 6x throughput improvement over existing methods. | Tao ZHU Huiqi HU Weining QIAN Huan ZHOU Aoying ZHOU | 2019 | Frontiers of Computer Science2019，13，4： | 1 |
| 5 | Control of citrus postharvest green and blue mold and sour rot by tea saponin combined with imazalil and prochloraz显示文摘 | Weining Hao Meiying Hu Jianjun Luo | 2010 | Postharvest Biology and Technology2010，56，1： | 1 |
| 6 | Integrated control of citrus green and blue mold and sour rot by Bacillus amyloliquefaciens in combination with tea saponin显示文摘 | HAO Weining LI Hui HU Meiying | 2011 | Postharvest Biology and Technology2011，59，： | 1 |
| 7 | Integrated control of citrus green and blue mold and sour rot by Bacillus amyloliquefaciens in combination with tea saponin显示文摘 | Weining Hao Hui Li Meiying Hu Liu Yang Muhammad Rizwan-ul-Haq | 2010 | Postharvest Biology and Technology2010，，3： | 1 |
| 8 | Primary Establishment of EWE Model in Caohai Nature Reserve显示文摘According to environmental data,Ecopath with Ecosim (EWE) model can quantitatively describe the energy flow in the production and consumption of function components of system by using trophodynamics,and accurately assess the biomass and stable state of aquatic ecosystem.In the paper,the basic principle and parameters of EWE model were introduced firstly,and the relationship between Q/B (the important parameter of EWE model) and basic life indices of fish was discussed,then the current study and typical r... | OUYANG Li-jian1,LIU Wen2,WANG Yan-bin1,HU Si-yu1 1.Environment & Life Sciences Department,Bijie University,Bijie 551700,China 2.Administration Bureau of Caohai National Natural Reserve in Guizhou,Weining 553100,China | 2011 | Meteorological and Environmental Research2011，2，7： | 1 |
| 9 | Integrated control of citrus green and blue mold and sour rot by Bacillus amyloliquefaciens in combination with tea saponin显示文摘 | HAO Weining LI Hui HU Meiying | | 0，，03： | 1 |
| 10 | Integrated control of citrus green and blue mold and sour rot by Bacillus amyloliquefaciens in combination with tea saponin显示文摘 | Weining Hao Hui Li Meiying Hu Liu Yang Muhammad Rizwan-ul-Haq | 2010 | Postharvest Biology and Technology2010，，3： | 1 |
| 11 | Control of citrus postharvest green and blue mold and sour rot by tea saponin combined with imazalil and prochloraz显示文摘 | Weining Hao Guohua Zhong Meiying Hu Jianjun Luo Qunfang Weng Muhammad Rizwan-ul-Haq | 2009 | Postharvest Biology and Technology2009，，1： | 1 |
| 12 | Joint optimization of inspection-based and age-based preventive maintenance and spare ordering policies for single-unit systems显示文摘This paper presents a joint optimization policy of preventive maintenance(PM)and spare ordering for single-unit systems,which deteriorate subject to the delay-time concept with three deterioration stages.PM activities that combine a non-periodic inspection scheme with age-replacement are implemented.When the system is detected to be in the minor defective stage by an inspection for the first time,place an order and shorten the inspection interval.If the system has deteriorated to a severe defective stage,it is either repaired imperfectly or replaced by a new spare.However,an immediate replacement is required once the system fails,the maximal number of imperfect maintenance(IPM)is satisfied or its age reaches to a pre-specified threshold.In consideration of the spare’s availability as needed,there are three types of decisions,i.e.,an immediate or a delayed replacement by a regular ordered spare,an immediate replacement by an expedited ordered spare with a relative higher cost.Then,some mutually independent and exclusive renewal events at the end of a renewal cycle are discussed,and the optimization model of such a joint policy is further developed by minimizing the long-run expected cost rate to find the optimal inspection and age-replacement intervals,and the maximum number of IPM.A Monte-Carlo based integration method is also designed to solve the proposed model.Finally,a numerical example is given to illustrate the proposed joint optimization policy and the performance of the Monte-Carlo based integration method. | MA Weining ZHAO Fei LI Xin HU Qiwei SHANG Bingcong | 2022 | Journal of Systems Engineering and Electronics2022，33，5： | 1 |
| 13 | The simulation and analysis of pedestrian crowd and behavior显示文摘Pedestrian crowd in public buildings is usually a hidden trouble.The more serious the crowd,the higher the accident risk,and the heavier the casualties and loss may be.Based on the social force model,this paper puts forward an improved model which takes into account the anisotropic charac-teristic of pedestrian movement and the avoidance of dynamic congested areas.Furthermore,the al-gorithm has been optimized with the help of static force grid,so the simulation becomes more veritable and computational speed is also greatly accelerated.The improved model is also applied to research on the characters of pedestrian crowd,and the conclusion can provide a basis for the risk assessment of pedestrian crowd and the design of public buildings. | HU QingMei FANG WeiNing JIA YuQuan DENG Ye | 2009 | Science China(Technological Sciences)2009，52，6： | 1 |
| 14 | Incremental join view maintenance on distributed log-structured storage显示文摘Modern database systems desperate for the ability to support highly scalable transactions and efficient queries simultaneously for real-time applications.One solution is to utilize query optimization techniques on the on-line transaction processing(OLTP)systems.The materialized view is considered as a panacea to decrease query latency.However,it also involves the significant cost of maintenance which trades away transaction performance.In this paper,we examine the design space and conclude several design features for the implementation of a view on a distributed log-structured merge-tree(LSMtree),which is a well-known structure for improving data write performance.As a result,we develop two incremental view maintenance(IVM)approaches on LSM-tree.One avoids join computation in view maintenance transactions.Another with two optimizations is proposed to decouple the view maintenance with the transaction process.Under the asynchronous update,we also provide consistency queries for views.Experiments on TPC-H benchmark show our methods achieve better performance than straightforward methods on different workloads. | Huichao DUAN Huiqi HU Weining QIAN Aoying ZHOU | 2021 | Frontiers of Computer Science2021，15，4： | 1 |
| 15 | Pragmatic Functions of Discourse System Constructed by New Media in Public Health Emergencies-Taking Shanghai Fabu as an Example显示文摘This paper aims at studying the pragmatic functions of the discourse system constructed by the official version of Wechat, the Shanghai Fabu, when the city was challenged by the outbreak of COVID-19 since 2020. On the basis of analyzing the content and word frequency, the article tends to explore the pragmatic functions of the discourse, such as the emotional function, political function, and behavioural function, so as to provide relevant reference for the effective construction of discourse system and improvement of the new media’s role in response to public health emergencies. | LI Weining HU Man | 2023 | US-China Foreign Language2023，21，8： | 0 |
| 16 | Interferometry signatures of hydrodynamic sources with fluctuating initial conditions显示文摘We investigate the space-time evolution of the hydrodynamic particle-emitting sources with the fluctuating initial conditions generated by Heavy Ion Jet Interaction Generator(HIJING).In order to detect the event-by-event inhomogeneity of the sources,we examine the distribution of the error-inverse-weighted fluctuations,f,between the two-pion Bose-Einstein correlation functions of single and mixed events.We find that the distribution of f becomes wide for the fluctuating initial conditions.The large values of the distribution width and the root-mean-square frms are the signatures of the hydrodynamic particle-emitting sources with the fluctuating initial conditions. | HU Ying SU Zhongqian ZHANG Weining | 2013 | Nuclear Science and Techniques2013，24，5： | 0 |
| 17 | Multi-omics analyses of G6PD deficiency variants in Chinese population显示文摘Glucose-6-phosphate dehydrogenase(G6PD)deficiency is one of the most prevalent hereditary and X-linked enzyme disorders caused by the pathogenetic G6PD(NM_001042351.2)variants(Yang et al.,2016).The clinical manifestations of G6PD deficiency offer a wide spectrum of diverse disease phenotypes(Hecker et al.,2013).Investigations of prevalence and molecular epidemiology demonstrate that G6PD deficiency affects over 400 milion individuals worldwide and leads to thousands of deaths annually(Mortality and Causes of Death,2015). | He Ji Jiahuan Chen Peide Huang Zhimin Feng Weining Hu Mengyao Dai Xiaohui Sun Xiao Jin Guangquan Chen Guang Ning Lin Li Weiqing Wang Yanan Cao | 2024 | Journal of Genetics and Genomics2024，51，1： | 0 |
| 18 | Partition pruning for range query on distributed log-structured merge-tree显示文摘Log-structured merge tree(LSM-tree)is adopted by many distributed storage systems.It contains a Memtable and a number of SSTables.The Memtable is an in-memory structure and the SSTable is a disk-based structure.Data records are horizontally partitioned over the primary key and stored in different SSTables.Data writes on records are first served by the Memtable and then compacted to SSTables periodically.Although this design optimizes data writes by avoiding random disk writes,it is unfriendly to read request since the results should be retrieved and merged from both Memtable and SSTables.In particular,when the Memtable and SSTables are distributed on different nodes,it incurs expensive costs to serve range queries.A range query on nonprimary key columns has to scan all partitions,which generates many network and I/O expenses.In this paper,we propose a partition pruning strategy to save cost for range queries.A statistics cache is designed to determine whether a partition contains the desired data or not,which enables read requests to avoid scanning useless partitions.As records can be updated in Memtable freely,to prevent incorrect filtering,a version-based cache synchronization strategy is proposed to ensure the queries to obtain the latest data state.We implement the proposed method in an open source distributed database and conduct comprehensive experiments.Experimental results reveal that the performance of range queries increased 30%~40%with our partition pruning technique. | Chenchen HUANG Huiqi HU Xing WEI Weining QIAN Aoying ZHOU | 2020 | Frontiers of Computer Science2020，14，3： | 0 |
| 19 | Plover:parallel logging for replication systems显示文摘Logging and replication are commonly used recovery approaches in database systems.To guarantee that the database state is not corrupted due to system crash,database systems rely on a centralized logging method to persist log entries into a stable storage device;to prevent data loss due to device failure,a primary server in the database system periodically replicates its state to backup servers by copying log entries over networks.As the transaction execution in a modern database system is highly parallelized,the centralized logging with a single I/O channel tends to inhibit the scalability of the system.Meanwhile,log entries generated at high speed make a network with limited bandwidth a potential bottleneck for replication.In this paper,we propose an in-memory transaction engine named Plover with parallel logging and speedy replication for primary-backup replication systems.The parallel logging enables concurrent execution of logging by utilizing multiple log buffers associated with multiple stable storages.All log entries in the log buffers maintain a global sequence number(GSN),which ensures a partial order among transactions.The kernel of the speedy replication is an adaptive shipping method,which allows to transfer data increments instead of log entries to backups under heavy workloads.Experimental results using the YCSB and TPC-C benchmarks show that Plover scales well with the increasing number of worker threads and stable storage devices.And our adaptive shipping requires only one fifth network bandwidth of the conventional log shipping. | Huan ZHOU Jinwei GUO Huiqi HU Weining QIAN Xuan ZHOU Aoying ZHOU | 2020 | Frontiers of Computer Science2020，14，4： | 0 |
| 20 | Microbiota-mediated shaping of mouse spleen structure and immune function characterized by scRNA-seq and Stereo-seq显示文摘Gut microbes exhibit complex interactions with their hosts and shape an organism's immune system throughout its lifespan.As the largest secondary lymphoid organ,the spleen has a wide range of immunological functions.To explore the role of microbiota in regulating and shaping the spleen,we employ scRNA-seq and Stereo-seq technologies based on germ-free(GF)mice to detect differences in tissue size,anatomical structure,cell types,functions,and spatial molecular characteristics.We identify 18 cell types,9 subtypes of T cells,and 7 subtypes of B cells.Gene differential expression analysis reveals that the absence of microorganisms results in alterations in erythropoiesis within the red pulp region and congenital immune deficiency in the white pulp region.Stereo-seq results demonstrate a clear hierarchy of immune cells in the spleen,including marginal zone(MZ)macrophages,MZ B cells,follicular B cells and T cells,distributed in a well-defined pattern from outside to inside.However,this hierarchical structure is disturbed in GF mice.Ccr7 and Cxcl13 chemokines are specifically expressed in the spatial locations of T cells and B cells,respectively.We speculate that the microbiota may mediate the structural composition or partitioning of spleen immune cells by modulating the expression levels of chemokines. | Yin Zhang Juan Shen Wei Cheng Bhaskar Roy Ruizhen Zhao Tailiang Chai Yifei Sheng Zhao Zhang Xueting Chen Weiming Liang Weining Hu Qijun Liao Shanshan Pan Wen Zhuang Yangrui Zhang Rouxi Chen Junpu Mei Hong Wei Xiaodong Fang | 2023 | Journal of Genetics and Genomics2023，50，9： | 0 |
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