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| 1 | RNA-seq analysis of prostate cancer in the Chinese population identifies recurrent gene fusions, cancer-associated long noncoding RNAs and aberrant alternative splicings显示文摘在有前列腺癌症的不同赛跑的病人之中有显著不同;然而,位于这差别下面的机制仍然保持不清楚。这里,我们在场 transcriptome 的一处全面风景用 RNA-seq,越过关于基因熔化的前列腺癌症 transcriptomes 的揭示巨大的差异,长 noncoding RNA (长 ncRNA ) ,其他的拼接和体的变化从中国人口 14 主要前列腺癌症和他们的配对的正常对应物介绍。14 个肿瘤(21.4%) 中的三个在中国病人怀有 TMPRSS2 尔格熔化,和这熔化的低流行进一步在一个另外的肿瘤集合(10/54=18.5%) 被证实。尤其是,二新奇基因熔化, CTAGE5-KHDRBS3 (20/54=37%) 和 USP9Y-TTTY15 (19/54=35.2%) ,在我们的耐心的队经常发生了。介绍的进一步系统的 transcriptional 识别了是在肿瘤表示的差别的众多的长 ncRNAs。在长 ncRNA 和基因的表示之间的关联的分析建议长 ncRNAs 可以在 transcriptional 规定以外有功能。这研究在中国人口产出新卓见进前列腺癌症的致病。 | Shancheng Ren Zhiyu Peng Jian-Hua Mao Yongwei Yu Changjun Yin Xin Gao Zilian Cui Jibin Zhang Kang Yi Weidong Xu Chao Chen Fubo Wang Xinwu Guo Ji Lu Jun Yang Min Wei Zhijian Tian Yinghui Guan Liang Tang Chuanliang Xu Linhui Wang Xu Gao Wei Tian Jian Wang Huanming Yang Jun Wang Yinghao Sun | 2012 | Cell Research2012，22，5： | 66 |
| 2 | Characterization of dissolved organic matter in urban sewage using excitation emission matrix fluorescence spectroscopy and parallel factor analysis显示文摘Wastewater dissolved organic matter (DOM) from different processing stages of a sewage treatment plant in Xiamen was characterized using fluorescence and absorption spectroscopy. Parallel factor analysis modeling of excitation-emission matrix spectra revealed five fluorescent components occurring in sewage DOM: one protein-like (C1), three humic-like (C2, C4 and C5) and one xenobiotic-like (C3) components. During the aerated grit chamber and primary sedimentation tank stage, there was only a slight decrease in fluorescence intensity and the absorption coefficient at 350 nm (a 350 ). During the second aeration stage, high concentration of protein-like and short-wavelength-excited humic-like components were significantly degraded accompanied by significant loss of DOC (80%) and a 350 (30%), indicating that C1 and C2 were the dominant constituents of sewage DOM. As a result, long-wavelength-excited C4 and C5 became the dominant humic-like components and the DOM molecular size inferred from the variation of spectral slope S (300-650 nm) and specific absorption (a 280 /DOC) increased. Combination use of F max of C1 and the ratio of C1/C5, or a 350 may provide a quantitative indication for the relative amount of raw or treated sewage in aquatic environment. | Weidong Guo Jing Xu Jiangping Wang Yingrou Wen Jianfu Zhuo Yuchao Yan | 2010 | Journal of Environmental Sciences2010，22，11： | 36 |
| 3 | Coastal acidification in summer bottom oxygen-depleted waters in northwestern-northern Bohai Sea from June to August in 2011显示文摘Dissolved oxygen(DO) and pH in the central part of the Bohai Sea were surveyed in late June and late August,2011.During the June cruise,the bottom DO was in the range of 215-290 μmol-O2 kg-1(i.e.85%-115% of the saturation level),and the bottom pH was in the range of 7.82-8.04 on the total-hydrogen-ion scale.In August,however,both the bottom DO and the pH had significantly declined in the northwestern-northern near-shore areas,where the water depth was no more than 35 m.The lowest bottom DO was 100-110 μmol-O2 kg-1(only 44%-47% of the June DO values) in the northern near-shore area,where the bottom pH was 7.64-7.68 on the total-hydrogen-ion scale(0.16-0.20 units lower than the June pH value).The largest decreases in DO and in pH were observed in the northwestern near-shore bottom waters,corresponding to declines of 170 μmol-O2 kg-1(as high as 59% of the June DO value) and 0.29 pH units,respectively.The greatest pH decline of 0.29 pH units meant that the total-hydrogen-ion concentration doubled in the bottom waters from June to August.Based on field measurements of bottom DO/pH combined with a simplified model simulation,we suggest that respiration/remineralization-derived CO2 increased the acidity in the bottom oxygen-depleted waters of northwestern-northern near-shore areas in the Bohai Sea as a result of coastal red tides and/or marine aquaculture.This aquatic chemistry is suggested to be partially responsible for scallop-breeding failures in the northwestern Bohai Sea in summer 2011. | ZHAI WeiDong ZHAO HuaDe ZHENG Nan XU Yi | 2012 | Chinese Science Bulletin2012，57，9： | 22 |
| 4 | Deep carbon cycles constrained by a large-scale mantle Mg isotope anomaly in eastern China显示文摘Although deep carbon recycling plays an important role in the atmospheric CO_2 budget and climate changes through geological time,the precise mechanisms remain poorly understood.Since recycled sedimentary carbonate through plate subduction is the main light-δ^(26)Mg reservoir within deep-Earth,Mg isotope variation in mantle-derived melts provides a novel perspective when investigating deep carbon cycling.Here,we show that the Late Cretaceous and Cenozoic continental basalts from 13 regions covering the whole of eastern China have low δ^(26)Mg isotopic compositions,while the Early Cretaceous basalts from the same area and the island arc basalts from circum-Paciic subduction zones have mantle-like or heavy Mg isotopic characteristics.hus,a large-scale mantle low δ^(26)Mg anomaly in eastern China has been delineated,suggesting the contribution of sedimentary carbonates recycled into the upper mantle,but limited into the lower mantle.his large-scale spatial and temporal variation of Mg isotopes in the mantle places severe constraints on deep carbon recycling via oceanic subduction. | Shu-Guang Li Wei Yang Shah Ke Xunan Meng Hengci Tian Lijuan Xu Yongsheng He Jian Huang Xuan-Ce Wang Qunke Xia Weidong Sun Xiaoyong Yang Zhong-Yuan Ren Haiquan Wei Yongsheng Liu Fancong Meng Jun Yan | 2017 | National Science Review2017，4，1： | 23 |
| 5 | The recommendations of Chinese Parkinson’s disease and movement disorder society consensus on therapeutic management of Parkinson’s disease显示文摘Background:Parkinson’s disease(PD)is a chronic,progressive and debilitating disease,which affects over 2.5 million people in China.PD is characterized clinically by resting tremor,muscular rigidity,bradykinesia and postural instability.As the disease progresses,additional complications can arise such as non-motor and neurobehavioral symptoms.Pharmacological treatment and surgical intervention for PD have been implemented in China.Until 10 years ago,there was lack of standardization for the management of PD in different regions and among different physicians,leading to different treatment levels in different regions and different physicians.Since then,the Chinese Parkinson’s Disease and Movement Disorder Society have published three versions of guidelines for the management of PD in China,in 2006,2009 and 2014,respectively.Correspondingly,the overall level of treatment for PD in China improved.Objectives:To update the treatment guidelines based on current foreign and domestic practice guidelines and clinical evidence,and to improve the treatment options available to physicians in the management of PD.Summary:A variety of treatment recommendations in the treatment guidelines have been proposed,including physical activity and disease-modifying medication,which should be initiated at the early-stage of the disease.The principles of dosage titration should be followed to avoid acute adverse reactions to the drugs,to achieve a satisfactory clinical effect with a low dose and to reduce the incidence of long-term motor complications.Moreover,different treatment strategies should be considered at different stages of the disease.Importantly,treatment guidelines and personalized treatments should be valued equally.A set of treatment recommendations has been developed to assist physicians to improve and optimize clinical outcomes for patients with PD in China. | Shengdi Chen Piu Chan Shenggang Sun Haibo Chen Baorong Zhang Weidong Le Chunfeng Liu Guoguang Peng Beisha Tang Lijuan Wang Yan Cheng Ming Shao Zhenguo Liu Zhenfu Wang Xiaochun Chen Mingwei Wang Xinhua Wan Huifang Shang Yiming Liu Pingyi Xu Jian Wang Tao Feng Xianwen Chen Xingyue Hu Anmu Xie Qin Xiao | 2016 | Translational Neurodegeneration2016，5，1： | 23 |
| 6 | Long-term changes of phytoplankton community in Xiagu waters of Xiamen,China显示文摘Long-term changes of phytoplankton community by water sampling method in Xiagu Sea waters of Xiamen,China,were investigated in this study.Species composition of the phytoplankton community in these waters changed greatly since the 1950s.The numbers of Dinophyta species increased significantly,although Bacillariophyta species are generally dominant.The succession of dominant species in phytoplankton community is obvious: large-size dominant species such as Biddulphia sinensis of the 1950s were gradually replaced by small-size ones such as Cyclotella striata and Nitzschia closterium,and species that still maintain dominant such as Skeletonema costatum are also small ones,leading the whole phytoplankton community of smaller size.Cell density of phytoplankton community increased greatly,among which cell density of the most dominant species Skeletonema costatum have been increasing in exponent function.Margalef index of phytoplankton community decreased,indicating decline of biodiversity of the community,and dominant character of Skeletonema costatum increased.Generally,the structure of the entire phytoplankton community is becoming more and more singular and unstable,which makes the occurrence of red tides more frequent.The succession in the phytoplankton community is related to the long-term changes in marine environment,influenced by human activities and global climate changes,especially the increases of nutrient content. | CHEN Baohong XU Zhuhua ZHOU Qiulin CHEN Changping GAO Yahui YANG Shengyun JI Weidong | 2010 | Acta Oceanologica Sinica2010，29，6： | 14 |
| 7 | Ultrasensitive skin‐like wearable optical sensors based on glass micro/nanofibers显示文摘Electronic skin,a class of wearable electronic sensors that mimic the functionalities of human skin,has made remarkable success in applications including health monitoring,human-machine interaction and electronic-biological interfaces.While electronic skin continues to achieve higher sensitivity and faster response,its ultimate performance is fundamentally limited by the nature of low-frequency AC currents.Herein,highly sensitive skin-like wearable optical sensors are demonstrated by embedding glass micro/nanofibers(MNFs)in thin layers of polydimethylsiloxane(PDMS).Enabled by the transition from guided modes into radiation modes of the waveguiding MNFs upon external stimuli,the skin-like optical sensors show ultrahigh sensitivity(1870 k·Pa^-1),low detection limit(7 mPa)and fast response(10μs)for pressure sensing,significantly exceeding the performance metrics of state-of-the-art electronic skins.Electromagnetic interference(EMI)-free detection of high-frequency vibrations,wrist pulse and human voice are realized.Moreover,a five-sensor optical data glove and a 2×2-MNF tactile sensor are demonstrated.These initial results pave the way toward a new category of optical devices ranging from ultrasensitive wearable sensors to optical skins. | Lei Zhang Jing Pan Zhang Zhang Hao Wu Ni Yao Dawei Cai Yingxin Xu Jin Zhang Guofei Sun Liqiang Wang Weidong Geng Wenguang Jin Wei Fang Dawei Di Limin Tong | 2020 | Opto-Electronic Advances2020，3，3： | 12 |
| 8 | Co-incorporation of rice straw and leguminous green manure can increase soil available nitrogen(N)and reduce carbon and N losses:An incubation study显示文摘Returning rice straw and leguminous green manure alone or in combination to soil is effective in improving soil fertility in South China.Despite the popularity of this practice,our understanding o f the underlying processes for straw and manure combined application is relatively poor.In this study,rice straw(carbon(C)/nitrogen(N)ratio of 63),green manure(hairy vetch,C/N ratio of 14),and their mixtures(C/N ratio of 25 and 35)were added into a paddy soil,and their effects on soil N availability and C or N loss under waterlogged conditions were evaluated in a 100-d incubation experiment.All plant residue treatments significantly enhanced C〇2 and CH4 emissions,but decreased N2O emission.Dissolved organic C(DOC)and N(DON)and microbial biomass C in soil and water-soluble organic C and N and mineral N in the upper aqueous layer above soil were also enhanced by all the plant residue treatments except the rice straw treatment,and soil microbial biomass N and mineral N were lower in the rice straw treatment than in the other treatments.Changes in plant residue C/N ratio,DOC/DON ratio,and cellulose content significantly affected greenhouse gas emissions and active C and N concentrations in soil.Additionally,the treatment with green manure alone yielded the largest C and N losses,and incorporation of the plant residue mixture with a C/N ratio of 35 caused the largest net global warming potential(nGWP)among the amended treatments.In conclusion,the co-incorporation of rice straw and green manure can alleviate the limitation resulting from only applying rice straw(N immobilization)or the sole application of leguminous green manure(high C and N losses),and the residue mixture with a C/N ratio of 25 is a better option because of lower nGWP. | Guopeng ZHOU Weidong CAO Jinshun BAI Changxu XU Naohua ZENG Songjuan GAO Robert M.REES Fugen DOU | 2020 | Pedosphere2020，30，5： | 10 |
| 9 | Radiofrequency ablation combined with transcatheter arterial chemoembolization therapy versus surgical resection for Barcelona-Clinic Liver Cancer(BCLC) A hepatocellular carcinoma: a meta-analysis显示文摘Purpose: The objective of our study was to compare the effectiveness of the combination of transcatheter arterial chemoembolization(TACE) and radiofrequency ablation(RFA) with that of surgical resection(SR) in Barcelona-Clinic Liver Cancer(BCLC) A hepatocellular carcinoma. Materials and Methods: PubMed, Medline, Embase, and Cochrane Library were searched for comparisons of the two therapies from January 2006 to December 2017. Overall survival rate(OS), recurrence-free survival rate(RFS), complications, and the average length of hospital stay were compared and analyzed. Review Manager v. 5.2 from the Cochrane Collaboration was used for statistical analyses. Results: Seven case-control studies and one randomized controlled trial were identified, of which 717 were treated with a combination of TACE and RFA and 785 were treated with SR. Meta-analysis data revealed that TACE plus RFA had significantly better effectiveness on 1.0-y OS(OR = 0.50, p =.009). The major complications(ORcomplications = 1.88, p =.02) after the combined therapy were significantly lower than those after SR. There were three studies that reported the average length of hospital stay. The hospital stay for the SR group vs the combined therapy group was 19.8 ± 8.4 d vs 7.4 ± 2.2 d, respectively(p <.0001); 18.7 ± 4.9 d vs 11.5 ± 6.9 d, respectively(p <.0001); and 16.6 ± 6.7 d vs 8.5 ± 4.1 d, respectively(p <.0001). There was no significant difference in 3.0-or 5.0-y OS and 1.0-, 3.0-, or 5.0-y RFS. Conclusion: The combination of TACE and RFA has advantages in improving 1.0-y OS, reducing complications, and shortening the length of hospital stay over that of SR in the treatment of patients with BCLC A HCC. | Weidong Wang Sinan Hou Zelong Zhong JiaYan Ni Xiongying Jiang Dong Chen Yaoting Chen Jianghong Luo Hongliang Sun Linfeng Xu | 2018 | Journal of Interventional Medicine2018，1，1： | 9 |
| 10 | High-temperature infrared camouflage with efficient thermal management显示文摘High-temperature infrared(IR)camouflage is crucial to the effective concealment of high-temperature objects but remains a challenging issue,as the thermal radiation of an object is proportional to the fourth power of temperature(T4).Here,we experimentally demonstrate high-temperature IR camouflage with efficient thermal management.By combining a silica aerogel for thermal insulation and a Ge/ZnS multilayer wavelength-selective emitter for simultaneous radiative cooling(high emittance in the 5-8μm non-atmospheric window)and IR camouflage(low emittance in the 8-14μm atmospheric window),the surface temperature of an object is reduced from 873 to 410 K.The IR camouflage is demonstrated by indoor/outdoor(with/without earthshine)radiation temperatures of 310/248 K for an object at 873/623 K and a 78% reduction in with-earthshine lock-on range.This scheme may introduce opportunities for high-temperature thermal management and infrared signal processing. | Huanzheng Zhu Qiang Li Chunqi Zheng Yu Hong Ziquan Xu HanWang Weidong Shen Sandeep Kaur Pintu Ghosh Min Qiu | 2020 | Light(Science & Applications)2020，9，1： | 8 |
| 11 | Ethylene oligomerization by novel iron(Ⅱ) diimine complexes/MAO显示文摘Two novel Fe(Ⅱ) diimine complexes have been synthesized. In combination with MAO, they generate active catalytic systems that oligomerize ethylene with both high catalytic activity and high selectivity for a-olefins. The effects of substituents on the aryl ring, reaction temperatures and molar ratios of Al/Fe on catalytic activity and product distribution are studied. | WANG Hang, YAN Weidong, JIANG Tao, LIU Binbin, XU Wenqing, MA Jianjiang & HU YouliangState Key Laboratory of Engineering Plastics, Center for Molecular Science, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100080, China Graduate Student of | 2002 | Chinese Science Bulletin2002，47，19： | 8 |
| 12 | Microstructural and mechanical behavior of a CoCrFeNiCu_4 non-equiatomic high entropy alloy显示文摘High entropy alloy(HEA)-based alloy design is experiencing a conceptual broadening from equiatomic alloys to non-equiatomic alloys.To provide experimental basis for designing Cu-rich non-equiatomic HEAs,in the current study,a dual phase(Cu-rich and CoCrFeNi-rich phases) face-centered cubic CoCrFeNiCu_(4) alloy was systematically investigated.We provided initial and experiment-based understanding of the behavioral change of the alloy during a variety of thermal cycles and thermomechanical processing.The current results indicate that,during heating,preferred precipitation of Cu-rich particles occurs,leading to more pronounced compositional differences between the two constituent FCC phases and increased relative volume fraction of the Cu-rich phase.The Alloy exhibits a continuous melting and discontinuous solidification of the Cu-rich and CoCrFeNi-rich phases.After being cold-rolled to ~90 % thickness reduction,the alloy exhibits a recrystallization temperature higher than 800℃.Annealing at 300 and 500℃ led to strength reduction and/or ductility decrease;further increasing annealing temperature monotonically caused softening and ductilization due to decreased density of pre-existing dislocations.The yield-drop phenomena observed for the 900℃-and 1000℃-annealed specimens are associated with the locking of pre-existing dislocations by some 'atmosphere',the nature of which warrants further elucidation. | Zijuan Xu Zhongtao Li Yang Tong Weidong Zhang Zhenggang Wu | 2021 | Journal of Materials Science & Technology2021，，1： | 8 |
| 13 | 35 W continuous-wave Ho:YAG single-crystal fiber laser显示文摘We report on a high-power Ho:YAG single-crystal fiber(SCF)laser inband pumped by a high-brightness Tm-fiber laser at 1908 nm.The Ho:YAG SCF grown by the micro-pulling-down technique exhibits a propagation loss of 0.05±0.005 cm^-1 at 2.09μm.A continuous-wave output power of 35.2 W is achieved with a slope efficiency of 42.7%,which is to the best of our knowledge the highest power ever reported from an SCF-based laser in the 2µm spectral range. | Yongguang Zhao Li Wang Weidong Chen Jianlei Wang Qingsong Song Xiaodong Xu Ying Liu Deyuan Shen Jun Xu Xavier Mateos Pavel Loiko Zhengping Wang Xinguang Xu Uwe Griebner Valentin Petrov | 2020 | High Power Laser Science and Engineering2020，8，2： | 7 |
| 14 | Multi-target state-estimation technique for the particle probability hypothesis density filter显示文摘A simple yet effective state-estimation algorithm is presented and demonstrated to have advantages over previous standard clustering techniques used for the particle probability hypothesis density filter.The idea behind the proposed algorithm is that it uses the latest available information(i.e.,the measurements) to direct particle clustering.The particle likelihood and target number estimation,computed during probability hypothesis density recursion,are both used to partition particles into clusters,and the center of each cluster gives the state estimation of an individual target.Simulation results indicate that the proposed algorithm outperforms the standard clustering approach using the k-means algorithm,achieving higher accuracy and shorter computational time. | LIN LiangKui XU Hui SHENG WeiDong AN Wei | 2012 | Science China(Information Sciences)2012，55，10： | 7 |
| 15 | Image formation of brain function in patients suffering from knee osteoarthritis treated with moxibustion显示文摘OBJECTIVES:Functional magnetic resonance imaging(fMRI) technology was used to study changes to the resting state blood flow in the brains of patients with knee osteoarthritis(KOA) before and after treatment with moxibustion at the acupoint of the left Dubi(ST 35) and to probe the cerebral mechanism underlying the effect of moxibustion.METHODS:The resting state brain function of 30 patients with left KOA was scanned with fMRI before and after treatment with moxibustion.The analytic methods of fractional amplitude of low frequency fluctuation(fALFF) and regional homogeneity(ReHo) were used to observe changes in resting state brain function.RESULTS:The fALFF values of the right cerebrum,extra-nucleus,left cerebellum,left cerebrum and white matter of patients after moxibustion treatment were higher than before treatment,and the fALFF values of the precentral gyrus,frontal lobe and occipital lobe were lower than before treatment(P<0.05,K≥85).The ReHo values of the thalamus,extra-nucleus and parietal lobe of patients were much higher than those before moxibustion treatment,and the ReHo values of the right cerebrum,left cerebrum and frontal lobe were lower than before treatment(P<0.05,K≥85).CONCLUSION:The influence of moxibustion on obvious changes in brain regions basically conforms to the way that pain and warmth is transmitted in the body,and the activation of sensitive systems in the body may be objective evidence of channel transmission.The regulation of brain function by moxibustion is not in a single brain region but rather in a network of many brain regions. | Hongwu Xie Fangming Xu Rixin Chen Tianyou Luo Mingren Chen Weidong Fang Fajin Lü Fei Wu Yune Song Jun Xiong | 2013 | Journal of Traditional Chinese Medicine2013，33，2： | 7 |
| 16 | Development and Analysis of an Electrically Actuated Lower Extremity Assistive Exoskeleton显示文摘一架电子上激活的更低的极限皮骨骼被开发,在哪个当有弹性的元素连接的另外的关节消极地被激活时,仅仅膝关节活跃地被激活。这份报纸描述批评设计标准并且介绍设计的进程和使活动系统的计算。一台灵活物理 Human-Robot-Interaction (pHRI ) 测量设备被设计并且适用检测人的运动,它包括纳入连接手铐的内部表面的二个力量传感器和二个气囊。联机适应 pHRI 最小化控制策略被建议并且实现了驱使机器的皮骨骼系统跟随人的手足的运动轨道。测量 pHRI 信息被变化加权的一般水准(VWA ) 方法熔化。pHRI 和控制转矩的吝啬的方形的价值(MSV ) 被利用评估皮骨骼的表演。改进舒适水平和还原剂精力消费,当控制法律被设计时,严肃赔偿被考虑。最后,实际实验在健康用户上被执行。试验性的结果证明建议系统能帮助人走,构画出的控制策略有效、有效。 | Yi Long Zhijiang Du Chaofeng Chen Weidong Wang Long He Xiwang Mao Guoqiang Xu Guangyu Zhao Xiaoqi Li Wei Dong | 2017 | Journal of Bionic Engineering2017，14，2： | 7 |
| 17 | Hierarchical Ni-Co-S@Ni-W-O core-shell nanosheet arrays on nickel foam for high-performance asymmetric supercapacitors显示文摘镍钴硫化物(Ni-Co-S ) 由于他们的优秀传导性和高电气化学的电容在电子设备为申请吸引了广泛的注意。为了便于 Ni-Co-S,优秀的率能力和这些的周期的稳定性的大规模实际申请,混合物必须充分被利用。因此,镍泡沫上的层次 Ni-Co-S@Ni-W-O (Ni-Co-S-W ) 核心 / 壳混血儿 nanosheet 数组经由一个灵巧的三步的热水的方法此处被设计并且综合,由在氩空气下面在一个管状的炉子退火列在后面。混合结构直接作为一个自立的电极被装配,它展出了 1,988 F | Weidong He Zhifu Liang Keyu ji Qingfeng Sun Tianyou Zhai Xijin Xu | 2018 | Nano Research2018，11，3： | 7 |
| 18 | Analysis of factors affecting the prognosis of transcatheter arterial chemoembolization for hepatitis B-related hepatocellular carcinoma显示文摘Objectives:The purpose of this study was to investigate the prognostic factors for transcatheter arterial chemoembolization(TACE)for hepatitis B-related hepatocellular carcinoma(HCC).Materials and methods:The variables that may affect overall survival(OS),such as age,gender,AFP,Child Pugh classification,body mass index,HBV-DNA,Hbe Ag,tumor number,tumor diameter,BCLC stage,embolization method,ablation therapy,and targeted therapy,were analyzed by single factor and many factor COX regression.In addition,predictive factors of OS were stratified and a Kaplan-Meier survival curve was drawn.Results:Among the 136 patients,the median follow-up time was 14.5 months(range:2–72 months).HCC patients with the tumor diameter<3 cm had the highest survival rate,followed by patients with a tumor diameter of 3–5 cm;the survival rate of patients with the tumor diameter(greater than 5 cm)was the lowest.Among the BCLC stages,stage A patients had the highest survival rate,followed by stage B and stage C patients,which had the lowest survival rate.The survival rate of Child Pugh grade A patients was higher than those with Child Pugh grade B.Compared with patients who did not undergo ablation treatment,the survival rate of patients with combined ablation treatment was relatively high.The survival rate of patients receiving drug-eluting beads transarterial chemoembolization(DEB-TACE)treatment was higher than those receiving conventional transarterial chemoembolization(c TACE)treatment.Additionally,repeated TACE treatment improved the OS rate of patients.These six factors were related to patient prognosis and the differences were statistically significant(P<0.05).Conclusions:Tumor diameter,BCLC stage,TACE repetition,and TACE combined with ablation were independent prognostic factors of OS. | Jiangping Cun Yonghui Xu Weidong Li Xingxiang Zhao | 2021 | Journal of Interventional Medicine2021，4，2： | 7 |
| 19 | sLe^(x) expression in invasive micropapillary breast carcinoma is associated with poor prognosis and can be combined with MUC1/EMA as a supplementary diagnostic indicator显示文摘Objective: Mucin 1(MUC1/EMA) and sialyl Lewis X(sLe^(x)) indicate polarity reversal in invasive micropapillary carcinoma(IMPC). The purpose of this study was to evaluate the expression of MUC1/EMA and sLe^(x) and to assess their diagnostic and prognostic value in patients with IMPC.Methods: The expression of sLe^(x) and MUC1/EMA in 100 patients with IMPC and a control group of 89 patients with invasive ductal carcinoma not otherwise specified(IDC-NOS) were analyzed with IHC. Fresh tumor tissues were collected from patients with IMPC or IDC-NOS for primary culture and immunofluorescence analysis.Results: The rate of nodal metastasis was higher in patients with IMPC than those with IDC-NOS, and IMPC cells tended to express more sLe^(x) and MUC1/EMA in the cytomembranes(the stroma-facing surfaces of the micropapillary clusters) than IDC-NOS cells. In IMPC, high cytomembrane expression of sLe^(x), but not MUC1/EMA, indicated poor prognosis. In addition, among the 100 patients with IMPC, 10 patients had sLe^(x)+/EMA-expression patterns, and 8 patients had sLe^(x)-/EMA+ expression patterns. The primary IMPC cells were suspended, non-adherent tumor cell clusters, whereas the primary IDC cells were adherent tumor cells. Immunofluorescence analysis showed that MUC1/EMA and sLe^(x) were co-expressed on the cytomembranes in IMPC cell clusters and in the cytoplasm in IDC-NOS cells.Conclusions: sLe^(x) can be used as a prognostic indicator and can be combined with MUC1/EMA as a complementary diagnostic indicator to avoid missed IMPC diagnosis. | Yawen Song Hui Sun Kailiang Wu Jianke Lyu Jingyue Zhang Feng Gu Yongjie Ma Beibei Shen Chijuan Wang Xiaojiao Chen Jing Xu Weidong Li Fangfang Liu Li Fu | 2021 | Cancer Biology & Medicine2021，18，2： | 7 |
| 20 | Hierarchical CuCo_2O_4@nickel-cobalt hydroxides core/shell nanoarchitectures for high-performance hybrid supercapacitors显示文摘Ni_(0.5)Co_(0.5)(OH)_2 nanosheets coated CuCo_2O_4 nanoneedles arrays were successfully designed and synthesized on carbon fabric. The core/shell nanoarchitectures directly served as the binder-free electrode with a superior capacity of 295.6 mAh g^(-1) at 1 Ag^(-1), which still maintained 220 mAh g^(-1) even at the high current density of 40 Ag^(-1), manifesting their enormous potential in hybrid supercapacitor devices. The asassembled CuCo_2O_4@Ni_(0.5)Co_(0.5)(OH)_2//AC hybrid supercapacitor device exhibited favorable properties with the specific capacitance as high as 90 Fg^(-1) at 1 Ag^(-1) and the high energy density of 32 Wh kg^(-1) at the power density of 800 Wkg^(-1). Furthermore, the as-assembled device also delivered excellent cycling performance(retaining 91.9% of the initial capacitance after 12,000 cycles at 8 Ag^(-1)) and robust mechanical stability and flexibility, implying the huge potential of present hierarchical electrodes in energy storage devices. | Chenggang Wang Kai Guo Weidong He Xiaolong Deng Peiyu Hou Fuwei Zhuge Xijin Xu Tianyou Zhai | 2017 | Science Bulletin2017，62，16： | 6 |
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