| 1 | Etoposide,dexamethasone,and pegaspargase with sandwiched radiotherapy in early-stage natural killer/T-cell lymphoma:A randomized phase III study显示文摘Methotrexate,etoposide,dexamethasone,and pegaspargase(MESA)with sandwiched radiotherapy is known to be effective for early-stage extranodal natural killer/T-cell lymphoma,nasal type(NKTCL).We explored the efficacy and safety of reduced-intensity,non-intravenous etoposide,dexamethasone,and pegaspargase(ESA)with sandwiched radiotherapy.This multicenter,randomized,phase III trial enrolled patients aged between 14 and 70 years with newly diagnosed early-stage nasal NKTCL from 27 centers in China.Patients were randomly assigned(1:1)to receive ESA(pegaspargase 2,500 IU/m^(2)intramuscularly on day 1,etoposide 200 mg orally,and dexamethasone 40 mg orally on days 2–4)or MESA(methotrexate 1 g/m^(2)intravenously on day 1,etoposide 200 mg orally,and dexamethasone 40 mg orally on days 2–4,and pegaspargase 2,500 IU/m^(2)intramuscularly on day 5)regimen(four cycles),combined with sandwiched radiotherapy. | Huijuan Zhong Shu Cheng Xi Zhang Bing Xu Jiayi Chen Xufeng Jiang Jie Xiong Yu Hu Guohui Cui Juying Wei Wenbin Qian Xiaobing Huang Ming Hou Feng Yan Xin Wang Yongping Song Jianda Hu Yuanhua Liu Xuejun Ma Fei Li Chongyang Wu Junmin Chen Li Yu Ou Bai Jingyan Xu Zunmin Zhu Li Liu Xin Zhou Li Huang Yin Tong Ting Niu Depei Wu Hao Zhang Chaofu Wang Binshen Ouyang Hongmei Yi Qi Song Gang Cai Biao Li Jia Liu Zhifeng Li Rong Xiao Luqun Wang Yujie Jiang Yanyan Liu Xiaoyun Zheng Pengpeng Xu Hengye Huang Li Wang Saijuan Chen Weili Zhao | 2023 | The Innovation2023，4，3： | 0 |
| 2 | The Practical Challenges and Ecological Construction of the Lifelong Learning System in the Digital Era显示文摘At present,intelligent digital technology is irreversibly influencing all levels of the education field.The construction of an education system serving lifelong learning has also become an essential field of digital transformation.In the face of the impact of marketization,aging,and networking,as well as the update and iteration of intelligent digital technology,the construction of the lifelong learning system not only needs to realize the transformation with the help of digital technology but also needs to clarify the internal correlation of transformation goals,computing power support,multiple collaboration,and learning evaluation from the framework structure.At the same time,it is necessary to realize that the penetration of technology into lifelong learning may cause the misunderstanding of technology supremacy and the trap of tool rationality.Therefore,technological empowerment and enablement can accelerate the digital transformation of the lifelong learning system and coordinate with community education,elderly education,vocational education,higher education,and other fields to construct an integrated environment.Additionally,being critical issues requiring attention from society,they are also vital ways to overcome the above dis advantages,promote interactions between communities,governments,and professional education organizations,and improve the digital and intelligent learning environment. | WU Zunmin JIANG Guiyou | 2022 | Frontiers of Education in China2022，17，4： | 0 |
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