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| 1 | 初级保健中原发性醛固酮增多症的患病率和临床表现显示文摘原发性醛固酮增多症(primaryaldosteronism,PA)是一种异质性疾病,以高血压和相对自主于肾素血管紧张素系统产生过量醛固酮为特征。与心血管病风险相似的原发性高血压患者相比,PA患者发生心脑血管并发症的风险以及代谢综合征患病率增加,提示正确诊断PA的重要性。 | Monticone S Burrello J Tizzani D Bertello C Viola A Buffolo F Gabetti L Mengozzi G Williams TA Rabbia F Veglio F Mulatero P 练桂丽 叶鹏 | 2017 | 中华高血压杂志2017，25，5： | 58 |
| 2 | More anxious than depressed:prevalence and correlates in a 15-nation study of anxiety disorders in people with type 2 diabetes mellitus显示文摘Background Anxiety disorder, one of the highly disabling, prevalent and common mental disorders, is known to be more prevalent in persons with type 2 diabetes mellitus (T2DM) than the general population, and the comorbid presence of anxiety disorders is known to have an impact on the diabetes outcome and the quality of life. However, the information on the type of anxiety disorder and its prevalence in persons with T2DM is limited. Aims To assess the prevalence and correlates of anxiety disorder in people with type 2 diabetes in different countries. Methods People aged 18-65 years with diabetes and treated in outpatient settings were recruited in 15 countries and underwent a psychiatric interview with the Mini-International Neuropsychiatric Interview. Demographic and medical record data were collected. Results A total of 3170 people with type 2 diabetes (56.2% women;with mean (SD) duration of diabetes 10.01 (7.0) years) participated. The overall prevalence of anxiety disorders in type 2 diabetic persons was 18%;however, 2.8% of the study population had more than one type of anxiety disorder. The most prevalent anxiety disorders were generalised anxiety disorder (8.1%) and panic disorder (5.1%). Female gender, presence of diabetic complications, longer duration of diabetes and poorer glycaemic control (HbA1c levels) were significantly associated with comorbid anxiety disorder. A higher prevalence of anxiety disorders was observed in Ukraine, Saudi Arabia and Argentina with a lower prevalence in Bangladesh and India. Conclusions Our international study shows that people with type 2 diabetes have a high prevalence of anxiety disorders, especially women, those with diabetic complications, those with a longer duration of diabetes and poorer glycaemic control. Early identification and appropriate timely care of psychiatric problems of people with type 2 diabetes is warranted. | Santosh K Chaturvedi Shayanth Manche Gowda Helal Uddin Ahmed Fahad D Alosaimi Nicola Andreone Alexey Bobrov Viola Bulgari Giuseppe Carra Gianluca Castelnuovo Giovanni de Girolamo Tomasz Gondek Nikola Jovanovic Thummala Kamala Andrzej Ki Nebojsa Lalic Dusica Lecic-Tosevski Fareed Minhas Victoria Mutiso David Ndetei Golam Rabbani Suntibenchakul Somruk Sathyanarayana Srikanta Rizwan Taj Umberto Valentini Olivera Vukovic Wolfgang Wolwer Larry Cimino Arie Nouwen Cathy Lloyd Norman Sartorius | 2019 | General Psychiatry2019，32，4： | 11 |
| 3 | Sofosbuvir plus daclatasvir for post-transplant recurrent hepatitis C: potent antiviral activity but no clinical benefit if treatment is given late显示文摘 | Adriano M. Pellicelli Marzia Montalbano Raffaella Lionetti Christine Durand Peter Ferenci Gianpiero D’Offizi Viola Knop Andrea Telese Ilaria Lenci Arnaldo Andreoli Stefan Zeuzem Mario Angelico | 2014 | Digestive and Liver Disease2014，，： | 2 |
| 4 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 5 | Cystic neoplasm mistaken for pan creatic Pseudocyst显示文摘 | Civewo IM Frontera D Viola B | 1996 | Hepatogastroenterology1996，43，： | 1 |
| 6 | Drug targets in immunity and inflammation显示文摘 | Viola A Luster A D | 2008 | Annu Rev Pharmacol Toxicol2008，48，： | 1 |
| 7 | BRAF(V600E) mutation and outcome of patients with papillary thyroid carcinoma: a 15-year median follow-up study显示文摘 | Elisei R Ugolini C Viola D | 2008 | J Clin Endocrinol Metab2008，93，10： | 1 |
| 8 | Identification and Comparison of Phenolic Compounds in the Prepara tion of Oolong Tea Manufactured by Semifermentation and Drying Processes 显示文摘 | JIANPENG D VIOLA S L JASON T T | 2007 | J Agric Food Chem2007，，55： | 1 |
| 9 | Magnetic behavior of Ca2NiWO6 double perovskite显示文摘 | Lopez C A Curiale J Viola M D C | 2007 | Physica B: Condensed Matter2007，398，2： | 1 |
| 10 | Nceadjuvant endocrine therapy for locally advanced breast cancer显示文摘 | Viola G Sergi D Conti F | 2007 | Clin Ter2007，158，5： | 1 |
| 11 | An idic (15) associated with POF (premature ovarian failure): Molecular cytogenetic definition of a case and review of the literature显示文摘 | Bertini V Viola D Vitti P | 2012 | Gene2012，503，1： | 1 |
| 12 | Biosynthesis and Catabolism of L-Asoorbic Acid in Plants显示文摘 | HANCOCK R D VIOLA R | 2005 | Plant Sciences2005，24，3： | 1 |
| 13 | Detecting pedestrians using pat- terns of motion and appearance 显示文摘 | VIOLA P JONES M J SNOW D | 2005 | International Journal of Com- puter Vision2005，63，2： | 1 |
| 14 | The cornea in Sj(o)gren's syndrome:an in vivo confocal study显示文摘 | Villani E Galimberti D Viola F | 2007 | Invest Ophthalmol Vis Sci2007，48，： | 1 |
| 15 | Biotechnological approaches for L - ascorbic acid production 显示文摘 | Hancock R D R Viola | 2002 | Trends Biotechnol2002，，20： | 1 |
| 16 | Detecting pedestrians usingpatterns of motion and appearance显示文摘 | Viola P Jones M J Snow D | 2005 | International Journalof Computer Vision2005，63，2： | 1 |
| 17 | Development of a dense SNP-based linkage map of an apple rootstock progeny using the Malus infinium whole genome genotyping array显示文摘 | Antanaviciute L Fernandez-Fernandez F Jansen J Banchi E Evans K M Viola R Velasco R Dunwell J M Troggio M Sargent D J | | 0，，： | 1 |
| 18 | Managing skeletal re lated events resulting from bone metastases显示文摘 | Wilkinson A N Viola R Brundage M D | 2008 | BMJ2008，337，： | 1 |
| 19 | Hyaluro- nan: biosynthesis and signaling显示文摘 | VIGETTI D KAROUSOU E VIOLA M | 2014 | Biochimica et Bio- physica Acta2014，1840，8： | 1 |
| 20 | A digital chip timing recovery loop for band-limited direct-sequence spread-spectrum signals显示文摘 | Gaudenzi R D Luise M Viola R | 1993 | IEEE Trans on Communications1993，41，： | 1 |
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