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| 1 | Hepatitis B vaccine by intradermal route in non responder patients:An update显示文摘Vaccination is the main prophylactic measure to reduce the mortality caused by hepatitis B virus(HBV)infection in healthy subjects since the immune response to hepatitis B recombinant vaccination occurs in over 90%of general population.Individuals who develop an antiHBs titer less than 10 mIU/mL after primary vaccination cycle are defined'no responders'.Many factors could cause a non response to the HBV vaccination,such as administration of the vaccine in buttocks,impaired vaccine storage conditions,drug abuse,smoking,infections and obesity.Moreover there are some diseases,like chronic kidney disease,human immunodeficiency virus infection,chronic liver disease,celiac disease,thalassaemia,typeⅠdiabetes mellitus,down’s syndrome and other forms of mental retardation that are characterized by a poorer response to HBV vaccination than healthy subjects.To date it is still unclear how to treat this group of patients at high risk of hepatitis B infection.Recent studies seem to indicate that the administration of HBV recombinant vaccine by the intradermal route is very effective and could represent a more useful strategy than intramuscular route.This review focuses on the use of anti hepatitis B vaccine by intradermal route as alternative to conventional intramuscular vaccine in all non responder patients.A comprehensive review of the literature using PubMed database,with appropriate terms,was undertaken for articles in English published since 1983.The literature search was undertaken in September 2013. | Martina Filippelli Elena Lionetti Alessia Gennaro Angela Lanzafame Teresa Arrigo Carmelo Salpietro Mario La Rosa Salvatore Leonardi | 2014 | World Journal of Gastroenterology2014，20，30： | 12 |
| 2 | Thiopurine metabolites variations during co-treatment with aminosalicylates for inflammatory bowel disease:Effect of N-acetyl transferase polymorphisms显示文摘AIM: To evaluate variation of the concentration of thiopurine metabolites after 5-aminosalicylate(5-ASA) interruption and the role of genetic polymorphisms of N-acetyl transferase(NAT) 1 and 2. METHODS: Concentrations of thioguanine nucleotides(TGN) and methymercaptopurine nucleotides(MMPN), metabolites of thiopurines, were measured by high performance liquid chromatography in 12 young patients(3 females and 9 males, median age 16 years) with inflammatory bowel disease(6 Crohn's disease and 6 ulcerative colitis) treated with thiopurines(7 mercaptopurine and 5 azathioprine) and 5-ASA. Blood samples were collected one month before and one month after the interruption of 5-ASA. DNA was extracted and genotyping of NAT1, NAT2, inosine triphosphate pyrophosphatase(ITPA) and thiopurine methyl transferase(TPMT) genes was performed using PCR assays. RESULTS: Median TGN concentration before 5-ASA interruption was 270 pmol/8 x 108 erythrocytes(range: 145-750); after the interruption of the aminosalicylate, a 35% reduction in TGN mean concentrations(absolutemean reduction 109 pmol/8 × 108 erythrocytes) was observed(median 221 pmol/8 × 108 erythrocytes, range: 96-427, P value linear mixed effects model 0.0011). Demographic and clinical covariates were not related to thiopurine metabolites concentrations. All patients were wild-type for the most relevant ITPA and TPMT variants. For NAT1 genotyping, 7 subjects presented an allele combination corresponding to fast enzymatic activity and 5 to slow activity. NAT1 genotypes corresponding to fast enzymatic activity were associated with reduced TGN concentration(P value linear mixed effects model 0.033), putatively because of increased 5-ASA inactivation and consequent reduced inhibition of thiopurine metabolism. The effect of NAT1 status on TGN seems to be persistent even after one month since the interruption of the aminosalicylate. No effect of NAT1 genotypes was shown on MMPN concentrations. NAT2 genotyping revealed that 6 patients presented a genotype corresponding to fast enzymatic activity and 6 to slow activity; NAT2 genotypes were not related to thiopurine metabolites concentration in this study. CONCLUSION: NAT1 genotype affects TGN levels in patients treated with thiopurines and aminosalicylates and could therefore influence the toxicity and efficacy of these drugs; however the number of patients evaluated is limited and this has to be considered a pilot study. | Gabriele Stocco Eva Cuzzoni Sara De Iudicibus Diego Favretto Noelia Malusà Stefano Martelossi Elena Pozzi Paolo Lionetti Alessandro Ventura Giuliana Decorti | 2015 | World Journal of Gastroenterology2015，21，12： | 5 |
| 3 | Helicobacter pylori infection and atopic diseases:Is there a relationship? A systematic review and meta-analysis显示文摘AIM:To review and conduct a meta-analysis of the existing literature on the relationship between Helicobacter pylori(H.pylori),atopy and allergic diseases.METHODS:Studies published in English assessing the prevalence of atopy and/or allergic diseases in patients with H.pylori infection and the prevalence of H.pylori infection in patients with atopy and/or allergic diseases were identified through a MEDLINE search(1950-2014).Random-effect model was used for the meta-analysis.RESULTS:Pooled results of case-control studies showed a significant inverse association of H.pylori infection with atopy/allergic disease or with exclusively atopy,but not with allergic disease,whereas pooled results of cross-sectional studies showed only a significant association between allergic disease and H.pylori infection.CONCLUSION:There is some evidence of an inverse association between atopy/allergic diseases and H.pylori infection,although further studied are needed. | Elena Lionetti Salvatore Leonardi Angela Lanzafame Maria Teresa Garozzo Martina Filippelli Stefania Tomarchio Viviana Ferrara Carmelo Salpietro Alfredo Pulvirenti Ruggiero Francavilla Carlo Catassi | 2014 | World Journal of Gastroenterology2014，20，46： | 3 |
| 4 | Hepatitis B vaccine in celiac disease:Yesterday,today and tomorrow显示文摘Some studies showed that in celiac patients the immunological response to vaccination is similar to that one found in general population except for vaccine against hepatitis B virus (HBV).The non-responsiveness to HBV vaccine has also been described in healthy people,nevertheless the number of non-responders has been demonstrated to be higher in celiac disease (CD) patients than in healthy controls.Several hypothesis explaining this higher rate of unresponsiveness to HBV vaccine in CD patients have been described,such as the genetic hypothesis,according with CD patients carrying the disease-specific haplotype HLA-B8,DR3,and DQ2,show a lower response to HBV vaccine both in clinical expressed CD patients and in healthy people carrying the same haplotype.On the other hand,it has been demonstrated that the gluten intake during the vaccination seems to influence the response to the same vaccine.Moreover,it has been demonstrated a possible genetic predisposition to hepatitis B vaccine nonresponsiveness likely due to the presence of specific human leukocyte antigen haplotypes and specific single nucleotide polymorphism in genes of cytokine/cytokinereceptors and toll like receptors,but the pathogenic mechanism responsible for this low responsiveness still remains unclear.The aim of this review is to focus on the possible pathogenic causes of unresponsiveness to HBV vaccine in CD patients and to propose an alternative vaccination schedule in order to improve the responsiveness to HBV vaccine in this at-risk patients. | Giovanna Vitaliti Andrea Domenico Praticò Carla Cimino Giovanna Di Dio Elena Lionetti Mario La Rosa Salvatore Leonardi | 2013 | World Journal of Gastroenterology2013，19，6： | 3 |
| 5 | Intraoperative use of indocyanine green fluorescence imaging in rectal cancer surgery: The state of the art显示文摘Indocyanine green(ICG)fluorescence imaging is widely used in abdominal surgery.The implementation of minimally invasive rectal surgery using new methods like robotics or a transanal approach required improvement of optical systems.In that setting,ICG fluorescence optimizes intraoperative vision of anatomical structures by improving blood and lymphatic flow.The purpose of this review was to summarize all potential applications of this upcoming technology in rectal cancer surgery.Each type of use has been separately addressed and the evidence was investigated.During rectal resection,ICG fluorescence angiography is mainly used to evaluate the perfusion of the colonic stump in order to reduce the risk of anastomotic leaks.In addition,ICG fluorescence imaging allows easy visualization of organs such as the ureter or urethra to protect them from injury.This intraoperative technology is a valuable tool for conducting lymph node dissection along the iliac lymphatic chain or to better identifying the rectal dissection planes when a transanal approach is performed.This is an overview of the applications of ICG fluorescence imaging in current surgical practice and a synthesis of the results obtained from the literature.Although further studies are need to investigate the real clinical benefits,these findings may enhance use of ICG fluorescence in current clinical practice and stimulate future research on new applications. | Roberto Peltrini Mauro Podda Simone Castiglioni Maria Michela Di Nuzzo Michele D'Ambra Ruggero Lionetti Maurizio Sodo Gaetano Luglio Felice Mucilli Salomone Di Saverio Umberto Bracale Francesco Corcione | 2021 | World Journal of Gastroenterology2021，27，38： | 3 |
| 6 | Sofosbuvir plus daclatasvir for post-transplant recurrent hepatitis C: potent antiviral activity but no clinical benefit if treatment is given late显示文摘 | Adriano M. Pellicelli Marzia Montalbano Raffaella Lionetti Christine Durand Peter Ferenci Gianpiero D’Offizi Viola Knop Andrea Telese Ilaria Lenci Arnaldo Andreoli Stefan Zeuzem Mario Angelico | 2014 | Digestive and Liver Disease2014，，： | 2 |
| 7 | 3,5-diiodo- l -thyronine, by modulating mitochondrial functions, reverses hepatic fat accumulation in rats fed a high-fat diet显示文摘 | Maria Pina Mollica Lillà Lionetti Maria Moreno Assunta Lombardi Pieter De Lange Alessandro Antonelli Antonia Lanni Gina Cavaliere Antonio Barletta Fernando Goglia | 2009 | Journal of Hepatology2009，，2： | 2 |
| 8 | Intramuscular vs intradermal route for hepatitis B booster vaccine in celiac children显示文摘AIM:To compare intradermal(ID) and intramuscular(IM) booster doses,which have been used in healthy and high risk subjects,such as healthcare workers,haemodialysis patients,human immunodeficiency virus patients,and renal transplant recipients unresponsive to initial hepatitis B vaccination,in celiac individuals.METHODS:We conducted our study on 58 celiac patients,vaccinated in the first year of life,whose blood analysis had showed the absence of protective hepatitis B virus(HBV) antibodies.All patients had received the last vaccine injection at least one year before study enrolment and they had been on a gluten free diet for at least 1 year.In all patients we randomly performed an HBV vaccine booster dose by ID or IM route.Thirty celiac patients were revaccinated with recombinant hepatitis B vaccine(Engerix B) 2 g by the ID route,while 28 celiac patients were revaccinated with Engerix B 10 g by the IM route.Four weeks after every booster dose,the anti-hepatitis B surface(HBs) antibody titer was measured by an enzyme-linked immuneadsorbent assay.We performed a maximum of three booster doses in patients with no anti-HBs antibodies after the first or the second vaccine dose.The cut off value for a negative anti-HBs antibody titer was 10 IU/L.Patients with values between 10 and 100 IU/L were considered 'low responders' while patients with an antibody titer higher than 1000 IU/L were considered 'high responders'.RESULTS:No significant difference in age,gender,duration of illness,and years of gluten intake was found between the two groups.We found a high percentage of 'responders' after the first booster dose(ID = 76.7%,IM = 78.6%) and a greater increase after the third dose(ID = 90%,IM = 96.4%) of vaccine in both groups.Moreover we found a significantly higher number of high responders(with an anti-HBs antibody titer > 1000 IU/L) in the ID(40%) than in the IM(7.1%) group,and this difference was evident after the first booster dose of vaccination(P < 0.01).No side effects were recorded in performing delivery of the vaccine by either the ID or IM route.CONCLUSION:Our study suggests that both ID and IM routes are effective and safe options to administer a booster dose of HBV vaccine in celiac patients.However the ID route seems to achieve a greater number of high responders and to have a better cost/benefit ratio. | Salvatore Leonardi Andrea Domenico Praticò Elena Lionetti Massimo Spina Giovanna Vitaliti Mario La Rosa | 2012 | World Journal of Gastroenterology2012，18，40： | 2 |
| 9 | Improved efficacy of 10-day sequential treatment for helicobacter pylorieradication in children:a randomized trial显示文摘 | Francavilla R Lionetti E Castellaneta SP et Al | 2005 | Gastroenterology2005，129，5： | 1 |
| 10 | Improved efficacy of 10-Day sequential treatmentfor helicobacter pylori eradication in children:arandomized trial显示文摘 | Francavilla R Lionetti E Castellaneta SP | 2005 | Gastroenterology2005，129，5： | 1 |
| 11 | An integrative ge- nomic approach reveals coordinated expression of intronic miR-335,miR-342,and miR-561 with deregulated host genes in multiple myeloma显示文摘 | Ronehetti D Lionetti M Mosca L | 2008 | BMC Med Genomics2008，1，： | 1 |
| 12 | Lack of phosphoinositide 3-kinase- attenuates ventilator-induced lung injury显示文摘 | Lionetti V Lisi A Patrucco E | 2006 | Crit Care Med2006，34，1： | 1 |
| 13 | Extracellular vesicles fromhuman cardiac progenitor cells inhibit cardiomyocyte apoptosisand improve cardiac function after myocardial infarction显示文摘 | Barile L Lionetti V Cervio E | 2014 | Car- diovas Res2014，103，4： | 1 |
| 14 | Improved efficacy of 102 day sequential treatment for Helieobacter pylori eradication in children:a randomized trial显示文摘 | Francavilla R Lionetti E Castellaneta SP | 2005 | Gastroenterology2005，129，5： | 1 |
| 15 | Altered cardiac metabolic phenotype after prolonged inhibition of NO synthesis in chronically instrumented dogs显示文摘 | d'Agostino C Labinskyy V Lionetti V | | 0，，04： | 1 |
| 16 | Anti-TNF agents as therapeutic choice in immune-mediated inflammatory diseases: focus on adalimumab 显示文摘 | Armuzzi A Lionetti P Blandizzi C | 2014 | Int J Immunopathol Pharmacol2014，27，1： | 1 |
| 17 | The effect of orientation difference on grain boundary energies显示文摘 | DUNN C G LIONETTI F | 1949 | Trans AIME1949，185，： | 1 |
| 18 | Anti-TNF agents as therapeutic choice in immune-mediated inflammatory diseases: focus on adalimumab 显示文摘 | Armuzzi A Lionetti P Blandizzi C | 2014 | J Immunopathol Pharmacol2014，27，1： | 1 |
| 19 | Early detection of acute lung injury uncoupled to hypoxemia in pigs using ultrasound lung comets 显示文摘 | Gargani L Lionetti V Di CC | 2007 | Crit Care Med2007，35，12： | 1 |
| 20 | Headache in Pediatric Patients With Celiac Disease and Its Prevalence as a Diagnostic Clue显示文摘 | Elena Lionetti Ruggiero Francavilla Luigi Maiuri Martino Ruggieri Massimo Spina Piero Pavone Teresa Francavilla Anna Maria Magistà Lorenzo Pavone | 2009 | Journal of Pediatric Gastroenterology and Nutrition2009，，2： | 1 |
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