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| 1 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 2 | 急性缺血性卒中的机械取栓治疗:ESO、ESMINT、ESNR和EAN共同支持的2014/2015 ESO-卡罗林斯卡卒中更新会议共识声明显示文摘这份卒中后机械取栓治疗共识声明的原始版本于2014年11月16—18日在斯德哥尔摩召开的欧洲卒中组织(European Stroke Organisation, ESO)-卡罗林斯卡卒中更新会议期间得到批准。根据会议安排,在2015年利用新的临床试验数据对该声明进行了更新。2015年2月,在瑞士伯尔尼召开的ESO冬季培训会期间组织了面对面会议对共识声明进行修订,然后通过电子邮件交换意见,最终版本得到各学会的认可。推荐意见与原始版本一致,证据等级更新到2015年2月20日为止,在2015年5月15日获得确认。ESO-卡罗林斯卡卒中更新会议的目的在于总结卒中治疗研究的最新进展并探讨如何将这些最新研究结果应用于临床实践。共识会议选择了一些议题进行讨论,与会者草拟一份共识声明并进行讨论。该声明接受了ESO指南委员会的指导。这份共识声明包括对急性卒中后机械取栓治疗的推荐意见,得到欧洲卒中组织ESO、欧洲神经微创治疗学会(European Society of Minimally Invasive Neurological Therapy, ESMINT)、欧洲神经放射学学会(European Society of Neuroradiology, ESNR)和欧洲神经病学学会(European Academy of Neurology, EAN)的支持。 | Nils Wahlgren Tiago Moreira Patrik Michel Thorsten Steiner Olav Jansen Christophe Cognard Heinrich P Mattle Wim van Zwam Staffan Holmin Turgut Tatlisumak Jesper Petersson Valeria Caso Werner Hacke Mikael Mazighi Marcel Arnold Urs Fischer Istvan Szikora Laurent Pierot Jens Fiehler Jan Gralla Franz Fazekas Kennedy R Lees 高洁 徐格林 | 2016 | 国际脑血管病杂志2016，24，1： | 5 |
| 3 | Two-dimensionalHyCoSy with contrast tuned imaging technology and asecond-generation contrast media for the assessment of tubalpatency in an infertility program显示文摘 | Chiara L Valeria S Francesco P | 2009 | Fertil Steril2009，92，3： | 1 |
| 4 | Potentiometric,spectroscopic and antioxidant activity studies of SOD mimics containing carnosine显示文摘 | RAFFAELE P B VALERIA B ENRICO C | 2003 | J Chem Soc Dalton Trans2003，19，23： | 1 |
| 5 | Influence of castration- induced testosterone and estradiol deficiency on obesity and glucose metabolism in male Gtittingen minipigs 显示文摘 | BER1T O C LAUST P G VALERIA G | 2010 | Steroids2010，75，10： | 1 |
| 6 | Multi-residue Method for the Determination of Organochlorine Pesticides in Fish Feed Based on a Cleanup Approach Followed by Gas Chromatography-Triple Quadrupole Tandem Mass Spectrometry显示文摘 | VALERIA N DANIELA D CARMEN P | 2010 | Journal of Chromatography A2010，1217，30： | 1 |
| 7 | Leukemic IDH1 and IDH2 Mutations Result in a Hypermethylation Phenotype, Disrupt TET2 Function, and Impair Hematopoietic Differentiation显示文摘 | Maria E. Figueroa Omar Abdel-Wahab Chao Lu Patrick S. Ward Jay Patel Alan Shih Yushan Li Neha Bhagwat Aparna Vasanthakumar Hugo F. Fernandez Martin S. Tallman Zhuoxin Sun Kristy Wolniak Justine K. Peeters Wei Liu Sung E. Choe Valeria R. Fantin Elisabeth P | 2010 | Cancer Cell2010，，6： | 1 |
| 8 | Effect of chitosan coating combined with postharvest calcium treatment on strawberry,(Fragaria ananassa) quality during refrigerated storage显示文摘 | Hernández-Mu (n)oz P Almenar E Valeria D V | | 0，，10： | 1 |
| 9 | Effects of novel hybrids of caffeic acid phenethyl ester and NSAIDs on experimental ocular in- flammation显示文摘 | Valeria P | 2015 | European Journal of Pharmacology2015，，752： | 1 |
| 10 | Two opposite effects of cofilin on the thermal unfolding of F- actin : a differential scanning calorimetric study 显示文摘 | Irina V Dedova Olga P Nikolaeva Valeria V Mikhailova | 2004 | Biophysical Chemistry2004，110，： | 1 |
| 11 | Multi-residue method for the determination of organochlorine pesticides in fish feed based on a cleanup approach followed by gas chromatography-triple quadrupole tandem mass spectrometry 显示文摘 | VALERIA N DANIELA D CARMEN P | 2010 | J ChromatogrA2010，1217，30： | 1 |
| 12 | Eosinophil eaqciency compromises parasite survival in chronic nematode infection显示文摘 | Valeria F Daniel P B Susan K B | 2009 | J Inmmnol2009，182，： | 1 |
| 13 | EBV Chronic Infections显示文摘 | Eligio P Delia R Valeria G | 2010 | Medi terr J Hematol Infect Dis2010，2，20： | 1 |
| 14 | Cytochrome b Gene Structure and Consequences for Resistance to Qo Inhibitor Fungicides in Plant Pathogens显示文摘 | VALERIA G SIMONA P HELGE S | 2006 | Pest Manag Sci2006，62，： | 1 |
| 15 | Species-dependent chromium accumulation,lipid peroxidation,and glutathione lev-els in germinating kiwifruit pollen under Cr(III)and Cr(VI)stress显示文摘 | Valeria S Marta L Maria F P | 2008 | Chemosphere2008，73，7： | 1 |
| 16 | Argon plasma coagulation for prevention of recurrent bleeding from GI angiadysplasias显示文摘 | JORGE AO MARIANO M VALERIA P | 2004 | Gastrointestinal Endoscopy2004，60，6： | 1 |
| 17 | Truncated binary multipliers with variable correction and minimum mean square error 显示文摘 | NICOLA P DAVIDE D C VALERIA G | 2010 | IEEE Transactions on Circuits and Systems: I Regular Papers2010，57，6： | 1 |
| 18 | Lactoferrin inhibits early steps of human BK polyomavirus infection显示文摘 | Giovanna L Valeria P Monica M | 2006 | Antiviral Res2006，72，： | 1 |
| 19 | Voltammetric Determination of the Neonicotinoid Insecticide Thiamethoxam Using a Tricresyl Phosphate-based Carbon Paste Electrode显示文摘 | ZSIGMOND J P VALERIA J G SZYMON K | 2010 | Journal of the Serbian Chemical Society2010，75，5： | 1 |
| 20 | Modification of epoxy resin:a comparison of different types of elastomer 显示文摘 | Ramos Valeria D Helson M Da Costa Soares Vera L P | 2005 | Polymer Testing2005，24，3： | 1 |
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