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| 1 | Intravenous immune globulin suppresses angiogenesis in mice and humans显示文摘Human intravenous immune globulin(IVIg),a purified IgG fraction composed of~60%IgG1 and obtained from the pooled plasma of thousands of donors,is clinically used for a wide range of diseases.The biological actions of IVIg are incompletely understood and have been attributed both to the polyclonal antibodies therein and also to their IgG(IgG)Fc regions.Recently,we demonstrated that multiple therapeutic human IgG1 antibodies suppress angiogenesis in a target-independent manner via FcγRI,a high-affinity receptor for IgG1.Here we show that IVIg possesses similar anti-angiogenic activity and inhibited blood vessel growth in five different mouse models of prevalent human diseases,namely,neovascular age-related macular degeneration,corneal neovascularization,colorectal cancer,fibrosarcoma and peripheral arterial ischemic disease.Angioinhibition was mediated by the Fc region of IVIg,required FcγRI and had similar potency in transgenic mice expressing human FcγRs.Finally,IVIg therapy administered to humans for the treatment of inflammatory or autoimmune diseases reduced kidney and muscle blood vessel densities.These data place IVIg,an agent approved by the US Food and Drug Administration,as a novel angioinhibitory drug in doses that are currently administered in the clinical setting.In addition,they raise the possibility of an unintended effect of IVIg on blood vessels. | Reo Yasuma Valeria Cicatiello Takeshi Mizutani Laura Tudisco Younghee Kim Valeria Tarallo Sasha Bogdanovich Yoshio Hirano Nagaraj Kerur Shengjian Li Tetsuhiro Yasuma Benjamin J Fowler Charles B Wright Ivana Apicella Adelaide Greco Arturo Brunetti Balamurali K Ambati Sevim Barbasso Helmers Ingrid E Lundberg Ondrej Viklicky Jeanette HW Leusen J Sjef Verbeek Bradley D Gelfand Ana Bastos-Carvalho Sandro De Falco Jayakrishna Ambati | 2016 | Signal Transduction and Targeted Therapy2016，1，1： | 3 |
| 2 | Holliday junction processing activity of the BLM-Topo Ⅲα-BLAF75 complex显示文摘 | WENDY B STEVEN R VALERIA B | 2007 | J Bioll Chem2007，282，31： | 1 |
| 3 | Potentiometric,spectroscopic and antioxidant activity studies of SOD mimics containing carnosine显示文摘 | RAFFAELE P B VALERIA B ENRICO C | 2003 | J Chem Soc Dalton Trans2003，19，23： | 1 |
| 4 | Wear behaviour of thermally sprayed ceramic oxide coatings 显示文摘 | GIOVANNI B VALERIA C LUCA L | 2006 | Wear2006，261，1112： | 1 |
| 5 | Using large eddy simulation for understanding vented gas explosions in the presence of obstacles显示文摘 | Valeria D S Almerinda D B Gennaro R | | 0，，1： | 1 |
| 6 | Historical analysis of landscape change in the eastern boreal mixedwood:a case study in the context of cohort-based management 显示文摘 | Latremouille C Valeria O Harvey B D | 2013 | The Forestry Chronicle2013，89，3： | 1 |
| 7 | Vascular endothelial growth factor increase the migration and proliferation of smooth muscle cells through the mediation of growth factors released by endothelial cells显示文摘 | Alessandra C Valeria B Bruto R | 2003 | J Surg Res2003，109，： | 1 |
| 8 | Eosinophil eaqciency compromises parasite survival in chronic nematode infection显示文摘 | Valeria F Daniel P B Susan K B | 2009 | J Inmmnol2009，182，： | 1 |
| 9 | Nutrient-based dietarypatterns and the risk of oral and pharyngeal cancer 显示文摘 | Valeria E Francesca B Carlo LV? | 2010 | Oral On-col2010，5，46： | 1 |
| 10 | Tourist types and happiness a comparative study in Maremma, Italy显示文摘 | Salvatore B Valeria F | 2012 | Annals of Tourism Research2012，39，4： | 1 |
| 11 | Diffusion tensor imaging and tractography of the kidneys: assessment of chronic parenchymal diseases 显示文摘 | Caterina G Valeria C Fiorenza B | 2013 | Eur Radiol2013，9，1： | 1 |
| 12 | Identification of MEKK2/3 serine phosphorylation site targeted by the Toll like receptor and stress pathways显示文摘 | Zhang D Valeria Fac Su B | 2005 | EMBO2005，25，1： | 1 |
| 13 | Modularity and spatial reorientation in a simple mind:encoding of geometric and nongeometric properties of a spatial environment by fish显示文摘 | Valeria AS Angelo B Giorgio V | 2002 | Cognition2002，85，2： | 1 |
| 14 | Synthesis and thermal behaviour of potassium sialate geopolymers显示文摘 | KENNETH J D M | 2003 | Materials Letters2003，57，： | 1 |
| 15 | Synthesis and characterization of materials based on inorganic polymers of alumina and silica:sodium polysialate polymers显示文摘 | KENNETH J D M CLELIO THAUMATURGO | 2000 | International Journal of Inorganic Materials2000，2，： | 1 |
| 16 | p27 expression is associated with clineical outcome in advanced epithelial ovarian cancer:multivariare analysis显示文摘 | Valeria M Ferrandina G Pucci B | 2000 | Clin Cancer res2000，6，1： | 1 |
| 17 | Serotonin and epilepsy显示文摘 | Gyorgy B Valeria K Pai R | 2007 | J Neurochem2007，100，4： | 1 |
| 18 | Comparison of body composition methods in o- verweight and obese Brazilian women 显示文摘 | Valeria B B | 2010 | Arq Bras Endo- crinol Metab2010，，54： | 1 |
| 19 | Potentialfield inversion:choosing the appropriate technique to slove a geologic problem显示文摘 | Joao B C S Walter E M Valeria C F B | 2001 | Geophysics2001，66，2： | 1 |
| 20 | Optimizing therapy in the diabetic patient with renal disease:antihypertensive treatment显示文摘 | Giacomo D Maura R Valeria B | | 0，，10： | 1 |
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