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| 1 | Neo-adjuvant chemo(radio)therapy in gastric cancer: Current status and future perspectives显示文摘In the last 20 years, several clinical trials on neoadjuvant chemotherapy and chemo-radiotherapy as a therapeutic approach for locally advanced gastric cancer have been performed. Even if more data are necessary to define the roles of these approaches, the results of preoperative treatments in the combined treatment of gastric adenocarcinoma are encouraging because this approach has led to a higher rate of curative surgical resection. Owing to the results of most recent randomized phase III studies, neoadjuvant chemotherapy for locally advanced resectable gastric cancer has satisfied the determination of level I evidence. Remaining concerns pertain to the choice of the optimal therapy regimen, strict patient selection by accurate pre-operative staging, standardization of surgical procedures, and valid criteria for response evaluation. New well-designed trials will be necessary to find the best therapeutic approach in pre-operative settings and the best way to combine old-generation chemotherapeutic drugs with new-generation molecules. | Alberto Biondi Maria C Lirosi Domenico D'Ugo Valeria Fico Riccardo Ricci Francesco Santullo Antonia Rizzuto Ferdinando CM Cananzi Roberto Persiani | 2015 | World Journal of Gastrointestinal Oncology2015，7，12： | 13 |
| 2 | Role of magnetic resonance imaging in the detection and characterization of solid pancreatic nodules: An update显示文摘Pancreatic ductal adenocarcinoma is the most common malignant tumor of the pancreas. The remaining pancreatic tumors are a diverse group of pancreatic neoplasms that comprises cystic pancreatic neoplasms, endocrine tumors and other uncommon pancreatic tumors. Due to the excellent soft tissue contrast resolution, magnetic resonance imaging(MRI) is frequently able to readily separate cystic from noncystic tumors. Cystic tumors are often easy to diagnose with MRI; however, noncystic non-adenocarcinoma tumors may show a wide spectrum of imaging features, which can potentially mimic ductal adenocarcinoma. MRI is a reliable technique for the characterization of pancreatic lesions. The implementation of novel motionresistant pulse sequences and respiratory gating techniques, as well as the recognized benefits of MR cholangiopancreatography, make MRI a very accurate examination for the evaluation of pancreatic masses. MRI has the distinctive ability of non-invasive assessment of the pancreatic ducts, pancreatic parenchyma, neighbouring soft tissues, and vascular network in one examination. MRI can identify different characteristics of various solid pancreatic lesions, potentially allowing the differentiation of adenocarcinoma from other benign and malignant entities. In this review we describe the MRI protocols and MRI characteristics of various solid pancreatic lesions. Recognition of these characteristics may establish the right diagnosis or at least narrow the differential diagnosis, thus avoiding unnecessary tests or procedures and permitting better management. | Najwa Al Ansari Miguel Ramalho Richard C Semelka Valeria Buonocore Silvia Gigli Francesca Maccioni | 2015 | World Journal of Radiology2015，7，11： | 9 |
| 3 | It is safe to use transdermal glyceryl trinitrate to lower blood pressure in patients with acute ischaemic stroke with carotid stenosis显示文摘Background There is concern that blood pressure(BP)lowering in acute stroke may compromise cerebral perfusion and worsen outcome in the presence of carotid stenosis.We assessed the effect of glyceryl trinitrate(GTN)in patients with carotid stenosis using data from the Efficacy of Nitric Oxide in Stroke(ENOS)Trial.Methods ENOS randomised 4011 patients with acute stroke and raised systolic BP(140-220 mm Hg)to transdermal GTN or no GTN within 48 hours of onset.Those on prestroke antihypertensives were also randomised to stop or continue their medication for 7 days.The primary outcome was the modified Rankin Scale(mRS)at day 90.Ipsilateral carotid stenosis was split:<30%;30-<50%;50-<70%;≥70%.Data are ORs with 95%CIs adjusted for baseline prognostic factors.results 2023(60.5%)ischaemic stroke participants had carotid imaging.As compared with<30%,≥70%ipsilateral stenosis was associated with an unfavourable shift in mRS(worse outcome)at 90 days(OR 1.88,95%CI 1.44 to 2.44,p<0.001).Those with≥70%stenosis who received GTN versus no GTN had a favourable shift in mRS(OR 0.56,95%CI 0.34 to 0.93,p=0.024).In those with 50-<70%stenosis,continuing versus stopping prestroke antihypertensives was associated with worse disability,mood,quality of life and cognition at 90 days.Clinical outcomes did not differ across bilateral stenosis groups.Conclusions Following ischaemic stroke,severe ipsilateral carotid stenosis is associated with worse functional outcome at 90 days.GTN appears safe in ipsilateral or bilateral carotid stenosis,and might improve outcome in severe ipsilateral carotid stenosis. | Jason P Appleton Lisa J Woodhouse Andrew Belcher Daniel Bereczki Eivind Berge Valeria Caso Hui Meng Chang Hanne K Christensen Ronan Collins John Gommans Ann C Laska George Ntaios Serefnur Ozturk Gillian M Sare Szabolcs Szatmari Yongjun Wang Joanna M Wardlaw Nikola Sprigg Philip M Bath for the ENOS investigators | 2019 | Stroke & Vascular Neurology2019，4，1： | 6 |
| 4 | Hydrotherapy Versus Conventional Land-Based Exercise for the Management of Patients With Osteoarthritis of the Knee: A Randomized Clinical Trial显示文摘 | Silva Luciana E Valim Valeria Pessanha Ana Paula C Oliveira Leda M Myamoto Samira Jones Anamaria Natour Jamil | 2008 | Physical Therapy2008，，1： | 2 |
| 5 | 显示文摘 | Enrica Gianotti Valeria Dellarocca Erica C Oliveira | 2002 | Studies in Surface Science and Catalysis2002，142，： | 1 |
| 6 | Potentiometric,spectroscopic and antioxidant activity studies of SOD mimics containing carnosine显示文摘 | RAFFAELE P B VALERIA B ENRICO C | 2003 | J Chem Soc Dalton Trans2003，19，23： | 1 |
| 7 | Role of ammonia and nitric oxide in the decrease in plasmaprolactin levels in prehepatic portal hypertensive male rats 显示文摘 | Camila C Scorticati Juan C Perazzo Valeria Rettori | 2006 | Neuroimmunomodulation2006，13，3： | 1 |
| 8 | Influence of castration- induced testosterone and estradiol deficiency on obesity and glucose metabolism in male Gtittingen minipigs 显示文摘 | BER1T O C LAUST P G VALERIA G | 2010 | Steroids2010，75，10： | 1 |
| 9 | Wear behaviour of thermally sprayed ceramic oxide coatings 显示文摘 | GIOVANNI B VALERIA C LUCA L | 2006 | Wear2006，261，1112： | 1 |
| 10 | Synthesis and characterisation of materials based on inorganic polymers of alumina and silica: sodium polysialate polymers 显示文摘 | Barbosa J D MacKenzie K Thaumaturgo C | 2000 | International Journal of Inorganic Materials2000，，2： | 1 |
| 11 | Spatially-resolved EELS analysis of antibody distribution on biofunctionalized magnetic nanoparticles显示文摘 | Raul A Laura D M Laura C Alvaro M Marcel T Valeria G Jesus M D L F Clara M Ricardo 1 | 2013 | ACS Nano2013，7，5： | 1 |
| 12 | Historical analysis of landscape change in the eastern boreal mixedwood:a case study in the context of cohort-based management 显示文摘 | Latremouille C Valeria O Harvey B D | 2013 | The Forestry Chronicle2013，89，3： | 1 |
| 13 | A mild and easy one-pot procedure for the synthesis of 2-deoxy-sugars from glycols显示文摘 | VALERIA C CONCETTA I ERNESTO F | 2000 | Tetrahedron Letters2000，41，： | 1 |
| 14 | Chemokines in neuroectodermal mmour progression and metastasis 显示文摘 | Raffaghello L Cocco C Valeria M | | Semin Cancer Biol0，19，： | 1 |
| 15 | A Biosynthetically Significant New Bacterio-Hopanoid Present in Large Amounts in the Caribbean Sponge Plakortis Simplex显示文摘 | Valeria C Ernesto F | 2001 | Tetrahedron2001，57，10： | 1 |
| 16 | On the green and innovative side of trade competitiveness? The impact of environmental policies and innovation on EU exports显示文摘 | Valeria C Massimiliano M | 2012 | Research Policy2012，41，1： | 1 |
| 17 | Glycentin control with diet,sulfonylurea,metformin,or insulin in patients with type 2 diabetes mellitus:progressive requirement for multiple therapies (UKPDS 49)显示文摘 | Robert C T Carole A C Valeria F | 1999 | JAMA1999，281，： | 1 |
| 18 | Conservative surgi- cal management of stage IA endometrial carcinoma for fertility preservation 显示文摘 | Ivan M Giacomo C Valeria M | 2010 | Fertil Steril2010，93，4： | 1 |
| 19 | Recombinant aequorin and green fluorescent protein as valuable tools in the study of cell signaling 显示文摘 | Anna C Elena R Valeria T | 2001 | Biochem J2001，355，： | 1 |
| 20 | PhnE and glpT gene chance utilization of organophoshates in EscherichiacoliK12显示文摘 | Ilya Elashvili Joseph J Defrankr Valeria C Culotta | 1998 | Appl Environ Microbiol1998，67，7： | 1 |
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