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| 1 | Role of autophagy in the pathogenesis of inflammatory bowel disease显示文摘Inflammatory bowel disease(IBD) results from a complex series of interactions between susceptibility genes, the environment, and the immune system.Recently, some studies provided strong evidence that the process of autophagy affects several aspects of mucosal immune responses. Autophagy is a cellular stress response that plays key roles in physiological processes, such as innate and adaptive immunity, adaptation to starvation, degradation of aberrant proteins or organelles, antimicrobial defense, and protein secretion. Dysfunctional autophagy is recognized as a contributing factor in many chronic inflammatory diseases, including IBD. Autophagy plays multiple roles in IBD pathogenesis by altering processes that include intracellular bacterial killing, antimicrobial peptide secretion by Paneth cells, goblet cell function, proinflammatory cytokine production by macrophages, antigen presentation by dendritic cells, and the endoplasmic reticulum stress response in enterocytes. Recent studies have identified susceptibility genes involved in autophagy, such as NOD2, ATG16L1, and IRGM, and active research is ongoing all over the world. The aim of this review is a systematic appraisal of the current literature to provide a better understanding of the role of autophagy in the pathogenesis of IBD. Understanding these mechanisms will bring about new strategies for the treatment and prevention of IBD. | Tomoya Iida Kei Onodera Hiroshi Nakase | 2017 | World Journal of Gastroenterology2017，23，11： | 27 |
| 2 | Heparin bridge therapy and post-polypectomy bleeding显示文摘AIM To identify risk factors for post-polypectomy bleeding(PPB), focusing on antithrombotic agents. METHODS This was a case-control study based on medical records at a single center. PPB was defined as bleeding that occurred 6 h to 10 d after colonoscopic polypectomy and required endoscopic hemostasis. As risk factors for PPB, patient-related factors including anticoagulants, antiplatelets and heparin bridge therapy as well as polyp- and procedure-related factors were evaluated. All colonoscopic hot polypectomies, endoscopic mucosal resections and endoscopic submucosal dissections performed between January 2011 and December 2014 were reviewed. RESULTS PPB occurred in 29(3.7%) of 788 polypectomies performed during the study period. Antiplatelet or anticoagulant agents were prescribed for 210(26.6%)patients and were ceased before polypectomy except for aspirin and cilostazol in 19 cases. Bridging therapy using intravenous unfractionated heparin was adopted for 73 patients. The univariate analysis revealed that anticoagulants, heparin bridge, and anticoagulants plus heparin bridge were significantly associated with PPB(P < 0.0001) whereas antiplatelets and antiplatelets plus heparin were not. None of the other factors including age, gender, location, size, shape, number of resected polyps, prophylactic clipping and resection method were correlated with PPB. The multivariate analysis demonstrated that anticoagulants and anticoagulants plus heparin bridge therapy were significant risk factors for PPB(P < 0.0001). Of the 29 PPB cases, 4 required transfusions and none required surgery. A thromboembolic event occurred in a patient who took anticoagulant. CONCLUSION Patients taking anticoagulants have an increased risk of PPB, even if the anticoagulants are interrupted before polypectomy. Heparin-bridge therapy might be responsible for the increased PPB in patients taking anticoagulants. | Toshiyuki Kubo Kentaro Yamashita Kei Onodera Tomoya Iida Yoshiaki Arimura Masanori Nojima Hiroshi Nakase | 2016 | World Journal of Gastroenterology2016，22，45： | 2 |
| 3 | Reconstruction after proximal gastrectomy for early gastric cancer in the upper third of the stomach: An analysis of our 13-year experience显示文摘 | Masaki Nakamura Mikihito Nakamori Toshiyasu Ojima Masahiro Katsuda Takeshi Iida Keiji Hayata Shuuichi Matsumura Tomoya Kato Junya Kitadani Makoto Iwahashi Hiroki Yamaue | 2014 | Surgery2014，，： | 2 |
| 4 | Postoperative lumbar spinal instability occurring or progressing secondary to laminectomy显示文摘 | Iida Yasuo Kataoka Osamu Sho Tomoya | 1990 | Spine1990，15，： | 1 |
| 5 | Postoperative Lumbar Spinal Instability Occurring or Progressing Secondary to Laminectomy显示文摘 | YASUO IIDA OSAMU KATAOKA TOMOYA SHO MASATOSHI SUMI TETSUJI HIROSE YASUO BESSHO DAISUKE KOBAYASHI | 1990 | Spine1990，，11： | 1 |
| 6 | rare type of pancreatitis as the first presentation ofanti-neutrophil cytoplasmic antibody-related vasculitis显示文摘A pancreatic tumor was suspected on the abdominal ultrasound of a 72-year-old man. Abdominal computed tomography showed pancreatic enlargement as well as a diffuse, poorly enhanced area in the pancreas; endoscopic ultrasound-guided fine needle aspiration biopsy and endoscopic retrograde cholangiopancreatography failed to provide a definitive diagnosis. Based on the trend of improvement of the pancreatic enlargement, the treatment plan involved follow-up examinations. Later, he was hospitalized with an alveolar hemorrhage and rapidly progressive glomerulonephritis; he tested positive for myeloperoxidase-anti-neutrophil cytoplasmic antibody(ANCA) and was diagnosed with ANCArelated vasculitis, specifically microscopic polyangiitis. It appears that factors such as thrombus formation caused by the vasculitis in the early stages of ANCArelated vasculitis cause abnormal distribution of the pancreatic blood flow, resulting in non-uniform pancreatitis. Pancreatic lesions in ANCA-related vasculitis are very rare. Only a few cases have been reported previously. Therefore, we report our case and a review of the literature. | Tomoya Iida Takeya Adachi Tetsuya Tabeya Suguru Nakagaki Takashi Yabana Akira Goto Yoshihiro Kondo Kiyoshi Kasai | 2016 | World Journal of Gastroenterology2016，22，7： | 0 |
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