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| 1 | Gastro-esophageal reflux disease symptoms are more common in general practice in Japan显示文摘AIM: To accurately assess the prevalence of GERD symptoms in general practice. METHODS: 4139 consecutive patients (2025 men and 2114 women with a mean age of 43 years), who fi rst attended the Outpatient Department of General Medicine and Emergency Care at Toho University Omori Hospital, were asked to respond to the F-scale questionnaire regardless of their chief complaints. The questionnaire is a self-report instrument, written in a simple and easy-to-understand language, containing 12 questions. RESULTS: Of 4139 subjects, 1554 patients (37.6%) were identifi ed as GERD according to their F-scale score (> 7). However, there were only 45 consultations (1.1%) for typical GERD symptoms. Although GERD symptoms are common in adults of all ages, the prevalence of GERD was highest in the 20-29 years age group and the age group 70-79 years had the lowest prevalence for both males and females. CONCLUSION: Although there was a high rate indicating GERD in our primary care population, only 1.1% of outpatients attended our hospital with a chief complaint of GERD symptoms. Since about one-third of GERD patients are affected by atypical symptoms, general physicians need to be cautious about extrapolating these results to patients with a chief complaint other than typical GERD symptoms. | Toshiyasu Watanabe Yoshihisa Urita Motonobu Sugimoto Kazumasa Miki | 2007 | World Journal of Gastroenterology2007，13，31： | 12 |
| 2 | Verification of the Silica Deficiency Hypothesis Based on Biogeochemical Trends in the Aquatic Continuum of Lake BiwaYodo River-Seto Inland Sea,Japan显示文摘硅酸缺乏假设提出,水力变化引起的静水增加以及高的氮、磷排放都会加快淡水中硅藻的生长,因为硅藻可以吸收天然风化供给的溶解硅酸盐(DSi)。海洋中DSi供给减少的结果对沿海海洋生态系统中鞭毛藻类(非硅质的,且有潜在的害处)而非硅藻类(硅质.良性的)是很有利的。由于缺少相关的数据,尤其是亚洲的数据,这个假设的验证受到了阻碍。我们调查了日本由琵琶湖-淀川-濑户内海组成的流域连续体,那里天然条件使得硅酸缺乏现象很少发生,因为有固有的丰富的DSi供给。研究结果表明,在湖里和河1:2附近都有硅酸滞留的发生。硅藻和鞭毛藻之间的相对优势不能仅仅通过化学计量参数来解释,而是要通过对他们行为特征以及在河1:2附近的过程的差异的讨论来获得有利的支持。河1:2附近是氮、磷的直接输八场所,即使上游水库中的Si/N比值降低了,硅流出物还是会加速硅藻的大量聚集。因而,在湖里和河1:2附近这两个地方易发生DSi滞留,因为那里也是其他形式氮、磷直接载入的地方。DSi滞留造度与社会经济变化有相关关系,如20世纪60年代后期的经济高速增长以及20世纪80年代以后的经济发展减缓。这个连续体对硅过程的敏感程度表明了这个假设对全球具有重要意义。 | Akira Harashima Takashi Kimoto Takashi Wakabayashi Tadao Toshiyasu 李发东(译) | 2006 | AMBIO-人类环境杂志2006，35，1： | 3 |
| 3 | Thermoelectric properties of Bi–Sb semiconducting alloys prepared by quenching and annealing显示文摘 | Hiroyuki Kitagawa Hiroyuki Noguchi Toshiyasu Kiyabu Masaki Itoh Yasutoshi Noda | 2004 | Journal of Physics and Chemistry of Solids2004，，7： | 2 |
| 4 | Clinicopathological Characteristics of Remnant Gastric Cancer After a Distal Gastrectomy显示文摘 | Toshiyasu Ojima Makoto Iwahashi Mikihito Nakamori Masaki Nakamura Teiji Naka Masahiro Katsuda Takeshi Iida Toshiaki Tsuji Keiji Hayata Katsunari Takifuji Hiroki Yamaue | 2010 | Journal of Gastrointestinal Surgery2010，，2： | 2 |
| 5 | Endoscopic lithotripsy with peroral direct cholangioscopy using a conventional endoscope显示文摘Recently,peroral direct cholangioscopy(PDCS) using an ultra-slim endoscope has come into the spotlight.However,the working channel is too small to use various devices for lithotripsy.We report a case of endoscopic lithotripsy with PDCS using a conventional endoscope as a cholangioscope.Computed tomography scan on an 80-year-old female who was admitted with acute cholangitis showed two large stones in the bile duct.Endoscopic retrograde cholangiopancreatography was attempted first.However,mechanical lithotripsy failed because the stone was too large for the basket catheter.Finally,electric hydraulic lithotripsy with PDCS using a conventional endoscope was performed allowed the stones to be cleared completely.In conclusion,PDCS using a conventional endoscope can be an alternative solution for endoscopic lithotripsy for patients with large stones in the dilated bile duct. | So Nakaji Nobuto Hirata Toshiyasu Shiratori Masayoshi Kobayashi Masami Inase | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，3： | 2 |
| 6 | Reconstruction after proximal gastrectomy for early gastric cancer in the upper third of the stomach: An analysis of our 13-year experience显示文摘 | Masaki Nakamura Mikihito Nakamori Toshiyasu Ojima Masahiro Katsuda Takeshi Iida Keiji Hayata Shuuichi Matsumura Tomoya Kato Junya Kitadani Makoto Iwahashi Hiroki Yamaue | 2014 | Surgery2014，，： | 2 |
| 7 | Antiangiogenic activity of β-eudesmol in vitro and in vivo显示文摘 | Hiroshi Tsuneki En-Long Ma Shinjiro Kobayashi Naoto Sekizaki Kouji Maekawa Toshiyasu Sasaoka Min-Wei Wang Ikuko Kimura | 2005 | European Journal of Pharmacology2005，，2： | 1 |
| 8 | Time-Series Analysis of Continuously Monitored Blood Glucose: The Impacts of Geographic and Daily Lifestyle Factors显示文摘 | Sean T. Doherty Stephen P. Greaves Toshiyasu Sasaoka | 2015 | Journal of Diabetes Research2015，，： | 1 |
| 9 | Gene mutations of K- ras in gallbladder mucosae and gallbladder carcinoma with an anomalous junction of the pancreaticobiliary duct显示文摘 | Keiji Hanada Akira Tsuchida Toshiyasu Iwao Noriaki Eguchi Tamito Sasaki Kenji Morinaka Kenji Matsubara Yosuke Kawasaki Shigeru Yamamoto Goro Kajiyama | 1999 | The American Journal of Gastroenterology1999，，： | 1 |
| 10 | Analysis of the prognostic factors and evaluation of surgical treatment for synchronous liver metastases from gastric cancer显示文摘 | Kentaro Ueda Makoto Iwahashi Mikihito Nakamori Masaki Nakamura Teiji Naka Koichiro Ishida Toshiyasu Ojima Hiroki Yamaue | 2009 | Langenbeck’s Archives of Surgery2009，，4： | 1 |
| 11 | Production of the Blood Pressure Lowing Peptides from Brown Alga(Undaria pinnatifida)显示文摘Brown alga (Undaria pinnatifida) was treated with alginate lyase and hydrolyzed using 17 kinds of proteases andthe inhibitory activity of the hydrolysates for the angiotensin-I-converting enzyme (ACE) was measured. Four hydrolysateswith potent ACE-inhibitory activity were administered singly and orally to spontaneously hypertensive rats (SHRs). The sys-tolic blood pressure of SHRs decreases significantly after single oral administration of the brown alga hydrolysates by pro-tease S ’Amano’ (from Bacillus stearothermophilus) at the concentration of 10 (mg protein) (kg body weight)-1. In the 17weeks of feeding experiment, 7-week-old SHRs were fed standard diet supplemented with the brown alga hydrolysates for 10weeks. In SHRs fed 1.0 and 0.1% brown alga hydrolysates, elevating of systolic bloodpressure was significantly suppressedfor 7 weeks. To elucidate the active components, the brown alga hydrolysates were fractionated by 1-butanol extraction andHPLC on a reverse-phase column. Seven kinds of ACE-inhibitory peptides were isolated and identified by amino acid compo-sition analysis, sequence analysis, and LC-MS with the results Val-Tyr, Ile-Tyr, Ala-Trp, Phe-Tyr, Val-Trp, Ile-Trp, andLeu-Trp. Each peptide was determined to have an antihypertensive effect after a single oral administration in SHRs. Thebrown alga hydrolysates were also confirmed to decrease the blood pressure in humans. | Sato Minoru Oba Takashi Hosokawa Takao Yamaguchi Toshiyasu Nakano Toshiki Saito Tadao Muramoto Koji Kahara Takashi Funayama Katsura Kobayashi Akio Nakano Takahisa | 2005 | Journal of Ocean University of China2005，4，3： | 1 |
| 12 | Selective conversion of carbon dioxide to dimethyl carbonate by molecular catalysis显示文摘 | Toshiyasu Sakakura Satito Makoto Okano | 1998 | J Org Chem1998，63，： | 1 |
| 13 | Metal-catalyzed dimethyl carbonate synthesin from carbon dioxide and acetals显示文摘 | Toshiyasu Sakakura Jun-Chul Choi Yuko Satito | 1999 | J Org Chem1999，64，： | 1 |
| 14 | Association of Allogeneic Blood Transfusions and Long-Term Survival of Patients with Gastric Cancer after Curative Gastrectomy显示文摘 | Toshiyasu Ojima Makoto Iwahashi Mikihito Nakamori Masaki Nakamura Teiji Naka Masahiro Katsuda Takeshi Iida Keiji Hayata Hiroki Yamaue | 2009 | Journal of Gastrointestinal Surgery2009，，10： | 1 |
| 15 | The effects of the early administration of sivelestat sodium, a selective neutrophil elastase inhibitor, on the postoperative course after radical surgery for esophageal cancer显示文摘 | Junichi Nishiyama Mitsumasa Matsuda Satoko Ando Miyoko Hirasawa Toshiyasu Suzuki Hiroyasu Makuuchi | 2012 | Surgery Today2012，，7： | 1 |
| 16 | Association of the polymorphisms in the 5′-untranslated region of PTEN gene with type 2 diabetes in a Japanese population显示文摘 | Hajime Ishihara Toshiyasu Sasaoka Syota Kagawa Shihou Murakami Kazuhito Fukui Yukio Kawagishi Katsuya Yamazaki Akira Sato Minoru Iwata Masaharu Urakaze Manabu Ishiki Tsutomu Wada Saori Yaguchi Hiroshi Tsuneki Ikuko Kimura Masashi Kobayashi | 2003 | FEBS Letters2003，，3： | 1 |
| 17 | Cyclic carbonate synthesis from supercritical carbon dioxide and epoxide over lanthanide oxychloride显示文摘 | Hiroyuki Y Liang-nian H Toshiyasu S | 2002 | Journal of Catalysis2002，209，2： | 1 |
| 18 | 查看详情显示文摘 | Sakakura Toshiyasu Choi Junchul Yasuda Hiroyuki | | 0，，： | 1 |
| 19 | The impact of abdominal shape index of patients on laparoscopy-assisted distal gastrectomy for early gastric cancer显示文摘 | Toshiyasu Ojima Makoto Iwahashi Mikihito Nakamori Masaki Nakamura Katsunari Takifuji Masahiro Katsuda Takeshi Iida Toshiaki Tsuji Keiji Hayata Hiroki Yamaue | 2012 | Langenbeck’s Archives of Surgery2012，，3： | 1 |
| 20 | Three‐dimensional tumor volume and serum alpha‐fetoprotein are predictors of hepatocellular carcinoma recurrence after liver transplantation: refined selection criteria显示文摘 | Samy Kashkoush Walid El Moghazy Toshiyasu Kawahara Boris Gala‐Lopez Christian Toso Norman M. Kneteman | 2014 | Clin Transplant2014，，6： | 1 |
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