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| 1 | Irritable bowel syndrome: A microbiome-gut-brain axis disorder?显示文摘Irritable bowel syndrome(IBS) is an extremely prevalent but poorly understood gastrointestinal disorder. Consequently, there are no clear diagnostic markers to help diagnose the disorder and treatment options are limited to management of the symptoms. The concept of a dysregulated gut-brain axis has been adopted as a suitable model for the disorder. The gut microbiome may play an important role in the onset and exacerbation of symptoms in the disorder and has been extensively studied in this context. Although a causal role cannot yet be inferred from the clinical studies which have attempted to characterise the gut microbiota in IBS, they do confirm alterations in both community stability and diversity. Moreover, it has been reliably demonstrated that manipulation of the microbiota can influence the key symptoms, including abdominal pain and bowel habit, and other prominent features of IBS. A variety of strategies have been taken to study these interactions, including probiotics, antibiotics, faecal transplantations and the use of germ-free animals. There are clear mechanisms through which the microbiota can produce these effects, both humoral and neural. Taken together, these findings firmly establish the microbiota as a critical node in the gut-brain axis and one which is amenable to therapeutic interventions. | Paul J Kennedy John F Cryan Timothy G Dinan Gerard Clarke | 2014 | World Journal of Gastroenterology2014，20，39： | 20 |
| 2 | Passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts and assessment of clinical outcomes显示文摘AIM To assess for passive expansion of sub-maximally dilated transjugular intrahepatic portosystemic shunts(TIPS) and compare outcomes with maximally dilated TIPS.METHODS Polytetrafluoroethylene covered TIPS(Viatorr) from July 2002 to December 2013 were retrospectively reviewed at two hospitals in a single institution. Two hundred and thirty patients had TIPS maximally dilated to 10 mm(m TIPS), while 43 patients who were at increased risk for hepatic encephalopathy(HE), based on clinical evaluation or low pre-TIPS portosystemic gradient(PSG), had 10 mm TIPS sub-maximally dilated to 8 mm(sm TIPS). Group characteristics(age, gender, Model for End-Stage Liver Disease score, post-TIPS PSG and clinical outcomes were compared between groups, including clinical success(ascites or varices), primary patency,primary assisted patency, and severe post-TIPS HE. A subset of fourteen patients with sm TIPS underwent follow-up computed tomography imaging after TIPS creation, and were grouped based on time of imaging(< 6 mo and > 6 mo). Change in diameter and crosssectional area were measured with 3D imaging software to evaluate for passive expansion.RESULTS Patient characteristics were similar between the sm TIPS and m TIPS groups, except for pre-TIPS portosystemic gradient, which was lower in the sm TIPS group(19.4 mm Hg ± 6.8 vs 22.4 mm Hg ± 7.1, P = 0.01). Primary patency and primary assisted patency between sm TIPS and m TIPS was not significantly different(P = 0.64 and 0.55, respectively). Four of the 55 patients(7%) with sm TIPS required TIPS reduction for severe refractory HE, while this occurred in 6 of the 218 patients(3%) with m TIPS(P = 0.12). For the 14 patients with follow-up computed tomography(CT) imaging, the median imaging follow-up was 373 d. There was an increase in median TIPS diameter, median percent diameter change, median area, and median percent area change in patients with CT follow-up greater than 6 mo after TIPS placement compared to follow-up within 6 mo(8.45 mm, 5.58%, 56.04 mm^2, and 11.48%, respectively, P = 0.01).CONCLUSION Passive expansion of sm TIPS does occur but clinical outcomes of sm TIPS and m TIPS were similar. Sub-maximal dilation can prevent complications related to overshunting in select patients. | Michael C Hsu Charles N Weber S William Stavropoulos Timothy W Clark Scott O Trerotola Richard D Shlansky Goldberg Michael C Soulen Gregory J Nadolski | 2017 | World Journal of Hepatology2017，9，12： | 11 |
| 3 | Evaluation of biomarker panels for early stage ovarian cancer detection and monitoring for disease recurrence显示文摘 | Laura J. Havrilesky Clark M. Whitehead Jennifer M. Rubatt Robert L. Cheek John Groelke Qin He Douglas P. Malinowski Timothy J. Fischer Andrew Berchuck | 2008 | Gynecologic Oncology2008，，3： | 7 |
| 4 | European LeukemiaNet recommendations for the management of chronic myeloid leukemia: 2013显示文摘 | Michele Baccarani Michael W. Deininger Gianantonio Rosti Andreas Hochhaus Simona Soverini Jane F. Apperley Francisco Cervantes Richard E. Clark Jorge E. Cortes Fran?ois Guilhot Henrik Hjorth-Hansen Timothy P. Hughes Hagop M. Kantarjian Dong-Wook Kim Richa | 2013 | Blood2013，，6： | 3 |
| 5 | 扁桃体鳞癌中HPV感染与EGFR、VEGF表达的相关性研究显示文摘目的:研究扁桃体鳞癌(squamous cell carcinomas of the tonsil tonsillar,SCCs)中人乳头瘤病毒(human papillomavirus,HPV)感染与血管内皮生长因子(vascular endothelial growth factor,VEGF)和表皮生长因子受体(epidermal growth factor,EGFR)表达的关系,探讨HPV与EGFR和VEGF在扁桃体鳞癌发生中的交互效应。方法:采用多重实时荧光定量聚合酶链反应(multiplex real-time polymerase chain reaction,MT-PCR)检测85例扁桃体鳞癌HPV DNA及型别,通过HPV DNA分析进行HPV感染状况的测定;同时采用半定量免疫组化检测HPV(+)组和HPV(-)组中VEGF、EGFR蛋白表达情况。结果:扁桃体鳞癌中HPV感染率为49.4%(42/85),HPV-16型占所有感染者的比例为90.5%(38/42),明显高于其他型别;HPV(+)组EGFR蛋白表达明显低于HPV(-)组(P值均<0.01);HPV(+)组与HPV(-)组VEGF蛋白表达无明显差异;此外,VEGF表达与EGFR、患者的年龄、性别、TNM分期、组织学分级均无明显相关性。结论:HPV感染与扁桃体鳞癌的发生存在相关性,HPV相关的扁桃体鳞癌中,HPV基因可能通过改变EGFR表达致癌,为HPV致癌机理进一步研究提供一个新的视角,具有重要的理论意义。 | 费继敏 Timothy A Dobbins Deanna Jones C Soon Lee Christine Loo Jonathan Clark Barbara Rose | 2015 | 现代肿瘤医学2015，23，4： | 3 |
| 6 | Gut memories: Towards a cognitive neurobiology of irritable bowel syndrome显示文摘 | Paul J. Kennedy Gerard Clarke Eamonn M.M. Quigley John A. Groeger Timothy G. Dinan John F. Cryan | 2011 | Neuroscience and Biobehavioral Reviews2011，，1： | 2 |
| 7 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 8 | Serum Bilirubin and Early Mortality after Transjugular Intrahepatic Portosystemic Shunts: Results of a Multivariate Analysis显示文摘 | Dheeraj K. Rajan Ziv J. Haskal Timothy W.I. Clark | 2002 | Journal of Vascular and Interventional Radiology2002，，2： | 2 |
| 9 | Prospective multicentre randomised controlled trial of early enteral nutrition for patients undergoing major upper gastrointestinal surgical resection显示文摘 | Rachael Barlow Patricia Price Thomas D. Reid Sarah Hunt Geoffrey W.B. Clark Timothy J. Havard Malcolm C.A. Puntis Wyn G. Lewis | 2011 | Clinical Nutrition2011，，5： | 2 |
| 10 | Foreign Country Priorities in the Internationalization Process: A Measure and an Exploratory Test on British Firms 显示文摘 | Clark Timothy Derek S | 2001 | International Business Review2001，10，3： | 1 |
| 11 | Vision-based Target Geo-location using a Fixed-wing Miniature Air Vehicle显示文摘 | D. Blake Barber Joshua D. Redding Timothy W. McLain Randal W. Beard Clark N. Taylor | 2006 | Journal of Intelligent and Robotic Systems2006，，4： | 1 |
| 12 | Asymmetry loss is local rather than global in adolescent onset schizophrenia显示文摘 | Clark GM Crow TJ Timothy J | 2010 | Schizophr Res2010，120，1： | 1 |
| 13 | DLL4 Blockade Inhibits Tumor Growth and Reduces Tumor-Initiating Cell Frequency显示文摘 | Timothy Hoey Wan-Ching Yen Fumiko Axelrod Jesspreet Basi Lucas Donigian Scott Dylla Maureen Fitch-Bruhns Sasha Lazetic In-Kyung Park Aaron Sato Sanjeev Satyal Xinhao Wang Michael F. Clarke John Lewicki Austin Gurney | 2009 | Cell Stem Cell2009，，2： | 1 |
| 14 | Chalcone synthase as a reporter in virus-induced gene silencing studies of flower senescence显示文摘 | Jen-Chih Chen Cai-Zhong Jiang Timothy Gookin Donald Hunter David Clark Michael Reid | 2004 | Plant Molecular Biology2004，，4： | 1 |
| 15 | Heightened resistance of the neonatal brain to ischemia-reperfusion involves a lack of mitochondrial damage in the nerve terminal 显示文摘 | Keenlan J Bates Timothy E Clark JB | 1999 | Brain-Res1999，821，1： | 1 |
| 16 | Gradient Index Lenses显示文摘 | Timothy CLARK Keith WANSER BALL V S | 2001 | Photonics Spectra2001，4，： | 1 |
| 17 | Chemoembolization and Bland Embolization of Neuroendocrine Tumor Metastases to the Liver显示文摘 | Alexander T. Ruutiainen Michael C. Soulen Catherine M. Tuite Timothy W.I. Clark Jeffrey I. Mondschein S. William Stavropoulos Scott O. Trerotola | 2007 | Journal of Vascular and Interventional Radiology2007，，7： | 1 |
| 18 | Toward a Theory of International Service: Marketing Intangibles in a World of Nations 显示文摘 | Terry Clark Daniel Rajaratnam Timothy Smith | 1996 | Journal of International Marketing1996，4，2： | 1 |
| 19 | Reporting Standards for Endovascular Treatment of Pulmonary Embolism显示文摘 | Filip Banovac Donna C. Buckley William T. Kuo Denver Matthew Lough Louis G. Martin Steven F. Millward Timothy W.I. Clark Sanjoy Kundu Dheeraj K. Rajan David Sacks John F. Cardella | 2010 | Journal of Vascular and Interventional Radiology2010，，1： | 1 |
| 20 | Prevalence and outcomes of comorbid metabolic and cardiovascular conditions in middle- and older-age adults显示文摘 | Neil B. Oldridge Timothy E. Stump Faryle K. Nothwehr Daniel O. Clark | 2001 | Journal of Clinical Epidemiology2001，，9： | 1 |
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