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| 1 | 在在母亲胎儿的接口的天生、适应的有免疫力的房间之间的不平衡发生在导致内毒素的 preterm 出生以前显示文摘Preterm 出生(PTB ) 是新生的病态和世界范围的死亡的领先的原因。到在母亲并且在母亲胎儿的接口的一个支持 inflammatory 状态的来自一个反煽动性的状态的转变在微生物引起导致 preterm 劳动的 pathophysiology 被含有。然而,房间哪个免疫者调停,是不清楚的这转变。我们假设了那在在母亲胎儿的接口的天生、适应的有免疫力的房间之间的不平衡将发生在微生物引起导致 preterm 劳动以前。用导致内毒素的 PTB 的一个确定的鼠科的模型,我们的结果证明在交货以前,有 CD4+ 的减小;在子宫的纸巾的规章的 T 房间(Tregs ) 。这减小被子宫的纸巾也不在脾连接到 Tregs 的一个减少的数字,也不到 IL10, CCL17,或 CCL22 的损害生产。到怀孕老鼠的内毒素管理不改变受动器 CD4+在母亲胎儿的接口的 T 房间。然而,它引起在 Tregs 之间的不平衡(CD4+并且 CD8+) ,受动器 CD8+在怒气的 T 房间,和 Th17 房间。另外,到怀孕老鼠的内毒素管理象丰富的 neutrophils 一样由子宫的纸巾导致 CCL2, CCL3, CCL17,和 CCL22 的过多的生产。在子宫的微型环境的这不平衡被象巨噬细胞和 MHC II+ 那样的少见的象 APC 一样房间伴随;neutrophils。一起,这些结果证明到怀孕老鼠的内毒素管理在母亲胎儿的接口引起在天生、适应的有免疫力的房间之间的不平衡。 | Marcia Arenas-Hernandez Roberto Romero Derek St Louis Sonia S Hassan Emily B Kaye Nardhy Gomez-Lopez | 2016 | Cellular & Molecular Immunology2016，13，4： | 6 |
| 2 | Relationships among bile tolerance, bile salt deconjungation and assimilation of cholesterol by lactobacillus acidophilus显示文摘 | Derek K Walker D K Gilliland S E | 1993 | J Dairy SCI1993，76，： | 2 |
| 3 | Thrombospondin peptide ABT-898 inhibits inflammation and angiogenesis in a colitis model显示文摘AIM: To evaluate the efficacy of the improvedthrombospondin mimetic peptide ABT-898 in a murine model of ulcerative colitis. METHODS: The dextran sodium sulfate(DSS) was used for the induction of colitis in both TSP-1 deficient(TSP-1-/-) and wild type(WT) mice during 7 d. While mice were receiving the DSS dissolved in the drinking water, the ABT-898 peptide was dissolved in sterile 5% glucose solution and delivered using mini pumps subcutaneously implanted. Plasma samples were analyzed for interleukin(IL)-6 by ELISA assay and colonic tissues were harvested, fixed and processed for histological evaluation. Immunohistochemistry using antibodies for the detection of CD31 and MECA in endothelial cells was performed. Inflammation was graded in colonic sections and the number of microvessels in each lesion was assessed. Activation of signal transducer and activator of transcription 3(STAT3) in colonic samples was quantified by immunohistochemistry and Western blotting using antibodies against total STAT3 and phosphorylated STAT3(p STAT3)(Ser727).RESULTS: Treatment with ABT-898 considerably diminished the inflammatory response in WT and TSP-1-/- mice(P < 0.0001 in both groups vs control). Identification of blood vessels highlighted by CD31/MECA immunohistochemistry, showed significantly reduced vessel counts in colitic lesions of WT and TSP-1-/- mice treated with ABT898(TSP-1-/- controls/TSP-1-/- treated, P = 0.0002; WT controls/WT treated, P = 0.0005). Consistently, IL-6 was significantly diminished in plasma samples of TSP-1-/- and WT treated with the peptide when compared to the control mice(P = 0.0002 and P = 0.0148, respectively). p STAT3 positive cells were quantified in WT and TSP-1-/- treated with ABT-898. A significant decrease in positive cells for p STAT3 was observed in treated mice(TSP-1-/- controls/TSP-1-/- treated, P = 0.0089; WT/WT treated, P = 0.0110). These results were confirmedby Western blotting analyses showing lower levels of p STAT3 in colitic lesions from mice treated with the peptide ABT-898.CONCLUSION: These findings indicate that the new peptide ABT-898 ameliorates inflammation and angiogenesis and might be a therapeutic alternative in IBD and inflammatory diseases. | Linda S Gutierrez Jun Ling Derek Nye Konstantina Papathomas Catherine Dickinson | 2015 | World Journal of Gastroenterology2015，21，20： | 2 |
| 4 | Foreign Country Priorities in the Internationalization Process: A Measure and an Exploratory Test on British Firms 显示文摘 | Clark Timothy Derek S | 2001 | International Business Review2001，10，3： | 1 |
| 5 | Lethal and sub-lethal effects of the salmon delousing agent dichlorvos on the larvae of the lobster (Homarus gammarus L) and herring (Clupea harengus L)显示文摘 | JOHN G M DEREK S DUNCAN D S | 1991 | Aquaculture1991，98，： | 1 |
| 6 | Hydrogen Generation Via Anaerobic Fermentation of Paper Mill Wastes显示文摘 | Idania V V Richard S Derek R | 2005 | Bioresource Technology2005，96，： | 1 |
| 7 | Two Brassica napus polygalacturonase inhibitory protein genes are expressed at different levels in response to biotic and abiotic stresses显示文摘 | Rugang Li Roger Rimmer Min Yu Andrew G. Sharpe Ginette Séguin-Swartz Derek Lydiate Dwayne D. Hegedus | 2003 | Planta2003，，2： | 1 |
| 8 | Reduced Amygdala Response to Fearful Expressions in Children and Adolescents With Callous-Unemotional Traits and Disruptive Behavior Disorders显示文摘 | Marsh Abigail A Finger Elizabeth C Mitchell Derek G V Reid Marguerite E Sims Courtney Kosson David S Towbin Kenneth E Leibenluft Ellen Pine Daniel S Blair R J R | 2008 | The American Journal of Psychiatry2008，，6： | 1 |
| 9 | Propofol attenuates capacitatire calcium entry in pulmonary artery smooth muscle cells 显示文摘 | Mayumi H Izumi K Derek S | 2001 | Anesthesiology2001，85，9： | 1 |
| 10 | Epidemiologic and economic conse- quences of the global epidemics of obesity and diabetes显示文摘 | Derek Y David S Kelly DB | 2006 | Nature Med2006，12，： | 1 |
| 11 | Comparison of various online IGRT strategies : The benefits of online treatment plan re-optimization 显示文摘 | Derek S Liang J Yan D | 2009 | Radiother Onco12009，90，3： | 1 |
| 12 | Waterborne epoxy protective coatings for metal显示文摘 | Jim D Elmore Derek S Kincaid Pratap C Komar | 2002 | Journal of Coatings Technology2002，74，931： | 1 |
| 13 | Optimization of electricity retailer's contract portfolio subject to risk preferences显示文摘 | Janne K Ahti S Derek W B | 2010 | IEEE Transactions on Power Systems2010，25，1： | 1 |
| 14 | A novel repair model for imperfect maintanance显示文摘 | WU S DEREK C | 2006 | IMA Journal Management Mathematics2006，17，3： | 1 |
| 15 | Properties of air mass mixing and humidity in the subtropics from measurements of the D/H isotope ratio of water vapor at the Mauna Loa Observatory显示文摘 | Noone David Galewsky Joseph Sharp Zachary D. Worden John Barnes John Baer Doug Bailey Adriana Brown Derek P. Christensen Lance Crosson Eric Dong Feng Hurley John V. Johnson Leah R. Strong Mel Toohey Darin Pelt Aaron Van Wright Jonathon S | 2011 | Journal of Geophysical Research Atmospheres2011，，22： | 1 |
| 16 | STATE OF THE CLIMATE IN 2011显示文摘 | Blunden Jessica Arndt Derek S | 2012 | EN2012，，7： | 1 |
| 17 | Wire - Antenna De signs using Genetic Algorithm显示文摘 | Edward E Altshuler Derek S Linden | 1997 | IEEE Antenna and Prop agation Magazine1997，39，2： | 1 |
| 18 | Molecular phylogeny of symbiotic dinoflagellates inferred from partial chloroplast large subunit (23S)-rDNA sequences显示文摘 | SCOTT R SANTO S DEREK J | 2002 | Mol Phylogen Evol2002，23，2： | 1 |
| 19 | Allosterie inhibition of lysyl oxidase - like - 2 impedes the development of a pathologic microenvironment显示文摘 | Hamilton VB Rhyannon S Derek M | 2010 | Nat Med2010，16，9： | 1 |
| 20 | 1/f,g-r and burst noise used as a screening threshold for reliability estimation of optoelectronic coupled device 显示文摘 | XU J S DEREK A DAI Y S | 2000 | Microelectronics Reliability2000，40，1： | 1 |
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