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| 1 | Lack of CD44 variant 6 expression in rectal cancer invasive front associates with early recurrence显示文摘AIM: To investigate the prognostic value of CD44 variant 6 (CD44v6), a membranous adhesion molecule, in rectal cancer. METHODS: Altogether, 210 rectal cancer samples from 214 patients treated with short-course radiotherapy (RT, n = 90), long-course (chemo) RT (n = 53) or surgery alone (n = 71) were studied with immunohistochemistry for CD44v6. The extent and intensity of membranous and cytoplasmic CD44v6 staining, and the intratumoral membranous staining pattern, were analyzed.RESULTS: Membranous CD44v6 expression was seen in 84% and cytoplasmic expression in 81% of the cases. In 59% of the tumors with membranous CD44v6 expression, the staining pattern in the invasive front was determined as 'front-positive' and in 41% as 'front-negative'. The latter pattern was associated with narrower circumferential margin (P = 0.01), infiltrative growth pattern (P < 0.001), and shorter disease-free survival in univariate survival analysis (P = 0.022) when compared to the 'front-positive' tumors. CONCLUSION: The lack of membranous CD44v6 in the rectal cancer invasive front could be used as a method to identify patients at increased risk for recurrent disease. | Suvi Tuulia Avoranta Eija Annika Korkeila Kari Juhani Syrjnen Seppo Olavi Pyrhnen Jari Toivo Tapio Sundstrm | 2012 | World Journal of Gastroenterology2012，18，33： | 9 |
| 2 | Evolution of aluminosilicate structure and mullite crystallization from homogeneous nanoparticulate sol–gel precursor with organic additives显示文摘 | Jarkko Leivo Mika Lindén Jessica M. Rosenholm Merja Ritola Cilaine V. Teixeira Erkki Lev?nen Tapio A. M?ntyl? | 2008 | Journal of the European Ceramic Society2008，，9： | 1 |
| 3 | Band structure and optical parameters of the Sn02 ( 110 ) surface 显示文摘 | Matti A Jaskari M Tapio T R | 2001 | Physical Review B2001，64，07： | 1 |
| 4 | Utilisation of a multitubular reactor system for parallel screening of catalysts for ring opening of decalin in continuous mode显示文摘 | Kalle Arve P?ivi M?ki-Arvela Kari Er?nen Marja Tiitta Tapio Salmi Dmitry Yu. Murzin | 2014 | Chemical Engineering Journal2014，，： | 1 |
| 5 | Surgical treatment of unstable fractures of the distal clavicle: A comparative study of Kirschner wire and clavicular hook plate fixation显示文摘 | Tapio Flinkkil? Jukka Ristiniemi Pekka Hyv?nen Martti H?m?l?inen | 2002 | Acta Orthopaedica2002，，1： | 1 |
| 6 | Overexpression of Multiple Dehydrin Genes Enhances Tolerance to Freezing Stress in Arabidopsis显示文摘 | Tuula Puhakainen Michael W. Hess Pirjo M?kel? Jan Svensson Pekka Heino E. Tapio Palva | 2004 | Plant Molecular Biology2004，，5： | 1 |
| 7 | Deoxygenation of dodecanoic acid under inert atmosphere显示文摘 | Heidi Bernas Kari Er?nen Irina Simakova Anne-Riikka Leino Krisztián Kordás Jukka Myllyoja P?ivi M?ki-Arvela Tapio Salmi Dmitry Yu. Murzin | 2009 | Fuel2009，，8： | 1 |
| 8 | Band structure and optical parameters of the SnO2(110)surface显示文摘 | MATTI A JASKARI M TAPIO T R | 2001 | Physical Review B2001，64，07： | 1 |
| 9 | Contribution of omega-3 fatty acid desaturase and 3-ketoacyl-ACP synthase Ⅱ (KASⅡ) genes in the modulation of glycerolipid fatty acid composition during cold acclimation in birch leaves显示文摘 | FRANCOISE M SARI K TAPIO E P | | 0，，04： | 1 |
| 10 | Lactose modifications enhance its drug performance in the novel multiple dose Taifun DPI 显示文摘 | Pa ivi H Vesa- Pekka L Krista M Eero S Tapio L Petteri P Kristiina J | 2002 | European Journal of Pharmaceutical Sciences2002，16，： | 1 |
| 11 | Sheep mitochondrial DNA variation in European,Caucasian,and Central Asian areas显示文摘 | Marzanov N Ozerov M | 2006 | Molecular Biology Evolution2006，23，9： | 1 |
| 12 | The Role of Acetyl chloride in the Homogeneously Catalyzed Chlorination of Acetic acid显示文摘 | Paivi M A Tapio S | 1994 | J Chem Technol Biotechno1994，61，： | 1 |
| 13 | Homogeneous duplex polymerase chain reaction assay using switchable lanthanide fluorescence probes显示文摘 | Ari Lehmusvuori Antti-Heikki Tapio Petra M?ki-Teeri Kaisu Rantakokko-Jalava Qi Wang Harri Takalo Tero Soukka | 2013 | Analytical Biochemistry2013，，： | 1 |
| 14 | Kinetics of Chlorination of Acetic Acid and Thionyl Chloride显示文摘 | Paivi M Tapio S | 1994 | Ind Eng Chem Res1994，33，： | 1 |
| 15 | Molecular anatomy of the cytoplasmic domain of bovine growth hormone receptor, a quantitative trait locus显示文摘 | Varvio S.-L Iso-Touru T Kantanen J Viitala S Tapio I M? ki-Tanila A Zerabruk M Vilkki J | 2008 | 2008 (1642)2008，，1642： | 1 |
| 16 | Kinetics of linoleic acid hydrogenation on Pd/C catalyst显示文摘 | ANDREAS B JUKKA M TAPIO S | 2009 | Applied Catalysis A:General2009，353，2： | 1 |
| 17 | Microsatellite variation in the Baltic sheep breeds 显示文摘 | Grigaliunaite I Tapio M Viinalass H | 2003 | Veterinarija Ir Zootechnika2003，21，： | 1 |
| 18 | Analysis of solidconcentration distribution in dense solid 一 liquid stirred tanks by elec-trical resistance tomography 显示文摘 | CLAUDIO C GIUSEPPINA M TAPIO W | 2014 | Chemical Engineering Science2014，119，： | 1 |
| 19 | Recent progress in synthesis of fine and specialty chemicals from wood and other biomass by heterogeneous catalytic proeesses显示文摘 | Paivi M A Arne H Tapio S | 2007 | Catalysis Reviews2007，49，： | 1 |
| 20 | Sheep mitochondrial DNA variation in European,Caucasian,and Central Asian areas显示文摘 | Tapio M Marzanov N Ozerov M | | 0，，09： | 1 |
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