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| 1 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 2 | Fabrication of W-Mo-Ti system flier-plate with graded impedance for generating quasi-isentropic compression显示文摘A fully dense W-Mo-Ti system flier-plate with graded impedance in its thickness direction was successfully fabricated by the method of powder metallurgy. The result of the impact experiment on a light gas gun showed that dynamic quasi-isentropic compression has been created. | SHEN Qiang ZHANG Lianmeng XIONG Huaping HUA Jinsong TAN Hua | 2000 | Chinese Science Bulletin2000，45，15： | 8 |
| 3 | A glove-based system for object recognition via visual-tactile fusion显示文摘Dear editor,In our daily life,information such as tactile and visual information is widely used to recognize objects when we manipulate them.Research has shown that the human brain makes use of multisensory models of objects(1)However,the issue of how to combine visual and tactile information for classification. | Bin FANG Fuchun SUN Huaping LIU Chuanqi TAN Di GUO | 2019 | Science China(Information Sciences)2019，62，5： | 2 |
| 4 | Study of extraction and pyrolysis of Chinese oil sands显示文摘 | Li shuyuan Wang jianqiu Tan Huaping | | 0，，08： | 1 |
| 5 | Novel multiarm PEG-based hydrogels for tissue engineering显示文摘 | Tan Huaping DeFail A J Rubin J P | 2010 | J Biomed Mater Res A2010，92，3： | 1 |
| 6 | Covalently immobilized gelatin gradients within three-dimensional porous scaffolds显示文摘A stable gelatin gradient providing continuous increment of signaling for cell adhesion and proliferation was fabricated within 3D poly(L-lactic acid) (PLLA) scaffolds. The porous PLLA scaffold fabricated by NaCl particle leaching was vertically fixed on a glass vial. 1,6-Hexanediamine/propanol solution was continuously injected into the vial by a micropump to aminolyze the PLLA scaffold. As a result of reaction time difference, the introduced -NH2 groups increased continuously along with the longitude of the PLLA scaffold in the z-direction. After covalent immobilization of gelatin by glutaraldehyde coupling, the gelatin gradient scaffold was thus obtained. In vitro chondrocyte culture showed that the cells had higher viability and more extending morphology in the gelatin gradient scaffold than that in the uniform gelatin control. | WU JinDan TAN HuaPing LI LinHui GAO ChangYou | 2009 | Chinese Science Bulletin2009，54，18： | 1 |
| 7 | Study of extraction and pyrolysis of Chinese oil sands 显示文摘 | LI Shuyuan WANG Jianqiu TAN Huaping | 1995 | Fuel1995，74，8： | 1 |
| 8 | Gelatin/chitosan/hyaluronan ternary complex scaffold containing basic fibroblast growth factor for cartilage tissue engineering显示文摘 | Huaping Tan Yihong Gong Lihong Lao Zhengwei Mao Changyou Gao | 2007 | Journal of Materials Science: Materials in Medicine2007，，10： | 1 |
| 9 | Enhanced composite thermal conductivity by percolated networks of in-situ confined-grown carbon nanotubes显示文摘Despite the ever-increasing demand of nanofillers for thermal enhancement of polymer composites with higher thermal conductivity and irregular geometry,nanomaterials like carbon nanotubes(CNTs)have been constrained by the nonuniform dispersion and difficulty in constructing effective three-dimensional(3D)conduction network with low loading and desired isotropic or anisotropic(specific preferred heat conduction)performances.Herein,we illustrated the in-situ construction of CNT based 3D heat conduction networks with different directional performances.First,to in-situ construct an isotropic percolated conduction network,with spherical cores as support materials,we developed a confined-growth technique for CNT-core sea urchin(CNTSU)materials.With 21.0 wt.%CNTSU loading,the thermal conductivity of composites reached 1.43±0.13 W/(m·K).Secondly,with aligned hexagonal boron nitride(hBN)as an anisotropic support,we constructed CNT-hBN aligned networks by in-situ CNT growth,which improved the utilization efficiency of high density hBN and reduced the thermal interface resistance between matrix and fillers.With~8.5 wt.%loading,the composites possess thermal conductivity up to 0.86±0.14 W/(m·K),374%of that for neat matrix.Due to the uniformity of CNTs in hBN network,the synergistic thermal enhancement from one-dimensional(1D)+two-dimensional(2D)hybrid materials becomes more distinct.Based on the detailed experimental evidence,the importance of purposeful production of a uniformly interconnected heat conduction 3D network with desired directional performance can be observed,particularly compared with the traditional direct-mixing method.This study opens new possibilities for the preparation of high-power-density electronics packaging and interfacial materials when both directional thermal performance and complex composite geometry are simultaneously required. | Xiao Zhang Wei Tan Tian Carey Bo Wen Delong He Adrees Arbab Alex Groombridge Fiona Smail Jean de La Verpilliere Chengning Yao Yanchun Wang Xiaojun Wei Huaping Liu Sishen Xie Felice Torrisi Michael De Volder Weiya Zhou Adam Boies | 2023 | Nano Research2023，16，11： | 0 |
| 10 | Polysaccharide-based supramolecular drug delivery systems mediated via host-guest interactions of cucurbiturils显示文摘With excellent biocompatibility and biodegradability,natural polysaccharides and their derivative s have exhibited great potential in constructing drug delivery ve hicles for tissue engineering and therapeutics.Cucurbit[n]uril(CB[n])-mediated reversible crosslinking of polysaccharides possess intrinsic stimuliresponsiveness towards competitive guests and have been extensively investigated to fabricate various particles and hydrogels for multiple stimuli-re sponsive drug release by incorpo ration with other stimuli including photo,redox,and enzyme.Through host-guest interactions between CB[6]and aliphatic diamines,functional tags covalently connected with CB[6]can be readily anchored into polysaccharidebased hydrogels,realizing multiple functionalization.The rheological prope rty and drug release profile of polysaccharide-based supramolecular hydrogels can be facilely tuned through CB[8]-mediated dyna mic homo or hetero crosslinking of polysaccharides and/or other polymers.In this review,we introduce and summarize recent progress regarding polysaccharide-based supramolecular drug delivery systems mediated via host-guest interactions of CB[6]and CB[8],covering both bulk hydrogels and particular systems.At the end,possible utilization of CB[7]-based host-guest interactions in constructing polysaccharide-based drug delivery systems and future perspectives of this research direction are also discussed. | Yiyun Gao Yan Gao Yuanfu Ding Huaping Tan Aihua Zou Shengke Li | 2021 | Chinese Chemical Letters2021，32，3： | 0 |
| 11 | Aberrant nuclear lamina contributes to the malignancy of human gliomas显示文摘Glioma is the most common type of tumor in the central nervous system, accounting for around 80% of all malignant brain tumors. Previous studies showed a significant association between nuclear morphology and the malignant progress of gliomas. By virtue of integrated proteomics and genomics analyses as well as experimental validations, we identify three nuclear lamin genes(LMNA, LMNB1, and LMNB2) that are significantly upregulated in glioma tissues compared with normal brain tissues. We show that elevated expressions of LMNB1, LMNB2, and LMNA in glioma cells are highly associated with the rapid progression of the disease and the knockdown of LMNB1, LMNB2, and LMNA dramatically suppresses glioma progression in both in vitro and in vivo mouse models. Moreover, the repression of glioma cell growth by lamin knockdown is mediated by the p Rb-mediated G1-S inhibition. On the contrary, overexpression of lamins in normal human astrocytes dramatically induced nuclear morphological aberrations and accelerated cell growth. Together, our multi-omics-based analysis has revealed a previously unrecognized role of lamin genes in gliomagenesis, providing a strong support for the key link between aberrant tumor nuclear shape and the survival of glioma patients. Based on these findings, lamins are proposed to be potential oncogene targets for therapeutic treatments of brain tumors. | Shunqi Pei Xuehui Wang Xuan Wang Hao Huang Huaping Tao Binghua Xie Aifen Yang Mengsheng Qiu Zhou Tan | 2022 | Journal of Genetics and Genomics2022，49，2： | 0 |
| 12 | Supramolecular nano drug delivery systems mediated via host-guest chemistry of cucurbit[n]uril(n=6 and 7)显示文摘As a novel family of macrocyclic molecules,cucurbit[n]urils(CB[n]s) have emerged as promising building blocks of supramolecular nano drug delivery systems(SNDDS) in recent years.Direct encapsulation of amphiphilic guests by CB[6] and CB[7] can modulate their amphiphilicity,resulting in formation of supramolecular amphiphiles that self-assemble into supramolecular nanoparticles for drug delivery.Additionally,CB[n]'s host-guest chemistry on the surface of mesoporous nanoparticles makes CB[n] an ideal blocking agent to control drug release from delivery vehicles.These SNDDS possess intrinsic stimuli responsiveness towards external guest or host,which can further incorporate re s ponsiveness to a variety of other stimuli including pH,thermal,redox,photo and enzyme,to realize multiple stimuli-responsive drug release.Moreover,the recent breakthrough in direct functionalization of CB[n]s has provided a feasible method for preparing superior CB[6] and CB[7] derivatives that can be employed to build multifunctional SNDDS with unoccupied macrocycles located on surface,which could be decorated with various functional 'tags' through host-guest chemistry.In this review,we summarized the recent progress of CB[6] and CB[7] based SNDDS through formation of supramolecular amphiphiles,supramolecular nanovalves as well as supramolecularly tailorable surface,which we hope to further promote the development of CB[n]s family as building blocks for advanced SNDDS. | Shengke Li Yan Gao Yuanfu Ding Anni Xu Huaping Tan | 2021 | Chinese Chemical Letters2021，32，1： | 0 |
| 13 | Selenium-Sulfur-Doped Carbon Dots with Thioredoxin Reductase Activity显示文摘Thioredoxin reductase(TrxR)is an essential enzyme for regulating the redox balance in cells,promoting cell proliferation,and inhibiting cellular apoptosis.The biochemical pathway of TrxR metabolism involves a series of selenium-sulfur(Se-S)dynamic chemistry.Theoretically,nanomaterials with Se-S dynamic bonds could exhibit TrxRmimetic activities to tune TrxR activity,affecting cellular activities.Herein,we report the fabrication of Se-S-doped carbon dots(Se-S-CDs),synthesized by a facile hydrothermal method.The Se-S-CDs exhibited good stability and solubility in an aqueous solution,with a quantum yield of 13.27%.The doping of Se-S bonds endowed the Se-S-CDs with great capability of enhancing the TrxR activity,and consequently,a remarkable promotion of cell viability.The significance of Se-S bonds,as well as CDs’role as matrices,are discussed.Moreover,the Se-S-CDs could also revive the cells from the damage induced by oxidative stress.The abovementioned properties demonstrated the potential of the Se-S-CDs for cells and tissues culturing,solving the poor cell viability issue,which is desperately needed for organ transplantation and revitalization of prematurely aging cells,especially those exposed to oxidative stress. | Luo Zhang Chenxing Sun Yizheng Tan Huaping Xu | 2022 | CCS Chemistry2022，4，7： | 0 |
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