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| 1 | Electrospun poly(vinylidene fluoride-trifluoroethylene)/ zinc oxide nanocomposite tissue engineering scaffolds with enhanced cell adhesion and blood vessel formation显示文摘响应机械紧张产生电的信号的压电的材料能在设计刺激房间增长的织物被使用。Poly (vinylidene fluoride-trifluoroethylene )(P (VDF-TrFE )) ,压电的聚合物,广泛地在 biomaterial 应用被使用。我们假设了进 P (VDF-TrFE ) 矩阵的 nanoparticles 能支持的锌氧化物(ZnO ) 的那加入房间的粘附,移植,和增长,以及血容器形成(angiogenesis ) 。在这研究,我们制作了并且包括地描绘了新奇 electrospun P (VDF-TrFE )/ZnO nanocomposite 织物设计支架。我们由扫描电子显微镜学分析了聚合矩阵的词法特征,并且利用了红外线的光谱学, X 光检查衍射,和检验的微分扫描热量测定由于 nanoparticles 的增加在共聚物的水晶的阶段改变的 Fourier 变换。我们不检测了,显示 P (VDF-TrFE )/ZnO nanocomposite 脚手架对设计应用的织物合适或关于在 vitro, biocompatibility,和 cytotoxicity 的血相容性的 biomaterials 的最小的不利效果。有趣地,人的间充质的干细胞(hMSCs ) 和在 nanocomposite 脚手架上有教养的人的脐的静脉 endothelial 房间与在织物文化盘子或整洁的 P (VDF-TrFE ) 上有教养的房间相比展出了更高的房间生存能力,粘附,和增长脚手架。植入进老鼠与或没有 hMSCs 的 Nanocomposite 脚手架没得到免疫学的回答,由宏观的分析和组织学估计了。重要地, nanocomposite 脚手架支持了 angiogenesis,它在脚手架被增加与 hMSCs 预先播种。总的来说,我们的结果在织物工程为使用加亮这些新奇 P (VDF-TrFE )/ZnO nanocomposites 的潜力,由于他们支持房间粘附和 angiogenesis 的 biocompatibility 和能力。 | Robin Augustine Pan Dan Alejandro Sosnik Nandakumar Kalarikkal Nguyen Tran Brice Vincent Sabu Thomas Patrick Menu Didier Rouxel | 2017 | Nano Research2017，10，10： | 8 |
| 2 | Polymeric nanocarriers for nose-to-brain drug delivery in neurodegenerative diseases and neurodevelopmental disorders显示文摘Neurodegenerative diseases are progressive conditions that affect the neurons of the central nervous system(CNS)and result in their damage and death.Neurodevelopmental disorders include intellectual disability,autism spectrum disorder,and attention-deficit/hyperactivity disorder and stem from the disruption of essential neurodevelopmental processes.The treatment of neurodegenerative and neurodevelopmental conditions,together affecting~120 million people worldwide,is challenged by the blood—brain barrier(BBB)and the blood—cerebrospinal fluid barrier that prevent the crossing of drugs from the systemic circulation into the CNS.The nose-to-brain pathway that bypasses the BBB and increases the brain bioavailability of intranasally administered drugs is promising to improve the treatment of CNS conditions.This pathway is more efficient for nanoparticles than for solutions,hence,the research on intranasal nano-drug delivery systems has grown exponentially over the last decade.Polymeric nanoparticles have become key players in the field owing to the high design and synthetic flexibility.This review describes the challenges faced for the treatment of neurodegenerative and neurodevelopmental conditions,the molecular and cellular features of the nasal mucosa and the contribution of intranasal nano-drug delivery to overcome them.Then,a comprehensive overview of polymeric nanocarriers investigated to increase drug bioavailability in the brain is introduced. | Rania Awad Avi Avital Alejandro Sosnik | 2023 | Acta Pharmaceutica Sinica B2023，13，5： | 2 |
| 3 | Sodium and epithelial sodium channels participate in the regulation of the capacitation - associated hyperpolarization in mouse sperm 显示文摘 | HERNANDEZ GONZALEZ E O SOSNIK J EDWARDS J | 2006 | J Biol Chem2006，281，9： | 1 |
| 4 | Transformarion from temporal to rate coding in a somatosensory thalamocortical pathway显示文摘 | Ehud Ahissar Ronen Sosnik Sebastian Haidarliu | 2000 | Nature2000，406，： | 1 |
| 5 | New old challenges in tuberculosis:potentially effective nanotechnologies in drug delivery显示文摘 | Sosnik A Carcaboso AM Glisoni RJ | | 0，，4： | 1 |
| 6 | Nanoteehnology solutions for infectious diseases in developing nations显示文摘 | SOSNIK A AMIJI M | 2010 | Adv Drug Del Rev2010，62，3： | 1 |
| 7 | Poly(ethylene oxide)-poly(propylene oxide)block copolymer micelles as drug delivery agents:Improved hydrosolubility,stability and bioavailability of drugs显示文摘 | Chiappetta DA Sosnik A | | 0，，03： | 1 |
| 8 | Drug de- livery systems in HIV phammcotherapy: What has been done and the challenges standing ahead 显示文摘 | SOSNIK A CHIAPPETTA D A CARCABOSO A M | 2009 | J Controlled Release2009，138，1： | 1 |
| 9 | New old challenges in tuberculosis: Potentially effective nanotechnologies in drug delivery 显示文摘 | SOSNIK A CARCABOSO A M GLISONI R J | 2010 | Adv Drug Del Rev2010，62，4： | 1 |
| 10 | Transformation from temporal to rate coding in a somatosensory thalamocortical pathway显示文摘 | Ahissar E Sosnik R Haidarliu S | 2000 | Nature2000，406，6793： | 1 |
| 11 | PEO-PPO-PEO-based poly ( ether ester urethane)s as degradable reverse thermo-responsive multiblock copolyraers 显示文摘 | Cohn D Lando G Sosnik A | 2006 | Biomaterials2006，27，： | 1 |
| 12 | Poly (ethylene glycol)-poly (epsilon- caprolactone) block oligomers as injectable materials 显示文摘 | SOSNIK A COHN D | 2003 | Polymer2003，44，23： | 1 |
| 13 | Sodium and epithelial sodium channels participate in the regulation of the capacitation-associated hyperpolarization in mouse sperm显示文摘 | Hernandez-Gonzalez EO Sosnik J Edwards J | 2006 | J Biol Chem2006，281，9： | 1 |
| 14 | Effect of superovufation on lactating Holsteins显示文摘 | Cowon P Sosnik U | 1987 | Theriogenology1987，，28： | 1 |
| 15 | PEO-PPO-PEO-based poly (ether ester urethane)s as degradable reverse ther- mo-responsive multibloek copolymers显示文摘 | Cohn D Lando G Sosnik A | 2006 | Biomaterials2006，27，9： | 1 |
| 16 | Downregulation of mdrl and abcg2 genes is a mechanism of inhibition of efflux pumps mediated by polymeric amphiphiles显示文摘 | Cuestas ML Castillo AI Sosnik A | 2012 | Bioorg Med Chem Lett2012，22，21： | 1 |
| 17 | Mi- crowave-assisted polymer synthesis (MAPS) as a tool in biomaterials science~ How new and how powerful显示文摘 | Alejandro Sosnik Gustavo Gotelli Gustavo A Abraham | 2010 | Prog Polym Sci2010，14，： | 1 |
| 18 | Microwave-assisted Polymer Synthesis (MAPS) as aTool in Biomaterials Science: How New and How Powerful显示文摘 | Sosnik A Gotelli G Abraham G A | 2011 | Progress in Polymer Science2011，36，： | 1 |
| 19 | Improved reverse thermo-responsive polymeric systems显示文摘 | Cohn D Sosnik A Levy A | 2003 | Biomaterials2003，24，21： | 1 |
| 20 | Ethoxysilane-capped PEO-PPO-PEO triblocks:a new family of reverse thermo-responsive polymers显示文摘 | Sosnik A Cohn D | 2004 | Biomaterials2004，25，14： | 1 |
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