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| 1 | Hepatitis B virus X protein induces hepatic stem cell-like features in hepatocellular carcinoma by activating KDM5B显示文摘AIM To determine the role of hepatitis B virus X protein(HBx), HBx in regulating hepatic progenitor cell(HPC)-like features in hepatocellular carcinoma(HCC) and the underlying molecular mechanisms.METHODS We used a retrovirus vector to introduce wild type HBx or empty vector into Hep G2 cells. We then used these cells to analyze cell proliferation, senescence, transformation, and stem-like features. Gene expression profiling was carried out on Affymetrix GeneC hip Human U133A2.0 ver.2 arrays according to the manufacturer's protocol. Unsupervised hierarchical clustering analysis and Class Comparison analysis were performed by BRB-Array Tools software Version 4.2.2. A total of 238 hepatitis B virus(HBV)-related HCC patients' array data were used for analyzing clinical features.RESULTS The histone demethylase KDM5 B was significantlyhighly expressed in HBV-related HCC cases(P < 0.01). In HBV proteins, only HBx up-regulated KDM5 B by activating c-myc. Hepatic stem cell(Hp SC) markers(EpC AM, AFP, PROM1, and NANOG) were significantly highly expressed in KDM5B-high HCC cases(P < 0.01). KDM5 B played an important role in maintaining HpS Clike features and was associated with a poor prognosis. Moreover, inhibition of KDM5 B suppressed spheroid formation and cell invasion in vitro.CONCLUSION HBx activates the histone demethylase KDM5 B and induces HPC-like features in HCC. Histone demethylases KDM5 B may be an important therapeutic target against HBV-related HCC cases. | Xuyang Wang Naoki Oishi Tetsuro Shimakami Taro Yamashita Masao Honda Seishi Murakami Shuichi Kaneko | 2017 | World Journal of Gastroenterology2017，23，18： | 10 |
| 2 | Effect of hepatitis C virus(HCV)NS5B-nucleolin interaction on HCV replication with HCV subgenomic replicon显示文摘 | Shimakami T Honda M Kusakawa T Murata T Shimotohno K Kaneko S Murakami S | | 0，，07： | 1 |
| 3 | Hepatitis C:recent successes and continuing challenges in the development of improved treatment modalities显示文摘 | Shimakami T Lanford R E Lemon S M | | 0，，05： | 1 |
| 4 | Effect of hepatitis C virus (HCV) NS5B-nueleolin interaction on HCV replication with HCV subgenomic replieon显示文摘 | Shimakami T Honda M Kusakawa T Murata T | 2006 | J Virol2006，80，7： | 1 |
| 5 | Effect of interaction between hepatitis C virus NSSA and NS5B on hepatitis C virus RNA replication with the hepatitis C virus replicon 显示文摘 | Shimakami T Hijikata M Luo H | 2004 | J Virol2004，78，6： | 1 |
| 6 | Two cases of a nonfunctioning pancreatic endocrine tumor found on a medical checkup显示文摘 | Nio K Shimakami T Yamashita T | | 0，，： | 1 |
| 7 | Effect of hepatitis C virus (HCV)NS5B- nucleolin interaction on HCV replication with HCV subgenomicreplicon 显示文摘 | Shimakami T Honda M Kusakawa T | 2006 | J Virol2006，80，7： | 1 |
| 8 | Effect of interac- tion between hepatitis C virus NS5A and NS5B on hepati- tis C virus RNA replication with the hepatitis C virus replicon显示文摘 | Shimakami T Hijikata M Luo H | 2004 | J Virol2004，7，8： | 1 |
| 9 | Malnutrition Impairs Interferon Signaling Through mTOR and FoxO Pathways in Patients With Chronic Hepatitis C显示文摘 | Masao Honda Kenji Takehana Akito Sakai Yusuke Tagata Takayoshi Shirasaki Shinobu Nishitani Takahiko Muramatsu Tatsuya Yamashita Yasunari Nakamoto Eishiro Mizukoshi Yoshio Sakai Taro Yamashita Mikiko Nakamura Tetsuro Shimakami MinKyung Yi Stanley M. Lemon | 2011 | Gastroenterology2011，，1： | 1 |
| 10 | Effect of interaction between hepatitis C virus NS5A and NS5B on hepatitis C virus RNA replication with the hepatitis C virus replicon显示文摘 | Shimakami T Hijikata M Luo H | 2004 | J Virol2004，78，： | 1 |
| 11 | Hepatitis C: recent successes and continuing challenges in the development of improved treatment modalities显示文摘 | Shimakami T Lanford R Lemon S | 2009 | Curr opin pharmacol2009，9，5： | 1 |
| 12 | Effect of interaction between hepatitis C virus NS5A and NS5B on hepatitis C virus RNA replication with the hepatitis C Virus replicon显示文摘 | Shimakami T Hijikata M Luo H | 2004 | J Virol2004，78，6： | 1 |
| 13 | Hepatic interferon stimula- ted genes are differentially regulated in the liver of chronic hepatitis C patients with different interleukin - 28B genotypes 显示文摘 | Honda M Shirasaki T Shimakami T | 2014 | Hepatology2014，59，： | 1 |
| 14 | Effect of interaction between hepatitis C virus NS5A and NS5B on hepatitis C virus RNA replication with the hepatitis C virus replicon 显示文摘 | SHIMAKAMI T HIJIKATA M LUO H | 2004 | J Virol2004，78，6： | 1 |
| 15 | MicroRNA-27a reg-ulates lipid metabolism and inhibits hepatitis C virus replication in human hepatoma cells 显示文摘 | Shirasaki T Honda M Shimakami T | 2013 | J Virul2013，87，9： | 1 |
| 16 | Hepatitis C, recent successes and continuing challenges in the development of improved treatment modalities 显示文摘 | Shimakami T Lanford RE Lemon SM | 2009 | Curr Opin Pharmacol2009，9，5： | 1 |
| 17 | Hepatitis C: recent successes and continuing challenges in the development of improved treatment modalities显示文摘 | Tetsuro Shimakami Robert E Lanford Stanley M Lemon | 2009 | Current Opinion in Pharmacology2009，，5： | 1 |
| 18 | Hepatitis C :recent successes and continuing challenges in the development of improved treatment modalities显示文摘 | Shimakami T Lanford RE Lemon SM | 2009 | Curr Opin Pharmacol2009，9，5： | 1 |
| 19 | Effect of interaction between hepatitis C virus NSSA and NSSB on hepatitis C virus RNA replication with the hepatitis C virus replicon显示文摘 | Hijikata M Luo H | 2004 | J Virol2004，78，6： | 1 |
| 20 | Effect of hepatitis C virus (HCV) NS5B-nucleolin interaction on HCV replication with HCV subgenomic replicon 显示文摘 | Shimakami T Honda M Kusakawa T Murata T Shimotohno K Kaneko S Murakami S | 2006 | J Virol2006，80，7： | 1 |
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