|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Effect of intestinal ischemia-reperfusion on expressions of endogenous basic fibroblast growth factor and transforming growth factor β in lung and its relation with lung repair显示文摘AIM To study the changes of endogenoustransforming growth factor β(TGFβ)and basicfibroblast growth factor(bFGF)in lung followingintestinal ischemia and reperfusion injury andtheir effects on lung injury and repair.METHODS Sixty Wistar rats were divided intofive groups,which underwent sham-operation,ischemia(45 minutes),and reperfusion(6,24and 48 hours,respectively)after ischemia(45minutes).Immunohistochemical method wasused to observe the localization and amounts ofboth growth factors.RESULTS Positive signals of both growthfactors could be found in normal lung,mainly inalveolar cells and endothelial cells of vein.Afterischemia and reperfusion insult,expressions ofboth growth factors were increased and theiramounts at 6 hours were larger than those ofnormal control or of 24 and 48 hours after insult.CONCLUSION The endogenous bFGF and TGF βexpression appears to be up-regulated in thelung following intestinal ischemia andreperfusion,suggesting that both growth factorsmay be involved in the process of lung injury andrepair. | Xiao Bing Fu Yin Hui Yang Tong Zhu Sun Xiao Man Gu Li Xian Jiang Xiao Oing Sun Zhi Yong Sheng Research Laboratory,304th Hospital of PLA,Beijing 100037,China | 2000 | World Journal of Gastroenterology2000，6，3： | 21 |
| 2 | Association of Dietary Pattern during Pregnancy and Gestational Diabetes Mellitus: A Prospective Cohort Study in Northern China显示文摘Objective To examine the association of maternal dietary patterns during pregnancy with gestational diabetes mellitus(GDM) in northern China.Methods The dietary intakes of pregnant women were recorded twice by 24‐hour dietary recalls for three days prior to having been diagnosed with GDM, at 5‐15 and 24‐28 gestational weeks, respectively.GDM was diagnosed, and serum glycosylated hemoglobin(HbA1c) was measured at 24‐28 weeks.Dietary patterns were assessed by factor analysis. The association of the dietary pattern with GDM and HbA1c was examined by multiple logistic models.Results Of 753 participants, 64(8.5%) were diagnosed with GDM. Four dietary patterns were identified: Western pattern(dairy, baked/fried food and white meat), traditional pattern(light‐colored vegetables, fine grain, red meat and tubers), mixed pattern(edible fungi, shrimp/shellfish and red meat)and prudent pattern(dark‐colored vegetables and deep‐sea fish). Compared with the prudent pattern,both the Western pattern and the traditional pattern were associated with an increased risk of GDM(a OR = 4.40, 95% CI: 1.58‐12.22; a OR = 4.88, 95% CI: 1.79‐13.32) and a high level of HbA1c(a OR = 12.37,95% CI: 1.47‐103.91; a OR = 26.23, 95% CI: 2.54‐270.74). Compared to the lowest quartile(Q), Q3 of the Western pattern scores and Q3‐Q4 of the traditional pattern scores were associated with a higher risk of GDM.Conclusion The consumption of the Western pattern or the traditional pattern during pregnancy may increase the risk of GDM. | DU Hong Yi JIANG Hong O Karmin CHEN Bo XU Lin Ji LIU Shu Ping YI Jian Ping HE Geng Sheng QIAN Xu | 2017 | Biomedical and Environmental Sciences2017，30，12： | 16 |
| 3 | 大气二氧化氮与每日总死亡率、心血管和呼吸系统疾病死亡率的短期关联:398个城市的多中心分析显示文摘目的:采用统一的分析方案,评估全球多个国家/地区的二氧化氮(NO_(2))与总死亡率、心血管和呼吸系统疾病死亡率之间的短期关联。研究设计:采用两阶段的时间序列分析方法、过度离散的广义线性模型和多水平meta分析。研究地点:22个低到高收入国家/地区的398个城市。主要结局指标:1973—2018年逐日总死亡人数(6280万人)、心血管疾病死亡人数(1970万人)和呼吸系统疾病死亡人数(550万人)。结果:平均而言,NO_(2)浓度在滞后1天(前1天)每增加10μg/m^(3),会导致总死亡率、心血管和呼吸系统疾病死亡率分别增加0.46%(95%可信区间0.36%~0.57%)、0.37%(0.22%~0.51%)、0.47%(0.21%~0.72%)。在对共污染物(PM_(10)、PM_(2.5)、臭氧、二氧化硫和一氧化碳)进行调整后,这些关联仍然很稳定。所有3种死因的暴露-反应曲线几乎是线性的,没有明显的阈值。在398个城市中,可归因于高过假定零水平的NO_(2)浓度造成的死亡比例为1.23%(95%可信区间0.96%~1.51%)。结论:这项多中心研究提供了关于NO_(2)短期暴露与总死亡率、心血管和呼吸系统死亡风险之间的独立和线性关联的关键证据,说明通过加强NO_(2)的控制和监管限制标准,可获得人群水平的健康收益。 | 孟夏 刘聪(校) 陈仁杰 郑湃(译) 阚海东(校) Francesco Sera Ana Vicedo-Cabrera Ai Milojevic Maria Guo Yuming Tong Shilu Micheline de Sousa Zanotti Stagliorio Coelh Paulo Hilario Nascimento Saldiva Eric Lavigne Patricia Matus Correa Nicolas Valdes Ortega Samuel Osorio Garcia Jan Kysely Ales Urban Hans Orru Marek Maasikmets Jouni J K Jaakkola Niilo Ryti Veronika Huber Alexandra Schneider Klea Katsouyanni Antonis Analitis Masahiro Hashizume Yasushi Honda Chris Fook Sheng Ng Baltazar Nunes João Paulo Teixeira Iulian Horia Holobaca Simona Fratianni Ho Kim Aurelio Tobias Carmeníniguez Bertil Forsberg ChristoferÅström Martina S Ragettli Yue-Liang Leon Guo Shih-Chun Pan Shanshan Li Michelle L Bell Antonella Zanobetti Joel Schwartz Tangchun Wu Antonio Gasparrini | 2021 | 英国医学杂志中文版2021，24，8： | 7 |
| 4 | Polysaccharide-based nanomedicines for cancer immunotherapy:A review显示文摘Cancer immunotherapy is an effective antitumor approach through activating immune systems to eradicate tumors by immunotherapeutics.However,direct administration of“naked”immunotherapeutic agents(such as nucleic acids,cytokines,adjuvants or antigens without delivery vehicles)often results in:(1)an unsatisfactory efficacy due to suboptimal pharmacokinetics;(2)strong toxic and side effects due to low targeting(or off-target)efficiency.To overcome these shortcomings,a series of polysaccharide-based nanoparticles have been developed to carry immunotherapeutics to enhance antitumor immune responses with reduced toxicity and side effects.Polysaccharides are a family of natural polymers that hold unique physicochemical and biological properties,as they could interact with immune system to stimulate an enhanced immune response.Their structures offer versatility in synthesizing multifunctional nanocomposites,which could be chemically modified to achieve high stability and bioavailability for delivering therapeutics into tumor tissues.This review aims to highlight recent advances in polysaccharide-based nanomedicines for cancer immunotherapy and propose new perspectives on the use of polysaccharide-based immunotherapeutics. | Yujun Zeng Yufan Xiang Ruilong Sheng Helena Tomás João Rodrigues Zhongwei Gu Hu Zhang Qiyong Gong Kui Luo | 2021 | Bioactive Materials2021，6，10： | 3 |
| 5 | The influence of sulphate reducing bacteria biofilm on the corrosion of stainless steel AISI 316显示文摘 | SHENG Xiao-xia TING Yen-peng PEHKONEN S O | 2007 | Corrosion Science2007，49，5： | 1 |
| 6 | Seasonal changes in nutrient concentrations of ‘Newhall’and ‘Skagg’s Bonanza’ navel oranges显示文摘 | Sheng O Yan X Peng S A | 2009 | Communications in Soil Science and Plant Analysis2009，40，1920： | 1 |
| 7 | Urban consolidation and house prices: a case study of Melbourne 1990–2004显示文摘 | Sun Sheng Han Kevin O'Connor | | GeoJournal0，，： | 1 |
| 8 | The influence of ionic strength, nutrients and pH on bacterial adhesion to metals 显示文摘 | Sheng X X Ting Y P Pehkonen S O | 2008 | Journal of Colloid and Interface Science2008，321，： | 1 |
| 9 | Uptake of trifruralin and Lindane from water by rtyegrass显示文摘 | LI H SHENG G SHENG W XU O | 2002 | Chemosphere2002，48，： | 1 |
| 10 | A large eddy PIV method for turbulence dissipation rate estimation显示文摘 | SHENG J MENG H FOX R O | 2000 | Chem Eng Sci2000，55，20： | 1 |
| 11 | Seasonal Changes in Nutrient Concentrations of ' Newhall' and ' Skagg's Bonanza' Navel Oranges显示文摘 | Sheng O Yan X Peng S A | 2009 | Communications in soil science and plant analysis2009，40，1920： | 1 |
| 12 | Infection of primary hu- man microglia and monocyte-derived macrophages with human immunodeficiency virus type 1 isolates: evidence of differential tropism显示文摘 | Strizki J M Albright A V Sheng H O'Connor M Perrin L Gonzdlez-Scarano F | 1996 | J Virol1996，70，11： | 1 |
| 13 | A sophisticated parallel MLFMA for scattering by extremely large targets显示文摘 | PAN X M SHENG X O | 2008 | IEEE antennas and magzine2008，50，3： | 1 |
| 14 | Evaluation of an organic corrosion inhibitor on abiotic corrosion and microbiologically influenced corrosion of mild steel显示文摘 | Sheng X Ting Y P Pehkonen S O | 2007 | Ind Eng Chem Res2007，46，22： | 1 |
| 15 | Stability and optimal feedback controls for time-delayed linear periodic systems 显示文摘 | SHENG Jie ELBEYLI O SUNG Jian-Qiao | 2004 | AIAA Journal2004，42，5： | 1 |
| 16 | Comparing BP and ARt II neural network classifiers for facility location显示文摘 | Colin O Benjamin Sheng - Chai Chi Tarek Gaber Catherine A Riordan | 1995 | Computers & Industrial Engineering1995，28，1： | 1 |
| 17 | Robust and adaptive backstepping control for nonlinear systems using RBF neural networks 显示文摘 | LI Yahui SHENG Qiang ZHUANG Xianyi KANYNAK O | 2004 | IEEE Trans Neural Networks2004，15，3： | 1 |
| 18 | Examining the Technology Acceptance Model Using Physician Acceptance of Telemedicine Technology显示文摘 | Hu P J Chau P Y K Sheng O R L and Tam K Y | 1999 | Journal of Management Information Systems(16:2)1999，，： | 1 |
| 19 | Effects of exogenous B supply on growth, B accumulation and distribution of two navel orange cultivars显示文摘 | Sheng O Song S W Chen Y J | 2009 | Trees2009，23，： | 1 |
| 20 | Examining the technology acceptance model using physician acceptance of telemedicine technology 显示文摘 | Hu P J Chau P Y K Sheng O R L Tam K Y | 1999 | Journal of Management Information Systems1999，16，2： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员