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| 1 | Tribenuron-Methyl Induces Male Sterility through Anther-Specific Inhibition of Acetolactate Synthase Leading to Autophagic Cell Death显示文摘Tribenuron 甲基(TM ) 是禁止分支链的强大的 sulfonylurea 除草剂由指向 acetolactate synthase (ALS ) 的催化子单元(CSR1 ) 的氨基酸(BCAA ) 生合成。由在低剂量的 TM 的叶的喷洒的男绝育的选择正式就职广泛地在油菜籽(Brassica 马来麝) 为混合种子生产被使用了;然而,内在的机制仍然保持未知。这里,我们 reportgreater TM 累积和在花药的 BCAA 饥饿比在在 TM 申请以后的叶子和茎。csr1-1D (aCSR1 异种) 的组成或花药特定的表示消除了花药选择的 ALS 抑制并且在油菜籽和 Arabidopsis 颠倒了导致 TM 的男无菌的显型。TM 涂抹茎实验的结果,在叶肉或韧皮部由 TM 新陈代谢基因 Bel 的指向的表示在导致 TM 的男绝育的花药和回复与很少 TM 累积的观察结合了,建议叶水花的 TM 通过叶肉和韧皮部主要对花药极运输。显微镜学和 immunoblotting 揭示了那 autophagy,在房间死亡期间导致的一个体积降级过程,在导致 TM 的男无菌的花药并且由被提高花药特定 ALS 击倒。而且,导致 TM 的花粉流产被 autophagy 禁止者 3 麻省显著地禁止。这些数据最终建议 TM 对花药极运输,导致经由花药特定的 ALS 抑制的 BCAA 饥饿并且,,在花药的 autophagic 房间死亡。 | Lun Zhao Xue Jing Li Chen Yingjun Liu Yanan Su Tingting Liu Changbin Gao Bin Yi Jing Wen Chaozhi Ma Jinxing Tu Jitao Zou Tingdong Fu Jinxiong Shen | 2015 | Molecular Plant2015，8，12： | 7 |
| 2 | Patient-derived non-small cell lung cancer xenograft mirrors complex tumor heterogeneity显示文摘Objective:Patient-derived xenograft(PDX)models have shown great promise in preclinical and translational applications,but their consistency with primary tumors in phenotypic,genetic,and pharmacodynamic heterogeneity has not been well-studied.This study aimed to establish a PDX repository for non-small cell lung cancer(NSCLC)and to further elucidate whether it could preserve the heterogeneity within and between tumors in patients.Methods:A total of 75 surgically resected NSCLC specimens were implanted into immunodeficient NOD/SCID mice.Based on the successful establishment of the NSCLC PDX model,we compared the expressions of vimentin,Ki67,EGFR,and PD-L1 proteins between cancer tissues and PDX models using hematoxylin and eosin staining and immunohistochemical staining.In addition,we detected whole gene expression profiling between primary tumors and PDX generations.We also performed whole exome sequencing(WES)analysis in 17 first generation xenografts to further assess whether PDXs retained the patient heterogeneities.Finally,paclitaxel,cisplatin,doxorubicin,atezolizumab,afatininb,and AZD4547 were used to evaluate the responses of PDX models to the standard-of-care agents.Results:A large collection of serially transplantable PDX models for NSCLC were successfully developed.The histology and pathological immunohistochemistry of PDX xenografts were consistent with the patients’tumor samples.WES and RNA-seq further confirmed that PDX accurately replicated the molecular heterogeneities of primary tumors.Similar to clinical patients,PDX models responded differentially to the standard-of-care treatment,including chemo-,targeted-and immuno-therapeutics.Conclusions:Our established PDX models of NSCLC faithfully reproduced the molecular,histopathological,and therapeutic characteristics,as well as the corresponding tumor heterogeneities,which provides a clinically relevant platform for drug screening,biomarker discovery,and translational research. | Xuanming Chen Cheng Shen Zhe Wei Rui Zhang Yongsheng Wang Lili Jiang Ke Chen Shuang Qiu Yuanli Zhang Ting Zhang Bin Chen Yanjun Xu Qiyi Feng Jinxing Huang Zhihui Zhong Hongxia Li Guowei Che Kai Xiao | 2021 | Cancer Biology & Medicine2021，18，1： | 5 |
| 3 | Bibliometric analysis and system review of vehicle routing optimization for emergency material distribution显示文摘Determining the optimal vehicle routing of emergency material distribution(VREMD)is one of the core issues of emergency management,which is strategically important to improve the effectiveness of emergency response and thus reduce the negative impact of large-scale emergency events.To summarize the latest research progress,we collected 511VREMD-related articles published from 2010 to the present from the Scopus database and conducted a bibliometric analysis using VOSviewer software.Subsequently,we cautiously selected 49 articles from these publications for system review;sorted out the latest research progress in model construction and solution algorithms;and summarized the evolution trend of keywords,research gaps,and future works.The results show that domestic scholars and research organizations held an unqualified advantage regarding the number of published papers.However,these organizations with the most publications performed poorly regarding the number of literature citations.China and the US have contributed the vast majority of the literature,and there are close collaborations between researchers from both countries.The optimization model of VREMD can be divided into single-,multi-,and joint-objective models.The shortest travel time is the most common optimization objective in the single-objective optimization model.Several scholars focus on multiobjective optimization models to consider conflicting objectives simultaneously.In recent literature,scholars have focused on the impact of uncertainty and special events(e.g.,COVID-19)on VREMD.Moreover,some scholars focus on joint optimization models to optimize vehicle routes and central locations(or material allocation)simultaneously.Solution algorithms can be divided into two primary categories,i.e.,mathematical planning methods and intelligent evolutionary algorithms.The branch and bound algorithm is the most dominant mathematical planning algorithm,while genetic algorithms and their enhancements are the most commonly used intelligent evolutionary algorithms.It is shown that the nondominated sorting genetic algorithmⅡ(NSGA-Ⅱ)can effectively solve the multiobjective model of VREMD.To further improve the algorithm’s performance,researchers have proposed improved hybrid intelligent algorithms that combine the advantages of NSGA-Ⅱand certain other algorithms.Scholars have also proposed a series of optimization algorithms for specific scenarios.With the development of new technologies and computation methods,it will be exciting to construct optimization models that consider uncertainty,heterogeneity,and temporality for large-scale real-world issues and develop generalized solution approaches rather than those applicable to specific scenarios. | Jinxing Shen Kun Liu Changxi Ma Yongpeng Zhao Chuwei Shi | 2022 | Journal of Traffic and Transportation Engineering(English Edition)2022，9，6： | 5 |
| 4 | Admissibility analysis and control synthesis for switched linear singular systems显示文摘The problem of admissibility analysis and control synthesis of discrete-time switched linear singular (SLS) systems for arbitrary switching laws is solved.By using the switched Lyapunov function approach,some new sufficient conditions under which the SLS system is admissible for arbitrary switching laws are derived in terms of linear matrix inequalities(LMIs).Based on the admissibility results,control synthesis is then to design switched state feedback and static output feedback controllers,guaranteeing that the resulting closed-loop system is admissible.The presented results can be viewed as the extensions of previous works on switched Lyapunov function approach from the regular switched systems to singular switched cases.Examples are provided to demonstrate the reduced conservatism and effectiveness of the proposed conditions. | Lin Jinxing Fei Shumin Shen Jiong | 2009 | Journal of Systems Engineering and Electronics2009，20，5： | 4 |
| 5 | Three-dimensional reconstruction of Picea wilsonii Mast. pollen grains using automated electron microscopy显示文摘Three-dimensional electron microscopy(3 D-EM) has attracted considerable attention because of its ability to provide detailed information with respect to developmental analysis. However, large-scale high-resolution 3 D reconstruction of biological samples remains challenging. Herein, we present a 3 D view of a Picea wilsonii Mast. pollen grain with 100 nm axial and38.57 nm lateral resolution using AutoCUTS-SEM(automatic collector of ultrathin sections-scanning electron microscopy). We established a library of 3,127 100 nm thick serial sections of pollen grains for preservation and observation, demonstrating that the protocol can be used to analyze large-volume samples. After obtaining the SEM images, we reconstructed an entire pollen grain comprising 734 serial sections. The images produced by 3D reconstruction clearly revealed the main components of the P.wilsonii pollen grain, i.e., two sacci and pollen corpus, tube cell, generative cell, and two degenerated prothallial cells, and their internal organization. In addition, we performed a quantitative analysis of the different pollen grain cells, including sacci, and found that there were 202 connections within a saccus SEM image. Thus, for the first time, this study provided a global 3D view of the entire pollen grain, which will be useful for analyzing pollen development and growth. | Weiwei Shen Lingyu Ma Xi Zhang Xixia Li Yuanyuan Zhao Yanping Jing Yun Feng Xueke Tan Fei Sun Jinxing Lin | 2020 | Science China(Life Sciences)2020，63，2： | 3 |
| 6 | Plant multiscale networks:charting plant connectivity by multi-level analysis and imaging techniques显示文摘In multicellular and even single-celled organisms,individual components are interconnected at multiscale levels to produce enormously complex biological networks that help these systems maintain homeostasis for development and environmental adaptation.Systems biology studies initially adopted network analysis to explore how relationships between individual components give rise to complex biological processes.Network analysis has been applied to dissect the complex connectivity of mammalian brains across different scales in time and space in The Human Brain Project.In plant science,network analysis has similarly been applied to study the connectivity of plant components at the molecular,subcellular,cellular,organic,and organism levels.Analysis of these multiscale networks contributes to our understanding of how genotype determines phenotype.In this review,we summarized the theoretical framework of plant multiscale networks and introduced studies investigating plant networks by various experimental and computational modalities.We next discussed the currently available analytic methodologies and multi-level imaging techniques used to map multiscale networks in plants.Finally,we highlighted some of the technical challenges and key questions remaining to be addressed in this emerging field. | Xi Zhang Yi Man Xiaohong Zhuang Jinbo Shen Yi Zhang Yaning Cui Meng Yu Jingjing Xing Guangchao Wang Na Lian Zijian Hu Lingyu Ma Weiwei Shen Shunyao Yang Huimin Xu Jiahui Bian Yanping Jing Xiaojuan Li Ruili Li Tonglin Mao Yuling Jiao Sodmergen Haiyun Ren Jinxing Lin | 2021 | Science China(Life Sciences)2021，64，9： | 3 |
| 7 | Robust stability and stabilization for uncertain discrete-time switched singular systems with time-varying delays显示文摘The problems of robust stability and stabilization via memoryless state feedback for a class of discrete-time switched singular systems with time-varying delays and linear fractional uncertainties are investigated.By constructing a novel switched Lyapunov-Krasovskii functional,a delay-dependent criterion for the unforced system to be regular,causal and uniformly asymptotically stable is established in terms of linear matrix inequalities(LMIs).An explicit expression for the desired memoryless state feedback stabilization controller is also given.The merits of the proposed criteria lie in their less conservativeness and relative simplicity,which are achieved by considering additionally useful terms(ignored in previous methods) when estimating the upper bound of the forward difference of the Lyapunov-Krasovskii functional and by avoiding utilizing any model augmentation transformation.Some numerical examples are provided to illustrate the validity of the proposed methods. | Jinxing Lin Shumin Fei Jiong Shen | 2010 | Journal of Systems Engineering and Electronics2010，21，4： | 2 |
| 8 | The Brassica napus GATA transcription factor BnA5.ZML1 is a stigma compatibility factor显示文摘Self-incompatibility(SI)is a genetic mechanism that rejects self-pollen and thus prevents inbreeding in some hermaphroditic angiosperms.In the Brassicaceae,SI involves a pollen-stigma recognition system controlled by a single locus known as the S locus,which consists of two highly polymorphic genes that encode S-locus cysteine-rich protein(SCR)and S-receptor kinase(SRK).When self-pollen lands on the stigma,the S-haplotype-specific interaction between SCR and SRK triggers SI.Here,we show that the GATA transcription factor BnA5.ZML1 suppresses SI responses in Brassica napus and is induced after compatible pollination.The loss-of-function mutant bna5.zml1 displays reduced self-compatibility.In contrast,overexpression of BnA5.ZML1 in self-incompatible stigmas leads to a partial breakdown of SI responses,suggesting that BnA5.ZML1 is a stigmatic compatibility factor.Furthermore,the expression levels of SRK and ARC1 are up-regulated in bna5.zml1 mutants,and they are down-regulated in BnA5.ZML1 overexpressing lines.SRK affects the cellular localization of BnA5.ZML1 through direct protein–protein interaction.Overall,our findings highlight the fundamental role of BnA5.ZML1 in SI responses in B.napus,establishing a direct interaction between BnA5.ZML1 and SRK in this process. | Zhiqiang Duan Yatao Zhang Jinxing Tu Jinxiong Shen Bin Yi Tingdong Fu Cheng Dai Chaozhi Ma | 2020 | Journal of Integrative Plant Biology2020，62，8： | 2 |
| 9 | An in planta haploid induction system in Brassica napus显示文摘Doubled haploid technology is widely used to accelerate plant breeding,but its use in the important oilseed crop Brassica napus L.is limited because B.napus haploids could only be obtained through in vitro anther or microspore cultures.Recently,maize(Zea mays)lines containing mutations in Domain of unknown function 679 membrane protein(DMP)were used as haploid inducer lines.This new haploid induction mechanism has been extended to several other plants,including the dicots Arabidopsis thaliana,tomato(Solanum lycopersicum),and tobacco(Nicotiana tabacum).Here,we knocked out four BnaDMP genes in the B.napus cultivar Westar using a clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated protein 9 vector with an enhanced green fluorescent protein expression cassette.Plants with DMP mutations in B.napus in the T_(0),T_(1),and T_(2) generations exhibited a haploid induction rate up to 2.53%.These results suggest that targeting BnaDMP could be useful for haploid induction in B.napus. | Yifan Li Dan Li Qing Xiao Huadong Wang Jing Wen Jinxing Tu Jinxiong Shen Tingdong Fu Bin Yi | 2022 | Journal of Integrative Plant Biology2022，64，6： | 2 |
| 10 | Global COVID-19 Pandemic Waves: Limited Lessons Learned Worldwide over the Past Year显示文摘The occurrence of coronavirus disease 2019(COVID-19)was followed by a small burst of cases around the world;afterward,due to a series of emergency non-pharmaceutical interventions(NPIs),the increas-ing number of confirmed cases slowed down in many countries.However,the lifting of control measures by the government and the public’s loosening of precautionary behaviors led to a sudden increase in cases,arousing deep concern across the globe.arousing deep concern across the globe.This study evaluates the situation of the COVID-19 pandemic in countries and territories worldwide from January 2020 to February 2021.According to the time-varying reproduction number(R(t))of each country or territory,the results show that almost half of the countries and territories in the world have never controlled the epidemic.Among the countries and territories that had once contained the occurrence,nearly half failed to maintain their prevention and control,causing the COVID-19 pandemic to rebound across the world—resulting in even higher waves in half of the rebounding countries or territories.This work also proposes and uses a time-varying country-level transmission risk score(CTRS),which takes into account both R(t)and daily new cases,to demonstrate country-level or territory-level transmission potential and trends.Time-varying hierarchical clustering of time-varying CTRS values was used to successfully reveal the countries and territories that contributed to the recent aggravation of the global pandemic in the last quarter of 2020 and the beginning of 2021,and to identify countries and territories with an increasing risk of COVID-19 transmission in the near future.Furthermore,a regression analysis indicated that the introduction and relaxation of NPIs,including workplace closure policies and stay-at-home requirements,appear to be associated with recent global transmission changes.In conclu-sion,a systematic evaluation of the global COVID-19 pandemic over the past year indicates that the world is now in an unexpected situation,with limited lessons learned.Summarizing the lessons learned could help in designing effective public responses for constraining future waves of COVID-19 worldwide. | Yongyue Wei Jinxing Guan Xiao Ning Yuelin Li Liangmin Wei Sipeng Shen Ruyang Zhang Yang Zhao Hongbing Shen Feng Chen | 2022 | Engineering2022，8，6： | 1 |
| 11 | Bn.YCO affects chloroplast development in Brassica napus L.显示文摘Mature chloroplasts,as the main sites of photosynthesis,are essential for seedling growth in higher plants.Loss of function of genes involved in chloroplast development changes plant phenotype.We obtained a YELLOW COTYLEDON (YCO) mutant in rapeseed (Brassica napus L.) using CRISPR-Cas9.Bn.YCO,a gene of unknown function,has two homologous copies (Bna A01.YCO and Bna C01.YCO) in B.napus.Homozygous mutation of these two homologs resulted in yellow cotyledons and chlorotic true leaves.Transmission electron microscopy revealed that the formation of thylakoid membranes was inhibited in yellow cotyledons.Sequence similarity search revealed that YCO was conserved in different species,and a subcellular location assay verified that Bn.YCO was located in the chloroplast.Bn.YCO was expressed in multiple tissues,most highly in cotyledons.Knockout of Bn.YCO blocked the transcription of plastid genes,especially those of photosystem genes transcribed by plastid-encoded polymerase.Transcriptome sequencing showed that the majority of genes involved in ribosome assembly and photosynthesis were down-regulated in Bn.yco mutants.These results suggested that loss of function of Bn.YCO affected plastid gene transcription,which influenced chloroplast biogenesis in rapeseed seedlings. | Tingting Liu Baolong Tao Hanfei Wu Jing Wen Bin Yi Chaozhi Ma Jinxing Tu Tingdong Fu Lixia Zhu Jinxiong Shen | 2021 | The Crop Journal2021，9，5： | 1 |
| 12 | Influence of pulp fiber subscribe on conductivity of polyaniline-coated conductive paper prepared by in-situ polymerization显示文摘 | Qian Xueren Shen Jinx Yu Gang | 2010 | BioResources2010，5，2： | 1 |
| 13 | Numerical simulation of cutterhead and soil interaction in slurry shield tunneling显示文摘 | SHEN J Q JINX L LI Y | 2009 | Engineering Computations2009，26，78： | 1 |
| 14 | Immune genetic optimization algorithm based on multilayer fuzzy control显示文摘 | LIN Jinxing SHEN Jiong XIAO Guotao | 2005 | Journal of Southeast University2005，35，1： | 1 |
| 15 | High dynamic range image tone mapping and retexturing using fast rilateral filtering 显示文摘 | SHEN J B JINX G SUN H Q | 2007 | Visual Comput2007，23，911： | 1 |
| 16 | Simulated evaluation of pedestrian safety for flat-front vehicle显示文摘 | SHEN J JINX L ZHANG X Y | 2008 | International Journal of Crashworthiness2008，13，3： | 1 |
| 17 | Geochemistry and occurrence of a biogenic gas accumulations in the Chinese sedimentary basins显示文摘 | DAI JINXING YANG SHUFENG CHEN HANLIN SHEN XAIOHUA | 2005 | Organic Geochemistry2005，36，： | 1 |
| 18 | Mapping of BnMs4 and BnRf to a common microsyntenic region of Arabidopsis thaliana chromosome 3 using intron polymorphism markers显示文摘 | Shengqian Xia Ling Cheng Feng Zu Xiaoling Dun Zhengfu Zhou Bin Yi Jing Wen Chaozhi Ma Jinxiong Shen Jinxing Tu Tingdong Fu | 2012 | Theoretical and Applied Genetics2012，，7： | 1 |
| 19 | Autonomous bus services:current research status and future recommendations显示文摘Implementing autonomous bus services in several cities has garnered substantial research attention worldwide.However,the benefits and challenges of this emerging mode remain insufficiently understood.Consequently,VOSviewer was employed for a bibliometric analysis involving 300 publications,investigating the associations among authors,journals,and keywords.Subsequently,we comprehensively reviewed the current state of research on two topics and proposed future recommendations.Results indicate that the first document related to autonomous bus services was published in 2009.Most user attitude-related research data are obtained via questionnaires and analyzed using statistical techniques.Autonomous bus services are expected to benefit passengers regarding travel time,cost,safety,etc.,while passenger preferences are inconsistent.However,integrating the service into existing bus systems requires careful consideration of the schedule sequences.Notably,modular autonomous bus services present a new opportunity for the further optimization of bus services.In future studies,standardized data acquisition procedures should be developed to achieve comparable results.Regarding traveler choice behavior,the effect of specific autonomous bus service policies over time and the heterogeneity due to cultural or social contexts across regions should be assessed.To further promote autonomous bus services,based on fluctuating travel demands,the effects of vehicle capacity,speed,and cost of fleet composition should be evaluated comprehensively to optimize the bus network and schedule sequence.Owing to the protracted nature of the transition from conventional to fully autonomous buses,one should prioritize semi-autonomous bus services.Another essential future research direction is to integrate modular autonomous bus assembly or disassembly strategies with different fine-grained operation optimization techniques in various scenarios. | Jinxing Shen Qinxin Liu Zi Ye Wenfeng Jiang Changxi Ma | 2023 | Digital Transportation and Safety2023，2，3： | 1 |
| 20 | BEM with mixed special shape fuctions for 2D eddy current problems显示文摘 | Jinxing Shen Arnulf Kost | 1992 | IEEE Transactions on Magnetics1992，28，2： | 1 |
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