7篇
您的检索式：作者名="Shahsavandi"
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| 1 | Design of a heterosubtypic epitope-based peptide vaccine fused with hemokinin-1 against influenza viruses显示文摘Influenza viruses continue to emerge and re-emerge, posing new threats for public health. Control and treatment of influenza depends mainly on vaccination and chemoprophylaxis with approved antiviral drugs. Identification of specific epitopes derived from influenza viruses has significantly advanced the development of epitope-based vaccines. Here, we explore the idea of using HLA binding data to design an epitope-based vaccine that can elicit heterosubtypic T-cell responses against circulating H7N9, H5N1, and H9N2 subtypes. The hemokinin-1(HK-1) peptide sequence was used to induce immune responses against the influenza viruses. Five conserved high score cytotoxic T lymphocyte(CTL) epitopes restricted to HLA-A*0201-binding peptides within the hemagglutinin(HA) protein of the viruses were chosen, and two HA CTL/HK-1 chimera protein models designed. Using in silico analysis, which involves interferon epitope scanning, protein structure prediction, antigenic epitope determination, and model quality evaluation, chimeric proteins were designed. The applicability of one of these proteins as a heterosubtypic epitopebased vaccine candidate was analyzed. | Shahla Shahsavandi Mohammad Majid Ebrahimi Kaveh Sadeghi Homayoon Mahravani | 2015 | Virologica Sinica2015，30，3： | 1 |
| 2 | Specific subtyping of influenza A virus using a recombinant hemagglutinin protein expressed in baculovirus显示文摘 | SHAHSAVANDI S SALMANIAN A H GHORASHI S A | 2011 | Mol Biol Rep2011，38，5： | 1 |
| 3 | Specific subtyping of influenza A virus using a recombinanthemagglutinin pro- tein expressed in baculovirus显示文摘 | Shahsavandi S Salmanian AH Ghorashi SA | 2011 | Mol Biol Rep2011，，38： | 1 |
| 4 | Evolutionary characterization of hemagglutinin gene of H9N2 influenza viruses isolated from Asia显示文摘 | Shahla Shahsavandi Ali-Hatef Salmanian Seyed Ali Ghorashi Shahin Masoudi Mohammad Majid Ebrahimi | 2011 | Research in Veterinary Science2011，，1： | 1 |
| 5 | Evolutionary characterization of hemagglutinin gene of H9N2 influenza viruses isolated from Asia显示文摘 | Shahsavandi S Salmanian AH Ghorashi SA | | 0，，： | 1 |
| 6 | Develop- ment of rHA1-ELISA for specific and sensitive detection of H9 subtype influenza virus 显示文摘 | Shahsavandi S Salmanian A H Ghorashi S A | 2011 | J Virol Methods2011，171，1： | 1 |
| 7 | Dose-and timedependent apoptosis induced by avian H9N2 influenza virus in human cells显示文摘 | Shahsavandi S Ebrahimi MM Sadeghi K | 2013 | Biomed Res Int2013，2013，10： | 1 |
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