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| 1 | Dedifferentiated liposarcoma arising from the sigmoid mesocolon: A case report显示文摘Dedifferentiated liposarcoma is a variant of liposarcoma with a more aggressive course. It occurs most commonly in the retroperitoneum and rarely in other anatomic locations. In the present report, we describe a case of dedifferentiated liposarcoma that occurred in an unusual location, sigmoid mesocolon, which has not yet been documented. | Brody Winn John Gao Homayoon Akbari Baishali Bhattacharya | 2007 | World Journal of Gastroenterology2007，13，30： | 5 |
| 2 | Suppository naproxen reduces incidence and severity of post-endoscopic retrograde cholangiopancreatography pancreatitis: Randomized controlled trial显示文摘AIM: To determine the efficacy of rectally administered naproxen for the prevention of post-endoscopic retrograde cholangiopancreatography(ERCP) pancreatitis(PEP).METHODS: This double-blind randomized control trial conducted from January 2013 to April 2014 at the Gastrointestinal and Liver Diseases Research Center in Rasht, Iran. A total of 324 patients were selected from candidates for diagnostic or therapeutic ERCP by using the simple sampling method. Patients received a single dose of Naproxen(500 mg; n = 162) or a placebo(n = 162) per rectum immediately before ERCP. The overall incidence of PEP, incidence of mild to severe PEP, serum amylase levels and adverse effects were measured. The primary outcome measure was the development of pancreatitis onset of pain in the upper abdomen and elevation of the serum amylase level to > 3 × the upper normal limit(60-100 IU/L) within 24 h after ERCP. The severity of PEP was classified according to the duration of therapeutic intervention for PEP: mild, 2-3 d; moderate 4-10 d; and severe, > 10 d and/or necessitated surgical or intensive treatment, or contributed to death.RESULTS:PEP occurred in 12 %(40/324) o f participants, and was significantly more frequent in the placebo group compared to the naproxen group(P < 0.01). Of the participants, 25.9%(84/324) developed hyperamylasemia within 2 h of procedure completion, among whom only 35 cases belonged to the naproxen group(P < 0.01). The incidence of PEP was significantly higher in female sex, in patients receiving pancreatic duct injection, more than 3 times pancreatic duct cannulations, and ERCP duration more than 40 min(P s < 0.01). There were no statistically significant differences between the groups regarding the procedures or factors that might increase the risk of PEP, sphincterotomy, precut requirement, biliary duct injection and number of pancreatic duct cannulations. In the subgroup of patients with pancreatic duct injection, the rate of pancreatitis in the naproxen group was significantly lower than that in the placebo(6 patients vs 23 patients, P < 0.01, RRR = 12%, AR = 0.3, 95%CI: 0.2-0.6). Naproxen reduced the PEP in patients with ≥ 3 pancreatic cannulations(P < 0.01, RRR = 25%, AR = 0.1, 95%CI: 0.1-0.4) and an ERCP duration > 40 min(P < 0.01, RRR = 20%, AR = 0.9, 95%CI: 0.4-1.2).CONCLUSION: Single dose of suppository naproxen administered immediately before ERCP reduces the incidence of PEP. | Fariborz Mansour-Ghanaei Farahnaz Joukar Zahra Taherzadeh Homayoon Sokhanvar Tolou Hasandokht | 2016 | World Journal of Gastroenterology2016，22，21： | 4 |
| 3 | New empirical model to evaluate groundwater flow into circular tunnel using multiple regression analysis显示文摘There are various analytical, empirical and numerical methods to calculate groundwater inflow into tunnels excavated in rocky media. Analytical methods have been widely applied in prediction of groundwater inflow to tunnels due to their simplicity and practical base theory. Investigations show that the real amount of water infiltrating into jointed tunnels is much less than calculated amount using analytical methods and obtained results are very dependent on tunnel‘s geometry and environmental situations.In this study, using multiple regression analysis, a new empirical model for estimation of groundwater seepage into circular tunnels was introduced. Our data was acquired from field surveys and laboratory analysis of core samples. New regression variables were defined after perusing single and two variables relationship between groundwater seepage and other variables. Finally, an appropriate model for estimation of leakage was obtained using the stepwise algorithm. Statistics like R, R^2, R_P^2 and the histogram of residual values in the model represent a good reputation and fitness for this model to estimate the groundwater seepage into tunnels. The new experimental model was used for the test data and results were satisfactory. Therefore, multiple regression analysis is an effective and efficient way to estimate the groundwater seepage into tunnels. | Farhadian Hadi Katibeh Homayoon | 2017 | International Journal of Mining Science and Technology2017，27，3： | 4 |
| 4 | Omeprazole-based triple therapy with low-versus high-dose of clarithromycin plus amoxicillin for H pylori eradication in Iranian population显示文摘AIM: To investigate the efficacy and tolerability of H pylori eradication in an omeprazole-based triple therapy with high-and low-dose of clarithromycin and amoxicillin. METHODS: One hundred and sixty H pylori positive patients were randomly assigned to two groups based on the following 2 wk investigation; (1) group A or low-dose regimen received omeprazole 20 mg b.i.d, clarithromycin 250 mg b.i.d and amoxicillin 500 mg b.i.d; and (2) group B or high-dose regimen received omeprazole 20 mg b.i.d, clarithromycin 500 mg b.i.d and amoxicillin 1000 mg b.i.d. During the study H pylori status was assessed by histology and rapid urease test prior and by 13C-urea breath test 6 wk after the therapy. Standard questionnaires were administered to determine the compliance to treatment and possible adverse events of therapy. Data were subject to χ2 to compare the eradication rates in the two groups. The significant level of 95% (P ≤ 0.05) was considered statistically different. RESULTS: We found that the per-protocol eradication rate was 88% (68/77) in group A, and 89% (67/75) in group B. The intension-to-treat eradication rate was 85% (68/80) in group A and 83.75% (67/80) in group B. Overall adverse events were 26% in group A and 31% in group B. The adverse events were generally mild in nature and tolerated well in both groups with a compliance of 98% in group A vs 96% in group B. CONCLUSION: The omeprazole-based low dose regimen of clarithromycin and amoxicillin for two weeks in H pylori eradication is as effective as high dose regimen in Iranian population. | Ali Asghar Keshavarz Homayoon Bashiri Mahtab Rahbar | 2007 | World Journal of Gastroenterology2007，13，6： | 3 |
| 5 | Prevalence of shiga toxins(stx_1,stx_2),eaeA and hly genes of Escherichia coli O157:H7 strains among children with acute gastroenteritis in southern of Iran显示文摘Objective:To survey the prevalence severe diarrhea arising from these bacteria in children under 5 years old in Marvdasht.Methods:In this study faecal sample from 615 children aged <5years old who were hospitalized lor gastroenteritis in Fars hospitals in Iran were collected and then enriched in Escherichia coli(E.coli) broth and modified tryplone soy broth with novobiocin media,fermentation of sorbitol,lactose and β— glucoronidase activity of isolated strains was examined by CT—SMAC,VRBA and chromogenic media respectively.Then isolation of E.coli O157:H7 have been confirmed with the use of specific antisera and with multiplex PCR method presence of virulence genes including:xtx_1.stx_2,eae.A.hly has been analyzed.Results:E.coli O157:H7 was detected in 7(1.14%) stool specimens.A significanl difference was seen between detection rale of isolated bacteria from age groups 18-23 months and other age groups(P=0.004).Out of considered virulence genes.only 1 of the isolated strains(0.16%)he stx,and eaeA genes were seen and also all isolated hacleria had resistance to penicillin,ampicillin and erythromycin antibiotics.Conclusions:We found thai children < 2 years of age were at highest risk of infection with E.coli O157:H7.Regarding severity of E.coli O157:H7 pathogenesis,low infectious dose and lack of routine assay for detection ol these bacleria in clinical laboratory,further and completed studies on diagnosis and genolyping of this E.coli O157:H7 strain has been recommended. | Mohammad Kargar Maryam Homayoon | 2015 | Asian Pacific Journal of Tropical Medicine2015，8，1： | 2 |
| 6 | Estimating seismic demand parameters using the endurance time method显示文摘The endurance time (ET) method is a time history based dynamic analysis in which structures are subjected to gradually intensifying excitations and their performances are judged based on their responses at various excitation levels. Using this method, the computational effort required for estimating probable seismic demand parameters can be reduced by an order of magnitude. Calculation of the maximum displacement or target displacement is a basic requirement for estimating performance based on structural design. The purpose of this paper is to compare the results of the nonlinear ET method with the nonlinear static pushover (NSP) method of FEMA 356 by evaluating performances and target displacements of steel frames. This study will lead to a deeper insight into the capabilities and limitations of the ET method. The results are further compared with those of the standard nonlinear response history analysis. We conclude that results from the ET analysis are in proper agreement with those from standard procedures. | Ramin MADARSHAHIAN Homayoon ESTEKANCHI Akbar MAHVASHMOHAMMADI | 2011 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2011，12，8： | 2 |
| 7 | Comparison of Immune Responses against FMD by a DNA Vaccine Encoding the FMDV/O/IRN/2007 VP1 Gene and the Conventional Inactivated Vaccine in an Animal Model显示文摘Foot-and-mouth disease virus (FMDV) is highly contagious and responsible for huge outbreaks among cloven hoofed animals. The aim of the present study is to evaluate a plasmid DNA immunization system that expresses the FMDV/O/IRN/2007 VP1 gene and compare it with the conventional inactivated vaccine in an animal model. The VP1 gene was sub-cloned into the unique Kpn I and BamH I cloning sites of the pcDNA3.1+ and pEGFP-N1 vectors to construct the VP1 gene cassettes. The transfected BHKT7 cells with sub-cloned pEGFP-N1-VP1 vector expressed GFP-VP1 fusion protein and displayed more green fluorescence spots than the transfected BHKT7 cells with pEGFP-N1 vector, which solely expressed the GFP protein. Six mice groups were respectively immunized by the sub-cloned pcDNA3.1+-VP1 gene cassette as the DNA vaccine, DNA vaccine and PCMV-SPORT-GMCSF vector (as molecular adjuvant) together, conventional vaccine, PBS (as negative control), pcDNA3.1+ vector (as control group) and PCMV-SPORT vector that contained the GMCSF gene (as control group). Significant neutralizing antibody responses were induced in the mice which were immunized using plasmid vectors expressing the VP1 and GMCSF genes together, the DNA vaccine alone and the conventional inactivated vaccine (P<0.05). Co-administration of DNA vaccine and GMCSF gene improved neutralizing antibody response in comparison with administration of the DNA vaccine alone, but this response was the most for the conventional vaccine group. However, induction of humeral immunity response in the conventional vaccine group was more protective than for the DNA vaccine, but T-cell proliferation and IFN-γ concentration were the most in DNA vaccine with the GMCSF gene. Therefore the group that was vaccinated by DNA vaccine with the GMCSF gene, showed protective neutralizing antibody response and the most Th1 cellular immunity. | Farahnaz Motamedi Sedeh Hoorieh Soleimanjahi AmirReza Jalilian Homayoon Mahravani | 2012 | Virologica Sinica2012，27，5： | 2 |
| 8 | Effect of magnesium and sulfate ions on durability of silica fume blended mixes exposed to the seawater tidal zone 显示文摘 | ESHMAIEL G~ HOMAYOON S P | 2005 | Cem Concr Res2005，35，7： | 1 |
| 9 | Changes in peroxidase and polyphenol oxidase activities in susceptible and resistant wheat heads inoculated with Fusarium graninearum and induced resistance显示文摘 | MOJTABA MOHAMMADI HOMAYOON KAZEMI | 2002 | Plant Sci2002，162，： | 1 |
| 10 | Clinical and Immunologic Progression in HIV-Infected US Women Before and After the Introduction of Highly Active Antiretroviral Therapy显示文摘 | Kenneth H. Mayer Joseph W. Hogan Dawn Smith Robert S. Klein Paula Schuman Joseph B. Margolick Christina Korkontzelou Homayoon Farzedegan David Vlahov Charles C.J. Carpenter | 2003 | JAIDS Journal of Acquired Immune Deficiency Syndromes2003，，5： | 1 |
| 11 | Design of a heterosubtypic epitope-based peptide vaccine fused with hemokinin-1 against influenza viruses显示文摘Influenza viruses continue to emerge and re-emerge, posing new threats for public health. Control and treatment of influenza depends mainly on vaccination and chemoprophylaxis with approved antiviral drugs. Identification of specific epitopes derived from influenza viruses has significantly advanced the development of epitope-based vaccines. Here, we explore the idea of using HLA binding data to design an epitope-based vaccine that can elicit heterosubtypic T-cell responses against circulating H7N9, H5N1, and H9N2 subtypes. The hemokinin-1(HK-1) peptide sequence was used to induce immune responses against the influenza viruses. Five conserved high score cytotoxic T lymphocyte(CTL) epitopes restricted to HLA-A*0201-binding peptides within the hemagglutinin(HA) protein of the viruses were chosen, and two HA CTL/HK-1 chimera protein models designed. Using in silico analysis, which involves interferon epitope scanning, protein structure prediction, antigenic epitope determination, and model quality evaluation, chimeric proteins were designed. The applicability of one of these proteins as a heterosubtypic epitopebased vaccine candidate was analyzed. | Shahla Shahsavandi Mohammad Majid Ebrahimi Kaveh Sadeghi Homayoon Mahravani | 2015 | Virologica Sinica2015，30，3： | 1 |
| 12 | The use of an electronic portal imaging system to measure portal dose and portal dose profiles 显示文摘 | Homayoon Parsaei Ellen E1-Khatib | 1998 | Med Phys1998，25，： | 1 |
| 13 | Probabilistic seismic loss estimation via endurance time method显示文摘Probabilistic Seismic Loss Estimation is a methodology used as a quantitative and explicit expression of the performance of buildings using terms that address the interests of both owners and insurance companies.Applying the ATC 58 approach for seismic loss assessment of buildings requires using Incremental Dynamic Analysis(IDA), which needs hundreds of time-consuming analyses, which in turn hinders its wide application.The Endurance Time Method(ETM) is proposed herein as part of a demand propagation prediction procedure and is shown to be an economical alternative to IDA.Various scenarios were considered to achieve this purpose and their appropriateness has been evaluated using statistical methods.The most precise and efficient scenario was validated through comparison against IDA driven response predictions of 34 code conforming benchmark structures and was proven to be sufficiently precise while offering a great deal of efficiency.The loss values were estimated by replacing IDA with the proposed ETM-based procedure in the ATC 58 procedure and it was found that these values suffer from varying inaccuracies, which were attributed to the discretized nature of damage and loss prediction functions provided by ATC 58. | Ehsan Tafakori Saeid Pourzeynali Homayoon E. Estekanchi | 2017 | Earthquake Engineering and Engineering Vibration2017，16，1： | 1 |
| 14 | Changes in peroxidase and polyphenol oxidase activities in susceptible and resistant wheat heads inoculated with Fusarium graminearum and induced resistance显示文摘 | Mojtaba Mohammadi Homayoon Kazemi | 2002 | Plant Science2002，，162： | 1 |
| 15 | Antiretroviral Therapy Adherence and Viral Suppression in HIV- Infected Drug Users:Comparison of Self-Report and Electronic Monitoring 显示文摘 | Julia H Arnsten Penelope A Demas Homayoon Farzadegan | 2001 | Clinical Infectious Diseases2001，33，： | 1 |
| 16 | Epididymal cysts in children:natural history显示文摘 | Homayoon K Suhre CD Steinhardt GF | 2004 | J Urol2004，171，3： | 1 |
| 17 | Results of a Phase I trial of concurrent chemotherapy and escalating doses of radiation for unresectable non–small-cell lung cancer显示文摘 | Steven E. Schild William L. McGinnis David Graham Shauna Hillman Tom R. Fitch Donald Northfelt Yolanda I. Garces Homayoon Shahidi Loren K. Tschetter Paul L. Schaefer Alex Adjei James Jett | 2006 | International Journal of Radiation Oncology Biology Physics2006，，4： | 1 |
| 18 | Determination of glomerular filtration rate using a dual-detector gamma camera and the geometric mean of renal activity:correlation with the ^99Tc^m-DTPA plasma clearance method显示文摘 | Delpassand ES Homayoon K Madden T | 2000 | Clin Nucl Med2000，25，4： | 1 |
| 19 | Changes in peroxidase and polyphenol oxidase activities in susceptible and resistant wheat heads inoculated with Fusarium graminearum and induced resistance 显示文摘 | Mojtaba Mohammadi Homayoon Kazemi | 2002 | Plant Science2002，，162： | 1 |
| 20 | Efect of Magnesium and Sul- fate Ions on Durability of Silica Fume Blended Mixes Exporsed to the Seawater Tidal Zone 显示文摘 | ESHMAIEL G HOMAYOON S P | 2005 | Cem Concr Res2005，35，7： | 1 |
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