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| 1 | Characteristics of hepatocellular carcinoma in cirrhotic and non-cirrhotic non-alcoholic fatty liver disease显示文摘AIM: To determine characteristics and prognosticpredictors of patients with hepatocellular carcinoma(HCC) in association with non-alcoholic fatty liver disease(NAFLD).METHODS: We reviewed the records of all patients with NAFLD associated HCC between 2000 and 2012. Data collected included demographics; histology; presence or absence of cirrhosis, size and number of HCC, alpha-fetoprotein, body mass index(BMI), and the presence of diabetes, hypertension, or dyslipidaemia.RESULTS: Fifty-four patients with NAFLD associated HCC were identified. Mean age was 64 years with 87% male. Fifteen percent(8/54) were not cirrhotic. 11%, 24% and 50% had a BMI of < 25 kg/m2, 25-29 kg/m2 and ≥ 30 kg/m2 respectively. Fifty-nine percent were diabetic, 44% hypertensive and 26% hyperlipidaemic. Thirty-four percent of the patients had ≤ 1 of these risk factors. Non-cirrhotics had a significantly larger mean tumour diameter at diagnosis than cirrhotics(P = 0.041). Multivariate analysis did not identify any other patient characteristics that predicted the size or number of HCC.CONCLUSION: HCC can develop in NAFLD without cirrhosis. At diagnosis such tumours are larger than those in cirrhotics, conferring a poorer prognosis. | Christopher Leung Sern Wei Yeoh Desmond Patrick Shara Ket Kaye Marion Paul Gow Peter W Angus | 2015 | World Journal of Gastroenterology2015，21，4： | 24 |
| 2 | 马来西亚职业技术教育的现状与挑战显示文摘在过去几年里,马来西亚的职业技术教育的重要性越来越得到政府的认可,然而总的来说,职业技术教育在马来西亚教育体系内仍是一个相对弱势的分支,这一方面是因为传统上职业技术教育的社会地位不高,另一方面则与其职业教育所能提供的有限的生涯发展途径有关,在其国家资格框架体系中,职业教育实际上被局限在中等教育的层次。马来西亚职业教育面临的另一个问题则是其多元管理和缺乏协调。政府采取了提升形象和认可度、改变治理模式以及提高产业界参与等方式来应对这些困难。 | 李俊 Lai Chee Sern 白滨 | 2016 | 职教论坛2016，32，36： | 4 |
| 3 | Valsartan-induced improvement in insulin sensitivity is not paralleled by changes in microvascular function in individuals with impaired glucose metabolism显示文摘 | Nynke J. van der Zijl Erik H. Serné Gijs H. Goossens Chantalle C.M. Moors Richard G. IJzerman Ellen E. Blaak Michaela Diamant | 2011 | Journal of Hypertension2011，，10： | 1 |
| 4 | A dual-loop clock and data recovery circuit with compact quarterrate CMOS linear phase fetector显示文摘 | Yung Sern Tan Kiat Seng Yeo Chirn Chye Boon | 2012 | IEEE Transactions on Circuits and Systems Ⅰ:Regular Papers2012，59，6： | 1 |
| 5 | Implementation of a parallel genetic algorithm on a cluster of work- stations: traveling salesman problem, a case study显示文摘 | Sena G A Megherlu D Sern G I | 2001 | Future Generation Computer Systems2001，17，： | 1 |
| 6 | Impaired skin capillary recruitment in essential hypertension is caused by both func- tional and structural capillary rarefaction显示文摘 | Serne EH GansRo Maaten Jc | 2001 | Hypertension2001，38，2： | 1 |
| 7 | Free fatty acid levels modulate microvascular function relevance for obesity-associated insulin resistance,hypertension,and microangiopathy显示文摘 | DE JONGH R T SERNE E H IJZERMAN R G | 2004 | Am Diabetes Assoc2004，53，11： | 1 |
| 8 | Cigarette smoking is associated with an acute impairment of microvascular function in humans显示文摘 | IJZERMAN RG SERNE EH VAN WEISSENBRUCH MM | 2003 | Clin Sci (Lond)2003，104，3： | 1 |
| 9 | Rapid Decrease in Delivery of Chemotherapy to Tumors after Anti-VEGF Therapy: Implications for Scheduling of Anti-Angiogenic Drugs显示文摘 | Astrid A.M. Van der Veldt Mark Lubberink Idris Bahce Maudy Walraven Michiel P. de Boer Henri N.J.M. Greuter N. Harry Hendrikse Jonas Eriksson Albert D. Windhorst Pieter E. Postmus Henk M. Verheul Erik H. Serné Adriaan A. Lammertsma Egbert F. Smit | 2012 | Cancer Cell2012，，： | 1 |
| 10 | Microvascular function is preserved in newly diagnosed rheumatoid arthritis and low systemic inflammatory activity显示文摘 | van Eijk IC SernéEH Dijkmans BA | 2011 | Clin Rheumatol2011，30，8： | 1 |
| 11 | Effect of the abandonment of mountain pastureson the orthoptera population in the northwest of Spain显示文摘 | Sern V C | 1994 | Articulata1994，9，2： | 1 |
| 12 | Valsartan-induced improvement in insulin sensitivity is not paralleled by changes in microvascular function in individuals with impaired glucose metabolism显示文摘 | Nynke J. van der Zijl Erik H. Serné Gijs H. Goossens Chantalle C.M. Moors Richard G. IJzerman Ellen E. Blaak Michaela Diamant | 2011 | Journal of Hypertension2011，，10： | 1 |
| 13 | Impaired local microvascular vasodilatory effects of insulin and reduced skin microvascular vasomotion in obese women显示文摘 | Renate T. de Jongh Erik H. Serné Richard G. IJzerman Harald Thune J?rstad Coen D.A. Stehouwer | 2007 | Microvascular Research2007，，2： | 1 |
| 14 | Free fatty acid levels modulate microvascular function rlevance for obesityassociated insulin resistance,hypertension,and microangiopathy显示文摘 | de Jongh R T Serne E H Ijzerman R G | 2004 | Diabetes2004，53，： | 1 |
| 15 | Hypochloremia in Acute Decompensated Heart Failure显示文摘 | Hoong Sern Lim | 2015 | Journal of the American College of Cardiology2015，，： | 1 |
| 16 | Chemoselective synthesis of substituted imines, secondary amines,and B-amino carbon- yl compounds from nitroaromatics through cascade reactions on gold catalysts显示文摘 | Santos L L Sern P Corma A | 2009 | Chemistry A : European Journal2009，15，33： | 1 |
| 17 | Physiological hyperinsulinaemia increases intramuscular microvascular reactive hyperaemia and vasomotion in healthy volunteers显示文摘 | R. T. Jongh A. D. H. Clark R. G. IJzerman E. H. Serné G. Vries C. D. A. Stehouwer | 2004 | Diabetologia2004，，6： | 1 |
| 18 | Obese but not normalweight women with polycystic ovary syndrome are characterized by metabolic and microvascular insulin resistance显示文摘 | Ketel IJ Stehouwer CD Serne EH | 2008 | J Clin Endocrinol Metab2008，93，9： | 1 |
| 19 | The effect of polymers and surfactants on the pour point of palm oil methyl esters显示文摘 | Sern C H May C Y Zakaria Z | 2007 | Eur J Lipid Sci Technol[J]2007，109，4： | 1 |
| 20 | The effect of polymers and surfactants on the pour point of palm oil methyl esters 显示文摘 | SERN C H MAY C Y ZAKARIA Z DAIKA R FOONB C S | 2007 | Eur J Lipid Sci Technot2007，109，4： | 1 |
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