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| 1 | 精准医学发展趋势:从定量成像到放射组学(英文)显示文摘放射学(影像学)及影像引导的介入手段能提供多参数的形态学及功能信息,在精准医学中扮演着越来越重要的角色。因此,放射科医生需要理解影像表型,并将这些表型与潜在的疾病相关联,进而描述图像特征。但是为了能理解并描述异质性实体肿瘤的分子表型(基因组学信息),就需要通过活检取得这些组织更进一步的序列信息。因此,放射科医生为了能获得详尽的影像表型,需要从不同视图和角度采集图像,而这就产生了大量的数据。从所有这些影像数据中提取有意义的细节非常具有挑战性,并衍生出了大数据这个命题。因为影像组学有对诊断支持提供有意义的诠释性和预测性信息的潜力,所以近年来对于影像组学的关注越来越多。影像组学是传统的计算机辅助诊断、深度学习和人类技能的结合,因此它能被用来定量描述肿瘤表型。本文对影像组学流程的概览、基于不同手段(如计算机断层扫描(CT)、磁共振成像(MRI)和正电子发射计算机断层扫描(PET))的影像组学研究结果、面临的挑战和影像组学对于精准医学潜在的贡献等方面进行了讨论。 | U.Rajendra ACHARYA Yuki HAGIWARA Vidya K.SUDARSHAN Wai Yee CHAN Kwan Hoong NG | 2018 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2018，19，1： | 9 |
| 2 | Recurrent giant fibrovascular polyp of the esophagus显示文摘Giant fibrovascular polyps of the esophagus and hypopharynx are rare benign esophageal tumors. They arise most commonly in the upper esophagus and may, rarely, originate in the hypopharynx. They can vary significantly in size. Even though they are benign, they may be lethal due to either bleeding or, rarely, asphyxiation if a large polyp is regurgitated. Patients commonly present with dysphagia or hematemesis. The polyps may not be well visualized on endoscopy and imaging plays a vital role in aiding diagnosis as well as providing important information for preoperative planning, such as the location of the pedicle, the vascularity of the polyp and the tissue elements of the mass. They can also be recurrent in rare cases, especially if the resection margins of the base are involved. We review the recent literature and report a case of a 61-year-old man with a recurrent giant esophageal fibrovascular polyp with illustrative contrast barium swallow, CT and intra-operative images, who required several surgeries via a combination of endoscopic, trans-oral, trans-cervical, trans-thoracic and trans-abdominal approaches. | Ser Yee Lee Weng Hoong Chan Ranjiv Sivanandan Dennis Teck Hock Lim Wai Keong Wong | 2009 | World Journal of Gastroenterology2009，15，29： | 7 |
| 3 | A Mini Review: Can Graphene Be a Novel Material for Perovskite Solar Cell Applications?显示文摘Perovskite solar cells(PSCs) have raised research interest in scientific community because their power conversion efficiency is comparable to that of traditional commercial solar cells(i.e., amorphous Si, GaAs,and CdTe). Apart from that, PSCs are lightweight, are flexible, and have low production costs. Recently, graphene has been used as a novel material for PSC applications due to its excellent optical, electrical, and mechanical properties. The hydrophobic nature of graphene surface can provide protection against air moisture from the surrounding medium, which can improve the lifetime of devices. Herein, we review recent developments in the use of graphene for PSC applications as a conductive electrode,carrier transporting material, and stabilizer material. By exploring the application of graphene in PSCs, a new class of strategies can be developed to improve the device performance and stability before it can be commercialized in the photovoltaic market in the near future. | Eng Liang Lim Chi Chin Yap Mohammad Hafizuddin Hj Jumali Mohd Asri Mat Teridi Chin Hoong Teh | 2018 | Nano-Micro Letters2018，10，2： | 3 |
| 4 | Dual prognostic role of 2-oxoglutarate-dependent oxygenases in ten cancer types:implications for cell cycle regulation and cell adhesion maintenance显示文摘Background: Tumor hypoxia is associated with metastasis and resistance to chemotherapy and radiotherapy. Genes involved in oxygen-sensing are clinically relevant and have significant implications for prognosis. In this study, we examined the pan-cancer prognostic significance of oxygen-sensing genes from the 2-oxoglutarate-dependent oxygenase family. Methods: A multi-cohort, retrospective study of transcriptional profiles of 20,752 samples of 25 types of cancer was performed to identify pan-cancer prognostic signatures of 2-oxoglutarate-dependent oxygenase gene family (a family of oxygen-dependent enzymes consisting of 61 genes). We defined minimal prognostic gene sets using three independent pancreatic cancer cohorts (n = 681). We identified two signatures, each consisting of 5 genes. The ability of the signa-tures in predicting survival was tested using Cox regression and receiver operating characteristic (ROC) curve analyses. Results: Signature 1 (KDM8, KDM6B, P4HTM, ALKBH4, ALKBH7) and signature 2 (KDM3A, P4HA1, ASPH, PLOD1, PLOD2) were associated with good and poor prognosis. Signature 1 was prognostic in 8 cohorts representing 6 cancer types (n = 2627): bladder urothelial carcinoma (P = 0.039), renal papillary cell carcinoma (P = 0.013), liver cancer (P = 0.033 and P = 0.025), lung adenocarcinoma (P = 0.014), pancreatic adenocarcinoma (P < 0.001 and P = 0.040), and uterine corpus endometrial carcinoma (P < 0.001). Signature 2 was prognostic in 12 cohorts representing 9 cancer types (n = 4134): bladder urothelial carcinoma (P = 0.039), cervical squamous cell carcinoma and endocervical adenocar-cinoma (P = 0.035), head and neck squamous cell carcinoma (P = 0.038), renal clear cell carcinoma (P = 0.012), renal papillary cell carcinoma (P = 0.002), liver cancer (P < 0.001, P < 0.001), lung adenocarcinoma (P = 0.011), pancreatic adenocarcinoma (P = 0.002, P = 0.018, P < 0.001), and gastric adenocarcinoma (P = 0.004). Multivariate Cox regression confirmed independent clinical relevance of the signatures in these cancers. ROC curve analyses confirmed superior performance of the signatures to current tumor staging benchmarks. KDM8 was a potential tumor suppressor down- regulated in liver and pancreatic cancers and an independent prognostic factor. KDM8 expression was negatively correlated with that of cell cycle regulators. Low KDM8 expression in tumors was associated with loss of cell adhesion phenotype through HNF4A signaling. Conclusion: Two pan-cancer prognostic signatures of oxygen-sensing genes were identified. These genes can be used for risk stratification in ten diverse cancer types to reveal aggressive tumor subtypes. | Wai Hoong Chang Donall Forde Alvina G.Lai | 2019 | Cancer Communications2019，39，1： | 3 |
| 5 | 配位聚合物[HgI_2(bpea)]_n[bpea=1,2-双(4-吡啶基)乙烷]的合成结构表征和光学折射效应(英文)显示文摘制备44连吡啶基二卤加和物MX244′bipyn仍然有较大困难。这类化合物数量不多且已报道的多为难处理的微晶材料。本文在室温下通过简单的操作合成了新的碘化汞连吡啶乙烷加和物HgI2bpean。X射线单晶衍射分析表明其中的汞原子通过与两个碘原子以及吡啶乙烷的两个氮原子配位形成扭曲的四面体构型。每个HgI2单元由bpea桥连形成锯齿状链。其非线性光学性质用8纳秒激光在532nm波长进行了研究。该化合物相对于入射光表现为一定的光学吸收和强的自聚焦效应,其三阶非线性吸收系数α2=1.1×10-11m·W-1折射系数n2=5.29×10-18m2·W-1。 | 牛云垠 宋瑛林 侯红卫 郑和根 FUN Hoong -Kun 忻新泉 | 2001 | 无机化学学报2001，17，5： | 2 |
| 6 | Evaluation of time-varying availability in multi-echelon spare parts systems with passivation显示文摘 | Hoong C L | 2006 | European Journal of Operational Research2006，170，1： | 1 |
| 7 | Infliximab versus cyclosporine as rescue therapy in acute severe steroid-refractory ulcerative colitis: a systematic review and meta-analysis显示文摘 | Kah Hoong Chang John P. Burke J. Calvin Coffey | 2013 | International Journal of Colorectal Disease2013，，： | 1 |
| 8 | Measurement of traffic conflicts显示文摘 | Chin Hoong chor Quek Ser Tong | 1997 | Safety Science1997，26，3： | 1 |
| 9 | Hydrogen sulfide regulates intracellular pH in ratprimary cultured glia cells显示文摘 | Lu Ming Chooi Hoong Choo Hu Li-fang | 2010 | Neurosci Res2010，66，1： | 1 |
| 10 | Improved emergy indices for the evaluation of indus- trial systems incorporating waste management 显示文摘 | Hanfeng Mu Xiao Feng Khim Hoong Chu | 2011 | Eco- logical Engineering2011，，37： | 1 |
| 11 | Synthesis of transesterified palm olein - based polyol and rigid polyurethanes from this polyol显示文摘 | Arniza M Z Hoong S S Idris Z | 2015 | Journal of the American Oil Chemists'' Society2015，92，2： | 1 |
| 12 | Evaluation of Time-varyingAvailability in Multi-echelon Spare Parts Systems with Passivation显示文摘 | Hoong C L Huawei S Chuen T S | 2006 | European Journal of Operational Research(S0377-2217)2006，101，97： | 1 |
| 13 | Fortification of sulfited tannin from the bark of acacia mangium with phenol-formaldehyde for use as plywood adhesive显示文摘 | Hoong Y B Paridah M T Luqman C A | 2009 | Ind Crop Prod2009，30，： | 1 |
| 14 | Planar air breathing PEMFC with self- humidifying MEA and open cathode geometry design for portable applications 显示文摘 | Bussayajarn N Ming H Hoong K | 2009 | International Journal of Hydrogen Energy2009，34，： | 1 |
| 15 | Vehicle Routing Problem with Time Windows and a Limited Number of Vehicles显示文摘 | Hoong Chuin Lau Melvyn Sim | 2003 | European Journal of Operational Research2003，148，： | 1 |
| 16 | Vehicle Routing Problem with Time Windows and a Limited Number of Vehicles 显示文摘 | Hoong C L Melvyn S Kwong M T | 2003 | European Journal of Operational Research2003，148，： | 1 |
| 17 | Enzyme-mediated enantioselective preparation of pure enantiomers of the antiviral agent 2', 3'-dideoxy-5-fluoro-Y-thiacytidine (FTC) and related compounds显示文摘 | Hoong LK Strange LE Liotta DC | 1992 | J Org Chem1992，57，21： | 1 |
| 18 | Ganoderma Disease of oil palm in Sabah显示文摘 | Hoong Hak Wan | 2007 | The Planter2007，83，： | 1 |
| 19 | Vehicle routing problem with time windows and a limited number of vehicles显示文摘 | Hoong Chuin Lau Melvyn Sim Kwong Meng Teo | 2003 | European Journal of Operational Research2003，148，： | 1 |
| 20 | Hypochloremia in Acute Decompensated Heart Failure显示文摘 | Hoong Sern Lim | 2015 | Journal of the American College of Cardiology2015，，： | 1 |
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