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| 1 | Quantitative analysis of hepatic hypoxia-inducible factor-1α and its abnormal gene expression during the formation of hepatocellular carcinoma显示文摘BACKGROUND:Hepatic hypoxia-inducible factor-1(HIF-1) is activated in the progression of hepatocellular carcinoma (HCC).This study aimed to investigate the dynamic alterations of HIF-1αand its gene expression so as to explore the relationship between HIF-1αexpression and hepatocarcinogenesis at the early stage of HCC. METHODS:A hepatoma model was made with 2-fluorenyl- acetamide(2-FAA)in male Sprague-Dawley rats.Morphological changes of rat hepatocytes were assessed pathologically (HE staining).The dynamic expression of hepatic and circulating HIF-1αwas quantitatively analyzed by ELISA. The gene fragments of hepatic HIF-1αmRNA were amplified by RT-PCR and confirmed by sequencing.The cellular distribution of hepatic HIF-1αexpression was confirmed by immunohistochemistry. RESULTS:Histological examination confirmed granulelike degeneration to atypical hyperplasia and HCC development in rat hepatocytes and progressive increases in the levels of hepatic and circulating HIF-1αand its gene expression during the course.The levels of HIF-1α expression in the liver and blood of rats with hepatoma were significantly higher than those in normal ratsand those with degeneration.Immunohistochemical analysis confirmed the positive expression and hepatocyte distribution of HIF-1αin the development of rat hepatoma. A positive relationship was found between HIF-1α expression in the liver and blood(P<0.01). CONCLUSIONS:The above observations support the hypothesis that the overexpression of HIF-1αand its gene are closely associated with the malignant transformation of hepatocytes and play an important role at the stage of hepatocarcinogenesis. | Deng-Fu Yao,Hua Jiang,Min Yao,Yue-Ming Li,Wen-Jing Gu,Yu-Cheng Shen, Li-Wei Qiu,Wei Wu,Xin-Hua Wu and Wen-Li Sai Research Center of Clinical Molecular Biology,Department of Laboratory Science,and Department of Oncology,Affiliated Hospital of Nantong University,Nantong 226001, China Third Department of Medicine,Jiaonan People’s Hospital,Jiaonan 266400,China | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，4： | 28 |
| 2 | Genome Analysis of the Ancient Tracheophyte Selaginella tama#scina Reveals Evolutionary Features Relevant to the Acquisition of Desiccation Tolerance显示文摘 | Zhichao Xu Tianyi Xin Dorothea Bartels Ying Li Wei Gu Hui Yao Sai Liu Haoying Yu Xiangdong Pu Jianguo Zhou Jiang Xu Caicai xi Hetian Lei Jingyuan song Shilin Chen | 2018 | Molecular Plant2018，11，7： | 20 |
| 3 | Characteristics of hepatic nuclear-transcription factor-kappa B expression and quantitative analysis in rat hepatocarcinogenesis显示文摘BACKGROUND:Hepatocellular carcinoma(HCC)is one of the most common malignant tumors.We analyzed the expression of nuclear-transcription factor-kappa B(NF-κB) during hepatocarcinogenesis in order to evaluate its dynamic expression and its clinical value in the development and diagnosis of HCC. METHODS:Hepatoma models were induced by oral administration of 2-acetamidoflurene(2-FAA)to male Sprague-Dawley rats.Morphological changes were observed after hematoxylin and eosin staining.The cellular distribution of NF-κB expression during different stages of cancer development was investigated by immunohistochemistry, and the level of NF-κB expression in liver tissues was quantitatively analyzed by ELISA.The gene fragments of hepatic NF-κB were amplified by nested-polymerase chain reaction assay. RESULTS:Hepatocytes showed vacuole-like degeneration during the early stages,then had a hyperplastic nodal appearance during the middle stages,and finally progressed to tubercles of cancerous nests with high differentiation. The NF-κB-positive material was buff-colored,fine particles localized in the nucleus,and the incidence of NF-κB-positive cells was 81.8%in degeneration,83.3%in precancerous lesions,and 100%in cancerous tissues.All of these values were higher than those in controls(P<0.01). Hepatic NF-κB expression and hepatic NF-κB-mRNA were also higher during the course of HCC development(P<0.01).CONCLUSION:The NF-κB signal transduction pathway is activated during the early stages of HCC development, and its abnormal expression may be associated with the occurrence of HCC. | Wu, Wei Yao, Deng-Fu Qiu, Li-Wei Sai, Wen-Li Shen, Jun-Jun Yu, Hong-Bo Wu, Xin-Hua Li, Yue-Ming Wang, Yi-Lang Gu, Wen-Jing | 2009 | Hepatobiliary & Pancreatic Diseases International2009，8，5： | 12 |
| 4 | Insight-HXMT observations of the first binary neutron star merger GW170817显示文摘Finding the electromagnetic(EM) counterpart of binary compact star merger, especially the binary neutron star(BNS) merger,is critically important for gravitational wave(GW) astronomy, cosmology and fundamental physics. On Aug. 17, 2017,Advanced LIGO and Fermi/GBM independently triggered the first BNS merger, GW170817, and its high energy EM counterpart,GRB 170817 A, respectively, resulting in a global observation campaign covering gamma-ray, X-ray, UV, optical, IR, radio as well as neutrinos. The High Energy X-ray telescope(HE) onboard Insight-HXMT(Hard X-ray Modulation Telescope) is the unique high-energy gamma-ray telescope that monitored the entire GW localization area and especially the optical counterpart(SSS17 a/AT2017 gfo) with very large collection area(~1000 cm^2) and microsecond time resolution in 0.2-5 MeV. In addition,Insight-HXMT quickly implemented a Target of Opportunity(ToO) observation to scan the GW localization area for potential X-ray emission from the GW source. Although Insight-HXMT did not detect any significant high energy(0.2-5 MeV) radiation from GW170817, its observation helped to confirm the unexpected weak and soft nature of GRB 170817 A. Meanwhile,Insight-HXMT/HE provides one of the most stringent constraints(~10^(-7) to 10^(-6) erg/cm^2/s) for both GRB170817 A and any other possible precursor or extended emissions in 0.2-5 MeV, which help us to better understand the properties of EM radiation from this BNS merger. Therefore the observation of Insight-HXMT constitutes an important chapter in the full context of multi-wavelength and multi-messenger observation of this historical GW event. | TiPei Li ShaoLin Xiong ShuangNan Zhang FangJun Lu LiMing Song XueLei Cao Zhi Chang Gang Chen Li Chen TianXiang Chen Yong Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong YuanYuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao CongZhan Liu GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge OU JinLu Qu Na Sai Liang Sun Yin Tan Lian Tao WenHui Tao YouLi Tuo GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BoBing WU Mei Wu GuangCheng Xiao He Xu YuPeng Xu LinLi Yan JiaWei Yang Sheng Yang YanJi Yang AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang Shu Zhang Tong Zhang Wei Zhang WanChang Zhang WenZhao Zhang Yi Zhang Yue Zhang YiFei Zhang YongJie Zhang Zhao Zhang ZiLiang Zhang HaiSheng Zhao JianLing Zhao XiaoFan Zhao ShiJie Zheng Yue Zhu YuXuan Zhu ChangLin Zou | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，3： | 12 |
| 5 | Relationship between Sleep Quality and Cognitive Function in Patients with Mild-to-Moderate Parkinson's Disease显示文摘 | Hui-Miao Liu Miao Chu Na Li Sai Zhang Yong-Zhi Zhang Ping Gu | 2018 | Chinese Medical Journal2018，，8： | 6 |
| 6 | Overview to the Hard X-ray Modulation Telescope (Insight-HXMT) Satellite显示文摘As China’s first X-ray astronomical satellite, the Hard X-ray Modulation Telescope (HXMT), which was dubbed as Insight-HXMT after the launch on June 15, 2017, is a wide-band(1-250 ke V) slat-collimator-based X-ray astronomy satellite with the capability of all-sky monitoring in 0.2-3 Me V. It was designed to perform pointing, scanning and gamma-ray burst(GRB)observations and, based on the Direct Demodulation Method (DDM), the image of the scanned sky region can be reconstructed.Here we give an overview of the mission and its progresses, including payload, core sciences, ground calibration/facility, ground segment, data archive, software, in-orbit performance, calibration, background model, observations and some preliminary results. | Shuang-Nan Zhang TiPei Li FangJun Lu LiMing Song YuPeng X u CongZhan Liu Yong Chen XueLei Cao QingCui Bu Zhi Chang Gang Chen Li Chen TianXiang Chen YiBao Chen YuPeng Chen Wei Cui WeiWei Cui JingKang Deng YongWei Dong Yuan Yuan Du MinXue Fu GuanHua Gao He Gao Min Gao MingYu Ge YuDong Gu Ju Guan Can Gungor ChengCheng Guo DaWei Han Wei Hu Yue Huang Jia Huo ShuMei Jia LuHua Jiang WeiChun Jiang Jing Jin YongJie Jin Bing Li ChengKui Li Gang Li MaoShun Li Wei Li Xian Li XiaoBo Li XuFang Li YanGuo Li ZiJian Li ZhengWei Li XiaoHua Liang JinYuan Liao GuoQing Liu HongWei Liu ShaoZhen Liu XiaoJing Liu Yuan Liu YiNong Liu Bo Lu XueFeng Lu Tao Luo Xiang Ma Bin Meng Yi Nang JianYin Nie Ge Ou JinLu Qu Na Sai RenCheng Shang GuoHong Shen Liang Sun Ying Tan Lian Tao YouLi Tuo Chen Wang ChunQin Wang GuoFeng Wang HuanYu Wang Juan Wang WenShuai Wang YuSa Wang XiangYang Wen BaiYang Wu BoBing Wu Mei Wu GuangCheng Xiao ShaoLin Xiong LinLi Yan JiaWei Yang Sheng Yang YanJi Yang QiBin Yi Bin Yuan AiMei Zhang ChunLei Zhang ChengMo Zhang Fan Zhang HongMei Zhang Juan Zhang Qiang Zhang ShenYi Zhangs Shu Zhang Tong Zhang WanChang Zhang Wei Zhang WenZhao Zhang Yi Zhang YiFei Zhang YongJie Zhang Yue Zhang Zhao Zhang Zhi Zhang ZiLiang Zhang HaiSheng Zhao XiaoFan Zhao ShiJie Zheng JianFeng Zhou YuXuan Zhu Yue Zhu RenLin Zhuang | 2020 | Science China(Physics,Mechanics & Astronomy)2020，63，4： | 2 |
| 7 | Effects of the CVB -D on expression of the cerebral ischemia GAP -43 and Neurocan in the hypertensive rats 显示文摘 | Tan Feng Gu Wei Wan Sai ying | 2008 | Nerve Regeneration Research2008，3，04： | 1 |
| 8 | Commercialization poten- tial of microalgae for biofuels produetion显示文摘 | JASVINDER SINGH SAI GU | 2010 | Renewable and Sustain able Energy Reviews2010，14，9： | 1 |
| 9 | A stable and efficient algorithm for the indefinite linear least-squares problems 显示文摘 | Chandrasekaran S Gu M Sayed A H | 1988 | SIAM Journal on Matrix Analysis and Applications1988，20，2： | 1 |
| 10 | Commercialization Potential of Microalgae for Biofu- els Production 显示文摘 | Jasvinder Singh Sai Gu | 2010 | Renewable and Sustainable Energy Reviews2010，14，9： | 1 |
| 11 | A comprehensive review of biomass resources and biofuels potential in Ghana显示文摘 | Moses Hensley Duku Sai Gu Essel Ben Hagan | 2010 | Renewable and Sustainable Energy Reviews2010，，1： | 1 |
| 12 | Regional regulation of palatal growth and patterning along the anterior-posterior axis in mice 显示文摘 | Hilliard SAI Yu L Gu S | 2005 | JAnat2005，207，5： | 1 |
| 13 | Identification of ROS1 rearrangement in gastric adenocarcinoma显示文摘 | Jeeyun Lee Seung Eun Lee So Young Kang In‐Gu Do Sujin Lee Sang Yun Ha Jeonghee Cho Won Ki Kang Jiryeon Jang Sai‐Hong Ignatius Ou Kyoung‐Mee Kim | 2013 | Cancer2013，，9： | 1 |
| 14 | Fabric-substrated capacitive biopotential sensors enhanced by dielectric nanoparticles显示文摘Wearable biopotential sensing devices are essential to long-term and real-time monitoring of human health.Non-contact,capacitive sensing electrodes prevent potential skin iritations,and are thus beneficial for long-term monitoring.Existing capacitive electrodes are either connected to a separate control circuit via external wires or have limited sensing capacitances,which leads to low signal qualities.This study demonstrates a stretchable capacitive sensing device with integrated electrodes and control electronics,with enhanced signal qualities.The electrodes and the control electronics are fabricated on a common fabric substrate for breathability and strain-limiting protection.The stretchable electrodes are based on an island-bridge design with a stretchability as high as-100%,and an area ratio as high as-80%.By using a dielectric calcium copper titanate(CCTO)composite as the adhesive layer,the electrode capacitance can be increased,yielding an enhanced signal-to-noise ratio(SNR)in the acquired biopotentials.This device offers a convenient and comfortable approach for long-term non-contact monitoring of biopotential signals. | Xiangjun Chen Xiaoxiang Gao Akihiro Nomoto Keren Shi Muyang Lin Hongjie Hu Yue Gu Yangzhi Zhu Zhuohong Wu Xue Chen Xinyu Wang Baiyan Qi Sai Zhou Hong Ding Sheng Xu | 2021 | Nano Research2021，14，9： | 1 |
| 15 | Clinicopathological features of hypoxia-inducible factor-1α and vascular endothelial growth factor expression in patients with lung cancer显示文摘Objective The aim of the study was to investigate the clinicopathological characteristics of hypoxiainducible factor-1α(HIF-1α) and vascular endothelial growth factor(VEGF) expression in patients with lung cancer.Methods Cancerous and noncancerous tissues were collected post-operation from 115 patients with lung cancers by the self-control method. Total RNA was extracted from the lung tissues. The status of tissue HIF-1α expression and intercellular distribution was observed by immunochemistry using a tissue microarray. The expression levels of circulating HIF-1α and VEGF were detected by enzyme-linked immunosorbent assay(ELISA).Results The expression of serum HIF-1α [(138.3 ± 28.8) μg/L] in the group of patients with lung cancer was significantly higher(P < 0.01) than that in the group of patients with pneumonia [(58.8 ± 14.5) μg/L] and the control group of patients ((24.1 ± 3.3) μg/L)There was a strong positive correlation of serum HIF-1α levels(r = 0.937, P < 0.01) with serum VEGF levels. The specific concentration of total RNA [(1.52 ± 1.14) μg/mg wet lung tissues] in the cancerous tissues was significantly higher(t = 8.494, P < 0.001) than that in the noncancerous tissues ((0.58 ± 0.33) μg/mg)The clinicopathological features of HIF-1α expression in lung cancer tissues revealed a significant relationship between positive HIF-1α expression and patient sex(χ~2 = 4.494, P = 0.034), tumor size(χ~2 = 4.679, P = 0.031), differentiation degree(χ~2= 8.846, P = 0.012), and presence of lymphatic node metastasis(χ~2= 6.604, P = 0.037).Conclusion Abnormal HIF-1α expression in lung cancer is closely related with nucleic acid metabolism and angiogenesis, and it may be helpful in the diagnosis and identification of lung cancer. | Xuli Yang Li Wang Wenli Sai Yin Cai Juanjuan Gu Xin Chen Dengfu Yao | 2016 | Oncology and Translational Medicine2016，2，6： | 1 |
| 16 | Developmentof a new benzo ( 12-b: 4,5-b) dithiophene-based copolymer with conjugated dithienylbenzothiadiazole-vinylene side chains for efficient solar cells显示文摘 | Gu Zhaojie Shen Ping Tsang Sai Wing | 2011 | Chem Commun2011，47，： | 1 |
| 17 | Biochar production potential in Ghana—A review显示文摘 | Moses Hensley Duku Sai Gu Essel Ben Hagan | 2011 | Renewable and Sustainable Energy Reviews2011，，8： | 1 |
| 18 | A stable and efficient algorithm for solving the indefinite linear least squares problem 显示文摘 | CHANDRASEKARAN S GU M SAYED A H | 1998 | SLAM J-Matrix Anal Appl1998，20，2： | 1 |
| 19 | Design and Dynamic Locomotion Control of Quadruped Robot with Perception-Less Terrain Adaptation显示文摘In this paper,a parallel quadrupedal robot was designed that is capable of versatile dynamic locomotion and perception-less terrain adaptation.Firstly,a quadrupedal robot with a symmetric legs and a powerful actuator was implemented for highly dynamic movement.Then,a fast and reliable method based on generalized least square was proposed for estimating the terrain parameters by fusing the body,leg,and contact information.On the basis of virtual model control(VMC)with the quadratic program(QP)method,the optimal foot force for terrain adaptation was achieved.Finally,the results obtained by simulation and indoor and outdoor experiments demonstrate that the robot can achieve a robust and versa tile dynamic locomotion on uneven terrain,and the rejection of disturbances is reliable,which proves the effectiveness and robustness of this proposed method. | Lei Wang Libo Meng Ru Kang Botao Liu Sai Gu Zhihao Zhang Fei Meng Aiguo Ming | 2022 | Cyborg and Bionic Systems2022，，1： | 1 |
| 20 | Commercialization potential of microalgae for biofuels production显示文摘 | JASVINDER SINGH SAI GU | 2010 | Renewable and Sustainable Energy Reviews2010，14，9： | 1 |
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