|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | National Cancer Data Linkage Platform of China:Design,Methods,and Application显示文摘Background:The National Cancer Center(NCC)and China CDC cooperatively designed a National Cancer Data Linkage(NCDL)Platform to fulfill the task of sharing cancer outcome data through an automatic web-based system.Methods:NCC and China CDC established a web-based NCDL Platform to link death information from China CDC with the cancer database from NCC.Overall,76,708 cancer patients’data were analyzed to assess the feasibility and match rate of the NCDL Platform for 7 major cancers.Results:The function of the platform includes a data application and approval system,data linkage module,and results visualization system.Through the platform,38.9%cases were identified as deaths cases from the NCDL Platform in the first 3 years after cancer diagnosis.The linkage rate was highest in liver cancer and lowest in breast cancer.Conclusions:The NCDL Platform provides a powerful and efficient way to link national vital statistics with national cancer programs’data.Expanding cancer outcome data linkage may not only improve data collection efficiency,but also improve data use. | Hongmei Zeng Yunning Liu Lijun Wang Peng Yin Baohua Wang Ruiying Fu Xianhui Ran Rongshou Zheng Siwei Zhang Jiangmei Liu Jinling You Kexin Sun Shaoming Wang Li Li Ru Chen Wenqiang Wei Maigeng Zhou Jing Wu Jie He | 2022 | China CDC weekly2022，4，13： | 1 |
| 2 | COVID-19 induces new-onset insulin resistance and lipid metabolic dysregulation via regulation of secreted metabolic factors显示文摘Abnormal glucose and lipid metabolism in COVID-19 patients were recently reported with unclear mechanism.In this study,we retrospectively investigated a cohort of COVID-19 patients without pre-existing metabolic-related diseases,and found new-onset in suli n resista nee,hyperglycemia,and decreased HDL-C in these patie nts.Mecha nistically,SARS-CoV-2 infecti on in creased the expression of RE1-silencing transcription factor(REST),which modulated the expression of secreted metabolic factors including myeloperoxidase,apelin,and myostatin at the transcriptional level,resulting in the perturbation of glucose and lipid metabolism.Furthermore,several lipids,including(±)5-HETE,(±)12-HETE,propionic acid,and isobutyric acid were identified as the potential biomarkers of COVID-19-induced metabolic dysregulation,especially in insulin resistance.Taken together,our study revealed insulin resistance as the direct cause of hyperglycemia upon COVID-19,and further illustrated the underlying mechanisms,providing potential therapeutic targets for COVID-19-induced metabolic complications. | Xi He Chenshu Liu Jiangyun Peng Zilun Li Fang Li Jian Wang Ao Hu Meixiu Peng Kan Huang Dongxiao Fan Na Li Fuchun Zhang Weiping Cai Xinghua Tan Zhongwei Hu Xilong Deng Yueping Li Xiaoneng Mo Linghua Li Yaling Shi Li Yang Yuanyuan Zhu Yanrong Wu Huichao Liang Baolin Liao Wenxin Hong Ruiying He Jiaojiao Li Pengle Guo Youguang Zhuo Lingzhai Zhao Fengyu Hu Wenxue Li Wei Zhu Zefeng Zhang Zeling Guo Wei Zhang Xiqiang Hong Wei kang Cai Lei Gu Ziming Du Yang Zhang Jin Xu Tao Zuo Kai Deng Li Yan Xinwen Chen Sifan Chen Chunliang Lei | 2022 | Signal Transduction and Targeted Therapy2022，7，1： | 0 |
| 3 | Overview of lethal human coronaviruses显示文摘Coronavirus infections of multiple origins have spread to date worldwide,causing severe respiratory diseases.Seven coronaviruses that infect humans have been identified:HCoV-229E,HCoV-OC43,HCoV-NL63,HCoV-HKU1,SARS-CoV,MERS-CoV,and SARS-CoV-2.Among them,SARS-CoV and MERS-CoV caused outbreaks in 2002 and 2012,respectively.SARS-CoV-2(COVID-19)is the most recently discovered.It has created a severe worldwide outbreak beginning in late 2019,leading to date to over 4 million cases globally.Viruses are genetically simple,yet highly diverse.However,the recent outbreaks of SARS-CoV and MERS-CoV,and the ongoing outbreak of SARS-CoV-2,indicate that there remains a long way to go to identify and develop specific therapeutic treatments.Only after gaining a better understanding of their pathogenic mechanisms can we minimize viral pandemics.This paper mainly focuses on SARS-CoV,MERS-CoV,and SARS-CoV-2.Here,recent studies are summarized and reviewed,with a focus on virus–host interactions,vaccine-based and drug-targeted therapies,and the development of new approaches for clinical diagnosis and treatment. | Bin Chen Er-Kang Tian Bin He Lejin Tian Ruiying Han Shuangwen Wang Qianrong Xiang Shu Zhang Toufic El Arnaout Wei Cheng | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 0 |
| 4 | Arbitrary skin metallization by pencil-writing inspired solid-ink rubbing for advanced energy storage and harvesting显示文摘The development of a durable metallic coating on diverse substrates is both intriguing and challenging,particularly in the research of metal-conductive materials for applications such as batteries,soft electronics,and beyond.Herein,by learning from the pencil-writing process,a facile solid-ink rubbing technology(SIR-tech)is invented to address the above challenge.The solid-ink is exampled by rational combination of liquid metal and graphite particles.By harnessing the synergistic effects between rubbing and adhesion,controllable metallic skin is successfully formed onto metals,woods,ceramics,and plastics without limitation in size and shape.Moreover,outperforming pure liquid-metal coating,the composite metallic skin by SIR-tech is very robust due to the self-lamination of graphite nanoplate exfoliated by liquid-metal rubbing.The critical factors controlling the structures-properties of the composite metallic skin have been systematically investigated as well.For applications,the SIR-tech is demonstrated to fabricate high-performance composite current collectors for next-generation batteries without traditional metal foils.Meanwhile,advanced skin-electrodes are further demonstrated for stable triboelectricity generation even under temperature fluctuation from-196 to 120℃.This facile and highly-flexible SIR-tech may work as a powerful platform for the studies on functional coatings by liquid metals and beyond. | Yonghan Zhou Zhongfeng Ji Wenrui Cai Xuewei He Ruiying Bao Xuewei Fu Wei Yang Yu Wang | 2024 | Journal of Energy Chemistry2024，88，1： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员