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| 1 | Contribution of genotype and ethnicity to bone mineral density variation in Caucasians and Chinese: a test for five candidate genes for bone mass显示文摘Background Ethnicity is shown to be one of important factors affacting bone mineral density (BMD). The present study was performed to compare the association of six markers for five candidate genes with BMD variation in two populations of different ethnicity, Caucasian and Chinese, and the contribution of genotype and ethnicity to this variation in the populations.Methods The studied restriction fragment length polymorphisms were Bsa H Ⅰ of the calcium-sensing receptor gene, Sac Ⅰ of the α2HS-glycoprotein (AHSG) gene, Pvu Ⅱ and Xba Ⅰ of the oestrogen receptor α gene, Apa Ⅰ of the vitamin D receptor (VDR) gene and BstB Ⅰ of the parathyroid hormone gene. The association of these markers with BMD was analysed by one-way and two-way ANOVA with adjustment for covariates. Results Two polymorphisms, AHSG- Sac Ⅰ and VDR- Apa Ⅰ, showed no association with BMD, while the others were associated with BMD variation at some skeletal sites in either males or females. The polymorphisms indicated clear distinctions between the associations depending on ethnicity, gender and skeletal site. Similar patterns were observed in their contribution to the total population BMD variation. Ethnicity appears to have a larger effect on the total population BMD variation in females than in males. It may account, on the average, for about 2% total population BMD variation at the spine of females and about 1% at the hip of males and females. Conclusion The results of the present study suggest that significant interethnic differentiation at some loci may contribute to the significant interethnic difference in BMD. However, this contribution apparently is not large. | Volodymyr Dvornyk LIU Peng-yuan LONG Ji-rong ZHANG Yuan-yuan LEI Shu-feng Robert R Recker DENG Hong-wen | 2005 | Chinese Medical Journal2005，，15： | 2 |
| 2 | Mutation Patterns at Dinucleotide Microsatellite Loci in Humans显示文摘 | Qing-Yang Huang Fu-Hua Xu Hui Shen Hong-Yi Deng Yong-Jun Liu Yao-Zhong Liu Jin-Long Li Robert R. Recker Hong-Wen Deng | 2002 | The American Journal of Human Genetics2002，，3： | 1 |
| 3 | ANKRD7 and CYTL1 are novel risk genes for alcohol drinking behavior显示文摘 | CHEN Xiang-ding XIONG Dong-hai YANG Tie-lin PEI Yu-fang GUO Yan-fang LI Jian YANG Fang PAN Feng TAN Li-jun YAN Han LIU Xiao-gang LEI Shu-feng LI Xi NING Ling-ling ZHU Xue-zhen Shawn Levy Henry R. Kranzler Lindsay A. Farrer Joel Gelernter Robert R. Recker DENG Hong-wen | 2012 | Chinese Medical Journal2012，，6： | 1 |
| 4 | Association Analyses of RANKL/RANK/OPG Gene Polymorphisms with Femoral Neck Compression Strength Index Variation in Caucasians显示文摘 | Shan-Shan Dong Xiao-Gang Liu Yuan Chen Yan Guo Liang Wang Jian Zhao Dong-Hai Xiong Xiang-Hong Xu Robert R. Recker Hong-Wen Deng | 2009 | Calcified Tissue International2009，，2： | 1 |
| 5 | Standardized nomenclature, symbols, and units for bone histomorphometry: A 2012 update of the report of the ASBMR Histomorphometry Nomenclature Committee显示文摘 | David W Dempster Juliet E Compston Marc K Drezner Francis H Glorieux John A Kanis Hartmut Malluche Pierre J Meunier Susan M Ott Robert R Recker A Michael Parfitt | 2012 | J Bone Miner Res2012，，1： | 1 |
| 6 | Effects of intermittent intravenous ibandronate injections on bone quality and micro-architecture in women with postmenopausal osteoporosis: The DIVA study显示文摘 | Robert R. Recker Louis-George Ste-Marie Bente Langdahl Edward Czerwinski Bernard Bonvoisin Daiva Masanauskaite Lucy Rowell Dieter Felsenberg | 2009 | Bone2009，，3： | 1 |
| 7 | Prevention of postmenopausal bone loss by a low-magnitude, high-frequency mechanical stimuli: a clinical trial assessing compliance, efficacy, and safety 显示文摘 | Clinton Rubin Robert Recker Diane Cullen | 2004 | Bone & Mineral Research2004，19，3： | 1 |
| 8 | Searching for osteoporosis genes in the post-genome era: progress and challenges显示文摘 | Qing-Yang Huang Robert R. Recker Hong-Wen Deng | 2003 | Osteoporosis International2003，，9： | 1 |
| 9 | Architecture and vertebral fracture显示文摘 | Robert R. Recker | 1993 | Calcified Tissue International1993，，1： | 1 |
| 10 | Change of bone mass in postmenopausal Caucasian women with and without hormone replacement therapy is associated with vitamin D receptor and estrogen receptor genotypes显示文摘 | H.-W. Deng Jian Li Jin-Long Li Mark Johnson Gordon Gong K. Michael Davis Robert R. Recker | 1998 | Human Genetics1998，，5： | 1 |
| 11 | Auditor-Client Affiliation : The Impact on ' Materiality' 显示文摘 | Bates Homer L Ingram Robert W and Reckers Philip M J | 1982 | Journal of Accountancy1982，，153： | 1 |
| 12 | Calcium absorption and achlorhydria显示文摘 | Recker R Robert | 1985 | N Engl J Med1985，313，： | 1 |
| 13 | Increased Marrow Adiposity in Premenopausal Women with Idiopathic Osteoporosis显示文摘 | Adi Cohen David W. Dempster Emily M. Stein Thomas L. Nickolas Hua Zhou Donald J. McMahon Ralph Müller Thomas Kohler Alexander Zwahlen Joan M. Lappe Polly Young Robert R. Recker Elizabeth Shane | 2012 | The Journal of Clinical Endocrinology & Metabolism2012，，： | 1 |
| 14 | TNFR2基因的CA重复多态性在两个独立的白人群体中与肥胖表型的连锁和关联(英文)显示文摘我们先前通过全基因组扫描发现1p36与体重指数显提示性连锁(LOD=2.09)。肿瘤坏死因子受体2(TNFR2)定位于1p36,是肥胖的一个极好的图位和功能侯选基因。本研究采用数量传递连锁不平衡检验在两个大的独立的白人样本中进行了TNFR2基因与肥胖表型的连锁与关联检验。第一组受试者由来自79个多代家系的1836个个体组成;第二组受试者由来自157个核心家庭的636个个体组成。所检测的肥胖表型包括体重指数、脂肪量和脂肪量百分数。在多代家系中我们发现TNFR2基因变异与BMI显著连锁(P=0.0056)。结果表明,TNFR2基因是影响白人BMI变异的一个数量性状位点。 | 黄青阳 SHEN Hui DENG Hong-Yi Theresa Conway Leo Elze K. Michael Davies Robert R. Recker 邓红文 | 2006 | Acta Genetica Sinica2006，33，9： | 1 |
| 15 | Bivariate whole-genome linkage scan for bone geometry and total body fat mass显示文摘To quantify the genetic correlations between total body fat mass(TBFM) and femoral neck geometric parameters(FNGPs) and, if possible, to detect the specific genomic regions shared by them, bivariate genetic analysis and bivariate whole-genome linkage scan were carried out in a large Caucasian population.All the phenotypes studied were significantly controlled by genetic factors(P < 0.001) with the heritabilities ranging from 0.45 to 0.68.Significantly genetic correlations were found between TBFM and CSA(cross-section area), W(sub-periosteal diameter), Z(section modulus) and CT(cortical thickness) except between TBFM and BR(buckling ratio).The peak bivariate LOD scores were 3.23(20q12), 2.47(20p11), 3.19(6q27), 1.68(20p12), and 2.47(7q11) for the five pairs of TBFM and BR, CSA, CT, W, and Z in the entire sample, respectively.Gender-specific bivariate linkage evidences were also found for the five pairs.6p25 had complete pleiotropic effects on the variations of TBFM & Z in the female sub-population, and 6q27 and 17q11 had coincident linkages for TBFM & CSA and TBFM & Z in the entire population.We identified moderate genetic correlations and several shared genomic regions between TBFM and FNGPs in a large Caucasian population. | Shufeng Lei Feiyan Deng Peng Xiao Kai Zhong Hongyi Deng Robert R. Recker Hongwen Deng | 2009 | Journal of Genetics and Genomics2009，36，2： | 0 |
| 16 | 绝经对血液单核细胞基因表达谱的影响:基因芯片初步研究(英文)显示文摘绝经是女性一生中很重要的生理现象之一,它能增加一系列复杂免疫、神经退化、新陈代谢和心血管方面的疾病。血液单核细胞能分化成各种各样的细胞,这些细胞在组织形态发生和免疫应答方面起着很重要的作用。本研究中采用了包含大约14,500个基因探针的Affymetrix Human U133A基因芯片来研究健康的绝经前和绝经后女性外周血液单核细胞中的基因表达谱。样本之间的对比分析表明有20个基因上调,20个基因下调。其中的28个基因根据它们的生物过程如细胞繁殖、免疫应答、细胞代谢等等被分成了6个主要的GO类别;剩下的12个基因其生物学功能还没有被鉴定。研究结果支持了我们的假设:血液单核细胞的功能状态确实受到绝经的影响,而且由此带来的改变可能是由全基因组范围的基因表达谱而决定的。本研究中鉴定的一些差异表达基因有可能作为以后研究与绝经相关的系统免疫、神经退化和心血管疾病的候选基因研究。此工作是这个研究方向的第一次尝试,为将来的进一步研究奠定了基础。 | Dvornyk Volodymyr 刘耀中 陆燕 沈汇 Lappe Joan M 雷署丰 Recker Robert R 邓红文 | 2007 | Journal of Genetics and Genomics2007，34，11： | 0 |
| 17 | Evidence for major pleiotropic effects on bone size variation from a principal component analysis of 451 Caucasian families显示文摘瞄准:识别在 Caucasians.Methods 在不同骨胳的地点影响骨头尺寸( BS )的多种的量的特点部位( QTL ):在从 451 个家谱包含 3899 个白种人的一件样品, 410 微卫星标记 spaced ~ 8.9 厘米分开越过人,染色体是 genotyped.Phenotypical 和在腰椎,臀部(大腿骨的颈,转子,和 intertrochanter 区域),和手腕的 BS 的基因关联(极端远侧,中间远侧,并且三分之一个个远侧的地点)用双性人变量被决定量的基因 analysis.A 主管部件分析( PCA )被执行获得当时是的因素使遭到了到变化部件连接分析鉴别区域连接了到 PC.Results 的主要部件( PC ):在不同骨胳的地点的 BS 的基因关联从 0.40~0.79 ( P<0.001 )。PCA 产出 PC 说出 PC_( 总数) ,它为整个样品在 7 个骨胳的地点向多达 76% 总数(co ) 解释了所有 BS 的变化。我们识别了在在 140 厘米的染色体 7 上影响多重骨胳的地点的 BS 的 QTL [机会( LOD )的对数 =2.85 ]在外套,为连接的sample.Sex特定的证据在男性唯一的数据 subset.Conclusion 在在 53 厘米( LOD=2.82 )的染色体 11 上被观察:我们的学习识别了几个 genomic 区域那可以在不同骨胳的地点上有多种的效果。这些区域可以包含在多重骨胳的地点在全面骨头开发和骨质疏松症起一个关键作用的基因,因此是生物学上并且临床上重要的。 | Li-jun TAN Yao-zhong LIU Peng XIAO Fang YANG Zi-hui TANG Peng-yuan LIU Robert R RECKER Hong-wen DENG | 2008 | Acta Pharmacologica Sinica2008，29，6： | 0 |
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