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| 1 | Laparoscopic Anterior 180-Degree Versus Nissen Fundoplication for Gastroesophageal Reflux Disease: Systematic Review and Meta-Analysis of Randomized Clinical Trials显示文摘 | Joris A. Broeders David J. Roks Usama Ahmed Ali David I. Watson Robert J. Baigrie ZhanGuo Cao Jens Hartmann Guy J. Maddern | 2013 | Annals of Surgery2013，，5： | 2 |
| 2 | Optimal Lymph Node Harvest in Rectal Cancer (UICC Stages II and III) after Preoperative 5-FU–based Radiochemotherapy. Acetone Compression is a New and Highly Efficient Method显示文摘 | Anastasia Gehoff Oliver Basten Thilo Sprenger Lena-Christin Conradi Carsten Bismarck Dirk Bandorski Sabine Merkelbach-Bruse Regine Schneider-Stock Robert Stoehr Ralph M. Wirtz Julia Kitz Annegret Müller Arndt Hartmann Heinz Becker B. Michael Ghadimi Torst | 2012 | The American Journal of Surgical Pathology2012，，2： | 1 |
| 3 | Focal progression in patients with gastrointestinal stromal tumors after initial response to imatinib mesylate: a three-center-based study of 38 patients显示文摘 | Salah-Eddin Al-Batran Joerg Thomas Hartmann Florian Heidel Jan Stoehlmacher Eva Wardelmann Claudius Dechow Markus Düx Jacob Robert Izbicki Thomas Kraus Thomas Fischer Elke J?ger | 2007 | Gastric Cancer2007，，3： | 1 |
| 4 | The broader context of antibiotic resistance: Zinc feed supplementation of piglets increases the proportion of multi-resistant Escherichia coli in vivo显示文摘 | Carmen Bednorz Kathrin Oelgeschl?ger Bianca Kinnemann Susanne Hartmann Konrad Neumann Robert Pieper Astrid Bethe Torsten Semmler Karsten Tedin Peter Schierack Lothar H. Wieler Sebastian Guenther | 2013 | 2013 (6-7)2013，，6： | 1 |
| 5 | The prognostic significance of subclinical hepatic encephalopathy显示文摘 | Ieneke J.C Hartmann Michael Groeneweg Juan C Quero Sylvia J Beijeman Robert A de Man Wim C.J Hop Solko W Schalm | 2000 | The American Journal of Gastroenterology2000，，8： | 1 |
| 6 | Flat epithelial atypia and risk of breast cancer: A Mayo cohort study显示文摘 | Samar M. Said Daniel W. Visscher Aziza Nassar Ryan D. Frank Robert A. Vierkant Marlene H. Frost Karthik Ghosh Derek C. Radisky Lynn C. Hartmann Amy C. Degnim | 2015 | Cancer2015，，： | 1 |
| 7 | Ki67: a time-varying biomarker of risk of breast cancer in atypical hyperplasia显示文摘 | Marta Santisteban Carol Reynolds Emily G. Barr Fritcher Marlene H. Frost Robert A. Vierkant Stephanie S. Anderson Amy C. Degnim Daniel W. Visscher V. Shane Pankratz Lynn C. Hartmann | 2010 | Breast Cancer Research and Treatment2010，，2： | 1 |
| 8 | MDR1 and ERCC1 Expression Predict Outcome of Patients with Locally Advanced Bladder Cancer Receiving Adjuvant Chemotherapy显示文摘 | Andreas-Claudius Hoffmann Peter Wild Christina Leicht Simone Bertz Kathleen D. Danenberg Peter V. Danenberg Robert St?hr Michael St?ckle Jan Lehmann Martin Schuler Arndt Hartmann | 2010 | Neoplasia2010，，： | 1 |
| 9 | The proto‐oncogene ERG is a target of micro RNA miR‐145 in prostate cancer显示文摘 | Martin Hart Sven Wach Elke Nolte Jaroslaw Szczyrba Roopika Menon Helge Taubert Arndt Hartmann Robert Stoehr Wolf Wieland Friedrich A. Gr?sser Bernd Wullich | 2013 | FEBS J2013，，： | 1 |
| 10 | The distribution and sources of polycyclic aromatic hydrocarbons in Narragansett Bay surface sediments显示文摘 | Paul C. Hartmann James G. Quinn Robert W. Cairns John W. King | 2003 | Marine Pollution Bulletin2003，，3： | 1 |
| 11 | Sorafenib perpetuates cellular anticancer effector functions by modulating the crosstalk between macrophages and natural killer cells显示文摘 | Martin Franz Sprinzl Florian Reisinger Andreas Puschnik Marc Ringelhan Kerstin Ackermann Daniel Hartmann Matthias Schiemann Arndt Weinmann Peter Robert Galle Marcus Schuchmann Helmut Friess Gerd Otto Mathias Heikenwalder Ulrike Protzer | 2013 | Hepatology2013，，： | 1 |
| 12 | Fecal cytolysin does not predict disease severity in acutely decompensated cirrhosis and acute-on-chronic liver failure显示文摘Background:Cirrhosis with acute decompensation(AD)and acute-on-chronic liver failure(ACLF)are characterized by high morbidity and mortality.Cytolysin,a toxin from Enterococcus faecalis(E.faecalis),is associated with mortality in alcohol-associated hepatitis(AH).It is unclear whether cytolysin also contributes to disease severity in AD and ACLF.Methods:We studied the role of fecal cytolysin in 78 cirrhotic patients with AD/ACLF.Bacterial DNA from fecal samples was extracted and real-time quantitative polymerase chain reaction(PCR)was performed.The association between fecal cytolysin and liver disease severity in cirrhosis with AD or ACLF was analyzed.Results:Fecal cytolysin and E.faecalis abundance did not predict chronic liver failure(CLIF-C)AD and ACLF scores.Presence of fecal cytolysin was not associated with other liver disease markers,including Fibrosis-4(FIB-4)index,‘Age,serum Bilirubin,INR,and serum Creatinine(ABIC)’score,Child-Pugh score,model for end-stage liver disease(MELD)nor MELD-Na scores in AD or ACLF patients.Conclusions:Fecal cytolysin does not predict disease severity in AD and ACLF patients.The predictive value of fecal cytolysin positivity for mortality appears to be restricted to AH. | Phillipp Hartmann Sonja Lang Robert Schierwagen Sabine Klein Michael Praktiknjo Jonel Trebicka Bernd Schnabl | 2023 | Hepatobiliary & Pancreatic Diseases International2023，22，5： | 0 |
| 13 | Synchronized ventilation during resuscitation in pigs does not necessitate high inspiratory pressures to provide adequate oxygenation显示文摘The optimal ventilation method for patients suffering from cardiac arrest and receiving cardiopulmonary resuscitation(CPR)remains unclear,and the recent guidelines do not provide detailed information.[1-3]During CPR,changing thoracic pressures due to chest compressions and ventilation pressure infl uence venous return and cardiac output,respectively.[4-6]Novel mechanical ventilation modes that are synchronized to chest compressions may improve blood flow and oxygenation.[4]In this porcine trial,we investigated the feasibility of a specially designed chest compression synchronized ventilation(CCSV)mode with peak pressures limited to 40 mbar(1 mbar=0.1 kPa)and an experimental synchronized ventilation(SV)limited to 20 mbar,respectively,intended to achieve a more lung-protective ventilation pattern during resuscitation.We evaluated whether the diff erent synchronized pressure levels ameliorate hemodynamics,gas exchange and pulmonary function and compared it to intermittent positive pressure ventilation(IPPV). | Miriam Renz Raphael RenéCinto Noack RenéRissel Katja Mohnke Julian Riedel Bastian Dunges Alexander Ziebart Erik Kristoff er Hartmann Robert Rummler | 2023 | World Journal of Emergency Medicine2023，14，5： | 0 |
| 14 | Observation of a single protein by ultrafast X-ray diffraction显示文摘The idea of using ultrashort X-ray pulses to obtain images of single proteins frozen in time has fascinated and inspired many.It was one of the arguments for building X-ray free-electron lasers.According to theory,the extremely intense pulses provide sufficient signal to dispense with using crystals as an amplifier,and the ultrashort pulse duration permits capturing the diffraction data before the sample inevitably explodes.This was first demonstrated on biological samples a decade ago on the giant mimivirus.Since then,a large collaboration has been pushing the limit of the smallest sample that can be imaged.The ability to capture snapshots on the timescale of atomic vibrations,while keeping the sample at room temperature,may allow probing the entire conformational phase space of macromolecules.Here we show the first observation of an X-ray diffraction pattern from a single protein,that of Escherichia coli GroEL which at 14 nm in diameter is the smallest biological sample ever imaged by X-rays,and demonstrate that the concept of diffraction before destruction extends to single proteins.From the pattern,it is possible to determine the approximate orientation of the protein.Our experiment demonstrates the feasibility of ultrafast imaging of single proteins,opening the way to single-molecule time-resolved studies on the femtosecond timescale. | Tomas Ekeberg Dameli Assalauova Johan Bielecki Rebecca Boll Benedikt J.Daurer Lutz A.Eichacker Linda E.Franken Davide E.Galli Luca Gelisio Lars Gumprecht Laura H.Gunn Janos Hajdu Robert Hartmann Dirk Hasse Alexandr Ignatenko Jayanath Koliyadu Olena Kulyk Ruslan Kurta Markus Kuster Wolfgang Lugmayr Jannik Lübke Adrian P.Mancuso Tommaso Mazza Carl Nettelblad Yevheniy Ovcharenko Daniel E.Rivas Max Rose Amit K.Samanta Philipp Schmidt Egor Sobolev Nicusor Timneanu Sergey Usenko Daniel Westphal Tamme Wollweber Lena Worbs Paul Lourdu Xavier Hazem Yousef Kartik Ayyer Henry N.Chapman Jonas A.Sellberg Carolin Seuring Ivan A.Vartanyants Jochen Küpper Michael Meyer Filipe R.N.C.Maia | 2024 | Light(Science & Applications)2024，13，1： | 0 |
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