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| 1 | Effects of Bacillus cereus var: toyoi on immune parameters of pregnant sows 显示文摘 | SCHIERACK P FILTER M SCHAREK L | 2009 | Vet Immunol Immunopathol2009，127，12： | 1 |
| 2 | Characterization of a porcine intestinal epithelial cell line for in vitro studies of microbial pathogenesis in swine 显示文摘 | SCHIERACK P NORDHOFF M POLLMANN M | 2006 | Histochemistry and Cell Biology2006，125，3： | 1 |
| 3 | The broader context of antibiotic resistance: Zinc feed supplementation of piglets increases the proportion of multi-resistant Escherichia coli in vivo显示文摘 | Carmen Bednorz Kathrin Oelgeschl?ger Bianca Kinnemann Susanne Hartmann Konrad Neumann Robert Pieper Astrid Bethe Torsten Semmler Karsten Tedin Peter Schierack Lothar H. Wieler Sebastian Guenther | 2013 | 2013 (6-7)2013，，6： | 1 |
| 4 | Parasite-specific immunomodulatory functions of filarial cystatin显示文摘 | SCHIERACK P LUCIUS R SONNENBURG B | 2003 | Infect Immun2003，71，5： | 1 |
| 5 | Influence of a probiotic Enterococcus faecium strain on development of the immune system of sows and piglets显示文摘 | L. Scharek J. Guth K. Reiter K.D. Weyrauch D. Taras P. Schwerk P. Schierack M.F.G. Schmidt L.H. Wieler K. Tedin | 2005 | Veterinary Immunology and Immunopathology2005，，1： | 1 |
| 6 | Characterization of a porcine intestinal epithelial cell line for in vitro studies of microbial pathogenesis in swine显示文摘 | Schierack P Nordhoff M Pollmann M | 2006 | Histochem Cell Biol2006，125，3： | 1 |
| 7 | Parasite-specific im-munomodulatory functions of filarial cystatin显示文摘 | Schierack P Lucius R Sonnenburg B | 2003 | Infect Immun2003，71，5： | 1 |
| 8 | Parasite- specific immunomodulatory functions of filaril cystatins显示文摘 | Schierack P Lucius R Sonnenburg B | 2003 | Infect Immun2003，71，5： | 1 |
| 9 | Characterization of a porcine intestinal epithelial cell line for in vitro studies of microbial pathogenesisin swine显示文摘 | Schierack P Nordhoff M Pollmann M | | 0，，03： | 1 |
| 10 | Parasite-specific immunomodulatory functions of filarial cystatin显示文摘 | Schierack P Lucius R Sonnenburg B | 2003 | Infect Immun2003，71，5： | 1 |
| 11 | Characterization of a porcine intestinal epithelial cell line for in vitro studies of microbial pathogenesis in swine 显示文摘 | SCHIERACK P NORDHOFF M POLLMANN M | 2006 | Histochemistry and Cell Biology2006，125，3： | 1 |
| 12 | Parasitespecific immunomodulatory functions of filarial cystatin 显示文摘 | Schierack P Lucius R Sonnenburg B | 2003 | Infect Immun2003，71，5： | 1 |
| 13 | Characterization of a porcine intestinal epithelial cell line for in vitro studies of microbial pathogenesis in swine显示文摘 | Schierack P Nordhoff M Pollmann M | 2006 | Histo Chemistry and Cell Biology2006，125，3： | 1 |
| 14 | Character- ization of a porcine intestinal epithelial cell line for in vitro studies of microbial pathogenesis in swine显示文摘 | Schierack P Nordhoff M Pollmann M | 2006 | His-tochem Cell Biol2006，125，： | 1 |
| 15 | Parasite-specificimmunomodulatory functions of filarial cystatin 显示文摘 | Schierack P Lucius R Sonnenburg B | 2003 | Infect Immun2003，71，5： | 1 |
| 16 | Parasite-specific immunomodulatory functions of filarial cystatin显示文摘 | Schierack P Lucius R Sonnenburg B | 2003 | Infect Immunity2003，71，5： | 1 |
| 17 | Characterization of a porcine intestinal epithelial cell line for in vitro studies of micro- bial pathogenesis in swine显示文摘 | Schierack P Nordhoff M Pollmann M | 2006 | Histochemistry and Cell Biology2006，125，3： | 1 |
| 18 | Location-based prediction model for Crohn’s disease regarding a novel serological marker,anti-chitinase 3-like 1 autoantibodies显示文摘BACKGROUND Defective neutrophil regulation in inflammatory bowel disease(IBD)is thought to play an important role in the onset or manifestation of IBD,as it could lead to damage of the intestinal mucosal barrier by the infiltration of neutrophils in the inflamed mucosa and the accumulation of pathogens.Like neutrophils in the context of innate immune responses,immunoglobulin A(IgA)as an acquired immune response partakes in the defense of the intestinal epithelium.Under normal conditions,IgA contributes to the elimination of microbes,but in connection with the loss of tolerance to chitinase 3-like 1(CHI3L1)in IBD,IgA could participate in CHI3L1-mediated improved adhesion and invasion of potentially pathogenic microorganisms.The tolerance brake to CHI3L1 and the occurrence of IgA autoantibodies to this particular target,the exact role and underlying mechanisms of CHI3L1 in the pathogenesis of IBD are still unclear.AIM To determine the predictive potential of Ig subtypes of a novel serological marker,anti-CHI3L1 autoantibodies(aCHI3L1)in determining the disease phenotype,therapeutic strategy and long-term disease course in a prospective referral cohort of adult IBD patients.METHODS Sera of 257 Crohn’s disease(CD)and 180 ulcerative colitis(UC)patients from a tertiary IBD referral center of Hungary(Division of Gastroenterology,Department of Internal Medicine,Faculty of Medicine,University of Debrecen)were assayed for IgG,IgA,and secretory IgA(sIgA)type aCHI3L1 by enzyme-linked immunosorbent assay using recombinant CHI3L1,along with 86 healthy controls(HCONT).RESULTS The IgA type was more prevalent in CD than in UC(29.2%vs 11.1%)or HCONT(2.83%;P<0.0001 for both).However,sIgA subtype aCHI3L1 positivity was higher in both CD and UC patients than in HCONT(39.3%and 32.8%vs 4.65%,respectively;P<0.0001).The presence of both IgA and sIgA aCHI3L1 antibodies was associated with colonic involvement(P<0.0001 and P=0.038,respectively)in patients with CD.Complicated disease behavior at sample procurement was associated with aCHI3L1 sIgA positivity(57.1%vs 36.0%,P=0.009).IgA type aCH3L1 was more prevalent in patients with frequent relapse during the disease course in the CD group(46.9%vs 25.7%,P=0.005).In a group of patients with concomitant presence of pure inflammatory luminal disease and colon involvement at the time of diagnosis,positivity for IgA or sIgA type aCH3L1 predicted faster progression towards a complicated disease course in time-dependent models.This association disappeared after merging subgroups of different disease locations.CONCLUSION CHI3L1 is a novel neutrophil autoantigenic target in IBD.The consideration of antibody classes along with location-based prediction may transform the future of serology in IBD. | Nora Sipeki Patricia Julianna Kovats Claudia Deutschmann Peter Schierack Dirk Roggenbuck Maria Papp | 2023 | World Journal of Gastroenterology2023，29，42： | 0 |
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