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| 1 | Immunity Genes and Susceptibility to Otitis Media:A Comprehensive Review显示文摘Otitis media(OM) is a middle ear infection associated with inflammation and pain.This disease frequently afflicts humans and is the major cause of hearing loss worldwide.OM continues to be one of the most challenging diseases in the medical field due to its diverse host targets and wide range of clinical manifestations.Substantial morbidity associated with OM is further exacerbated by high frequency of recurrent infections leading to chronic suppurative otitis media(CSOM).Children have greater susceptibility to,and thus,suffer most frequently from OM,which can cause significant deterioration in quality of life.Genetic factors have been demonstrated,in large part by twin and family studies,to be key determinants of OM susceptibility.In this review,we summarize the current knowledge on immunity genes and selected variants that have been associated with predisposition to OM.In particular,polymorphisms in innate immunity and cytokine genes have been strongly linked with the risk of developing OM.Future studies employing state-of-the-art technologies,including next-generation sequencing(NGS),will aid in the identification of novel genes associated with susceptibility to OM.This,in turn,will open up avenues for identifying high-risk individuals and designing novel therapeutic strategies based on precise targeting of these genes. | Rahul Mittal Giannina Robalino Robert Gerring Brandon Chan Denise Yan M'hamed Grati Xue-Zhong Liu | 2014 | Journal of Genetics and Genomics2014，41，11： | 5 |
| 2 | Mitigation of atrazine,S-metolachlor,and diazinon using common emergent aquatic vegetation显示文摘By the year 2050, the population of the United States is expected to reach over 418 million,while the global population will reach 9.6 billion. To provide safe food and fiber, agriculture must balance pesticide usage against impacts on natural resources. Challenges arise when storms cause runoff to be transported to aquatic receiving systems. Vegetated systems such as drainage ditches and constructed wetlands have been proposed as management practices to alleviate pesticide runoff. Twelve experimental mesocosms(1.3 × 0.71 × 0.61 m) were filled with sediment and planted with a monoculture of one of three wetland plant species(Typha latifolia, Leersia oryzoides, and Sparganium americanum).Three mesocosms remained unvegetated to serve as controls. All mesocosms were amended with 9.2 ± 0.8 μg/L, 12 ± 0.4 μg/L, and 3.1 ± 0.2 μg/L of atrazine, metolachlor, and diazinon, respectively, over a 4 hr hydraulic retention time to simulate storm runoff.Following the 4 hr amendment, non-amended water was flushed through mesocosms for an additional 4 hr. Outflow water samples were taken hourly from pre-amendment through8 hr, and again at 12, 24, 48, 72, and 168 hr post-amendment. L. oryzoides and T. latifolia had mean atrazine, metolachlor, and diazinon retentions from 51%–55% for the first 4 hr of the experiment. Aside from S. americanum and atrazine(25% retention), unvegetated controls had the lowest pesticide retention(17%–28%) of all compared mesocosms. While native aquatic vegetation shows promise for mitigation of pesticide runoff, further studies increasing the hydraulic retention time for improved efficiency should be examined. | Matthew T.Moore Martin A.Locke Robert Krǒger | 2017 | Journal of Environmental Sciences2017，29，6： | 2 |
| 3 | Microwave-assisted activation for electroless nickel plating on PMMA microspheres显示文摘 | Yen-Chung Chen Robert Lian-Huey Liu Xin-Liang Chen Hsiou-Jeng Shu Ming-Der Ger | 2011 | Applied Surface Science2011，，15： | 1 |
| 4 | Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma显示文摘 | Matthias L?hr Anne Hoffmeyer Jens-Christian Kr?ger Mathias Freund Johannes Hain Albrecht Holle Peter Karle Wolfram T Kn?fel Stefan Liebe Petra Müller Horst Nizze Matthias Renner Robert M Saller Thomas Wagner Karlheinz Hauenstein Walter H Günzburg Brian Sa | 2001 | The Lancet2001，，9268： | 1 |
| 5 | FoxO1 regulates asymmetric dimethylarginine via downregulation of dimethylaminohydrolase 1 in human endothelial cells and subjects with atherosclerosis显示文摘 | Rossella Menghini Viviana Casagrande Marina Cardellini Marta Ballanti Francesca Davato Iris Cardolini Robert Stoehr Marta Fabrizi Monica Morelli Lucia Anemona Isabel Bernges Edzard Schwedhelm Arnaldo Ippoliti Alessandro Mauriello Rainer H. B?ger Massimo F | 2015 | Atherosclerosis2015，，： | 1 |
| 6 | Cytotoxic T Lymphocyte Antigen–4 +49A/G polymorphism does not affect susceptibility to autoimmune hepatitis显示文摘 | Nicole M. F. Gerven Ynto S. Boer Antonie Zwiers Bart Hoek Karel J. Erpecum Ulrich Beuers Henk R. Buuren Joost P. H. Drenth Jannie W. den Ouden Robert C. Verdonk Ger H. Koek Johannes T. Brouwer Maureen M. J. Guichelaar Jan M. Vrolijk G. Kraal Chris J. J. M | 2013 | Liver Int2013，，7： | 1 |
| 7 | Focal progression in patients with gastrointestinal stromal tumors after initial response to imatinib mesylate: a three-center-based study of 38 patients显示文摘 | Salah-Eddin Al-Batran Joerg Thomas Hartmann Florian Heidel Jan Stoehlmacher Eva Wardelmann Claudius Dechow Markus Düx Jacob Robert Izbicki Thomas Kraus Thomas Fischer Elke J?ger | 2007 | Gastric Cancer2007，，3： | 1 |
| 8 | The broader context of antibiotic resistance: Zinc feed supplementation of piglets increases the proportion of multi-resistant Escherichia coli in vivo显示文摘 | Carmen Bednorz Kathrin Oelgeschl?ger Bianca Kinnemann Susanne Hartmann Konrad Neumann Robert Pieper Astrid Bethe Torsten Semmler Karsten Tedin Peter Schierack Lothar H. Wieler Sebastian Guenther | 2013 | 2013 (6-7)2013，，6： | 1 |
| 9 | Sarcoplasmic Reticulum Ca 2+ Release Declines in Muscle Fibers from Aging Mice显示文摘 | Ramón Jiménez-Moreno Zhong-Min Wang Robert C. Gerring Osvaldo Delbono | 2008 | Biophysical Journal2008，，8： | 1 |
| 10 | Association between the cerebral inflammatory and matrix metalloproteinase responses after severe traumatic brain injury in humans显示文摘 | Roberts DJ Jenne CN Léger C | 2013 | J Neurtraum2013，30，20： | 1 |
| 11 | Prognostic Significance of Free Peritoneal Tumor Cells in the Peritoneal Cavity Before and After Neoadjuvant Chemotherapy in Patients with Gastric Carcinoma Undergoing Potentially Curative Resection显示文摘 | Sylvie Lorenzen Benjamin Panzram Robert Rosenberg Hjalmar Nekarda Karin Becker Ulrich Schenk Heinz H?fler J?rg-Rüdiger Siewert Dirk J?ger Katja Ott | 2010 | Annals of Surgical Oncology2010，，10： | 1 |
| 12 | Suppression of Reactive Oxygen Species and Neurodegeneration by the PGC-1 Transcriptional Coactivators显示文摘 | Julie St-Pierre Stavit Drori Marc Uldry Jessica M. Silvaggi James Rhee Sibylle J?ger Christoph Handschin Kangni Zheng Jiandie Lin Wenli Yang David K. Simon Robert Bachoo Bruce M. Spiegelman | 2006 | Cell2006，，2： | 1 |
| 13 | Phospholipase A2 -mediated hydrolysis of cardiac phospholipids:the use of molecular and transgenic techniques显示文摘 | Leon J D E Robert S R Ger J V D V | 1998 | Molec Cell Biochem1998，180，： | 1 |
| 14 | A Comprehensive Mutation Analysis of RP2 and RPGR in a North American Cohort of Families with X-Linked Retinitis Pigmentosa显示文摘 | Debra K. Breuer Beverly M. Yashar Elena Filippova Suja Hiriyanna Robert H. Lyons Alan J. Mears Bersabell Asaye Ceren Acar Raf Vervoort Alan F. Wright Maria A. Musarella Patricia Wheeler Ian MacDonald Alessandro Iannaccone David Birch Dennis R. Hoffman Ger | 2002 | The American Journal of Human Genetics2002，，6： | 1 |
| 15 | Management of groin hernias by laparoscopy显示文摘 | Ralph Ger M.B. F.R.C.S. F.R.C.S.(Edin) F.A.C.S. Abdallah Mishrick M.D. F.R.C.S. F.A.C.S. Jessica Hurwitz M.D. F.A.C.S. Carlos Romero M.D. F.A.C.S. Robert Oddsen M.E | 1993 | World Journal of Surgery1993，，1： | 1 |
| 16 | Cue reactivity and its inhibition in pathological computer game players显示文摘 | Robert C. Lorenz Jenny‐Kathinka Krüger Britta Neumann Bj?rn H. Schott Christian Kaufmann Andreas Heinz Torsten Wüstenberg | 2012 | Addiction Biology2012，，： | 1 |
| 17 | Prognostic Significance of Free Peritoneal Tumor Cells in the Peritoneal Cavity Before and After Neoadjuvant Chemotherapy in Patients with Gastric Carcinoma Undergoing Potentially Curative Resection显示文摘 | Sylvie Lorenzen Benjamin Panzram Robert Rosenberg Hjalmar Nekarda Karin Becker Ulrich Schenk Heinz H?fler J?rg-Rüdiger Siewert Dirk J?ger Katja Ott | 2010 | Annals of Surgical Oncology2010，，10： | 1 |
| 18 | Prognostic Significance of Free Peritoneal Tumor Cells in the Peritoneal Cavity Before and After Neoadjuvant Chemotherapy in Patients with Gastric Carcinoma Undergoing Potentially Curative Resection显示文摘 | Sylvie Lorenzen Benjamin Panzram Robert Rosenberg Hjalmar Nekarda Karin Becker Ulrich Schenk Heinz H?fler J?rg-Rüdiger Siewert Dirk J?ger Katja Ott | 2010 | Annals of Surgical Oncology2010，，10： | 1 |
| 19 | Microencapsulated cell-mediated treatment of inoperable pancreatic carcinoma显示文摘 | Matthias L?hr Anne Hoffmeyer Jens-Christian Kr?ger Mathias Freund Johannes Hain Albrecht Holle Peter Karle Wolfram T Kn?fel Stefan Liebe Petra Müller Horst Nizze Matthias Renner Robert M Saller Thomas Wagner Karlheinz Hauenstein Walter H Günzburg Brian Sa | 2001 | The Lancet2001，，9268： | 1 |
| 20 | Dynamic pricing models for ERP systems under network externality显示文摘 | Adnéne Hajji Robert Pellerin Pierre-Majorique Léger Ali Gharbi Gilbert Babin | 2011 | International Journal of Production Economics2011，，2： | 1 |
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