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| 1 | Characterization of focal liver lesions with SonoVue~-enhanced sonography: International multicenter-study in comparison to CT and MRI显示文摘AIM: To evaluate in a multicenter study whether the sonographic characterization of focal liver lesions can be improved using SonoVueüà-enhancement; and to compare this method with computed tomography (CT) and magnetic resonance imaging (MRI). METHODS: One hundred and thirty four patients with one focal liver lesion detected in baseline ultrasound (US) were examined with conventional US, contrastenhanced US (n = 134), contrast-enhanced CT (n = 115) and/or dynamic contrast-enhanced MRI (n = 70). The lesions were classified as malignant, benign or indeterminate and the type of lesion was determined. The f inal diagnosis based on the combined information of all imaging examinations, clinical information and histology (n = 32) was used. Comparisons were made to see whether the addition of contrast-enhanced US led to the improvement of the characterization of doubtful focal liver lesions. RESULTS: In comparison with unenhanced US, SonoVue markedly improves sensitivity and specificity for the characterization (malignant/benign) of focal liver lesions. In comparison with CT and/or dynamic MRI, SonoVueüà -enhanced sonography applied for characterization of focal liver lesions was 30.2% more sensitive in the recognition of malignancy and 16.1% more specific in the exclusion of malignancy and overall 22.9% more accurate. In the subgroup with confirmative histology available (n = 30), sensitivity was 95.5% (CEUS), 72.2% (CT) and 81.8% (MRI), and specif icity was 75.0% (CEUS), 37.5% (CT) and 42.9% (MRI). The sensitivity and specif icity of CEUS for the identif ication of focal nodular hyperplasia (FNH) and hemangiomas was 100% and 87%, resulting in an accuracy of 94.5%. CONCLUSION: SonoVueüà-enhanced sonography emerges as the most sensitive, most specif ic and thus most accurate imaging modality for the characterization of focal liver lesions. | Hervé Trillaud Jean-Michel Bruel Pierre-Jean Valette Valérie Vilgrain Gérard Schmutz Raymond Oyen Wieslaw Jakubowski Jan Danes Vlastimil Valek Christian Greis | 2009 | World Journal of Gastroenterology2009，15，30： | 34 |
| 2 | Rescue Surgery for Unresectable Colorectal Liver Metastases Downstaged by Chemotherapy: A Model to Predict Long-term Survival显示文摘 | René Adam Valérie Delvart Gérard Pascal Adrian Valeanu Denis Castaing Daniel Azoulay Sylvie Giacchetti Bernard Paule Francis Kunstlinger Odile Ghémard Francis Levi Henri Bismuth | 2004 | Annals of Surgery2004，，4： | 2 |
| 3 | Oxidative stress promotes pathologic polyploidization in nonalcoholic fatty liver disease显示文摘 | Gentric Géraldine Maillet Vanessa Paradis Valérie Couton Dominique L’Hermitte Antoine Panasyuk Ganna Fromenty Bernard Celton-Morizur Séverine Desdouets Chantal | 2015 | Journal of Clinical Investigation2015，，： | 2 |
| 4 | Intracellular Pool of Vascular Endothelial Growth Factor in Human Neutrophils显示文摘 | Murielle G Olivier B Valérie A | 1997 | Blood1997，90，10： | 1 |
| 5 | The role of bacterial vaginosis in preterm labor and preterm birth: A case-control study 显示文摘 | Damien S I Val rie D Fran oise L G | 2002 | Euro J Obstet Gynecol Reprod Biol2002，101，1： | 1 |
| 6 | Developmentof a continuous electrodialysis fermentation system for production of lactic acid by Lactobacillus rhamnosus显示文摘 | GAO M T MICI-HTERU K RIE G | 2005 | Process Biochemistry2005，40，： | 1 |
| 7 | Development of a continuous electrodialysis fermentation system for production of lactic acid by Lactobacillus rhamnosus显示文摘 | GAO M T MICHITERU K RIE G | 2005 | Process Biochemistry2005，40，： | 1 |
| 8 | Clinical outcome in patients with locally advanced bladder carcinoma treated with conservative multimodality therapy显示文摘 | Luc George Franck Bladou Valérie Jeanne Bardou Gwenaelle Gravis Agnes Tallet Claude Alzieu Gérard Serment Naji Salem | 2004 | Urology2004，，3： | 1 |
| 9 | Temperature and power control in microwave drying显示文摘 | Zhenfeng Li G S V Raghavan Val 6 rie Orsat | 2010 | Journal of Food Engineering2010，97，： | 1 |
| 10 | Synthesis and char- acterization of polypropylene reinforced with cellulose I and II fibres 显示文摘 | BORJA Y RIE G LEDERER K | 2006 | J Appl Polym Sci2006，101，： | 1 |
| 11 | Impact of Point Spread Function Reconstruction on Thoracic Lymph Node Staging With 18F-FDG PET/CT in Non–Small Cell Lung Cancer显示文摘 | Charline Lasnon Rodney J. Hicks Jean-Mathieu Beauregard Alvin Milner Maria Paciencia Anne-Valérie Guizard Stéphane Bardet Radj Gervais Gabriel Lemoel Gérard Zalcman Nicolas Aide | 2012 | Clinical Nuclear Medicine2012，，10： | 1 |
| 12 | Rescue Surgery for Unresectable Colorectal Liver Metastases Downstaged by Chemotherapy: A Model to Predict Long-term Survival显示文摘 | René Adam Valérie Delvart Gérard Pascal Adrian Valeanu Denis Castaing Daniel Azoulay Sylvie Giacchetti Bernard Paule Francis Kunstlinger Odile Ghémard Francis Levi Henri Bismuth | 2004 | Annals of Surgery2004，，4： | 1 |
| 13 | Effects of temperature,8 - hydroxyquin-oline sulphate and sucrose on the vase life of cut rose flowers显示文摘 | Kazuo I Kohei K Rie G | 1999 | Postharvest Biology and Technology1999，15，： | 1 |
| 14 | Rescue Surgery for Unresectable Colorectal Liver Metastases Downstaged by Chemotherapy: A Model to Predict Long-term Survival显示文摘 | René Adam Valérie Delvart Gérard Pascal Adrian Valeanu Denis Castaing Daniel Azoulay Sylvie Giacchetti Bernard Paule Francis Kunstlinger Odile Ghémard Francis Levi Henri Bismuth | 2004 | Annals of Surgery2004，，4： | 1 |
| 15 | Application of wear-resistant PACVD coatings in aluminium die-casting: economical and ecological aspects显示文摘 | Teichmann G A Rie K T | 1999 | Surf & Coat Technol1999，112，： | 1 |
| 16 | Cyclosporin A and methotrexate are equally effective in reducing T cell numbers in psoriatic skin lesions but have no consistent effect on IFN-? and IL-4 expression in psoriatic skin in situ 显示文摘 | Piskin G Heydendael VMR de Rie MA | 2003 | Archives of dermatological research2003，294，12： | 1 |
| 17 | Maize and sunflower biomass estimation in southwest France using high spatial and temporal resolution remote sensing data显示文摘 | Martin Claverie Valérie Demarez Beno?t Duchemin Olivier Hagolle Danielle Ducrot Claire Marais-Sicre Jean-Fran?ois Dejoux Mireille Huc Pascal Keravec Pierre Béziat Remy Fieuzal Eric Ceschia Gérard Dedieu | 2012 | Remote Sensing of Environment2012，，： | 1 |
| 18 | Osf2/Cbfa1: A Transcriptional Activator of Osteoblast Differentiation显示文摘 | Patricia Ducy Rui Zhang Valérie Geoffroy Amy L Ridall Gérard Karsenty | 1997 | Cell1997，，5： | 1 |
| 19 | Probing non-enzymatic glycation of type I collagen:A novel approach using Raman and infrared biophotonic methods显示文摘 | Said M Happillon T Untereiner V Marie G Georges S Teddy H Valérie U Roselyne G Pierre J Ganesh D | 2013 | 1830(6):3525-35312013，1830，6： | 1 |
| 20 | Purification and Characterization of Laccases from the White-rot Basidiomycete Dichomitus squalens 显示文摘 | PE' RIE' F H REDDY G V BLACKBURN N J | 1998 | Arch Biochem Biophys1998，353，： | 1 |
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