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| 1 | Pathological changes in the lungs and lymphatic organs of 12 COVID-19 autopsy cases显示文摘Systematic autopsy and comprehensive pathological analyses of COVID-19 decedents should provide insights into the disease characteristics and facilitate the development of novel therapeutics.In this study,we report the autopsy findings from the lungs and lymphatic organs of 12 COVID-19 decedents—findings that evaluated histopathological changes;immune cell signature and inflammatory factor expression in the lungs,spleen and lymph nodes.Here we show that the major pulmonary alterations included diffuse alveolar damage,interstitial fibrosis and exudative inflammation featured with extensive serous and fibrin exudates,macrophage infiltration and abundant production of inflammatory factors(IL-6,IP-10,TNFo?and IL-I f).The spleen and hilar lymph nodes contained lesions with tissue structure disruption and immune cell dysregulation,including lymphopenia and macrophage accumulation.These findings provide pathological evidence that links injuries of the lungs and lymphatic organs with the fatal systematic respiratory and immune malfunction in critically ill COVID-19 patients. | Qian Liu Yu Shi Jun Cai Yaqi Duan Rongshuai Wang Hongyan Zhang Qiurong Ruan Jiansha Li Lei Zhao Yifang Ping Rong Chen Liang Ren Xiaochun Fei Heng Zhang Rui Tang Xi Wang Tao Luo Xindong Liu Xuequan Huang Zhenhua Liu Qilin Ao Yong Ren Jing Xiong Zhicheng He Haibo Wu Wenjuan Fu Pengnan Zhao Xinwei Chen Guoqiang Qu Yunyun Wang Xi Wang Jia Liu Dongfang Xiang Sanpeng Xu Xiaowei Zhou Qingrui Li Jinghong Ma Heng Li Jie Zhang Sizhe Huang Xiaohong Yao Yiwu Zhou Chaofu Wang Dingyu Zhang Guoping Wang Liang Liu Xiu-Wu Bian | 2020 | National Science Review2020，7，12： | 6 |
| 2 | In situ investigation of SiC powder's microwave sintering by SR-CT technique显示文摘Microwave sintering is being developed as a novel technique for the preparation of dense structural ceramics,but the mature theory has not been established due to the technical difficulties.The synchrotron radiation X-ray computed tomography(SR-CT) technique was introduced for the first time into the study of microwave sintering to in-situ observe the microstructure evolution of silicon carbide(SiC) material in this paper.By applying the SR-CT technique,the reconstructed 2D and 3D images of the specimen were obtained and the double logarithm curve of mean neck size and time(Ln(x)-Ln(t)) were obtained from these reconstructed images.Various sintering phenomena including sintering neck growth during microwave treatment were observed from the reconstructed images.Furthermore,the differences in microstructure evolution and sintering kinetics between microwave and conventional sintering were analyzed based on the reconstructed images and the Ln(x)-Ln(t) curve.1) The sharp surface of grains near the contact region distinctly grew blunt and the sintering neck growth between these grains were obviously observed at the early stage.Besides,the larger particles grew faster than smaller ones.The main reason for these phenomena may be the micro-focusing effect of electric fields.2) During each of the three sintering stages,the sintering kinetics curve of double logarithm relationship between mean neck size and time shows a good linear relationship,but at the middle stage the slope of the curve increases dramatically,which is quite larger than conventional sintering.The preliminary interpretation for these extraordinary phenomena has been discussed in details. | LI YongCun XU Feng HU XiaoFang QU HongYan MIAO Hong ZHANG Zhong XIAO TiQiao | 2011 | Science China(Technological Sciences)2011，54，6： | 4 |
| 3 | Land Surface Albedo Variations in Sanjiang Plain from 1982 to 2015: Assessing with GLASS Data显示文摘As a key parameter for indicating the fraction of surface-reflected solar incident radiation, land surface albedo plays an important role in the Earth’s surface energy budget(SEB). Since the Sanjiang Plain has been severely affected by human activities(e.g., reclamation and shrinking of wetlands), it is important to assess the spatiotemporal variations of surface albedo in this region using a long-term remote sensing dataset. In order to investigate the surface albedo climatology, trends, and mechanisms of change, we evaluated the surface albedo variations in the Sanjiang Plain, China from 1982 to 2015 using the Global LAnd Surface Satellite(GLASS) broadband surface albedo product. The results showed that: 1) an increasing annual trend(+0.000 58/yr) of surface albedo was discovered in the Sanjiang Plain based on the GLASS albedo dataset, with a much stronger increasing trend(+0.001 26/yr) occurring during the winter. Most of the increasing trends occurred over the cultivated land, unused land, and land use conversion types located in the northeastern Sanjiang Plain. 2) The increasing trend of land surface albedo in Sanjiang Plain can be largely explained by the changes of both snow cover extent and land use. The surface albedo in winter is highly correlated with the snow cover extent in the Sanjiang Plain, and the increasing trend of surface albedo can be further enhanced by the land use changes. | LI Xijja ZHANG Hongyan QU Ying | 2020 | Chinese Geographical Science2020，30，5： | 3 |
| 4 | Efficient oxidation of ethylbenzene catalyzed by cobalt zeolitic imidazolate framework ZIF-67 and NHPI显示文摘Efficient catalytic oxidation of ethylbenzene to acetophenone was realized using the catalytic system of cobalt zeolitic imidazolate framework ZIF-67/N-hydroxyphthalimide(NHPI) under mild conditions. 95.2% conversion of ethylbenzene with 90.3% selectivity to acetophenone could be obtained at 373 K under 0.3 MPa O2 for 9 h. The results show that there exists synergetic effect between ZIF-67 and NHPI. 1-Phenylethyl hydroperoxide(PEHP) was generated via a radical process involving the hydrogen abstraction from ethylbenzene by phthalimide N-oxyl, and subsequently effectively decomposed to acetophenone by ZIF-67. | Hongyan Li Hong Ma Xinhong Wang Jin Gao Chen Chen Song Shi Minjie Qu Na Feng Jie Xu | 2014 | Journal of Energy Chemistry2014，23，6： | 2 |
| 5 | Transcriptome responses to heat stress in hypothalamus of a meat-type chicken显示文摘Background:Heat stress has resulted in great losses in poultry production.To address this issue,we systematically analyzed chicken hypothalamus transcriptome responses to thermal stress using a 44 k chicken Agilent microarray,Methods:Hypothalamus samples were collected from a control group reared at 25℃,a heat-stress group treated at 34℃ for 24 h,and a temperature-recovery group reared at 25℃ for 24 h following a heat-stress treatment.We compared the expression profiles between each pair of the three groups using microarray data.Results:A total of 1,967 probe sets were found to be differentially expressed in the three comparisons with P < 0.05 and a fold change(FC) higher than 1.5,and the genes were mainly involved in self-regulation and compensation required to maintain homeostasis.Consistent expression results were found for 11 selected genes by quantitative real-time PCR.Thirty-eight interesting differential expression genes were found from GO term annotation and those genes were related to meat quality,growth,and crucial enzymes.Using these genes for genetic network analysis,we obtained three genetic networks.Moreover,the transcripts of heat-shock protein,including Hsp 40 and Hsp 90,were significantly altered in response to thermal stress.Conclusions:This study provides a broader understanding of molecular mechanisms underlying stress response in chickens and discovery of novel genes that are regulated in a specific thermal-stress manner. | Hongyan Sun Runshen Jiang Shengyou Xu Zebin Zhang Guiyun Xu Jiangxia Zheng Lujiang Qu | 2015 | Journal of Animal Science and Biotechnology2015，6，3： | 2 |
| 6 | Expression Profile and Function Analysis of Long Non-coding RNAs in the Infection of Coxsackievirus B3显示文摘The roles of IncRNAs in the infection of enteroviruses have been barely demonstrated.In this study,we used coxsackievirus B3(CVB3),a typical enterovirus,as a model to investigate the expression profiles and functional roles of IncRNAs in enterovirus infection.We profiled IncRNAs and mRNA expression in CVB3-infected HeLa cells by IncRNA-mRNA integrated microarrays.As a result,700 differentially expressed IncRNAs(431 up-regulated and 269 down-regulated)and 665 differentially expressed mRNAs(299 up-regulated and 366 down-regulated)were identified in CVB3 infection.Then we performed IncRNA-mRNA integrated pathway analysis to identify potential functional impacts of the differentially expressed mRNAs,in which IncRNA-mRNA correlation network was built.According to IncRNA-mRNA correlation,we found that XLOC-001188,an IncRNA down-regulated in CVB3 infection,was negatively correlated with NFAT5 mRNA,an anti-CVB3 gene reported previously.This interaction was supported by qPCR detection following siRNA-mediated knockdown of XLOC-001188,which showed an increase of NFAT5 mRNA and a reduction of CVB3 genomic RNA.In addition,we observed that four most significantly altered IncRNAs,SNHG11,RP11-145F16.2,RP11-1023L17.1 and RP11-1021N1.2 share several common correlated genes critical for CVB3 infection,such as BRE and IRF2BP1.In all,our studies reveal the alteration of IncRNA expression in CVB3 infection and its potential influence on CVB3 replication,providing useful information for future studies of enterovirus infection. | Lei Tong Ye Qiu Hui Wang Yunyue Qu Yuanbo Zhao Lexun Lin Yan Wang Weizhen Xu Wenran Zhao Hongyan He Guangze Zhao Mary HZhang Decheng Yang Xingyi Ge Zhaohua Zhong | 2019 | Virologica Sinica2019，34，6： | 2 |
| 7 | Dual-responsive nanovaccine for cytosolic delivery of antigens to boost cellular immune responses and cancer immunotherapy显示文摘Cancer vaccine contributing to the success of the treatment and prevention of tumors has attracted a huge attention as a strategy for tumor immunotherapy in recent years.A major challenge of cancer vaccine is to target cytosols of dendritic cells(DCs)in the lymph nodes(LNs)to enhance efficiency of antigen cross-presentation,which elicits high levels of cytotoxic T-lymphocytes to destruct tumor cells.Here,we address this issue by conjugating ovalbumin(OVA)to PEG-PCL using disulfide bond(-ss-),and the degradable pH-responsive polymer-PEI-PCL as delivery carrier.In addition,the mol ratio of PEG-PCL to PEI-PCL in the mixed micelles was tailored to deliver the OVA to LNs.Subsequently,CpG ODN_(1826),a TLR-9 agonist,was further introduced into a mixed micelle of 30nm or less as a unique tumor vaccine.Importantly,the results demonstrated the mixed micelles with 1:1mol of PCL-PEG and PCL-PEI can effectively migrate to distal LNs where antigen were efficiently captured by DCs,meanwhile,OVA was modified to the surface of mixed micelles via disulfide bonds(-ss-)for promotion efficiency of antigen cross-presentation.More surprisingly,combination of tumor vaccine with anti-PD-1,the therapy of ectopic melanoma(B16-OVA)and lung metastasis melanoma(B16-OVA)is excellent therapeutic effect.Taken together,our works offers a novel strategy for the cytosol delivery of antigens to achieve potent cancer immunotherapy. | Yang Sui Ji Li Jiqiang Qu Ting Fang Hongyan Zhang Jian Zhang Zheran Wang Mingyu Xia Yinghui Dai Dongkai Wang | 2022 | Asian Journal of Pharmaceutical Sciences2022，17，4： | 1 |
| 8 | Complex evolution of coal permeability during CO2 injection under variable temperatures显示文摘 | Qu Hongyan Liu Jishan Chen Zhongwei | 2012 | International Journal of Greenhouse Gas Control2012，，9： | 1 |
| 9 | Striatal dopamine receptor plasticity in neurotensin deficient mice 显示文摘 | Chastain LG Qu Hongyan Bourke CH | 2015 | Behav Brain Res2015，280，： | 1 |
| 10 | Complex evolution of coal permeability during CO 2 injection under variable temperatures显示文摘 | Hongyan Qu Jishan Liu Zhongwei Chen Jianguo Wang Zhejun Pan Luke Connell Derek Elsworth | 2012 | International Journal of Greenhouse Gas Control2012，，： | 1 |
| 11 | Interactions of multiple processes during CBM extraction: A critical review显示文摘 | Jishan Liu Zhongwei Chen Derek Elsworth Hongyan Qu Dong Chen | 2011 | International Journal of Coal Geology2011，，3： | 1 |
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