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| 1 | Regional Distribution and Sustainable Development Strategy of Mineral Resources in China显示文摘This paper summarizes the distribution and production layout of the major mineral resources in China,including coal,iron ore,copper and bauxite,from a national perspective.It also identifies the incompatibility between the mineral resources distribution and regional economic development.Significant issues with China's mineral resource industry cause challenges for the sustainable development of both the mining industry and the national socio-economy.The sustainability of regional mineral resources and the environmental pollution by mining in the western China were also analyzed.Results show that the distribution of China's mineral resources is misaligned with its regional layout of economic development.China's mineral resources have been over-exploited,and the mineral resources production in the eastern China is unsustainable.The continuously expanding production of mineral resources in the western China has heavily endangered the ecological environment.We propose strategies to boost the sustainable development of mineral resources,including measures to accelerate economic development and enhance the sustainability of domestic mineral resources.We also offer suggestions for scientifically planning the mineral resource prospecting and exploitation and regional economic layout,as well as for proactively undertaking industry transfer in the eastern China and raising the environmental benchmark requirements for the mineral industry in the central and western China. | LI Chaofeng WANG Anjian CHEN Xiaojin CHEN Qishen ZHANG Yanfei LI Ying | 2013 | Chinese Geographical Science2013，23，4： | 11 |
| 2 | Insulin expression in livers of diabetic mice mediated by hydrodynamics-based administration显示文摘AIM:Transfer and expression of insulin gene in vivo are an alternative strategy to improve glycemic control in type 1 diabetes. Hydrodynamics-based procedure has been proved to be very efficient to transfer naked DNA to mouse livers. The basal hepatic insulin production mediated by this rapid tail vein injection was studied to determine its effect on the resumption of glycemic control in type 1 diabetic mice.METHODS: Engineered insulin cDNA was inserted into plasmid vectors under a CMV promoter, and transferred into STZ induced diabetic mice by hydrodynamic procedure.Glucose levels, body weight of treated mice, insulin levels,immunohistology of the liver, and quantity of insulin mRNA in the liver were assayed to identify the improvement of hyperglycemic complication after plasmid administration.Sleeping Beauty, a transposon system, was also used to prolong the insulin expression in the liver.RESULTS: After plasmid administration, Plasma insulin was significantly increased in the diabetic mice and the livers were insulin-positive by immunostaining. At the same time the hyperglycemic complication was improved. The blood glucose levels of mice were reduced to normal. Glucose tolerance of the treated diabetic mice was improved. Body weight loss was also ameliorated. The rapid tail vein injection did not cause any fatal result.CONCLUSION: Our results suggested that insulin gene could be efficiently transferred into the livers of diabetic mice via rapid tail vein injection and it resulted in high level of insulin expression. The basal hepatic insulin production mediated by hydrodynamics-based administration improved the glycemic control in type 1 diabetes dramatically and ameliorated diabetic syndromes. Hydrodynamics-based administration offers a simple and efficient way in the study of gene therapy for type 1 diabetes. | Chen-XiaHe DingShi Wen-JunWu You-FaDing Deng-MinFeng BinLu Hao-MingChen Ji-HuaYao QiShen Da-RuLu Jing-LunXue | 2004 | World Journal of Gastroenterology2004，10，4： | 10 |
| 3 | A micro-adjusting attitude mechanism for autonomous drilling robot end-effector显示文摘Drilling end-effector is a key unit in autonomous drilling robot.The perpendicularity of the hole has an important influence on the quality of airplane assembly.Aiming at the robot drilling perpendicularity,a micro-adjusting attitude mechanism and a surface normal measurement algorithm are proposed in this paper.In the mechanism,two rounded eccentric discs are used and the small one is embedded in the big one,which makes the drill’s point static when adjusting the drill’s attitude.Thus,removal of drill’s point position after adjusting the drill attitude can be avoided.Before the micro-adjusting progress,four non-coplanar points in space are used to determine a unique sphere.The normal at the drilling point is measured by four laser ranging sensors.The adjusting angles at which the motors should be rotated to adjust attitude can be calculated by using the deviation between the normal and the drill axis.Finally,the motors will drive the two eccentric discs to achieve micro-adjusting progress.Experiments on drilling robot system and the results demonstrate that the adjusting mechanism and the algorithm for surface normal measurement are effective with high accuracy and efficiency. | YUAN PeiJiang WANG QiShen SHI ZhenYun WANG TianMiao WANG ChengKun CHEN DongDong SHEN LiHeng | 2014 | Science China(Information Sciences)2014，57，12： | 8 |
| 4 | New design of a compact aero-robotic drilling end effector: An experimental analysis显示文摘This paper presents the development of a normal adjustment cell(NAC) in aero-robotic drilling to improve the quality of vertical drilling, by using an intelligent double-eccentric disk normal adjustment mechanism(2-EDNA), a spherical plain bearing and a floating compress module with sensors. After the surface normal vector is calculated based on the laser sensors' feedback,the 2-EDNA concept is conceived specifically to address the deviation of the spindle from the surface normal at the drilling point. Following the angle calculation, depending on the actual initial position, two precise eccentric disks(PEDs) with an identical eccentric radius are used to rotate with the appropriate angles using two high-resolution DC servomotors. The two PEDs will carry the spindle to coincide with the surface normal, keeping the vertex of the drill bit still to avoid repeated adjustment and position compensation. A series of experiments was conducted on an aeronautical drilling robot platform with a precise NAC. The effect of normal adjustment on bore diameter, drilling force, burr size, drilling heat, and tool wear was analyzed. The results validate that using the NAC in robotic drilling results in greatly improved vertical drilling quality and is attainable in terms of intelligence and accuracy. | Shi Zhenyun Yuan Peijiang Wang Qishen Chen Dongdong Wang Tianmiao | 2016 | Chinese Journal of Aeronautics2016，29，4： | 4 |
| 5 | Enhancement of naked FIX minigene expression by chloroquine in mice显示文摘AIM: To study the effect of chloroquine on the expression of human clotting factor IX (hFIX) in mice. METHODS:Hydrodynamics-based naked DNA plasmid administration was performed by tail vein injection of 10 g of pCMV-hFIX and chloroquine (0, 100, 200, and 500 mol/L) in 2.2 mL of Ringer solution within 6-7 s, the level andstability of hFIX expression, liver damage and toxicity were then examined. RESULTS: The maximum expression ofhFIX level was 4.41.8 mg/L at 8 h after injection, 9.71.6 mg/L at 24 h only existed in 200 mol/L chloroquine-treated animals, which is 3-4 fold higher than that of control (P<0.01). There is no significant difference observedamong all the treated groups, 3 d later. Transaminase level and liver histological study showed the damage of liverwas not related to chloroquine (P>0.05). CONCLUSION: Chloroquine can enhance and sustain exogenous geneexpression in vivo without side effect under our experimental conditions. | Hong-yanCHEN Huan-zhangZHU BinLU XuanXU Ji-huaYAO QiSHEN Jing-lunXUE | 2004 | Acta Pharmacologica Sinica2004，25，5： | 2 |
| 6 | Radioprotective effect of extract from Spirulina platensis in mouse bone marrow cells studied by using the micronucleus test 显示文摘 | Qishen P Guo BJ Koliman A | 1989 | Toxicol Lett1989，48，2： | 1 |
| 7 | New Insights into the Mechanisms Involved in the Pleiotropic Actions of 1,25Dihydroxyvitamin D3显示文摘 | SYLVIACHRISTAKOS PUNEETDHAWAN QISHEN XIAORONGPENG BRYANBENN YANZHONG | 2006 | Annals of the New York Academy of Sciences2006，，1： | 1 |
| 8 | LC determination of luteolin-7-O-β-D-glucoside and apigenin-7-O-β-D-glucoside in rat plasma after administration of Humulus scandens extract and its application to pharmacokinetic studies显示文摘 | Zaixing Chen Xixiang Ying Shu Meng Xu Zhu Hong Jiang Qishen Cao Lin Wang Fanhao Meng | 2012 | Natural Product Research2012，，6： | 1 |
| 9 | Triblock copolymer syntheses of mesoporous silica with periodic 50 to 300 Angstrom pores 显示文摘 | Zhao Dongyuan Feng Jiangjin Huo Qishen | 1998 | Science1998，279，： | 1 |
| 10 | Osteopontin promotes the progression of gastric cancer through the NF-κBpathway regulated by the MAPK and PI3K显示文摘 | Jie Liu Qishen Liu Yali Wan Zhigang Zhao Honggang Yu Hesheng Luo Zhongzhi Tang | 2014 | International Journal of Oncology2014，，1： | 1 |
| 11 | Qualitative properties of vibration about non homogeneous circular membrane with axisymmetrical mass显示文摘 | Wu Lei Wang Qishen Wang Dajun | 2011 | Advanced Materials Research2011，216，3： | 1 |
| 12 | Nonionic triblock and star diblock copolymer and oligomeric surfactant syntheses of highly ordered, hy- drothermally stable, mesoporous silica structures 显示文摘 | Zhao Dongyuan Huo Qishen Feng Jianglin | 1998 | JAmer Chem Soc1998，120，： | 1 |
| 13 | In-situ and quantitative analysis of aged silicone rubber materials with laser-induced breakdown spectroscopy显示文摘Due to their weak weather ability,the ageing process of organic silicone rubber composites remarkably influences the service performance of composite insulators and bushings,especially in high-voltage transmission lines.In this study,laser-induced breakdown spectroscopy(LIBS)was used for analysing ageing composite insulator sheds for potential on-site application.A spectrum was recorded after each laser pulse and the element composition of ablated materials with different depth was observed.A calibration curve that revealed linear relationship between C,Si,Al spectrum line intensity and corresponding element concentration was established with the result of X-ray photoelectron spectroscopy test.Regularly line intensities of C,Si and Al changed dramatically from the surface to the bulk layer.Given the number of laser pulses with varying element concentrations,as well as the linear relationship described above,the depth of ageing layer could be calculated immediately.Also,the result was verified by secondary ion mass spectrometry and scanning electron microscope.LIBS method can be a promising and efficient technique to assess the ageing state of composite materials on site. | Wang Xilin Hong Xiao Chen Ping Zhao Chenlong Jia Zhidong Wang Liming Lv Qishen Huang Ronghui Liu Shungui | 2018 | High Voltage2018，3，2： | 1 |
| 14 | With a group of vas- cular flap transplantation clinical application 显示文摘 | Fan Qishen Zhou Xiangji Li Qingxi | 2005 | Chinese Journal of surgery2005，28，02： | 1 |
| 15 | Sweet false stalk crusher显示文摘 | ZHANG Changcong WANG Qishen ZHANG Yan | 2016 | International English Education Research2016，，2： | 0 |
| 16 | LAPLACE TRANSFORM-BOUNDARY ELEMENT COUPLING METHOD FOR VISCOUS FLUIDSTRUCTURE IMPACT ANALYSIS显示文摘Based on linearized 2-D Navier-Stokes equation,a Laplace transform-boundary element couplingmethod for viscous fluid-structure impact analysis is proposed.Under assumption of incompressibility for thefluid,the corresponding equivalent boundary integral equation in terms of the potential function and streamfunction is first established by Lamb’s transform in the Laplace transform domain.It enables us to solve im-pact water problems in frequency domain by the boundary element method,in which the effect of viscous flowon the dynamic response can be taken into account.Then a complete solution of the problem under consider-ation in time domain is obtained by means of Durbin’s formulas for the numerical inversion of the Laplacetransform.Finally,a practical example is given to confirm the validity of the present method. | Ren Zhiliang Huang Yuying Li Qishen | 2001 | Acta Mechanica Solida Sinica2001，14，3： | 0 |
| 17 | Improved Cubemap model for 3D navigation in geo-virtual reality显示文摘Due to advances in rendering techniques and hardware capability,stereoscopic 3D(s3D)visualization is becoming increasingly common in daily life.However,this does not change the fact that stereo effects and visual comfort depend greatly on how the related parameters are controlled during the production of the s3D images.In geovirtual reality systems,which are important browsers for Digital Earth,the maintenance of these parameters is deeply related to the navigation process.Therefore,the navigation method in such systems requires special care.This paper presents a new flying method based on a Cubemap structure.The method defines a Vehicle model and modifies the original Cubemap structure by adding a front view camera during the navigation;it allows the users to fly through a virtual geographic environment with automatic speed control,smooth collision resolution,and dynamic adjustment of the s3D-related parameters.A user test was conducted to compare this new method with the original method based on the Cubemap structure.The results show that the new method performs better than the former one for it provides a convenient interaction experience with improved stereoscopic effect,and diminishes visual discomfort. | Qishen Duan Jianhua Gong Wenhang Li Shen Shen Rong Li | 2015 | International Journal of Digital Earth2015，8，11： | 0 |
| 18 | A stream-based Parasitic Model for implementing Mobile Digital Earth显示文摘A Parasitic Model is proposed in this study for Digital Earth running on mobile phones through a mobile network.Because of mobile phones’limited capabilities in high-performance computing,rendering,storing,and networking(CRSN),these functions are accomplished by a superior host computer in this model.Rendered virtual scenes are compressed in a time-series as a data stream and are sent to the mobile phone through a mobile network,thus allowing Digital Earth to be operated on a mobile phone.This study examines a prototype and shows that a Mobile Digital Earth based on a Parasitic Model can achieve functionality beyond the mobile phone’s actual hardware capabilities and can reduce network traffic.These results demonstrate quasi-real-time interactions,but with bandwidth increases in next-generation mobile networks such as 4G and 5G,there is potential for real-time interactions in the near future. | Wenhang Li Jianhua Gong Ping Yu Qishen Duan Yuling Zou | 2014 | International Journal of Digital Earth2014，7，1： | 0 |
| 19 | Artificial Life: Visual Model with Simulation of a Plant Pet显示文摘This paper introduces an L-system model, which simulates a plant pet. The plant, named Wilson, is able to respond to the change of its virtual environment and to user's behaviors. However it does not speak or move. What users can see are only the changes of its appearance. The connection between the plant's appearance and external inputs is implemented with some parameters embedded in the L-system. | JIChen QIShen | 2004 | 上海大学学报(自然科学版)2004，10，B10： | 0 |
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