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| 1 | Cucurbitacin B induces rapid depletion of the G-actin pool through reactive oxygen species-dependent actin aggregation in melanoma cells显示文摘Cucurbitacin B (崽) ,从 Cucurbitaceae 植物孤立的 triterpenoid 混合物,作为一个有希望的反癌症代理人被报导了,还它的行动机制仍然是争论的。在这研究,我们在鼠科的 B16F10 黑瘤房间探索了崽的潜在的机制。反增长和反侵略效果在有教养的房间被估计,并且在 vivo 反肿瘤,活动在一个鼠科的下的黑瘤模型被评估。流动 cytometry 被采用分析细胞周期分发和反应的氧种(ROS ) 层次。肌动朊层次被西方的污点分析决定,并且微分表示蛋白质的侧面被一条量的 proteomic 途径识别。结果证明那崽在房间增长,殖民地形成,以及移植和黑瘤房间的侵略潜力上施加了禁止的效果。下的黑瘤的生长显著地在当时,与崽对待的老鼠被禁止与控制相比组。而且,崽治疗引起了快速的房间膜 blebbing 和变丑,并且导致了 G2/M-phase 拘捕和 multiploid 房间的形成。尤其是, G 肌动朊水池很快被弄空,肌动朊总数在崽处理以后快速被形成。很多细胞骨架规章的蛋白质是调整的差别。ROS 生产的阻塞显著地减少了 G 肌动朊弄空能力和崽的反肿瘤活动。这些调查结果显示那崽在黑瘤房间通过 ROS 依赖的肌动朊聚集导致 G 肌动朊水池的快速的弄空,它可以部分至少说明它的反肿瘤活动。 | Yanting Zhang Dongyun Ouyang Lihui Xu Yuhua Ji Qingbing Zha Jiye Cai Xianhui He | 2011 | Acta Biochimica et Biophysica Sinica2011，43，7： | 19 |
| 2 | Recent research progresses in ether-and ester-based electrolytes for sodium-ion batteries显示文摘Owing to the natural abundance and low cost of sodium resources,sodium-ion batteries(SIBs)have drawn considerable attention for state-of-the-art power storage devices over the last few years.To enable advanced SIBs with a brighter future,great effort has been made,not only through optimizing the electrode materials,but also with rationally designing various electrolyte systems.Among the available electrolyte systems,organic electrolytes,especially those based on esters as well as ethers,are the most promising ones for practical application in the foreseeable future,due to their numerous inherent advantages.This review is concerned with the recent research progresses on organic electrolytes for SIBs,focusing on etherbased and ester-based ones. | Zeheng Lin Qingbing Xia Wanlin Wang Weishan Li Shulei Chou | 2019 | InfoMat2019，1，3： | 12 |
| 3 | KDM4B promotes epithelial-mesenchymal transition through up-regulation of ZEB1 in pancreatic cancer显示文摘离氨酸(K) 特定的 demethylase 4B (KDM4B ) 是 histone H3K9 demethylase 并且被报导通过染色质结构的规定激活基因抄写。以前的研究表明了 KDM4B 在 colorectal,前列腺和胃的癌症起特殊规章的作用。然而,它在胰腺的癌症的生理的角色仍然保持大部分未知。在现在的学习,它是表明的 KDM4B 戏一在在胰腺的癌症的上皮间充质的转变(EMT ) 关键。siRNA 调停了 KDM4B 的 silencing 禁止房间移植,侵略和 EMT。而且, KDM4B 被表明 epigenetically 在 TGF 调整 ZEB1 的表示 -- 导致的 EMT 过程。在胰腺的癌症病人的肿瘤纸巾, KDM4B 的蛋白质水平断然与 ZEB1 被相关。在结论,我们的结果建议 KDM4B 是在 EMT 过程的一个关键调停人,并且可以为人的胰腺的癌症的变形前进用作一个重要预示的标记和治疗学的目标。 | Shuo Li Linlin Wu Qingbing Wang Yingyi Li Xiaolin Wang | 2015 | Acta Biochimica et Biophysica Sinica2015，47，12： | 8 |
| 4 | Phosphorus and phosphide nanomaterials for sodium-ion batteries显示文摘 | Qingbing Xia Weijie Li Zongcheng Miao Shulei Chou Huakun Liu | 2017 | Nano Research2017，10，12： | 7 |
| 5 | Surface quality of cold rolling aluminum strips under lubrication condition显示文摘The effects of oil film on the rolled surface,including surface roughness and topography,were investigated during cold rolling of aluminum strips.Various mineral oils with viscosities from 0.10 to 1.6 Pa.s were used to obtain different oil film thick- nesses.Results from experiment and calculation show that the thicker oil film protects the initial roughening surface so that it leads to an increase in roughness of the rolled surface,in particular when the surface roughness has the character of direction.The rolled surface roughness was determined byλ,which is the ratio of oil film thickness to the combined surface roughness.Whenλ>3,the rolled surface roughness increases rapidly with the increase in oil viscosity,whereas the surface roughening has already occurred whenλ<3,but the increase of the rolled surface roughness with increasing viscosity is not distinct. | Jianlin Sun Wang Lu Yanli Ma Qingbing Shi Aihua Zhang Jian Li | 2008 | Journal of University of Science and Technology Beijing2008，15，3： | 6 |
| 6 | Arsenic concentration in peripheral blood is correlated with efficacy of a Traditional Chinese Medicine regimen containing realgar for the treatment of myelodysplastic syndromes显示文摘OBJECTIVE:To explore the relationship between the efficacy of realgar for the treatment of myelodysplastic syndromes with multilineage dysplasia(MDS-MLD)and arsenic concentration in the peripheral blood of patients.METHODS:In this prospective study,a total of 50 MDS-MLD patients were treated with traditional Chinese drugs containing realgar for 3 months in Xiyuan Hospital from March 2018 to January 2019.Routine blood examination as well as liver and kidney function were monitored before and after treatment.The concentration of arsenic in the peripheral blood was measured using an atomic fluorescence spectrometer after treatment.The correlation between clinical effect and arsenic concentration was analyzed by Spearman’s method.RESULTS:The treatment response rate was 54%.Two patients(4%)achieved complete remission,50%(25 of 50)showed hematologic improvement,and 23 patients had stable disease(23%).No disease progression was observed.Arsenic concentration in the peripheral blood ranged from 14.60 to 85.96μg/L.Clinical efficacy was positively correlated with arsenic concentration(P<0.05).The incidence of mild adverse reactions was 16%.CONCLUSION:A relatively high concentration of arsenic in the peripheral blood may improve the clinical efficacy of realgar in MDS-MLD patients. | WANG Dexiu XU Yonggang DU Yu WANG Hongzhi LI Liu HU Xiaomei YANG Xiupeng MA Rou ZHOU Qingbing | 2021 | Journal of Traditional Chinese Medicine2021，41，4： | 3 |
| 7 | Histone deacetylase inhibitor valproic acid sensitizes B16F10 melanoma cells to cucurbitacin B treatment显示文摘Cucurbitacin B (崽) 被报导与其它一起由这个代理人的联合包括黑瘤,和更有效的政体在许多肿瘤上有反增长效果在调查下面。在这研究,崽的反黑瘤效果作为一个单个代理人并且在有 valproic 酸(VPA ) 的联合, histone deacetylase (HDAC ) 的一个禁止者,在 B16F10 被评估,一根老鼠黑瘤房间线。结果证明那崽以一种剂量依赖者方式禁止了房间线的增长。然而,它是可能的支持幸存的补偿回答,包含 autophagy 的正式就职和 anti-apoptotic Bcl-2 蛋白质的 upregulation,被崽处理导致,它可能极大地减少这个代理人的 cytotoxicity。支持这,黑瘤房间被发现对有 chloroquine 的崽的联合更敏感,一个著名 autophagy 禁止者。并且导致崽的 autophagy 与 c6 月 N 终端 kinase (JNK ) 被联系激活,至少部分,自从 JNK 的抑制,由 SP600125 的活动能减轻 autophagy。当崽与 VPA 被相结合时,二药由房间 apoptosis 的正式就职显示出 synergistic cytotoxicity。而且,崽的 multiploidization 效果也面对 VPA 被压制。与由崽的 JNK 的短暂激活相对照,崽和 VPA 的联合导致了延长 JNK 激活,尽管在在 4 h 以后的底层。我们的结果证明 HDAC 禁止者 VPA 能通过 apoptotic 小径的正式就职敏化 B16F10 房间到崽处理。 | Dongyun Ouyang Yanting Zhang Lihui Xu Jingjing Li Qingbing Zha Xianhui He | 2011 | Acta Biochimica et Biophysica Sinica2011，43，6： | 3 |
| 8 | Consumption of fruit, but not vegetables, may reduce risk of gastric cancer: Results from a meta-analysis of cohort studies显示文摘 | Qingbing Wang Yi Chen Xiaolin Wang Gaoquan Gong Guoping Li Changyu Li | 2014 | European Journal of Cancer2014，，： | 2 |
| 9 | Synthesis,Characterization of Rare-Earth Metal Chlorides Bearing Indolyl-Based NCN Pincer Ligand and Their Catalytic Activity toward 1,4-cis Polymerization of Isoprene显示文摘A novel indolyl-based NCN pincer ligand precursor HL(HL=(1-(2-(CH_(2))_(4)NCH_(2)CH_(2))-3-(2,6-ipr_(2)C_(6)H_(3)N=CH)C_(8)H_(5)N))was rationally and precisely designed,and successfully prepared in a high yield.Lithiation of HL with ^(n)BuLi in n-hexane,followed by treatment with RECl_(3) in THF led to the isolation of rare-earth metal chlorides in monomeric form(κ^(3)-L)RECI_(2)(THF)(RE=Sc(2),Yb(3)),and dimeric form[(κ^(3)-L)RECI(THF)(μ-Cl)]_(2)(RE=Er(4),Y(5))bearing the novel indolyl-based NCN pincer ligand in designed pincer ligation depending on different metal ionic radii;and the chloride bridged rare-earth metal and lithium mixed complexes in form(κ^(2)-L)_(2)RE(μ-Cl)_(2)Li(THF)_(2)(RE=Y(6),Dy(7)).All complexes were fully characterized and their structures were determined.The diamagnetic complexes 2,5 and 6 were furtherly characterized by the NMR spectroscopic method.The catalytic activity studies revealed that the central metal ions,borates,aluminum alkyls,and ligation of the central metal ions have influences on catalytic activity,and regio-and stereoselectivity for the polymerization of isoprene.With cooperation of the cocatalysts,the pincer-type yttrium chloride 5 initiated the isoprene polymerization with a high activity producing polymers with high regio-and stereoselectivity(1,4-cis polymers up to 99.6%),and the Mn as high as 8.76×10^(5). | Zeming Huang Shaowu Wang Xiancui Zhu Yun Wei Qingbing Yuan Shuangliu Zhou Xiaolong Mu Hua Wang | 2021 | Chinese Journal of Chemistry2021，39，12： | 2 |
| 10 | Model for measurement of thermal expansion coefficient of concrete by fiber optic sensor显示文摘 | Li Qingbing Yuan Libo Farhad Ansari | 2002 | International Journal of Solids and Structures2002，39，11： | 1 |
| 11 | Immune escape by SARS-CoV-2 Omicron variant and structural basis of its effective neutralization by a broad neutralizing human antibody VacW-209显示文摘Dear Editor,Coronavirus disease 2019(COVID-19)caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)and its variants is still a pandemic raging across the world(Supplementary information,Fig.S1a,b).A new variant,Omicron,was first detected in South Africa and got dominant in many regions.1 Omicron has been classified as a variant of concern by the World Health Organization(WHO),whose spike carried more than 30 mutations(Supplementary information,Fig.S1c).1,2 To make a comprehensive evaluation of the susceptibility of Omicron,we summarized plasma samples from 19 convalescent individuals infected with the wild-type(WT)virus,and measured their neutralizing activities against the WT,Beta,Delta,Mu,C.1.2,and Omicron(Supplementary information,Figs.S1d and S2).The Omicron showed more serious resistance to neutralizing antibodies(nAbs)than other variants including Beta and Mu(45.6-fold,9.6-fold,and 15.4-fold,respectively,compared with that against the WT)。 | Bin Ju Qingbing Zheng Huimin Guo Qing Fan Tingting Li Shuo Song Hui Sun Senlin Shen Xinrong Zhou Wenhui Xue Lingyan Cui Bing Zhou Shaowei Li Ningshao Xia Zheng Zhang | 2022 | Cell Research2022，32，5： | 1 |
| 12 | On two inequalities for the Hadamard product and the Fan product of matrices 显示文摘 | Liu Qingbing Chen Guoliang | 2009 | Lin Alg Appl2009，，431： | 1 |
| 13 | Some new bounds on the spectral radius of matrices 显示文摘 | Liu Qingbing Chen Guoliang Zhao Linlin | 2010 | Lin Alg Appl2010，，432： | 1 |
| 14 | Truncated glycoprotein E of varicella-zoster virus is an ideal immunogen for Escherichia coli-based vaccine design显示文摘Varicella-zoster virus(VZV)is a highly infectious agent responsible for both varicella and herpes zoster disease.Despite high efficacy,there remain safety and accessibility concerns with the licensed vaccines.Here,we sought to produce a VZV g E immunogen using an E.coli expression system.We found that the soluble expression and yield of g E protein could be enhanced via C-terminal truncations to the protein,thereby facilitating a robust and scalable purification process for the purpose of vaccine manufacturing.The lead truncated g E(aa 31–358),hereafter referred to as tg E,was a homogenous monomer in solution and showed excellent antigenicity.Finally,we assessed and compared the immunogenicity of tg E with commercial v Oka LAV and Shingrix vaccine.We found that aluminum-adjuvanted tg E was immunogenic as compared with v Oka LAV.When adjuvanted with AS01B,a two-dose immunization of tg E showed comparable or better potency in antibody responses and cell-mediated immunity with those of the Shingrix vaccine at the same dosage,especially in terms of the proportion of IFN-γ-expressing CD4^(+)T cells.In conclusion,this method of E.coli-mediate tg E expression offers a cost-effective and scalable strategy to generate an ideal VZV g E immunogen for the development of both varicella and zoster vaccines. | Tingting Chen Jie Sun Sibo Zhang Tingting Li Liqin Liu Wenhui Xue Lizhi Zhou Siting Liang Zhili Yu Qingbing Zheng Hai Yu Tong Cheng Jun Zhang Ying Gu Shaowei Li Ningshao Xia | 2023 | Science China(Life Sciences)2023，66，4： | 1 |
| 15 | Sliding wear performance of nano-SiO2/short carbon fiber/epoxy hybrid composites显示文摘 | GUO Qingbing RONG Minzhi JIA Guoliang | 2009 | Wear2009，266，78： | 1 |
| 16 | Sliding wear performance of nano-SiO2/short carbon fiber/epoxy hybrid composites 显示文摘 | GUO Qingbing RONG Minzhi JIA Guoliang | 2009 | Wear2009，266，78： | 1 |
| 17 | PRECONDITIONED HSS-LIKE ITERATIVE METHOD FOR SADDLE POINT PROBLEMS显示文摘一个新象 HSS 一样反复的方法首先基于为解决僵绳点问题 non-Hermitian (1,1 ) 切开块的象 HSS 一样被建议。为新方法的集中分析被给。同时,我们由 preconditioned Krylov subspace 方法考虑僵绳点系统的解决方案并且讨论一些光谱 preconditioned 僵绳的性质削尖矩阵。数字实验被给验证 preconditioners 的表演。[从作者抽象] | Qingbing Liu Guoliang Chen Caiqin Song | 2014 | Journal of Computational Mathematics2014，32，4： | 1 |
| 18 | Abdominal cocoon: multi-detector row CT with multiplanar reformation and review of literatures显示文摘 | Qingbing Wang Dengbin Wang | 2010 | Abdominal Imaging2010，，1： | 1 |
| 19 | Anti-thrombotic activity and chemical characterization of steroidal saponins from Dioscorea zingiberensis C.H. Wright显示文摘 | Hua Li Wen Huang Yanqing Wen Guohua Gong Qingbing Zhao Gang Yu | 2010 | Fitoterapia2010，，8： | 1 |
| 20 | Convergence analysis of the preconditioned Gauss-Seidel method for H- matrices显示文摘 | QINGBING LIU GUOLING CHEN JING CAI | 2008 | Computers and Mathematics with Applications2008，56，： | 1 |
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