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| 1 | Caspase-3 activation as a bifurcation point between plasticity and cell death显示文摘Death-mediating proteases such as caspases and caspase-3 in particular,have been implicated in neurodegenerative processes,aging and Alzheimer's disease.However,emerging evidence suggests that in addition to their classical role in cell death,caspases play a key role in modulating synaptic function.It is remarkable that active caspases-3,which can trigger widespread damage and degeneration,aggregates in structures as delicate as synapses and persists in neurons without causing acute cell death.Here,we evaluate this dichotomy,and discuss the hypothesis that caspase-3 may be a bifurcation point in cellular signaling,able to orient the neuronal response to stress down either pathological/apoptotic pathways or towards physiological cellular remodeling.We propose that temporal,spatial and other regulators of caspase activity are key determinants of the ultimate effect of caspase-3 activation in neurons.This concept has implications for differential roles of caspase-3 activation across the lifespan.Specifically,we propose that limited caspase-3 activation is critical for synaptic function in the healthy adult brain while chronic activation is involved in degenerative processes in the aging brain. | Shikha Snigdha Erica D Smith G Aleph Prieto Carl W Cotman | 2012 | Neuroscience Bulletin2012，28，1： | 91 |
| 2 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 3 | Transgenic sugarcane plants resistant to stem borer attack 显示文摘 | ARENCIBA A D VAZQUEZR I PRIETO D | 1997 | Molecular Breeding1997，，3： | 1 |
| 4 | Epidermal growth factor receptor (EGFR) expression in periocular and extraocular sebaceous carcinoma 显示文摘 | Ivan D Prieto VG Esmaeli B | 2010 | J Cutan PathoI2010，37，2： | 1 |
| 5 | Design and analysis of silicon antiresonant reflecting optical waveguides for evanescent field sensor显示文摘 | Prieto F Llobera A Jimenez D | 2000 | Journal of Lightwave Technology2000，18，： | 1 |
| 6 | Automatic analysis of the differenceimage for unsupervised change detection 显示文摘 | Bruzzone L Prieto D F | 2000 | IEEE Trans onGeoscience and Remote Sensing2000，38，3： | 1 |
| 7 | Hybridizing the fifth generation mesoscale model with artificial neural networks for short- term wind speed prediction显示文摘 | Prieto L Paredes D | 2009 | Renewable Energy2009，34，6： | 1 |
| 8 | Proteomics pattern: their potential for diseases diagnosis显示文摘 | XIAO Z PRIETO D CONRADS TP | 2005 | Mol Cell Endocrinol2005，230，12： | 1 |
| 9 | The pharmaeokinetics and metabolism of ivermectin in domestic animal species 显示文摘 | Canga A G Prieto A M S Li6bana M J D | 2009 | The Veterinary Journal2009，179，1： | 1 |
| 10 | Use of strontium titanate as an anode material for lithium-ion batteries显示文摘 | Johnson D C Prieto A L | 2001 | Journal of Power Sources2001，196，18： | 1 |
| 11 | On-line application of visible and near infrared reflectance spectroscopy to predict chemical-physical and sensory characteristics of beef quality显示文摘 | Prieto N Ross D W Navajas E A | 2009 | Meat Science2009，83，1： | 1 |
| 12 | Genomic organization and functional analysis of the gene encoding the Krtlppel-like transcription factor KLF6显示文摘 | Gehran RC D'Astolfo DS Prieto C | 2005 | Biochim Biophys Acta2005，1730，2： | 1 |
| 13 | Hyperlipidemia in liver transplant recipients: Prevalence and risk factors显示文摘 | C Gisbert M Prieto M Berenguer M Breto D Carrasco J u de J Mir J Berenguer | 1997 | Liver Transplantation1997，，4： | 1 |
| 14 | Endothelial dysfunction,obesity and insulin resistance显示文摘 | Prieto D Contreras C Sa nchez A | 2014 | Curr Vasc Pharmacol2014，12，3： | 1 |
| 15 | Apolipoprotein E geno- type, cardiovascular biomarkers and risk of stroke: systemat- ic review and meta-analysis of 14,015 stroke cases and pooled analysis of primary biomarker data from up to 60,883 individuals显示文摘 | Khan TA Shah T Prieto D eta1 | 2013 | Int J Epidemiol2013，42，2： | 1 |
| 16 | A Neural-statistical Approach to Multi-temporal and Multi-source Remote-sensing Image Classification 显示文摘 | BRUZZONE L PRIETO D F SERPICO S B | 1999 | IEEE Transactions on Geoscience and Remote Sensing1999，37，3： | 1 |
| 17 | Coronary artery bypass grafting in the awake patient combining high thoracic epidural and femoral nerve block:first series of 15 patients显示文摘 | Noiseux N Prieto I Bracco D | 2008 | Br J Anaesth2008，100，2： | 1 |
| 18 | Association between bisphosphonate use and implant survival after primary total arthro- plasty of the knee or hip : population based retrospective cohort study 显示文摘 | Prieto -Alhambra D Javaid MK Judge A | 2011 | BMI2011，6，： | 1 |
| 19 | Diarrhea caused by adenovirus and astrovirus in hospitalized immunodeficient patients显示文摘 | Prieto E Penalver D | 2001 | Enfermedades Infecciosasy Microbiologia clinica2001，19，1： | 1 |
| 20 | A side-by-side comparison of step feed BNR and simultaneous NDN 显示文摘 | Roderick D Reardon Brian M Karmasin Lisa M Prieto | 2003 | Proceedings of the Water Environment Federation2003，7，： | 1 |
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