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| 1 | p16 promoter hypermethylation:A useful serum marker for early detection of gastric cancer显示文摘AIM: To determine p16 promoter hypermethylation in gastric tumoral tissue and serum samples, its impact on p16-protein expression, and correlation with clinical and histological features. METHODS: Samples were obtained from 52 histologically confirmed cases of gastric adenocarcinoma. Gastric tissue and serum of 50 age- and sex-matched individuals with normal gastroscopy and biopsy were obtained as control samples. Methylation-specific polymerase chain reaction (MSP) was used to evaluate methylation status of p16 promoter. p16-protein expression was analyzed by immunohistochemical staining on paraffin-embedded sections. RESULTS: Methylation was detected in 44.2% (23/52) of tumoral tissues. 60.9% of them were also methylated in serum, i.e., 26.9% of all patients (14/52). Methylation was not detected in tissue and sera of control samples. p16-protein expression was decreased in 61.5% of cases (32/52), and was significantly associated with promoter hypermethylation (P < 0.001). Methylation was significantly more frequent in higher pathological grades (P < 0.05). Methylation was not associated with other clinicopathological features and environmental factors including H pylori infection and smoking. CONCLUSION: p16 promoter hypermethylation is an important event in gastric carcinogenesis. It is the principle mechanism of p16 gene silencing. It is related to malignant tumor behavior. Detection of DNA methylation in serum may be a biomarker for early detection of gastric cancer. | Mohammad Reza Abbaszadegan Omeed Moaven Hamid Reza Sima Kamran Ghafarzadegan Azadeh A'rabi Mohammad Naser Forghani Hamid Reza Raziee Ali Mashhadinejad Mostafa Jafarzadeh Ehsan Esmaili-Shandiz Ezzat Dadkhah | 2008 | World Journal of Gastroenterology2008，14，13： | 50 |
| 2 | Expression of cell adhesion molecule CD44 in gastric adenocarcinoma and its prognostic importance显示文摘AIM: To evaluate the relation of cluster of differentiation 44 (CD44) expression with clinicopathological features of gastric adenocarcinoma, and also its effect on prognosis with an emphasis on the differences between intestinal and diffuse types. METHODS: From 2000 to 2006, 100 patients with gastric adenocarcinoma, who had undergone total or subtotal gastrectomy without any prior treatment, were studied. Haematoxylin & eosin (HE) staining was used for histological evaluation, including the type (Lauren's classifi cation) and grading of the tumor. The expression of CD44 in the gastric adenocarcinoma mucosa and the adjacent mucosa were determined by immunohistochemistry. The survival analysis was obtained using the Kaplan-Meier test. RESULTS: Of 100 patients, 74 (74%) patients were male. The tumors were categorized as intestinal type (78%) or diffuse type (22%). Sixty-five percent of patients were CD44-positive. CD44 expression was not detected in normal gastric mucosa. Rather, CD44 was more commonly expressed in the intestinal subtype (P = 0.002). A signifi cant relation was seen between the grade of tumor and the expression of CD44 (P = 0.014). The survival analysis showed a poor prognosis of patients with CD44-positive tumors (P = 0.008); and this was more prominent in the intestinal (P = 0.001) rather than diffuse type. CONCLUSION: Cell adhesion molecule CD44 is highly expressed in gastric adenocarcinoma. CD44 expression is correlated with a poor prognosis in patients with the intestinal type of gastric adenocarcinoma. CD44 can, therefore, be utilized as a prognostic marker for this group of patients. | Kamran Ghaffarzadehgan Mostafa Jafarzadeh Hamid Reza Raziee Hamid Reza Sima Ehsan Esmaili-Shandiz Hanieh Hosseinnezhad Ali Taghizadeh Kermani Omeed Moaven Maryam Bahrani | 2008 | World Journal of Gastroenterology2008，14，41： | 18 |
| 3 | Association of p53/p21 expression with cigarette smoking and prognosis in esophageal squamous cell carcinoma patients显示文摘factors,such as cigarette smoking,in esophageal squamous cell carcinoma(ESCC)in northeastern Iran,a region with a high incidence of ESCC.METHODS:The expression of p53 and p21 proteins was investigated immunohistochemically in tumor tissue from 80 ESCC patients and in 60 available paraffinembedded blocks of adjacent normal specimens from the cases,along with normal esophageal tissue from 80 healthy subjects.RESULTS:Positive expression of p53 protein was detected in 56.2%(45/80)of ESCC cases,and in none of the normal esophageal tissue of the control group(P<0.001).Furthermore,73.8%(59/80)of ESCC cases and 43.8%(35/80)of controls had positive expression of p21 protein(P<0.001).Cigarette smoking was significantly associated with p53 over-expression in ESCC cases(P=0.010,OR=3.64;95%CI:1.32-10.02).p21 over-expression was associated with poorer clinical outcome among the ESCC patients(P=0.009).CONCLUSION:Over-expression of p53 in association with cigarette smoking may play a critical role in ESCC carcinogenesis among this high-risk population of northeastern Iran.Furthermore,p21 over-expression was found to be associated with poor prognosis,specifically in the operable ESCC patients. | Noushin Taghavi Firouzeh Biramijamal Masoud Sotoudeh Omeed Moaven Hooman Khademi Mohammad Reza Abbaszadegan Reza Malekzadeh | 2010 | World Journal of Gastroenterology2010，16，39： | 10 |
| 4 | Laparoscopic approach to suspected T1 and T2 gallbladder carcinoma显示文摘AIM To evaluate a laparoscopic approach to gallbladder lesions including polyps, wall-thickening lesions, and suspected T1 and T2 gallbladder cancer(GBC).METHODS We performed 50 cases of laparoscopic whole-layer cholecystectomy(LCWL) and 13 cases of laparoscopic gallbladder bed resection(LCGB) for those gallbladder lesions from April 2010 to November 2016. We analyzed the short-term and long-term results of our laparoscopic approach. RESULTS The median operation time was 108 min for LCWL and 211 min for LCGB. The median blood loss was minimal for LCWL and 28 ml for LCGB. No severe morbidity occurred in either procedure. Nine patients who underwent LCWL and 7 who underwent LCGB were postoperatively diagnosed with GBC. One of these patients had undergone LCGB for pathologically diagnosed T2 GBC after LCWL. All of the final surgical margins were negative. Three of these 15 patients underwent additional open surgery. The mean follow-up period was 26 mo, and only one patient developed recurrence.CONCLUSION LCWL and LCGB are safe and useful procedures that allow complete resection of highly suspected or earlystage cancer and achieve good short-term and longterm results. | Yusuke Ome Kazuki Hashida Mitsuru Yokota Yoshio Nagahisa Michio Okabe Kazuyuki Kawamoto | 2017 | World Journal of Gastroenterology2017，23，14： | 8 |
| 5 | Major hepatectomy using the glissonean approach in cases of right umbilical portion显示文摘Right umbilical portion(RUP) is a rare congenital anomaly associated with anomalous ramifications of the hepatic vessels and biliary system. As such, major hepatectomy requires a careful approach. We describe the usefulness of the Glissonean approach in two patients with vessel anomalies, such as RUP. The first patient underwent a right anterior sectionectomy for intrahepatic cholangiocarcinoma. We encircled several Glissonean pedicles that entered the right anterior section along the right side of the RUP. We temporarily clamped each pedicle, confirmed the demarcation area, and finally cut them. The operation was performed safely and was successful. The second patient underwent a left trisectionectomy for perihilar cholangiocarcinoma. We secured the right posterior Glissonean pedicle. The vessels in the pedicle were preserved, and the other vessels and contents were resected. Identifying the vessels for preservation facilitated the safe lymphadenectomy and dissection of the vessels to be resected. We successfully performed the operation. | Yusuke Ome Kazuyuki Kawamoto Tae Bum Park Tadashi Ito | 2016 | World Journal of Hepatology2016，8，34： | 2 |
| 6 | Role of hMLH1 and E-Cadherin Promoter Methylation in Gastric Cancer Progression显示文摘 | Meysam Moghbeli Omeed Moaven Bahram Memar Hamid Reza Raziei Azadeh Aarabi Ezzat Dadkhah Mohammad Mahdi Forghanifard Fatemeh Manzari Mohammad Reza Abbaszadegan | 2014 | Journal of Gastrointestinal Cancer2014，，1： | 2 |
| 7 | Dissociation between albuminuria andinsulinaemia in hypertensive and atherosclerotic men显示文摘 | Pedrineli R Dell Ome G Giampietro O | 1999 | J HumHypertens1999，13，2： | 1 |
| 8 | Small oxidative changes in atherogenic LDL concentrations irreversibly regulate adhesiveness of human endothelial cells: effect of the lazaroid U74500A 显示文摘 | Co~ome C Martinez- Gonzalez J Vidal F | 2000 | Atherosclernsis2000，149，2： | 1 |
| 9 | Misoprostol decreases oxidative stress and liver injury in bacterial lipopolysaccharide-induced endotoxemia in mice显示文摘 | Abdel-Salam OME Mohammed N A Morsy SMY | 2014 | Comp Clin Pathol2014，23，3： | 1 |
| 10 | Studies on anti-bacterial and anti-fungal activity of Cape Aloe 显示文摘 | SOEDA M OTOMO M OME M | 1996 | Nippon Saikingaku Zasshi1996，21，： | 1 |
| 11 | Association of oestrogen receptor alpha gene polymorphisms with postmenopausal bone loss,bone mass,and quantitative ultrasound properties of bone显示文摘 | Albagha OME Pettersson U Stewart A | 2005 | Med Genet2005，42，： | 1 |
| 12 | Decreased levels of BDNF protein in Alzheimer temporal cortex are independent of BDNF polymorphisms 显示文摘 | Lee J Fukumoto H Ome J | 2005 | Exp Neurol2005，194，1： | 1 |
| 13 | Emerging drugs for esophageal cancer显示文摘 | ome M Y Voest E E Siersema P D | 2009 | Expert Opin Emerging Drugs2009，14，2： | 1 |
| 14 | Intestinal Alkaline Phosphatase Prevents Antibiotic-Induced Susceptibility to Enteric Pathogens显示文摘 | Sayeda Nasrin Alam Halim Yammine Omeed Moaven Rizwan Ahmed Angela K. Moss Brishti Biswas Nur Muhammad Rakesh Biswas Atri Raychowdhury Kanakaraju Kaliannan Sathi Ghosh Madhury Ray Sulaiman R. Hamarneh Soumik Barua Nondita S. Malo Atul K. Bhan Madhu S. Malo | 2014 | Annals of Surgery2014，，4： | 1 |
| 15 | A mouse model of the recrudescence of latent tuberculosis in the elderly显示文摘 | Ome I M | 1988 | Am Rev Respir Dis1988，137，： | 1 |
| 16 | Atom transfer radical polymeriza- tion (ATRP) initiated by aryl diazonium salts: a new route for surface modification of muhiwalled car- bon nanotubes by tethered polymer chains 显示文摘 | Tarik Matrab J'er^ome Chancolon Martine Mayne L'hermite | 2006 | Physicochemistry Engine2006，28，： | 1 |
| 17 | Aide in decision-making:contribution to uncertainties in three-dimensional measurement显示文摘 | Jér^ome Bachmann Jean marc Linares Jean Michel Sprauel | 2004 | Precision Engineering2004，28，1： | 1 |
| 18 | Esmolol and anesthetic requirement for foss of responsiveness during propofal anesthesiaf显示文摘 | Ome R Lesfie K Umranikar A | 2002 | Anesth Anafg2002，94，1： | 1 |
| 19 | Studies on anti-bacterial and anti - fungal activity of Cape Aloe 显示文摘 | Soeda M Otomo M Ome M | 1966 | Nippon Saikingaku Zasshi1966，21，： | 1 |
| 20 | Implantable collamer posterior chamber intraocular lenses: a review of potential complications显示文摘 | Fernandes P Gonzdlez- MNj ome J M Madrid - Costa D | 2011 | J Refract Surg2011，27，10： | 1 |
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