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| 1 | 日粮中添加蛋氨酸锌对粤黄鸡繁殖性能和血浆中雌激素和孕酮水平的影响(英文)显示文摘将567只14周龄的粤黄母鸡分为7个组饲养于双层的种鸡笼中,各组饲以不同的日粮:Ⅰ)对照组,饲喂无外源添加锌和蛋氨酸的玉米-豆粕型基础日粮;Ⅱ)饲喂添加氧化锌的相同基础日粮;Ⅲ)饲喂添加蛋氨酸的相同基础日粮;Ⅳ)饲喂按N.R.C标准配制的基础日粮;Ⅴ)饲喂添加低剂量蛋氨酸锌的基础日粮;Ⅵ)饲喂添加中剂量蛋氨酸锌的基础日粮;Ⅶ)饲喂添加高剂量蛋氨酸锌的基础日粮.上述日粮中锌的水平分别为:30 09,70 09,30 09,70 09,78 69,97 19和134 20mg/kg.蛋氨酸的水平分别为:0 28%,0 28%,0 36%,0 36%,0 37%,0 38%和0 38%.实验表明:日粮中添加外源性的锌和蛋氨酸可影响母鸡的蛋质量、受精率、孵化率和血浆中孕酮和雌激素的水平,其中,锌水平分别为70 09,70 09和78 69mg/kg;蛋氨酸的水平分别为0 28%,0 36%和0 37%的第Ⅱ、第Ⅳ和第Ⅴ组,上述指标均显著高于对照组,但日粮中Zn和蛋氨酸的量高于78 69mg/kg和0 37%水平,对种鸡的受精率、孵化率、产蛋量以及血浆中孕酮和雌激素均无促进作用. | Naibi Sulaiman ABUBAKAR 傅伟龙 朱晓彤 | 2003 | 华南农业大学学报2003，24，2： | 12 |
| 2 | Transforming growth factor beta 1, a cytokine with regenerative functions显示文摘We review the biology and role of transforming growth factor beta 1(TGF-β1) in peripheral nerve injury and regeneration, as it relates to injuries to large nerve trunks(i.e., sciatic nerve, brachial plexus), which often leads to suboptimal functional recovery. Experimental studies have suggested that the reason for the lack of functional recovery resides in the lack of sufficient mature axons reaching their targets, which is a result of the loss of the growth-supportive environment provided by the Schwann cells in the distal stump of injured nerves. Using an established chronic nerve injury and delayed repair animal model that accurately mimics chronic nerve injuries in humans, we summarize our key findings as well as others to better understand the pathophysiology of poor functional recovery. We demonstrated that 6 month TGF-β1 treatment for chronic nerve injury significantly improved Schwann cell capacity to support axonal regeneration. When combined with forskolin, the effect was additive, as evidenced by a near doubling of regenerated axons proximal to the repair site. We showed that in vivo application of TGF-β1 and forskolin directly onto chronically injured nerves reactivated chronically denervated Schwann cells, induced their proliferation, and upregulated the expression of regeneration-associated proteins. The effect of TGF-β1 and forskolin on old nerve injuries is quite impressive and the treatment regiment appears to mediate a growth-supportive milieu in the injured peripheral nerves. In summary, TGF-β1 and forskolin treatment reactivates chronically denervated Schwann cells and could potentially be used to extend and prolong the regenerative responses to promote axonal regeneration. | Wale Sulaiman Doan H. Nguyen | 2016 | Neural Regeneration Research2016，11，10： | 9 |
| 3 | Recent Advances in Interface Engineering for Electrocatalytic CO_(2) Reduction Reaction显示文摘Electrocatalytic CO_(2) reduction reaction(CO_(2) RR) can store and transform the intermittent renewable energy in the form of chemical energy for industrial production of chemicals and fuels,which can dramatically reduce CO_(2) emission and contribute to carbon-neutral cycle. E cient electrocatalytic reduction of chemically inert CO_(2) is challenging from thermodynamic and kinetic points of view. Therefore,low-cost,highly e cient,and readily available electrocatalysts have been the focus for promoting the conversion of CO_(2). Very recently,interface engineering has been considered as a highly e ective strategy to modulate the electrocatalytic performance through electronic and/or structural modulation,regulations of electron/proton/mass/intermediates,and the control of local reactant concentration,thereby achieving desirable reaction pathway,inhibiting competing hydrogen generation,breaking binding-energy scaling relations of intermediates,and promoting CO_(2) mass transfer. In this review,we aim to provide a comprehensive overview of current developments in interface engineering for CO_(2) RR from both a theoretical and experimental stand-point,involving interfaces between metal and metal,metal and metal oxide,metal and nonmetal,metal oxide and metal oxide,organic molecules and inorganic materials,electrode and electrolyte,molecular catalysts and electrode,etc. Finally,the opportunities and challenges of interface engineering for CO_(2) RR are proposed. | Junjun Li Sulaiman Umar Abbas Haiqing Wang Zhicheng Zhang Wenping Hu | 2021 | Nano-Micro Letters2021，13，12： | 9 |
| 4 | Agrobacterium-Mediated Transformation of Rice: Constraints and Possible Solutions显示文摘Genetic transformation of rice(Oryza sativa L.) by introducing beneficial traits is now a central research instrument in plant physiology and a practical tool for plant improvement. Many approaches are verified for stable introduction of foreign genes into the plant genome. The review examined the different constraints that limit the success of rice genetic transformation via Agrobacterium-mediated approach and suggested possible solutions. Explant identification, gene transfer technique and construct to tailor the integration, transgene expression without collateral to genetic damage and transformant selection are among the technical challenges affecting the rice transformation. Despite the contests, Agrobacteriummediated transformation system has been a better option for producing transgenic rice varieties because of its exact T-DNA processing and simple integration of low copy-number transgene. This information is necessary for improving the transformation system for recalcitrant rice varieties. | Sulaiman MOHAMMED Azman Abd SAMAD Zaidah RAHMAT | 2019 | Rice science2019，26，3： | 6 |
| 5 | Antioxidants in aqueous extract of Myristica fragrans(Houtt.) suppress mitosis and cyclophosphamide-induced chromosomal aberrations in Allium cepa L.cells显示文摘In this study,freeze-dried water extract from the leaves of Myristica fragrans(Houtt.) was tested for mutagenic and antimutagenic potentials using the Allium cepa assay.Freeze-dried water extract alone and its combination with cyclophosphamide(CP)(50 mg/kg) were separately dissolved in tap water at 500,1000,2000,and 4000 mg/kg.Onions(A.cepa) were suspended in the solutions and controls for 48 h in the dark.Root tips were prepared for microscopic evaluation.2,2-Diphenyl-1-picrylhydrazyl(DPPH) free radicals' scavenging power of the extract was tested using butylated hydroxyanisole(BHA) and butylated hydroxytoluene(BHT) as standards.Water extract of Myristica fragrans scavenged free radicals better than BHA,but worse than BHT.The extract alone,as well as in combination with CP suppressed cell division,and induced chromosomal aberrations that were insignificantly different from the negative control(P≤0.05).However,cytotoxic and mutagenic actions of CP were considerably suppressed.The observed effects on cell division and chromosomes of A.cepa may be principally connected to the antioxidant properties of the extract.The obtained results suggest mitodepressive and antimutagenic potentials of water extract of the leaves of M.fragrans as desirable properties of a promising anticancer agent. | Akeem AKINBORO Kamaruzaman Bin MOHAMED Mohd Zaini ASMAWI Shaida Fariza SULAIMAN Othman Ahmad SOFIMAN | 2011 | Journal of Zhejiang University-Science B(Biomedicine & Biotechnology)2011，12，11： | 4 |
| 6 | Re-evaluating the role of epithelial-mesenchymal-transition in cancer progression显示文摘Epithelial-mesenchymal transition(EMT) and mesenchymal-epithelial transition(MET) are essential for embryonic development and also important in cancer progression. In a conventional model, epithelial-like cancer cells transit to mesenchymal-like tumor cells with great motility via EMT transcription factors; these mesenchymallike cells migrate through the circulation system, relocate to a suitable site and then convert back to an epithelial-like phenotype to regenerate the tumor. However, recent findings challenge this conventional model and support the existence of a stable hybrid epithelial/mesenchymal(E/M) tumor population. Hybrid E/M tumor cells exhibit both epithelial and mesenchymal properties, possess great metastatic and tumorigenic capacity and are associated with poorer patient prognosis. The hybrid E/M model and associated regulatory networks represent a conceptual change regarding tumor metastasis and organ colonization. It may lead to the development of novel treatment strategies to ultimately stop cancer progression and improve disease-free survival. | Andrew Sulaiman Zemin Yao Lisheng Wang | 2018 | The Journal of Biomedical Research2018，32，2： | 4 |
| 7 | Hepatitis B virus subgenotypes and basal core promoter mutations in Indonesia显示文摘AIM:To identify the distribution of hepatitis B virus (HBV) subgenotype and basal core promoter (BCP) mutations among patients with HBV-associated liver disease in Indonesia.METHODS: Patients with chronic hepatitis (CH, n=61), liver cirrhosis (LC, n=62), and hepatocellular carcinoma (HCC,n=48) were included in this study. HBV subgenotype was identified based on S or preS gene sequence, and mutations in the HBx gene including the overlapping BCP region were examined by direct sequencing.RESULTS: HBV genotype B (subgenotypes B2, B3, B4, B5 and B7) the major genotype in the samples, accounted for 75.4%, 71.0% and 75.0% of CH, LC and HCC patients, respectively, while the genotype C (subgenotypes C1, C2 and C3) was detected in 24.6%, 29.0%, and 25.0% of CH, LC, and HCC patients, respectively. Subgenotypes B3 (84.9%) and C1 (82.2%) were the main subgenotype in HBV genotype B and C, respectively. Serotype adw2 (84.9%) and adrq+ (89.4%) were the most prevalent in HBV genotype B and C, respectively. Double mutation (A1762T/G1764A) in the BCP was significantly higher in LC (59.7%) and HCC (54.2%) than in CH (19.7%), suggesting that this mutation was associated with severity of liver disease. The T1753V was also higher in LC (46.8%), but lower in HCC (22.9%) and CH (18.0%), suggesting that this mutation may be an indicator of cirrhosis.CONCLUSION: HBV genotype B/B3 and C/C1 are the major genotypes in Indonesia. Mutations in BCP, such as A1762T/G1764A and T1753V, might have an association with manifestations of liver disease. | Andi Utama Sigit Purwantomo Marlinang Diarta Siburian Rama Dhenni Rino Alvani Gani Irsan Hasan Andri Sanityoso Upik Anderiani Miskad Fardah Akil Irawan Yusuf Wenny Astuti Achwan Soewignjo Soemohardjo Syafruddin AR Lelosutan Ruswhandi Martamala Benyamin Lukito Unggul Budihusodo Laurentius Adrianus Lesmana Ali Sulaiman Susan Tai | 2009 | World Journal of Gastroenterology2009，15，32： | 4 |
| 8 | Effects of Heat Stress at Vegetative and Reproductive Stages on Spikelet Fertility显示文摘Seed-setting rate, yield components and grain quality traits of 169 accessions from an exotic rice germplasm were tested under high temperatures from 40 oC to 45 oC for 6 h during the daytime at the vegetative and reproductive stages, respectively. The results showed that heat stress significantly decreased the seed-setting rate of all the accessions, but the heat stress effects varied among accessions. Based on the decreases in seed-setting rate at high temperatures, N22 was the most tolerant, followed by AUS17, M9962, SONALEE and AUS16. Moreover, the reductions in seed-setting rate and yield under heat stress were more serious at the vegetative stage(45 d before heading) than at the booting stage(15 d before heading). In addition, heat stress also affected grain quality, especially by conferring chalkiness to most of the accessions, but SONALEE did not change much. The heat-tolerant accessions identified here and the phenotype protocols developed could be used in future genetic studies and breeding programmes focused on heat tolerance. | Sulaiman CHEABU Peerapon MOUNG-NGAM Siwaret ARIKIT Apichart VANAVICHIT Chanate MALUMPONG | 2018 | Rice science2018，25，4： | 4 |
| 9 | Screening for Spikelet Fertility and Validation of Heat Tolerance in a Large Rice Mutant Population显示文摘A total of 10 000 M4 individuals in Jao Hom Nil (JHN) mutant population was treated with high temperature (40 ℃ to 45 ℃) during the day time (6 h) from the booting to the harvesting stages, and ambient temperature (33 ℃ to 35℃) was used as the control. The results of screening and yield trials found that the mutant line M9962 had a high spikelet fertility of 78% under heat stress. In addition, the other mutant lines, including M3181 and M7988, had a spikelet fertility of approximately 70%. However, the JHN wild type, Sin Lek, RD15 and RD33 had very low spikelet fertility of 34%, 14%, 9% and 4%, respectively. The lower spikelet fertility at an elevated temperature resulted in a dramatic decrease of filled grain and contributed to a loss in 100-grain weight. M9962 is a potential genetic stock for use in a heat tolerance breeding programme. In addition, spikelet fertility at high temperature was representative of heat tolerance and can be used as a screening trait for heat tolerance during the reproductive phase on a large scale. | Sulaiman CHEABU Nat PANICHAWONG Prisana RATTANAMETTA Boonthong WASURI Poonpipope KASEMSAP Siwaret ARIKIT Apichart VANAVICHIT Chanate MALUMPONG | 2019 | Rice science2019，26，4： | 3 |
| 10 | Association of core promoter mutations of hepatitis B virus and viral load is different in HBeAg(+) and HBeAg(-) patients显示文摘AIM:To identify the prevalence of hepatitis B e antigen (HBeAg) and to assess the association of hepatitis B virus (HBV) core promoter mutations and viral load in Indonesian patients.METHODS:Sixty-four patients with chronic hepatitis,65 with liver cirrhosis and 50 with hepatocellular carcinoma were included in this study.HBeAg and hepatitis B e antibody (HBeAb) tests were performed using enzyme-linked immunosorbent assay and the mutations were analyzed by sequencing.Viral load was measured by real-time polymerase chain reaction.RESULTS:Of 179 patients,108 (60.3%) were HBeAg(-) and 86 (79.6%) of these HBeAg(-) patients had been seroconverted.The A1896 mutation was not found in HBeAg(+) patients,however,this mutation was detected in 70.7% of HBeAg(-) patients.This mutation was frequently found when HBeAg was not expressed (87.7%),compared to that found in HBeAg seroconverted patients (65.1%).The A1899 mutation was also more prevalent in HBeAg(-) than in HBeAg(+) patients (P=0.004).The T1762/A1764 mutation was frequently found in both HBeAg(+) and HBeAg(-) patients,however,the prevalence of this mutation did not significantly differ among the two groups (P=0.054).In HBeAg(+) patients,the T1762/A1764 mutation was correlated with lower HBV DNA (P < 0.001).The A1899 mutation did not correlate with HBV DNA (P=0.609).In HBeAg(-) patients,the T1762/A1764 mutation alone was not correlated with HBV DNA (P=0.095),however,the presence of either the T1762/A1764 or A1896 mutations was associated with increased HBV DNA (P < 0.001).CONCLUSION:The percentage of HBeAg(-) patients is high in Indonesia,and most of the HBeAg(-) patients had been seroconverted.The A1896 mutation was most likely the major cause of HBeAg loss.The T1762/A1764 mutation alone was associated with lower viral loads in HBeAg(+) patients,but not in HBeAg(-) patients. | Andi Utama Marlinang Diarta Siburian Sigit Purwantomo Mariana Destila Bayu Intan Tri Shinta Kurniasih Susan Tai Rino Alvani Gani Laurentius Adrianus Lesmana All Sulaiman Wenny Astuti Achwan Soewignjo Soemohardjo Arnelis Nasrul Zubir Julius Syafruddin AR Lelosutan Benyamin Lukito Tantoro Harmono | 2011 | World Journal of Gastroenterology2011，17，6： | 3 |
| 11 | Torque Characteristics of High Torque Density Partitioned PM Consequent Pole Flux Switching Machines With Flux Barriers显示文摘Unique double salient structure of Permanent Magnet Flux Switching Machines(PMFSM)with both Concentrated Armature inding(CAW)and Permanent Magnet(PM)on stator attract researcher's interest for high speed brushless application when high torque density(T den)and power density(P den)are the primal requirements.However,despite of stator leakage flux,high rare-earth PM usage,PMFSM is subjected to slot effects due to presence of both PM and CAW in stator and partial saturation due to double salient structure which generates cogging torque(T cog),torque ripples(Trip)and lower average torque(T avg).To overcomne aforesaid demerits,this paper presents Partitioned PM(PPM)Consequent Pole Flux Switching Machine(PPM-CPFSM)with flux barriers to enhance flux mnodulation,curtail PM usage and diminish stator leakage flux which reduces slotting effects and partial saturation to ultimately reduces T cog and Trip In comparison with the existing state of the art,proposed PPM-CPFSM reduces 46.5390 of the total PM volumne and offer Tavg higher up to 88.8%,suppress Trip naximun up to 24.8%,diminish Tcog up to 22.74%and offer 2.45 times Tden and Pden.Furthermore,torque characteristics of proposed PPM-CPFSM is investigated utilizing space harmonics injection i.e.inverse cosine,inverse cosine with 3rd harmonics and rotor pole shaping techniques i.e.,ecce ntric circle,chanfering and notching.Detailed electromagnetic perfornance analysis reveals that harmonics injection suppressed Tcog maximun up to 83.5%,Trip up to 40.72%at the cost of 4.71%Tavg.Finally,rotor mnechanical stress analysis is utilized for rotor withstand capability and 3D-FEA based Coupled Elctromagnetic Thermal Analysis(CETA)for thermal behavior of the developed PPM CPFSM.CETA reveals that open space along PPM act as cooling duct that inprove heat dissipation. | Wasiq Ullah Faisal Khan Erwan Sulaiman Muhammad Umair | 2020 | CES Transactions on Electrical Machines and Systems2020，4，2： | 3 |
| 12 | Adsorption of methylene blue on low-cost adsorbents: A review显示文摘 | Mohd. Rafatullah Othman Sulaiman Rokiah Hashim Anees Ahmad | 2009 | Journal of Hazardous Materials2009，，1： | 3 |
| 13 | Comparative Study on Growth Performance of Transgenic(Over-Expressed OsNHX1) and Wild-Type Nipponbare under Different Salinity Regimes显示文摘Transgenic Nipponbare which over-expressed a Na+/H+ antiporter gene OsNHX1 was used to compare its growth performance, water status and photosynthetic efficiency with its wild type under varying salinity regimes. Chlorophyll content, quantum yield and photosynthetic rate were measured to assess the impact of salinity stress on photosynthetic efficiency for transgenic and wild-type Nipponbare. Effects of salinity on water status and gas exchange to both lines were studied by measuring water use efficiency, instantaneous transpiration rate and stomatal conductance. Dry shoot weight and leaf area were determined after three months of growth to assess the impacts of salinity on the growth of those two lines. Our study showed that both lines were affected by salinity stress, however, the transgenic line showed higher photosynthetic efficiency, better utilization of water, and better growth due to low transpiration rate and stomatal conductance. Reduction of photosynthetic efficiency exhibited by the wild-type Nipponbare was correlated to its poor growth under salinity stress. | Nurul Kahrani ISHAK Zohrah SULAIMAN Kushan U.TENNAKOON | 2015 | Rice science2015，22，6： | 3 |
| 14 | A nationwide molecular epidemiological study on hepatitis B virus in Indonesia: identification of two novel subgenotypes, B8 and C7显示文摘 | Mulyanto Sulaiman Ngongu Depamede Kiely Surayah Fumio Tsuda Koji Ichiyama Masaharu Takahashi Hiroaki Okamoto | 2009 | Archives of Virology2009，，7： | 3 |
| 15 | Physical, Psychological, and Social Health Impact of Temperature Rise Due to Urban Heat Island Phenomenon and Its Associated Factors显示文摘The Urban Heat Island Effect(UHI)has now become a commonly observed phenomenon worldwide.Indeed,it has become a significant environmental effect of urbanisation.In Malaysia,research results showed that UHI effects are very evident in several cities such as Kuala Lumpur and Putrajaya[1,2].UHI effect has long been observed to cause temperature of cities.Temperature rise associated to UHI phenomenon may have | Li Ping WONG Haridah Alias Nasrin Aghamohammadi Sima Aghazadeh Nik Meriam Nik Sulaiman | 2018 | Biomedical and Environmental Sciences2018，31，7： | 3 |
| 16 | Correlation between the skull base fracture and the incidence of intracranial hemorrhage in patients w让h traumatic brain injury显示文摘Purpose:A head injury(HI)may cause a skull fracture,which may or may not be associated with injury to the brain.In essence,a skull base fracture(SBF)is a linear fracture at the base of the skull.Loss of consciousness and Glasgow coma score(GCS)may vary depending on an associated intracranial pathology.The pathomechanism is believed to be caused by high energy impact directly to the mastoid and supraorbital bone or indirectly from the cranial vault.Aim of this study is to define the correlation between SBF and intracranial hemorrhage(ICH)in patients with HI.Methods:Analysis of data obtained from a retrospective review of medical records and from a systematized database pertaining to diagnostic criteria of SBF patients based only on clinical symptoms associated with ICH caused by HI treated in the Department of Neurosurgery at Dr.Hasan Sadikin Hospital,Bandung,Indonesia from January 1,2012 to December 31,2017.The exclusion criteria in eluded age less than 15 years and no head computed tomography(CT)scan examination provided.Results:A total of 9006 patients were in eluded into this study in which they were divided into 3 groups:group 1,HI with no ICH;group 2,HI with single ICH and group 3,HI with multiple ICH.In all the SBF cases,SBF at anterior fossa accounted for 69.40%of them,which were mostly accompanied with mild HI(64.70%).Severity of HI and site of SBF correlated with the existence of traumatic brain lesions on CT scan,thus these factors were able to predict whether there were traumatic brain lesions or not.Most of the patients with epidural hemorrhage(EDH)has single traumatic lesion on CT scan,whereas most of the patients with cerebral contusion(CC)has multiple traumatic lesions on CT scan.On patients with both traumatic brain injury and SBF,most of the patients with anterior fossa SBF has EDH;whereas most of the patients with middle fossa SBF were accompanied with CC.Surgery was not required for most of the patients with SBF.Conclusion:SBFs were strongly correlated with traumatic ICH lesions patients with anterior fossa SBF were more likely to suffer EDH whereas with middle fossa SBF were more likely to suffer CC. | Ahmad Faried Danny Halim Ingrid Ayke Widjaya Rendy Febrian Badri Syailendra Fii Sulaiman Muhammad Z.Arifin | 2019 | Chinese Journal of Traumatology2019，22，5： | 3 |
| 17 | Control of a Two-wheeled Machine with Two-directions Handling Mechanism Using PID and PD-FLC Algorithms显示文摘This paper presents a novel five degrees of freedom (DOF) two-wheeled robotic machine (TWRM) that delivers solutions for both industrial and service robotic applications by enlarging the vehicle′s workspace and increasing its flexibility. Designing a two-wheeled robot with five degrees of freedom creates a high challenge for the control, therefore the modelling and design of such robot should be precise with a uniform distribution of mass over the robot and the actuators. By employing the Lagrangian modelling approach, the TWRM′s mathematical model is derived and simulated in Matlab/Simulink?. For stabilizing the system′s highly nonlinear model, two control approaches were developed and implemented: proportional-integral-derivative (PID) and fuzzy logic control (FLC) strategies. Considering multiple scenarios with different initial conditions, the proposed control strategies′ performance has been assessed. | Khaled M. Goher Sulaiman O. Fadlallah | 2019 | International Journal of Automation and computing2019，16，4： | 3 |
| 18 | Acid‐suppressive therapy is associated with spontaneous bacterial peritonitis in cirrhotic patients: A meta‐analysis显示文摘 | Abhishek Deshpande Vinay Pasupuleti Priyaleela Thota Chaitanya Pant Sulaiman Mapara Sohaib Hassan David D K Rolston Thomas J Sferra Adrian V Hernandez | 2013 | J Gastroenterol Hepatol2013，，2： | 3 |
| 19 | Study of the Effects of Water Level Depression in Euphrates River on the Water Quality显示文摘 | Ammar Harem Kamel Sadeq Oleiwi Sulaiman Ayad Sulaiby Mustaffa | 2013 | Journal of Civil Engineering and Architecture2013，7，2： | 3 |
| 20 | Hepatitis B virus pre-S2 start codon mutations in Indonesian liver disease patients显示文摘AIM: To identify the prevalence of pre-S2 start codon mutations and to assess their association with liver disease progression. METHODS: The mutations were identified by direct sequencing from 73 asymptomatic carriers, 66 chronic hepatitis (CH), 66 liver cirrhosis (LC) and 63 hepatocellular carcinoma (HCC) patients. Statistical significances were determined using Fisher's exact test, χ 2 test, and t -test analyses whenever appropriate. Pre-S mutation as a risk factor for advanced liver disease was estimated by unconditional logistic regression model adjusted with age, sex, and hepatitis B e antigen (HBeAg). P < 0.05 was considered significant. RESULTS: Mutation of the hepatitis B virus (HBV) pre-S2 start codon was found in 59 samples from 268 subjects (22.0%), with higher prevalence in patients with cirrhosis 27/66 (40.9%) followed by HCC 18/63 (28.6%), chronic hepatitis 12/66 (18.2%) and asymptomatic carriers 2/73 (2.7%) (P < 0.001). Logistic regression analysis showed that pre-S2 start codon mutation was an independent factor for progressive liver disease. Other mutations, at T130, Q132, and A138, were also associated with LC and HCC, although this was not statistically significant when adjusted for age, sex, and HBeAg. The prevalence of pre-S2 start codon mutation was higher in HBV/B than in HBV/C (23.0% vs 19.1%), whilst the prevalence of T130, Q132, and A138 mutation was higher in HBV/C than in HBV/B. The prevalence of pre-S2 start codon mutation was higher in LC (38.9%) and HCC (40.0%) than CH (5.6%) in HBeAg(+) group, but it was similar between CH, LC and HCC in HBeAg(-) group. CONCLUSION: Pre-S2 start codon mutation was higher in Indonesian patients compared to other Asian countries, and its prevalence was associated with advanced liver disease, particularly in HBeAg(+) patients. | Andi Utama Marlinang Diarta Siburian Ismail Fanany Mariana Destila Bayu Intan Rama Dhenni Tri Shinta Kurniasih Syafruddin AR Lelosutan Wenny Astuti Achwan Nasrul Zubir Arnelis Benyamin Lukito Irawan Yusuf Laurentius Adrianus Lesmana Ali Sulaiman | 2012 | World Journal of Gastroenterology2012，18，38： | 3 |
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